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Dietary supplement

Papaya Papain Enzyme 900 mg Ingredients & Drug Interactions

by NusaPure

Papaya Papain Enzyme 900 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Papain Enzyme 900 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Papain Enzyme 900 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papaya Papain Enzyme 900 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Papain Enzyme 900 mg by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Papain Enzyme 900 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: papain, an enzyme from papaya fruit that's dosed at 900 mg per capsule. The remaining ingredients are inactive — cellulose, silica, magnesium stearate, and rice flour — which serve as capsule material and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive enzyme support.
  • We looked for evidence on: Wound healing, Tonsillopharyngitis, Traumatic oral ulcers, Pressure ulcers, Venous leg ulcers, Diabetic foot ulcers — and 4 related terms.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Radiation dermatitis (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing, Venous leg ulcers, Diabetic foot ulcers, and more.

The evidence for papain isn't established in the data we hold. Effectiveness ratings for cancer, dental cavities, radiation skin damage, exercise muscle soreness, shingles, and intestinal parasites all show insufficient reliable evidence.

If you're considering this supplement for one of those reasons, talk with your pharmacist or doctor about what the current research actually supports.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as a food, but supplements can irritate your digestive tract and trigger allergic reactions in sensitive people. Short-term use at appropriate doses appears safe for most; however, high oral doses may be unsafe and can rarely cause serious problems like esophageal perforation or severe inflammation of the stomach lining.

Allergic reactions may include itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. If you're pregnant, concentrated papain and unripe papaya products are best avoided.

If you're breastfeeding, there isn't enough reliable safety information, so it's best to skip supplemental papain and talk with your doctor for personalized advice.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor if you take warfarin (Coumadin) or any other blood thinner — papain may increase its effects. For all other medications, no interactions are documented in our data for papain; still, run your complete list through the checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a single-ingredient papain supplement. If you take warfarin, you'll need to check with us or your doctor first — papain may strengthen its effect.

If you're pregnant or breastfeeding, talk with your pharmacist before starting. For anyone else, the main caution is allergic reactions in sensitive individuals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Papain Enzyme 900 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001WI7ZNF
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 307378
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Papain Enzyme 900 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
100
UPC/BARCODE
X001WI7ZNF
IngredientAmount% DV
Papain900 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Papaya Papain Enzyme 900 mg per serving

Papaya Papain Enzyme 3000 USP/mg

Formulation

Digestive enzyme support

GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Assembled in USA Tested Natural digestive enzyme support Supports healthy nutrient absorption Supports daily digestive health Max strength

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

General Statements

New

Please recycle.

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily with food, or as recommended by your healthcare practitioner.

Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in cool dry place. Avoid excessive heat or moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium quality Assembled in USA GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Manufactured in a cGMP inspected facility

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Papain Enzyme 900 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Papain Enzyme 900 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Papain Enzyme 900 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Papain

Interacts with
2 drugs
900 mg per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Papain Enzyme 900 mg by NusaPure Drug Interactions

Want to check YOUR meds against Papaya Papain Enzyme 900 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Papaya Papain Enzyme 900 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Papaya Papain Enzyme 900 mg interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Papain Enzyme 900 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Papain Enzyme 900 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Papaya Papain Enzyme 900 mg by NusaPure: Common Questions

Does Papaya Papain Enzyme 900 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Papaya Papain Enzyme 900 mg has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Papain Enzyme 900 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does papain do?
Papain is an enzyme from papaya. It's been studied for cancer, dental cavities, radiation skin damage, exercise muscle soreness, shingles, and intestinal parasites, but the evidence isn't strong enough yet to recommend it for any of those uses.
Can I take this if I'm pregnant?
No — concentrated papain and unripe papaya products are best avoided in pregnancy due to safety concerns. If you're thinking about it, talk with your doctor first.
Can I take this while breastfeeding?
There isn't enough reliable safety information, so it's best to avoid supplemental papain while breastfeeding. Talk with your pharmacist or doctor for personalized advice.
What side effects does papain have?
Most people tolerate it well at normal doses. Allergic reactions are the main concern — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. High doses may cause serious stomach or esophageal damage, though that's rare.
Is papain the only thing in this capsule?
Yes, papain is the only active ingredient. The capsule also contains cellulose, silica, magnesium stearate, and rice flour as inactive ingredients to hold it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papaya Papain Enzyme 900 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Papain Enzyme 900 mg label
Go deeper

The Full Monographs Behind Papaya Papain Enzyme 900 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papaya Papain Enzyme 900 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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