Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

SignaLean Plus Ingredients & Drug Interactions

by Purity Products

SignaLean Plus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SignaLean Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SignaLean Plus is a dietary supplement by Purity Products with 3 active ingredients. Its ingredients are commonly taken for digestive complaints and heartburn, minor skin irritation or burns (topical folk use), joint or muscle aches (traditional poultice).Based on those ingredients, 7 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potato Protein extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SignaLean Plus by Purity Products

Ask about any prescription or over-the-counter medication and we check it for interactions with SignaLean Plus by Purity Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SignaLean Plus by Purity Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Phytosterols” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Total phytosterols minimum 95% (400 mg) with Typical Profile” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

SignaLean Plus contains 7 active ingredients, most of them plant sterols (phytosterols) — compounds found naturally in plant sources that may help manage cholesterol. The core of the formula is a phytosterol blend providing at least 400 mg total, made up of beta-sitosterol, sitostanol, and three others: campesterol, stigmasterol, and brassicasterol.

It also includes potato protein extract and an ingredient called CardioAid. The tablet is made with inactive ingredients like dicalcium phosphate, vegetable stearine, croscarmellose sodium, magnesium stearate, and an aqueous film coating — these are fillers, binders, and the tablet shell.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy weight and cholesterol levels.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Familial hypercholesterolemia, Hypertension, Myocardial infarction (MI), Obesity — and 4 related terms.
  • The strongest evidence on file: Sitostanol is rated "Possibly Effective" for Familial hypercholesterolemia (Natural Medicines).
  • Also on file: Beta-sitosterol is rated "Possibly Effective" for Coronary heart disease (CHD), Familial hypercholesterolemia.
  • Also on file: Potato is rated "Possibly Ineffective" for Myocardial infarction (MI), Stroke.

Beta-sitosterol in this product is likely effective for benign prostatic hyperplasia (BPH, or prostate enlargement), and possibly effective for familial hypercholesterolemia (inherited high cholesterol) and coronary heart disease. Sitostanol is possibly effective for familial hypercholesterolemia as well.

The potato protein extract, however, is rated possibly ineffective for colorectal cancer, heart attack, stroke, and overall mortality — meaning the evidence doesn't support using it for those purposes. We don't have effectiveness data on file for campesterol, stigmasterol, brassicasterol, or CardioAid.

The evidence, ingredient by ingredient Potato

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-sitosterol is generally well tolerated in the short term, though you should check with your healthcare provider before starting. The most common side effects are constipation, diarrhea, gas, indigestion, and nausea.

There's also a case report of acute pancreatitis in one person, though symptoms didn't return when he stopped. Sitostanol is well tolerated; no adverse effects were reported in clinical trials, though it may theoretically cause diarrhea or excess fat in the stool because it reduces cholesterol absorption.

Potato protein extract is rated likely safe as food (cooked, whole potatoes), but the concentrated extract in this supplement hasn't been well studied in pregnancy or while breastfeeding — the safety data advises against medicinal potato use in those settings. Raw, green, or sprouted potatoes contain natural toxins (glycoalkaloids) that are not destroyed by cooking and can cause serious poisoning.

Potato juice has been linked to heartburn, abdominal bloating, diarrhea, and excess mucus production.

Side effects, ingredient by ingredient Potato

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Potato.
  • The most serious interaction on file is rated Moderate.
  • For scale: 7 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SignaLean Plus, double-check with your pharmacist or doctor if you take thrombolytic drugs (clot busters used after heart attack or stroke) or succinylcholine (a muscle relaxant used during anesthesia). Potato protein extract in this product can enhance or prolong the effects of both, which may increase bleeding risk or slow your recovery from surgery.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

SignaLean Plus is mainly a plant sterol blend aimed at cholesterol and prostate health; beta-sitosterol is well studied for those uses. The chief concern is the potato protein extract and its interactions with blood clot medications and surgical anesthetics.

If you take any prescription drugs, especially thrombolytics or are having surgery soon, check your medications against this product's ingredients with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SignaLean Plus, straight from the product label.

Brand Purity Products
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 13470
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Approved Health
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SignaLean Plus by Purity Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
IngredientAmount% DV
Phytosterols400 mg--
Campesterol126.3 mg--
Potato Protein extract15 mg--
CardioAid421 mg--
Total phytosterols minimum 95% (400 mg) with Typical Profile400 mg--
B-Sitosterol244.18 mg--
Stigmasterol92.62 mg--
Brassicasterol25.26 mg--
Sitostanol21.05 mg--

Other ingredients: Dicalcium Phosphate, Vegetable Stearine, Croscarmellose Sodium, Magnesium Stearate, Aqueous Film Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

**If you have high cholesterol or are taking prescription medication to control your cholesterol, please consult your health care professional before taking this product.**

Formulation

This product contains no milk, eggs, wheat, tree nuts, fish, shellfish or gluten.

General Statements

For weight management, results will vary with each individual. Weight loss will likely not exceed 1-2 pounds per week and must be part of a reduced calorie diet in conjunction with regular exercise. +Dietary supplements containing at least 400 mg per serving of plant sterols, taken twice a day with meals for a total of at least 800 mg, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease

30 day supply

Suggested/Recommended/Usage/Directions

SUGGESTED USE: * As a dietary supplement, adults take 1 tablet twice daily preferably 30 to 60 minutes prior to your two largest meals.

Formula

Contains: soybean

Brand IP Statement(s)

EVIDENCE-BASED NUTRITIONAL SUPPLEMENTS(TM)

SignaLEAN Plus(R) Naturally Manages Appetite and Hunger* Supports Healthy Cholesterol Levels Supports Healthy Body Weight* SignLEAN PLUS(R) - One Pill. Two Great Benefits.

For people who want to take control of both their weight and their cholesterol, SignaLEAN Plus(R) is Purity's next-generation evidence-based solution. SignaLEAN Plus features two proven active ingredients to help support both healthy weight management* and cholesterol levels.* The patented active weight management ingredient in SignaLEAN Plus(R), P12, is a unique protein derivative found only in potatoes. Clinical studies reveal that P12 molecules help set in motion the process by which a chemical signal is sent from the stomach to the brain, telling you that it's time to stop eating. This can help you feel full faster and stay satisfied longer.* The active cholesterol management ingredient in SignaLEAN Plus(R) is plant sterols. Plant Sterols are clinically proven to support healthy cholesterol levels and may help reduce your risk of heart disease. + Supporting healthy cholesterol levels goes hand in hand with any sensible weight management plan, which is why SignaLEAN Plus(R) is the ideal supplement for dieters. SignaLEAN Plus(R): -Naturally Manages Appetite and Hunger* -Supports Natural Cholesterol Levels+ -Supports Healthy Body Weight* -100% Natural Patented Extract

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SignaLean Plus by Purity Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SignaLean Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SignaLean Plus by Purity Products

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phytosterols

400 mg per serving
  • › CardioAid
  • › Total phytosterols minimum 95% (400 mg) with Typical Profile

Potato Protein extract

Interacts with
7 drugs
15 mg per serving Form: Proteinase Inhibitors

Potato is a common food, and as a supplement it is mostly used in folk remedies such as raw potato juice for stomach upset or as a topical poultice. S...

Potato Protein extract monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Vegetable Stearine, Croscarmellose Sodium, Magnesium Stearate, Aqueous Film Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

SignaLean Plus by Purity Products Drug Interactions

Want to check YOUR meds against SignaLean Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
7Drugs
7 Moderate

Ingredients driving the most interactions

Potato Protein extract 7

Individual Drug Interactions

The ingredients in SignaLean Plus interact with 7 drugs. Click any drug to see the details.

1 of the 3 ingredients in SignaLean Plus interact with drugs. Each result below shows which ingredient is responsible. Potato Protein extract

Each ingredient & the kinds of drugs it affects

For each ingredient in SignaLean Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potato Protein extract2 drug types · 7 drugs

Succinylcholine

In humans, consuming potatoes prior to preoperative fasting prolongs the duration of the succinylcholine-induced neuromuscular block and slows recovery from anesthesia. This interaction is possibly related to inhibition of the butyrylcholinesterase enzyme by potato glycoalkaloids.

Likelihood Probable Evidence B
Thrombolytic Drugs

Theoretically, concomitant use of potato may enhance the effects of thrombolytic drugs. A carboxypeptidase inhibitor isolated from potato tubers may have inhibitory effects on thrombin-activatable thrombolysis inhibitor, and thereby enhance the activity of thrombolytic agents.

Likelihood Possible Evidence D
Potato Protein extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SignaLean Plus, from the product label.

Purity Products

See all Purity Products products
Phone Number
1-800-256-6102
Pharmacist Counseling Corner

SignaLean Plus by Purity Products: Common Questions

Does SignaLean Plus by Purity Products interact with any medications?
Yes. Based on its ingredients, SignaLean Plus has a known interaction with 7 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SignaLean Plus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol?
The plant sterols in this product — especially beta-sitosterol — are possibly effective for inherited high cholesterol and possibly effective for coronary heart disease. If that's why you're considering it, there's evidence behind it, but talk with your doctor about whether it fits your specific situation.
Can I take this if I'm pregnant or breastfeeding?
Beta-sitosterol and sitostanol don't have enough safety data in pregnancy or breastfeeding, so it's best to avoid them in those settings. The potato protein extract is also not well studied at medicinal doses during pregnancy or breastfeeding. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or nursing.
What side effects might I get?
The most common are constipation, diarrhea, gas, indigestion, and nausea from the plant sterols. Potato protein extract can cause heartburn, bloating, diarrhea, and extra mucus production. One person had acute pancreatitis, though it went away when he stopped — a rare event, but worth knowing about.
Does this work for an enlarged prostate?
Beta-sitosterol in the blend is likely effective for benign prostatic hyperplasia. If that's what you're treating, there's solid evidence here. Check with your doctor to make sure it's right for your situation.
I'm having surgery soon — is this safe to take?
The potato protein extract can prolong the effects of succinylcholine, a muscle relaxant used during anesthesia, and may slow your recovery. Tell your anesthesiologist and surgeon that you're taking this product before your procedure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SignaLean Plus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SignaLean Plus label
Go deeper

The Full Monographs Behind SignaLean Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potato

Interacts with 7 drugs

Potato is a common food, and as a supplement it is mostly used in folk remedies such as raw potato juice for stomach upset or as a topical poultice. Solid scientific evidence for these uses...

Read the full Potato monograph →
Sources

Sources & How We Checked

SignaLean Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 48 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potato 15 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Klement P, Liao P, Bajzar L. A novel approach to arterial thrombolysis. Blood 1999;94:2735-43. DOI
  3. Redlitz A, Nicolini FA, Malycky JL, et al. Inducible carboxypeptidase activity. A role in clot lysis in vivo. Circulation 1996;93:1328-30. PubMed
  4. Larsson SC, Wolk A. Potato consumption and risk of cardiovascular disease: 2 prospective cohort studies. Am J Clin Nutr. 2016;104(5):1245-1252. PubMed
  5. Vinson JA, Demkosky CA, Navarre DA, Smyda MA. High-antioxidant potatoes: acute in vivo antioxidant source and hypotensive agent in humans after supplementation to hypertensive subjects. J Agric Food Chem. 2012;60(27):6749-54. PubMed
  6. Bestas A, Goksu H, Erhan OL. The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia. J Clin Monit Comput. 2013;27(6):609-12. PubMed
  7. Chrubasik S, Chrubasik C, Torda T, Madisch A. Efficacy and tolerability of potato juice in dyspeptic patients: a pilot study. Phytomedicine. 2006;13(1-2):11-5. PubMed
  8. Mensinga TT, Sips AJ, Rompelberg CJ, et al. Potato glycoalkaloids and adverse effects in humans: an ascending dose study. Regul Toxicol Pharmacol. 2005;41(1):66-72. PubMed
  9. Darooghegi Mofrad M, Milajerdi A, Sheikhi A, Azadbakht L. Potato consumption and risk of all cause, cancer and cardiovascular mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2020;60(7): PubMed
  10. Elefterova-Florova EV, Popova DN, Andreeva RV. An unusual and rare case of food-dependent exercise-induced anaphylaxis caused by ingestion of potatoes. Folia Med (Plovdiv). 2018;60(3):479-82. PubMed
  11. Schwingshackl L, Schwedhelm C, Hoffmann G, Boeing H. Potatoes and risk of chronic disease: a systematic review and dose-response meta-analysis. Eur J Nutr. 2019;58(6):2243-51. PubMed
  12. Tsang C, Smail NF, Almoosawi S, McDougall GJM, Al-Dujaili EAS. Antioxidant rich potato improves arterial stiffness in healthy adults. Plant Foods Hum Nutr. 2018;73(3):203-8. PubMed
  13. Stone MS, Martin BR, Weaver CM. Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults. Nutrients 2021;13( PubMed
  14. Darooghegi Mofrad M, Mozaffari H, Askari MR, et al. Potato Consumption and Risk of Site-Specific Cancers in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. Adv Nutr. 2021 Oct 1;12(5):1705-22. PubMed
  15. Yiannakou I, Pickering RT, Yuan M, Singer MR, Moore LL. Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults. J Nutr Sci. 2022 Sep 2;11:e73. PubMed

See these in context on the Potato monograph →

Beta-sitosterol 7 references
  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

See these in context on the Beta-sitosterol monograph →

Sitostanol 26 references
  1. Vuorio AF, Gylling H, Turtola H, et al. Stanol ester margarine alone and with simvastatin lowers serum cholesterol in families with familial hypercholesterolemia caused by the FH-north karelia mutation. Arterioscler Thromb Vasc Biol 2000;20:500-6. PubMed
  2. Becker M, Staab D, Von Bergmann K. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J Pediatr 1993;122:292-6. PubMed
  3. Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-43. PubMed
  4. Gylling H, Miettinen TA. Cholesterol reduction by different plant stanol mixtures and with variable fat intake. Metabolism 1999;48:575-80. PubMed
  5. Gylling H, Puska P, Vartiainen E, et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. J Lipid Res 1999;40:593-600. DOI
  6. Gylling H, Radhakrishnan R, Miettinen TA. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol. Circulation 199 PubMed
  7. Gylling H, Miettinen TA. Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment. Diabetologia 1994;37:773-80. DOI
  8. Gylling H, Miettinen TA. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. J Lipid Res 1996;37:1776-85. DOI
  9. Gylling H, Puska P, Vartiainen E, et al. Retinol, vitamin D, carotenes and alpha-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine. Am J Cardiol 1999;145:279-85.
  10. Hallikainen MA, Uusitupa MI. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am J Clin Nutr 1999;69:403-10. PubMed
  11. Heinemann T, Kullak-Ublick GA, Pietruck B, von Bergmann K. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol 1991;40 Suppl 1:S59-63. DOI
  12. Jones PJ, Ntanios FY, Raeini-Sarjaz M, et al. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 1999;69:1144-50. PubMed
  13. Gylling H, Siimes MA, Miettinen TA. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J Lipid Res 1995;36:1807-12. DOI
  14. Miettinen TA, Puska P, Gylling H, et al. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995;333(20):1308-12. PubMed
  15. Vanhanen HT, Kajander J, Lehtovirta H. Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin Sci (Colch) 1994;87:61-7. PubMed
  16. Plat J, van Onselen EN, van Heugten MM, Mensink RP. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000;54:671-7. PubMed
  17. Hallikainen MA, Sarkkinen ES, Uusitupa MI. Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations. Eur J Clin Nutr 1999;53:966-9. PubMed
  18. Hallikainen MA, Sarkkinen ES, Gylling H, et al. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr PubMed
  19. Williams CL, Bollella MC, Strobino BA, et al. Plant stanol ester and bran fiber in childhood: effects on lipids, stool weight and stool frequency in preschool children. J Am Coll Nutr 1999;18:572-81. PubMed
  20. Tammi A, Ronnemaa T, Gylling H, et al. Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: the STRIP project. Spec Turku Coronary Risk Factors Intervention Project. J Pediatr 2000;1 DOI
  21. Mensink RP, de Jong A, Lütjohann D, Haenen GR, Plat J. Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. Am J Clin Nutr. 2010 Jul;92(1): PubMed
  22. Vásquez-Trespalacios EM, Romero-Palacio J. Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NC
  23. Malhotra A, Shafiq N, Arora A, Singh M, Kumar R, Malhotra S. Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia. Cochrane Database Syst Rev. 2014 Jun 10;6:CD001918. PubMed
  24. Hallikainen M, Kurl S, Laakso M, Miettinen TA, Gylling H. Plant stanol esters lower LDL cholesterol level in statin-treated subjects with type 1 diabetes by interfering the absorption and synthesis of cholesterol. Atherosclerosis. 2011 Aug;217(2):473-8. PubMed
  25. Wang S, Zhao W, Li J, et al. Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study. Nutr Cancer 2022;74(10):3582-3591. PubMed
  26. Guo P, Feng R, Li Z, Han T. Gender differences in the relationships between dietary phytosterols intake and prevalence of obesity in Chinese population. Food Sci Nutr 2022;11(1):569-577. PubMed

See these in context on the Sitostanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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