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Dietary supplement

Sinutol Extra Strength Ingredients & Drug Interactions

by EuroMedica

Softgel Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sinutol Extra Strength is a dietary supplement by EuroMedica with 3 active ingredients. Its ingredients are commonly taken for cough and chest congestion, colds and flu symptoms, stuffy nose.Based on those ingredients, 878 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eucalyptus (Eucalyptus radiata) leaf oil, Lemon (Citrus limon) zest Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sinutol Extra Strength by EuroMedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Double Strength Proprietary Formula” is a proprietary blend — the label gives one combined amount (325 mg) without saying how much of each component you get.

Sinutol Extra Strength contains 3 active ingredients: eucalyptus leaf oil, myrtle leaf oil, and lemon zest oil — all in a proprietary formula blend. The softgel capsule also contains several inactive ingredients that help deliver and protect the oils: olive oil, gelatin, glycerol, and several stabilizing agents like sodium alginate and medium-chain triglycerides.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support sinus health and clear bronchial passages.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Bronchitis, Cough, Influenza, Respiratory tract infections — and 4 related terms.
  • The closest evidence on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections.
  • Also on file: Myrtle is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections.

The evidence we hold on the active ingredients in this product shows insufficient reliable evidence to rate how well they work for any of the conditions they're marketed toward — whether that's respiratory issues, infections, or other uses. That doesn't mean they don't work; it means the research backing them isn't established enough in our data to make a claim either way.

If you're considering this product, talk with your doctor or pharmacist about whether there's evidence supporting it for your specific situation.

The evidence, ingredient by ingredient Eucalyptus Myrtle Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eucalyptus oil is generally well tolerated in small, diluted amounts, but the undiluted oil can be toxic if swallowed — causing nausea, diarrhea, vomiting, and in rare cases serious effects like central nervous system depression, seizures, and even coma at doses as low as 1 mL. Topically it may cause burning, itching, or redness.

Myrtle leaf oil has limited safety data; serious rare side effects reported orally include low blood pressure and respiratory failure. Lemon oil in food amounts is well tolerated, but concentrated forms aren't well studied — regular fresh lemon juice at higher doses has caused heartburn and stomach upset in a meaningful number of trial participants.

Eucalyptus is rated likely safe in pregnancy and lactation. Myrtle, however, is rated likely unsafe in pregnancy and lactation — the safety data advises against it during these times.

Lemon has insufficient data for pregnancy and lactation, so there isn't enough information to know either way; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Eucalyptus Myrtle Lemon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Lemon, Eucalyptus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 879 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you're on any medications processed through CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes (a large group including many heart, psychiatric, and pain medications). Also flag it if you take blood sugar medications, amphetamines, pentobarbital, or itraconazole.

Eucalyptus oil's effects on these pathways are theoretical but documented enough to warrant confirmation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Sinutol Extra Strength is marketed for respiratory and sinus support, but we don't hold evidence that its ingredients work for those uses. More importantly, eucalyptus can interact with a wide range of medications through how your liver processes them, and the product also carries safety concerns if you're pregnant, breastfeeding, or taking certain drugs.

Check your medications on this page before starting, and talk it over with your doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sinutol Extra Strength, straight from the product label.

Brand EuroMedica
Barcode (UPC) 367703825034
Net contents 30 Enteric-Coated Softgel(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261771
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sinutol Extra Strength by EuroMedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Enteric Coated Softgel(s)
Maximum serving Sizes:
1 Enteric Coated Softgel(s)
Servings per container
30
UPC/BARCODE
367703825034
IngredientAmount% DV
Eucalyptus (Eucalyptus radiata) leaf oil0 NP--
Myrtle (Myrtus communis cineole) leaf oil0 NP--
Double Strength Proprietary Formula325 mg--
Lemon (Citrus limon) zest Oil0 NP--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerol, Water, Water, Purified, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Sinutol Extra Strength provides the soothing power of eucalyptus, myrtle, and lemon to support sinus health and maintain clear bronchial passages.

Formulation

Sinutol Extra Strength supports sinus cilia activity for healthy mucous drainage. This unique enteric-coated softgel is gentle for those with gastrointestinal sensitivities or those who need a high potency formula.

Supports sinus cavities and soothes mucous membranes

Non-GMO

No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.

Product of Belgium

Suggested/Recommended/Usage/Directions

Recommendations: 1 enteric-coated softgel, up to 3 times daily, or as recommended by your healthcare practitioner.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

Do not chew

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

See for yourself

Sinutol Extra Strength by EuroMedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sinutol Extra Strength by EuroMedica

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Enteric Coated Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerol, Water, Water, Purified, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sinutol Extra Strength by EuroMedica Drug Interactions

Want to check YOUR meds against Sinutol Extra Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
878Drugs
878 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Sinutol Extra Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Eucalyptus (Eucalyptus radiata) leaf oil7 drug types · 878 drugs

Amphetamines

Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.
Animal research suggests that inhaling eucalyptol may reduce the levels of amphetamines in the blood.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Animal research suggests that eucalyptus leaf might have hypoglycemic activity, and might have additive effects when used with antidiabetes drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP1A2, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, inhaling eucalyptol might reduce the effectiveness of pentobarbital.
Animal research suggests that inhaling eucalyptol reduces the level of pentobarbital that reaches the brain.

Likelihood Possible Evidence D

Lemon (Citrus limon) zest Oil1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Sinutol Extra Strength, from the product label.

EuroMedica

See all EuroMedica products
Name
EuroMedica
Street Address
955 Challenger Drive
City
Green Bay
State
WI
ZipCode
54311
Phone Number
866-842-7256
Pharmacist Counseling Corner

Sinutol Extra Strength by EuroMedica: Common Questions

Does Sinutol Extra Strength by EuroMedica interact with any medications?
Yes. Based on its ingredients, Sinutol Extra Strength has a known interaction with 878 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sinutol Extra Strength contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to use if I'm pregnant or breastfeeding?
The myrtle leaf oil in this product is rated likely unsafe during pregnancy and lactation — the safety data advises against it. Eucalyptus is rated likely safe for pregnancy and lactation. Lemon has insufficient data, meaning there isn't enough information either way. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to be, or breastfeeding.
Can eucalyptus in this product affect how my medications work?
Yes. In lab studies, eucalyptus oil slows how your liver breaks down drugs processed through several major pathways (CYP1A2, CYP2C19, CYP2C9, and CYP3A4), which could raise the levels of those medications in your blood. This hasn't been confirmed in humans yet, but it's significant enough to check before starting. Many common drugs — heart medications, psychiatric drugs, and others — go through these pathways.
What are the main side effects of eucalyptus oil?
Taken by mouth, diluted eucalyptus oil commonly causes diarrhea, nausea, and vomiting. Applied to skin it may cause burning, itching, redness, or stinging. Rarely, undiluted oil swallowed even in small amounts (as little as 1 mL) can cause serious toxicity — including central nervous system depression, seizures, and coma. Do not take the undiluted oil internally.
Does this product have any fillers or other ingredients besides the active oils?
Yes. The softgel capsule contains inactive ingredients including olive oil, gelatin, glycerol, and several stabilizers like sodium alginate, medium-chain triglycerides, and others that help deliver the active oils.
What is this product supposed to do?
Sinutol Extra Strength is marketed for sinus and respiratory support using eucalyptus, myrtle, and lemon oils. However, we don't hold reliable evidence that these ingredients actually work for those uses — the data simply isn't established enough to rate their effectiveness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sinutol Extra Strength is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sinutol Extra Strength label
Sources

Sources & How We Checked

Sinutol Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eucalyptus 23 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  3. De Vincenzi M, Silano M, De Vincenzi A, et al. Constituents of aromatic plants: eucalyptol. Fitoterapia 2002;73:269-75. PubMed
  4. Gray AM, Flatt PR. Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr 1998;128:2319-23. PubMed
  5. Whitman BW, Ghazizadeh H. Eucalyptus oil: therapeutic and toxic aspects of pharmacology in humans and animals. J Paediatr Child Health 1994;30:190-1. PubMed
  6. Barker SC and Altman PM. An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil,
  7. Vilaplana, J. and Romaguera, C. Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream. Contact Dermatitis 2000;43(2):118.
  8. Juergens, U. R. [Reducing the need for cortisone. Does eucalyptus oil work in asthma? (interview by Brigitte Moreano]. MMW.Fortschr Med 3-29-2001;143(13):14.
  9. Tascini, C., Ferranti, S., Gemignani, G., Messina, F., and Menichetti, F. Clinical microbiological case: fever and headache in a heavy consumer of eucalyptus extract. Clin Microbiol.Infect. 2002;8(7):437, 445-437, 446. PubMed
  10. Galdi, E., Perfetti, L., Calcagno, G., Marcotulli, M. C., and Moscato, G. Exacerbation of asthma related to Eucalyptus pollens and to herb infusion containing Eucalyptus. Monaldi Arch.Chest Dis. 2003;59(3):220-221.
  11. Spoerke, D. G., Vandenberg, S. A., Smolinske, S. C., Kulig, K., and Rumack, B. H. Eucalyptus oil: 14 cases of exposure. Vet Hum.Toxicol 1989;31(2):166-168.
  12. Jori, A., Bianchetti, A., Prestini, P. E., and Gerattini, S. Effect of eucalyptol (1,8-cineole) on the metabolism of other drugs in rats and in man. Eur.J Pharmacol 1970;9(3):362-366. PubMed
  13. Tibballs, J. Clinical effects and management of eucalyptus oil ingestion in infants and young children. Med J Aust 8-21-1995;163(4):177-180. PubMed
  14. Webb, N. J. and Pitt, W. R. Eucalyptus oil poisoning in childhood: 41 cases in south-east Queensland. J Paediatr.Child Health 1993;29(5):368-371. PubMed
  15. Gyldenløve M, Menné T, Thyssen JP. Eucalyptus contact allergy. Contact Dermatitis. 2014;71(5):303-304. PubMed
  16. Higgins C, Palmer A, Nixon R. Eucalyptus oil: contact allergy and safety. Contact Dermatitis. 2015;72(5):344-346. PubMed
  17. de Groot AC, Schmidt E. Eucalyptus oil and tea tree oil. Contact Dermatitis. 2015;73(6):381-386. PubMed
  18. Greive KA, Barnes TM. The efficacy of Australian essential oils for the treatment of head lice infestation in children: A randomised controlled trial. Australas J Dermatol. 2018;59(2):e99-e105. PubMed
  19. Paulsen E, Thormann H, Vestergaard L. Eucalyptus species as a cause of airborne allergic contact dermatitis. Contact Dermatitis. 2018;78(4):301-303.
  20. Mathew T, John SK, Kamath V, et al. Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults. Epilepsy Res. 2021;173:106626. PubMed
  21. Dudipala SC, Mandapuram P, Ch LK. Eucalyptus Oil-Induced Seizures in Children: Case Reports and Review of the Literature. J Neurosci Rural Pract 2021;12(1):112-115. PubMed
  22. Panda PK, Sharawat IK, Panda P, Dawman L, Kasinathan A. Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients. Trop Doct 2021;51(4):518-522. PubMed
  23. Sai Chandar D, Prashanthi M, Laxman Kumar C, Amith Kumar C. Eucalyptus Oil-Induced Seizures in Children: A Single-Center Prospective Study. Cureus 2021;13(3):e14109. PubMed

See these in context on the Eucalyptus monograph →

Myrtle 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Salmanian M, Shirbeigi L, Hashem-Dabaghian F, et al. The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study. J Pharmacopuncture 2020;23(4):220-229.
  3. Paknejad MS, Eftekhari K, Rahimi R, Vigeh M, Naghizadeh A, Karimi M. Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double-blind randomized clinical trial. Phytother Res 2021;35(11):6369-6376.

See these in context on the Myrtle monograph →

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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