Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Skin Boost Plus Orange Flavor Ingredients & Drug Interactions

by Sparkle

Skin Boost Plus Orange Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skin Boost Plus Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skin Boost Plus Orange Flavor is a dietary supplement by Sparkle with 6 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 466 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Skin Boost Plus Orange Flavor by Sparkle

Ask about any prescription or over-the-counter medication and we check it for interactions with Skin Boost Plus Orange Flavor by Sparkle — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Skin Boost Plus Orange Flavor by Sparkle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Skin Boost Plus Orange Flavor is a powder with 4 active ingredients. Vitamin C supports immune function and is effective for vitamin C deficiency and possibly helpful for anemia, heart rhythm problems, cataracts, and exercise-related respiratory infections.

Hyaluronic acid is a naturally occurring substance that may help with dry eyes and wound healing. Stevia leaf extract is a plant-based sweetener.

Collagen peptides (Verisol brand) are protein fragments that may support aging skin and dry skin. The product also contains inactive ingredients: citric acid, natural orange tangerine flavor, pineapple fruit powder, silica, and riboflavin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reduce fine lines and wrinkles, improve skin elasticity.
  • We looked for evidence on: Aging skin, Atrophic acne scars, Cellulite, Dermatoporosis, Dry skin, skin photoaging — and 2 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Vitamin C is rated "Insufficient Reliable Evidence To Rate" for Acne, Aging skin, Atrophic acne scars.

Vitamin C is established as effective for preventing or treating vitamin C deficiency and is possibly effective for anemia related to chronic disease, atrial fibrillation, cataracts, and infections triggered by intense exercise. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers; evidence for its use in aging skin, hay fever, and sexual dysfunction isn't established in our data.

Collagen peptides are possibly effective for aging skin and dry skin but are possibly ineffective for muscle strength; evidence for acne and athletic performance isn't established. Stevia leaf extract lacks established evidence for diabetes, high blood pressure, or weight loss.

The evidence, ingredient by ingredient Vitamin C Hyaluronic Acid Stevia Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal dietary doses, but doses above 2 grams daily can cause abdominal cramps, heartburn, diarrhea, nausea, vomiting, and in those prone to kidney stones, kidney stone formation. During pregnancy, normal amounts from food and prenatal vitamins are fine, but you should avoid high-dose supplements unless your doctor advises it.

The data also notes that very high intravenous doses have rarely caused serious kidney problems. Hyaluronic acid appears well tolerated but long-term safety of oral supplements isn't fully studied.

Stevia is generally recognized as safe at typical food amounts; high-dose supplements lack safety data. Collagen peptides are generally well tolerated as a dietary protein, with nausea, indigestion, diarrhea, and gas being rare.

We don't hold enough safety data to advise on collagen peptides in pregnancy; talk with your doctor. For all ingredients, the data on breastfeeding safety is either incomplete or not well established.

Side effects, ingredient by ingredient Vitamin C Hyaluronic Acid Stevia Collagen Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Stevia, Vitamin C.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 466 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take estrogen-based hormones (oral contraceptives or hormone replacement therapy)—vitamin C can raise their blood levels. Tell them too if you're on blood thinners like warfarin, chemotherapy drugs, the HIV medication indinavir, the antipsychotic fluphenazine, thyroid medication, the mood stabilizer lithium, diabetes medications, or blood pressure medications.

Stevia may affect lithium, diabetes, and blood pressure drug levels, though the evidence is limited.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to you if you're looking to support skin health through vitamin C, hyaluronic acid, and collagen, or if you prefer a stevia-sweetened option. If you take estrogen-based birth control, hormone replacement therapy, blood thinners, thyroid medication, chemotherapy drugs, lithium, diabetes medications, or blood pressure medications, you'll want to check this product against your specific medications before starting.

Talk with your doctor or pharmacist about whether it's right for you and your current prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skin Boost Plus Orange Flavor, straight from the product label.

Brand Sparkle
Barcode (UPC) 0852850005052
Net contents 8.1 Oz(s); 230 Gram(s)
Market status On market
Date entered into DSLD Dec 22, 2017
DSLD ID 80892
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skin Boost Plus Orange Flavor by Sparkle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.7 Gram(s)
Maximum serving Sizes:
7.7 Gram(s)
Servings per container
30
UPC/BARCODE
0852850005052
IngredientAmount% DV
Protein4.5 Gram(s)9%
Vitamin C100 mg167%
Hyaluronic Acid100 mg--
Stevia leaf extract120 mg--
Verisol Collagen Peptides5 Gram(s)--
Calories from Protein18 Calorie(s)--

Other ingredients: Citric Acid, natural Orange Tangerine flavor, Pineapple fruit powder, Silica, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Sparkle Skin Boost Plus Contains Three Key Nutrients For Beautiful Skin: Clinically studied Verisol Bioactive Collagen Peptides, Vitamin C plus Hyaluronic Acid.

Vitamin C Hyaluronic Acid Collagen Peptides (5.0g)

Brand IP Statement(s)

Sparkle Skin Boost Plus Contains Three Key Nutrients For Beautiful Skin: Clinically studied Verisol Bioactive Collagen Peptides, Vitamin C plus Hyaluronic Acid.

Verisol is a registered trademark of Gelita AG.

Verisol Beauty From within

General Statements

By helping the formation of collagen, Sparkle Skin Boost Plus delivers multiple benefits to the skin that include reducing the appearance of fine lines & wrinkles and improving skin elasticity.

30 days supply

For recipe ideas visit sparklecollagen.com

Reduces wrinkles, improves elasticity

This product is not a significant source of fat, cholesterol or dietary fiber.

Made in the USA, some ingredients imported.

Suggested/Recommended/Usage/Directions

Suggested Use mix one scoop (provided inside) into water, juice, smoothies or yogurt. Can be consumed hot or cold.

Precautions

Caution as with any supplement, if you are pregnant, nursing or taking medication, consult your doctor before use.

Keep out of reach of children.

Storage

Protect from heat, light, and moisture. Store at 15-30(0)C or 59-86(0)F.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skin Boost Plus Orange Flavor by Sparkle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skin Boost Plus Orange Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skin Boost Plus Orange Flavor by Sparkle

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

4.5 Gram(s) per serving

Vitamin C

Interacts with
207 drugs
100 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Hyaluronic Acid

No known
interactions
100 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Stevia leaf extract

Interacts with
259 drugs
120 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Verisol Collagen Peptides

No known
interactions
5 Gram(s) per serving

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Verisol Collagen Peptides monograph & interactions

Calories from Protein

18 Calorie(s) per serving

Other (inactive) ingredients: Citric Acid, Natural Orange Tangerine flavor, Pineapple fruit powder, Silica, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skin Boost Plus Orange Flavor by Sparkle Drug Interactions

Want to check YOUR meds against Skin Boost Plus Orange Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
466Drugs
102 Moderate 364 Minor

Ingredients driving the most interactions

Stevia leaf extract 259
Vitamin C 207

Individual Drug Interactions

The ingredients in Skin Boost Plus Orange Flavor interact with 466 drugs. Click any drug to see the details.

2 of the 6 ingredients in Skin Boost Plus Orange Flavor interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract Vitamin C

Each ingredient & the kinds of drugs it affects

For each ingredient in Skin Boost Plus Orange Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skin Boost Plus Orange Flavor, from the product label.

Sparkle

See all Sparkle products
Name
Duo Wen, Inc.
Street Address
245 Saw Mill River Road, Suite #106
City
Hawthorne
State
NY
ZipCode
10532
Phone Number
844 894 3487
Web Address
www.lovesparkle.life
Pharmacist Counseling Corner

Skin Boost Plus Orange Flavor by Sparkle: Common Questions

Does Skin Boost Plus Orange Flavor by Sparkle interact with any medications?
Yes. Based on its ingredients, Skin Boost Plus Orange Flavor has a known interaction with 466 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skin Boost Plus Orange Flavor contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Vitamin C in this product might increase how much estrogen from your birth control gets into your bloodstream—up to 55% in some cases—which could affect how well it works. Talk with your doctor or pharmacist before starting this supplement if you're on hormonal birth control.
What does the vitamin C in this do?
Vitamin C supports your immune system and is proven effective for vitamin C deficiency. It's possibly helpful for anemia, heart rhythm problems, cataracts, and preventing respiratory infections triggered by intense exercise.
Is this safe during pregnancy?
Normal amounts of vitamin C from food and prenatal vitamins are considered safe during pregnancy. The data advises against high-dose vitamin C supplements in pregnancy unless your doctor says otherwise. We don't hold enough information on hyaluronic acid, stevia, or collagen peptides during pregnancy—talk with your doctor for personalized advice.
What are the collagen peptides for?
Collagen peptides (Verisol brand) are possibly effective for aging skin and dry skin. There's not enough evidence yet to say whether they help with acne or athletic performance.
Will high doses of vitamin C cause problems?
Yes—doses above 2 grams daily can cause abdominal cramps, heartburn, diarrhea, nausea, and vomiting. If you're prone to kidney stones, high-dose vitamin C can increase that risk. Very high intravenous doses have rarely caused serious kidney injury.
Is the stevia sweetener safe?
Purified stevia at typical food amounts is generally recognized as safe. At higher supplement doses, safety isn't well studied, so use caution. Stevia may theoretically affect blood sugar and blood pressure, and it might increase lithium levels if you take that medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skin Boost Plus Orange Flavor label
Go deeper

The Full Monographs Behind Skin Boost Plus Orange Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Skin Boost Plus Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  10. Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
  11. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  12. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  13. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  14. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  15. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
  16. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  17. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  18. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  19. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  20. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  21. Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
  22. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  23. Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
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Hyaluronic Acid 4 references
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Stevia 10 references
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Collagen Peptides 2 references
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  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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