Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Similase BV Ingredients & Drug Interactions

by Integrative Therapeutics

Similase BV label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Similase BV against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Similase BV is a dietary supplement by Integrative Therapeutics with 8 active ingredients. Its ingredients are commonly taken for improving mineral absorption, breaking down phytic acid (phytate) in grains and legumes, supporting digestion of plant-based foods.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Protease I, II, III, IV. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Similase BV by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Similase BV by Integrative Therapeutics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Similase BV by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Microbial Enzymes” is listed as a grouped ingredient — the label gives one combined amount (633 mg) without saying how much of each component you get.

Similase BV contains 8 active ingredients, all digestive enzymes designed to break down different food components. Amylase breaks down carbohydrates, Lipase handles fats, and Protease I through IV (papain-based) digest proteins.

Alpha-Galactosidase, Sucrase, and Lactase tackle specific sugars—including the milk sugar lactose—while Phytase helps break down compounds in plant foods. The formula also includes a blend of Microbial Enzymes (from beneficial microorganisms) to round out the digestive support.

The capsule itself is plant-derived, and the inactive ingredients are Ascorbyl Palmitate (a vitamin C form) and Cellulose (a plant fiber used as filler).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Pancreatic insufficiency, Fat malabsorption, Bloating and gas.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence on these enzymes is limited. Lactase has solid support for lactose intolerance—it's rated Effective for that use.

For the other ingredients, the data we hold shows Insufficient Reliable Evidence To Rate them for conditions like inflammatory bowel disease, indigestion, exercise muscle soreness, or parasitic infections. Most digestive enzymes in this product haven't been studied enough in supplement form to make a clear claim about how well they work.

The evidence, ingredient by ingredient Phytase Lipase Lactase Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase and Lactase are generally well tolerated when used as directed. Phytase is considered low-risk in foods, but human supplement data are limited, so talk with your doctor before relying on it.

Protease (papain) is usually tolerated short-term at normal doses but can cause allergic reactions in sensitive people—including itchy eyes, sneezing, or stomach cramps. High doses of papain may be unsafe and could cause severe stomach irritation or esophageal damage.

In rare cases, occupational exposure to airborne papain powder has triggered asthma and other respiratory reactions. Lipase and Protease both carry cautions in pregnancy.

Papain is listed as Possibly Unsafe in pregnancy due to safety concerns with concentrated forms and unripe papaya products. For Lactase, the data suggest it's Likely Safe in pregnancy, but there isn't enough information on the other enzymes during pregnancy or breastfeeding, so check with your doctor before regular use if you're pregnant or nursing.

Side effects, ingredient by ingredient Phytase Lipase Lactase Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Warfarin (Coumadin)—a blood thinner—is the main medication to double-check. Papain in this product may increase warfarin's effects, raising your bleeding risk.

Although we could not check Amylase, Alpha-Galactosidase, and Sucrase for interactions, you should still review your complete medication list with your own doctor or pharmacist before taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Similase BV is a broad-spectrum digestive enzyme blend—useful if you have trouble digesting certain foods, especially lactose. If you take warfarin, you must discuss this product with your doctor or pharmacist before starting, since papain may strengthen its blood-thinning effects.

People with serious digestive conditions should also check with their healthcare provider first. Run your medications through the tool on this page to make sure nothing else in your regimen flags a concern.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Similase BV, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791000902
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251250
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Similase BV by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
871791000902
IngredientAmount% DV
Amylase0 NP--
Alpha-Galactosidase0 NP--
Phytase0 NP--
Lipase0 NP--
Sucrase0 NP--
Lactase0 NP--
Cellulase0 NP--
Microbial Enzymes633 mg--
Protease I, II, III, IV0 NP--

Other ingredients: plant-derived Capsule, Ascorbyl Palmitate, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information, please visit integrativepro.com

Precautions

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Caution: If you are pregnant, nursing, have diabetes, or if you are taking prescription drugs, consult your healthcare professional before use.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Seals/Symbols

Vegan Quality global sourcing Bottle & tested in the USA

Formulation

Vegan

Contains no salt, dairy, or artificial colors, or flavors.

Brand IP Statement(s)

Copyright 2021 Integrative Therapeutics, LLC

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Bean and vegetable digestive enzymes

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 or 2 capsules at the beginning of each meal, or as recommended by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Similase BV by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Similase BV label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Similase BV by Integrative Therapeutics

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Microbial Enzymes

633 mg per serving

Other (inactive) ingredients: Plant-derived Capsule, Ascorbyl Palmitate, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Similase BV by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Similase BV?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Protease I, II, III, IV 2

Individual Drug Interactions

The ingredients in Similase BV interact with 2 drugs. Click any drug to see the details.

1 of the 8 ingredients in Similase BV interact with drugs. Each result below shows which ingredient is responsible. Protease I, II, III, IV

Each ingredient & the kinds of drugs it affects

For each ingredient in Similase BV with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Protease I, II, III, IV1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Protease I, II, III, IV full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Similase BV, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800.931.1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Similase BV by Integrative Therapeutics: Common Questions

Does Similase BV by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Similase BV has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Similase BV contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with bloating and gas?
Similase BV is designed to break down foods your stomach might struggle with—carbs, fats, proteins, and dairy sugars—so it may help reduce bloating and gas if poor digestion is the cause. But the evidence is limited. If bloating persists or gets worse, talk with your doctor to rule out other causes.
Is it safe to take while pregnant?
Most of these enzymes don't have enough safety data in pregnancy to say for sure. Papain (the protease ingredient) is flagged as Possibly Unsafe, especially in concentrated forms. Talk with your doctor or pharmacist before taking Similase BV if you're pregnant—they can weigh the benefits and risks for your situation.
Can I take this if I'm breastfeeding?
Safety data during breastfeeding is limited for most of these enzymes. Lipase and Protease both carry cautions because not enough is known. Check with your doctor or pharmacist first to make sure it's okay for you and your baby.
What does lactase do?
Lactase breaks down lactose, the natural sugar in milk and dairy products. If you're lactose intolerant—meaning you have trouble digesting dairy—this enzyme can help your body process it. That's the one ingredient in this formula with solid evidence of effectiveness.
Can I take this with my other supplements?
We have no documented interactions between these enzymes and other supplements in our data, but we couldn't check all the ingredients here. Use the medication and supplement checker on this page with your complete list, or ask your pharmacist—they know your full regimen.
Are there any fillers in this?
The capsule is plant-derived, and the inactive ingredients are Ascorbyl Palmitate (a form of vitamin C) and Cellulose (a plant-based filler). So yes, there are inactive ingredients, but they're minimal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Similase BV is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Similase BV label
Go deeper

The Full Monographs Behind Similase BV’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Similase BV's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team