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Dietary supplement

Lion's Mane & BioPerine Ingredients & Drug Interactions

by NusaPure

Lion's Mane & BioPerine label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane & BioPerine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane & BioPerine is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane & BioPerine by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane & BioPerine by NusaPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane & BioPerine by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane extract, a compound derived from lion's mane mushroom. The capsules also contain inactive ingredients—cellulose, silica, magnesium stearate, and rice flour—which are fillers and binders that help form and stabilize the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for lion's mane extract isn't established yet. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment.

That doesn't mean it doesn't work—it means the studies aren't solid enough to say one way or the other. If you're considering it for one of these purposes, talk it over with your doctor to see if it's right for you.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane mushroom is generally well tolerated when used as a food. The most common side effects reported in studies were gastrointestinal discomfort, nausea, and skin rash.

However, long-term supplement safety hasn't been well studied, so we don't know what happens with extended use. Because there isn't enough safety data, the evidence advises against using lion's mane during pregnancy or while breastfeeding—talk with your doctor or pharmacist if you're in either situation and want to know your options.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes medications, or immunosuppressants. Lion's mane has moderate interactions with all three types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane extract may be worth considering if you're curious about cognitive or immune support, but the evidence for any specific benefit isn't strong enough yet to rely on. If you take blood thinners, diabetes medications, or drugs that suppress your immune system, you'll want to check with your doctor or pharmacist before starting—the interactions are real enough to matter.

For everyone else, the main caution is that long-term safety isn't well documented and some people experience stomach upset or nausea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane & BioPerine, straight from the product label.

Brand NusaPure
Barcode (UPC) X002WBJFTD
Net contents 120 Veg Cap(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274958
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane & BioPerine by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
X002WBJFTD
IngredientAmount% DV
Lion's Mane Extract1000 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two (2) capsules daily, preferably with a meal or as directed by a healthcare practitioner.

Precautions

Warning: For adults only.

Consult physician if pregnant, nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Not intended for use by persons under the age of 18.

Do not eat freshness packet. Keep in bottle.

Allergen Information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation ma occur in this product.

Made with non-GMO ingredients GMO free FDA registered facility gluten free

Assembled in USA Tested

Supports a healthy nervous system Supports immune system health

Max strength

Allergen Information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

Storage

Store in a cool, dry place after opening.

General Statements

Please recycle.

20,000mg per veggie caps - 120 veggie capsules New

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa Corporation.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA Gluten free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

Formula

Lion's Mane & BioPerine 1000 mg of a 20:1 extract per serving (20,000 mg equivalent)

30% Poylysaccharides & Beta Glucans

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane & BioPerine by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane & BioPerine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane & BioPerine by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lion's Mane Extract

Interacts with
327 drugs
1000 mg per serving Form: Beta Glucans, Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane & BioPerine by NusaPure Drug Interactions

Want to check YOUR meds against Lion's Mane & BioPerine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane & BioPerine interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane & BioPerine interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane & BioPerine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane & BioPerine, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

Lion's Mane & BioPerine by NusaPure: Common Questions

Does Lion's Mane & BioPerine by NusaPure interact with any medications?
Yes. Based on its ingredients, Lion's Mane & BioPerine has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane & BioPerine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lion's mane extract, and what's it supposed to do?
Lion's mane extract comes from the lion's mane mushroom. It's been studied for potential effects on brain health, anxiety, athletic performance, and immune function, but right now the evidence isn't strong enough to say it actually works for any of those. People take it hoping for cognitive or immune benefits, but we don't have reliable proof yet.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it—there isn't enough information to know either way. Talk with your doctor or pharmacist about your specific situation; they can help you decide whether it's right for you.
What are the most common side effects?
Gastrointestinal discomfort, nausea, and skin rash are the main ones people report. Most people tolerate it well, but some do experience stomach upset.
Does this product have any fillers?
Yes—the inactive ingredients are cellulose, silica, magnesium stearate, and rice flour. These help stabilize and form the capsule.
Why does the label mention BioPerine if this product has only one active ingredient?
Our product facts only cover the lion's mane extract. BioPerine is mentioned on the label, but we don't have detailed interaction or safety data on file for it—you may want to ask the manufacturer directly about its role and any effects it might have.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane & BioPerine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane & BioPerine label
Go deeper

The Full Monographs Behind Lion's Mane & BioPerine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane & BioPerine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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