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Dietary supplement

Skullcap 1600 mg Ingredients & Drug Interactions

by Nature's Answer

Skullcap 1600 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap 1600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap 1600 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap herb (Scutellaria lateriflora) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap 1600 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap 1600 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap 1600 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: skullcap herb extract from Scutellaria lateriflora, supplied at 1600 mg per dose in a liquid form. The extract is suspended in purified water, vegetable glycerin, and a small amount of certified organic alcohol (12–15%).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Relaxation and nervous system support.
  • We looked for evidence on: Anxiety, Stress, Insomnia, nervous tension, muscle tension.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence for skullcap is insufficient to establish whether it works for epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder (PMDD) — at least, that's what the research we hold shows. More and better studies would be needed to say one way or the other.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used short-term, but the evidence on its safety is limited and product quality varies, so use it with care. The most commonly reported side effects from oral use are sedation, cognitive impairment (trouble thinking clearly), and digestive disturbances — with mild digestive upset reported in a small fraction of people taking 350 mg three times daily.

A 100 mg dose didn't show cognitive effects in a single study, but higher doses of 200 mg or more may cause sedation and mental dulling. There isn't enough safety data to use skullcap during pregnancy or while breastfeeding, so those uses are best avoided.

Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before combining skullcap with central nervous system (CNS) depressants — sedatives, sleep aids, anti-anxiety medications, some pain relievers, and muscle relaxants — because the product can add to their sedating and mind-dulling effects. Talk it over with your doctor or pharmacist if you take any of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap is used traditionally for stress and nerve-related conditions, but we don't have strong evidence it actually works for these or most other uses. The bigger concern is that it can make you drowsy and cognitively impaired, especially at higher doses, and it can amplify that effect if you're also taking sedating medications.

If you take anything that slows your central nervous system — pain relievers, sleep aids, anti-anxiety drugs, or muscle relaxants — check with your doctor or pharmacist before adding this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap 1600 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000005022
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 59308
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap 1600 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
083000005022
IngredientAmount% DV
Skullcap herb (Scutellaria lateriflora) extract1600 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Scutellaria lateriflora

Low Alcohol

K Parve

General Statements

Super Concentrated 1600 mg

Our facility is cGMP certified, organic and kosher certified

Since 1972

Brand IP Statement(s)

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same ratios as in the plant

2013 Nature's Answer

Advanced Botanical Fingerprint

Formulation

Gluten Free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children

Warning: Do not use if pregnant or nursing

Do not use if safety seal is damaged or missing

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Gluten Free

K Parve

Bio-Chelated Cold Extraction Process

General

9293A Rev. 314

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap 1600 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap 1600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap 1600 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Skullcap herb (Scutellaria lateriflora) extract

Interacts with
248 drugs
1600 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap herb (Scutellaria lateriflora) extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap 1600 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Skullcap 1600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap herb (Scutellaria lateriflora) extract 248

Individual Drug Interactions

The ingredients in Skullcap 1600 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap 1600 mg interact with drugs. Each result below shows which ingredient is responsible. Skullcap herb (Scutellaria lateriflora) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap 1600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap herb (Scutellaria lateriflora) extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap herb (Scutellaria lateriflora) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap 1600 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Skullcap 1600 mg by Nature's Answer: Common Questions

Does Skullcap 1600 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Skullcap 1600 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap 1600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take skullcap if I'm pregnant or breastfeeding?
No, not based on the safety data we have. There isn't enough information to say it's safe during pregnancy or while breastfeeding, so it's best to avoid it in both situations. Talk with your doctor or pharmacist for personalized advice if you're considering it.
What are the side effects I might notice?
The most common ones are drowsiness, trouble thinking clearly, and digestive upset. A 100 mg dose didn't show thinking problems in studies, but higher doses — 200 mg or more — may cause sedation and mental dulling. A small fraction of people reported mild digestive disturbances.
Does skullcap actually work for stress?
The evidence isn't strong enough to say. We don't have reliable data showing it works for stress or most other conditions people use it for, so that's something to keep in mind before you start.
Why is this a liquid and not a capsule?
The product facts don't explain the form choice — just that it's supplied as a liquid extract in water, glycerin, and alcohol. If you prefer capsules or have a reason to avoid alcohol, you could ask your pharmacist about alternatives.
Can I take skullcap long-term?
It's often used short-term, but the evidence on long-term safety is limited and product quality varies. Use it with care, and talk with your doctor or pharmacist if you're thinking about taking it for weeks or months.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap 1600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap 1600 mg label
Go deeper

The Full Monographs Behind Skullcap 1600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap 1600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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