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Dietary supplement

Sinutol EM Ingredients & Drug Interactions

by EuroMedica

Sinutol EM label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sinutol EM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sinutol EM is a dietary supplement by EuroMedica with 2 active ingredients. Its ingredients are commonly taken for cough and chest congestion, colds and flu symptoms, stuffy nose.Based on those ingredients, 878 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eucalyptus (Eucalyptus radiata) leaf oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sinutol EM by EuroMedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Sinutol EM by EuroMedica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sinutol EM by EuroMedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Complex {Herb/Botanical}” is a proprietary blend — the label gives one combined amount (320 mg) without saying how much of each component you get.

Sinutol EM contains 2 active ingredients: eucalyptus leaf oil and myrtle leaf oil, both supplied as essential oils in a softgel capsule. The inactive ingredients are extra virgin olive oil, gelatin, glycerol, and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports sinus cavities and soothes mucous membranes.
  • We looked for evidence on: Rhinosinusitis, Cough, Respiratory tract infections, sinus congestion, nasal congestion, mucous membrane health.
  • The closest evidence on file: Myrtle is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Eucalyptus is rated "Insufficient Reliable Evidence To Rate" for Cough, Rhinosinusitis.

The evidence we hold for eucalyptus covers acne, bronchitis, asthma, burns, and cancer — all rated as insufficient reliable evidence to rate its effectiveness for any of these. Similarly, myrtle leaf oil is rated insufficient reliable evidence to rate for acne, bacterial vaginosis, respiratory tract infections, diarrhea, reflux, and gingivitis.

The data we have does not establish effectiveness for either ingredient in this product.

The evidence, ingredient by ingredient Eucalyptus Myrtle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eucalyptus leaf oil in diluted form is generally well tolerated, but the undiluted oil can be toxic if swallowed — toxicity signs including nervous system depression, shallow breathing, and in rare cases seizures or coma have been reported. The most common side effects from oral use are diarrhea, nausea, and vomiting; topical use may cause burning, itching, or redness.

A case of worsening asthma and sinus symptoms linked to eucalyptus consumption has been reported. Myrtle leaf oil has limited safety data overall; topically it is generally well tolerated but may cause dry skin.

Orally, very large amounts of undiluted myrtle oil theoretically could cause respiratory failure. During pregnancy, eucalyptus is rated likely safe, but myrtle is rated likely unsafe — the data advises against myrtle in pregnancy.

For breastfeeding, eucalyptus safety data is not established, and myrtle safety is unknown; discuss with your doctor or pharmacist before using while nursing.

Side effects, ingredient by ingredient Eucalyptus Myrtle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eucalyptus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 879 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Sinutol EM, check with your doctor or pharmacist if you take any of the following: blood sugar medications (risk of low blood sugar); drugs processed through your liver's CYP1A2, CYP2C19, CYP2C9, or CYP3A4 pathways (levels may rise); amphetamines; or pentobarbital. All interactions are rated Moderate and are based on laboratory evidence rather than confirmed human cases.

No interactions are documented for myrtle.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Sinutol EM is a combination of two essential oils with limited established effectiveness and several theoretical drug interactions tied to eucalyptus. If you take diabetes, heart, mood, or blood pressure medications, or any drug your liver processes heavily, you'll want to double-check this product with your own doctor or pharmacist before starting.

Pregnant women should avoid myrtle in particular. Talk it over with your healthcare provider to see if this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sinutol EM, straight from the product label.

Brand EuroMedica
Barcode (UPC) 367703810030
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 52986
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sinutol EM by EuroMedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
15
UPC/BARCODE
367703810030
IngredientAmount% DV
Eucalyptus (Eucalyptus radiata) leaf oil0 NP--
Myrtle (Myrtus communis cineole) leaf oil0 NP--
Proprietary Complex {Herb/Botanical}320 mg--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommendations: 1 to 2 softgels three times daily, or as recommended by your healthcare practitioner.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

FDA Disclaimer Statement

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

JC 34 91 + 3(5,6)EM L81003.06

General Statements

Supports Sinus Cavities and Soothes Mucous Membranes*

Product of Belgium

Eucalyptus has long been studied and shown to support sinus and bronchial health.

FDA Statement of Identity

Dietary Supplement

Formulation

No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.

Non-GMO

Brand IP Statement(s)

Sinutol EM supports sinus cilia activity for healthy mucus drainage.

Formula

This unique combination of eucalyptus oil and myrtle oil provides soothing relief for all respiratory functions, without drowsiness.*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sinutol EM by EuroMedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sinutol EM label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sinutol EM by EuroMedica

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Complex {Herb/Botanical}

320 mg per serving

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sinutol EM by EuroMedica Drug Interactions

Want to check YOUR meds against Sinutol EM?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
878Drugs
878 Moderate

Ingredients driving the most interactions

Eucalyptus (Eucalyptus radiata) leaf oil 878

Individual Drug Interactions

The ingredients in Sinutol EM interact with 878 drugs. Click any drug to see the details.

1 of the 2 ingredients in Sinutol EM interact with drugs. Each result below shows which ingredient is responsible. Eucalyptus (Eucalyptus radiata) leaf oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Sinutol EM with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Eucalyptus (Eucalyptus radiata) leaf oil7 drug types · 878 drugs

Amphetamines

Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.
Animal research suggests that inhaling eucalyptol may reduce the levels of amphetamines in the blood.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Animal research suggests that eucalyptus leaf might have hypoglycemic activity, and might have additive effects when used with antidiabetes drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP1A2, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, inhaling eucalyptol might reduce the effectiveness of pentobarbital.
Animal research suggests that inhaling eucalyptol reduces the level of pentobarbital that reaches the brain.

Likelihood Possible Evidence D
Eucalyptus (Eucalyptus radiata) leaf oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sinutol EM, from the product label.

EuroMedica

See all EuroMedica products
Name
EuroMedica
Street Address
955 Challenger Dr
City
Green Bay
State
WI
ZipCode
54311
Phone Number
866-842-7256
Web Address
EuroMedicaUSA.com
Pharmacist Counseling Corner

Sinutol EM by EuroMedica: Common Questions

Does Sinutol EM by EuroMedica interact with any medications?
Yes. Based on its ingredients, Sinutol EM has a known interaction with 878 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sinutol EM contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Sinutol EM while pregnant?
Eucalyptus in this product is rated likely safe in pregnancy, but myrtle is rated likely unsafe — the safety data advises against using myrtle when pregnant. Since this product contains both, talk with your doctor or pharmacist before taking it during pregnancy to weigh the ingredients for your situation.
What are the most common side effects?
From eucalyptus, the most common are diarrhea, nausea, and vomiting if taken by mouth, or burning, itching, and redness if applied to the skin. Myrtle has limited safety data; topically it may cause dry skin. The undiluted eucalyptus oil can be toxic if swallowed, so follow dosing carefully.
Does this product actually work for sinus or respiratory issues?
The evidence we have for both eucalyptus and myrtle in this product is insufficient to rate their effectiveness for acne, respiratory infections, bronchitis, asthma, or any other condition. We don't have reliable data showing it works for those purposes.
Is this safe to take with my blood pressure or heart medication?
Eucalyptus in this product may theoretically increase levels of drugs your liver processes, which could include some blood pressure and heart medications. Before taking Sinutol EM, check your exact medications with your doctor or pharmacist using the search tool on this page.
Can I take Sinutol EM while breastfeeding?
Safety data for eucalyptus while breastfeeding is not established, and myrtle safety is unknown. Talk with your doctor or pharmacist before using this product if you are nursing to get personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sinutol EM is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sinutol EM label
Go deeper

The Full Monographs Behind Sinutol EM’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eucalyptus

Interacts with 878 drugs

Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, short-term relief of cold symptoms, but t...

Read the full Eucalyptus monograph → Herb & supplement monograph

Myrtle

Myrtle (Myrtus communis) is a Mediterranean shrub used traditionally for respiratory, digestive, and skin complaints. Modern research is mostly limited to laboratory and small studies, so it...

Read the full Myrtle monograph →
Sources

Sources & How We Checked

Sinutol EM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eucalyptus 23 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  3. De Vincenzi M, Silano M, De Vincenzi A, et al. Constituents of aromatic plants: eucalyptol. Fitoterapia 2002;73:269-75. PubMed
  4. Gray AM, Flatt PR. Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr 1998;128:2319-23. PubMed
  5. Whitman BW, Ghazizadeh H. Eucalyptus oil: therapeutic and toxic aspects of pharmacology in humans and animals. J Paediatr Child Health 1994;30:190-1. PubMed
  6. Barker SC and Altman PM. An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil,
  7. Vilaplana, J. and Romaguera, C. Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream. Contact Dermatitis 2000;43(2):118.
  8. Juergens, U. R. [Reducing the need for cortisone. Does eucalyptus oil work in asthma? (interview by Brigitte Moreano]. MMW.Fortschr Med 3-29-2001;143(13):14.
  9. Tascini, C., Ferranti, S., Gemignani, G., Messina, F., and Menichetti, F. Clinical microbiological case: fever and headache in a heavy consumer of eucalyptus extract. Clin Microbiol.Infect. 2002;8(7):437, 445-437, 446. PubMed
  10. Galdi, E., Perfetti, L., Calcagno, G., Marcotulli, M. C., and Moscato, G. Exacerbation of asthma related to Eucalyptus pollens and to herb infusion containing Eucalyptus. Monaldi Arch.Chest Dis. 2003;59(3):220-221.
  11. Spoerke, D. G., Vandenberg, S. A., Smolinske, S. C., Kulig, K., and Rumack, B. H. Eucalyptus oil: 14 cases of exposure. Vet Hum.Toxicol 1989;31(2):166-168.
  12. Jori, A., Bianchetti, A., Prestini, P. E., and Gerattini, S. Effect of eucalyptol (1,8-cineole) on the metabolism of other drugs in rats and in man. Eur.J Pharmacol 1970;9(3):362-366. PubMed
  13. Tibballs, J. Clinical effects and management of eucalyptus oil ingestion in infants and young children. Med J Aust 8-21-1995;163(4):177-180. PubMed
  14. Webb, N. J. and Pitt, W. R. Eucalyptus oil poisoning in childhood: 41 cases in south-east Queensland. J Paediatr.Child Health 1993;29(5):368-371. PubMed
  15. Gyldenløve M, Menné T, Thyssen JP. Eucalyptus contact allergy. Contact Dermatitis. 2014;71(5):303-304. PubMed
  16. Higgins C, Palmer A, Nixon R. Eucalyptus oil: contact allergy and safety. Contact Dermatitis. 2015;72(5):344-346. PubMed
  17. de Groot AC, Schmidt E. Eucalyptus oil and tea tree oil. Contact Dermatitis. 2015;73(6):381-386. PubMed
  18. Greive KA, Barnes TM. The efficacy of Australian essential oils for the treatment of head lice infestation in children: A randomised controlled trial. Australas J Dermatol. 2018;59(2):e99-e105. PubMed
  19. Paulsen E, Thormann H, Vestergaard L. Eucalyptus species as a cause of airborne allergic contact dermatitis. Contact Dermatitis. 2018;78(4):301-303.
  20. Mathew T, John SK, Kamath V, et al. Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults. Epilepsy Res. 2021;173:106626. PubMed
  21. Dudipala SC, Mandapuram P, Ch LK. Eucalyptus Oil-Induced Seizures in Children: Case Reports and Review of the Literature. J Neurosci Rural Pract 2021;12(1):112-115. PubMed
  22. Panda PK, Sharawat IK, Panda P, Dawman L, Kasinathan A. Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients. Trop Doct 2021;51(4):518-522. PubMed
  23. Sai Chandar D, Prashanthi M, Laxman Kumar C, Amith Kumar C. Eucalyptus Oil-Induced Seizures in Children: A Single-Center Prospective Study. Cureus 2021;13(3):e14109. PubMed

See these in context on the Eucalyptus monograph →

Myrtle 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Salmanian M, Shirbeigi L, Hashem-Dabaghian F, et al. The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study. J Pharmacopuncture 2020;23(4):220-229.
  3. Paknejad MS, Eftekhari K, Rahimi R, Vigeh M, Naghizadeh A, Karimi M. Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double-blind randomized clinical trial. Phytother Res 2021;35(11):6369-6376.

See these in context on the Myrtle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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