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Dietary supplement

Skullcap Ingredients & Drug Interactions

by Oregon's Wild Harvest

Skullcap label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap is a dietary supplement by Oregon's Wild Harvest with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap by Oregon's Wild Harvest

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap by Oregon's Wild Harvest — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Skullcap by Oregon's Wild Harvest

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: skullcap, an herbal extract traditionally used for relaxation and nervous system support. The capsule itself is made with pullulan, an inactive ingredient that serves as the capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Relaxation, stress, sleep, and nervous tension.
  • We looked for evidence on: Anxiety, Insomnia, Stress, Nervous tension, Muscle tension.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence supporting skullcap for epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD) is insufficient — we don't have reliable data showing it works for any of these uses. If you're considering it for a specific condition, talk with your pharmacist or doctor about what the science actually supports.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is generally well tolerated in the short term, but the safety data is limited and product quality can vary, so use it with care. The most common side effects reported are cognitive impairment, digestive disturbances, and sedation; a small number of people taking higher doses (around 9% at 350 mg three times daily) reported mild digestive trouble.

A single 100 mg dose did not show adverse CNS effects in testing, but 200 mg and higher doses may cause sedation and cognitive impairment. There isn't enough safety data to use skullcap during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your pharmacist if you take any CNS depressants — sleeping pills, anti-anxiety medications, sedating antidepressants, opioids, or similar drugs — because skullcap can add to their sedating effects. Use the interaction checker below to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may be worth considering if you're looking for nervous system support and you're not taking CNS depressants like sleeping pills or anti-anxiety drugs. If you do take those medications, or if you're pregnant or nursing, check with your pharmacist first.

Because the evidence for specific uses is limited and product quality varies, use it short-term and with care.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap, straight from the product label.

Brand Oregon's Wild Harvest
Barcode (UPC) 706195004211
Net contents 90 Organic Vegan Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 336026
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap by Oregon's Wild Harvest, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
706195004211
IngredientAmount% DV
Skullcap1200 mg--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Organic to our roots As certified organic farmers since 1994, our regenerative practices heal the land and water and sequester carbon from the atmosphere, while ensuring that pure, potent herbal medicine is available today and for future generations. Peace.

Formulation

Free from: gluten, dairy and soy allergens.

Relax & soothe the mind

GF (Gluten free) Verified non-GMO Product verified non-GMO by SGS.

Certified Organic by Oregon Tilth. Oregon Tilth Certified Organic (OTCO)

Precautions

Caution: Excessive consumption may impair ability to drive or operate heavy machinery.

Keep out of reach of children.

If taking medication consult with a healthcare professional before use. Do not take if pregnant or nursing.

Discontinue use if unusual symptoms occur.

Do not exceed recommended dose.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Oregon's Wild Harvest Herbal Supplement Family Farm Since 1994

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Verified non-GMO

Oregon Tilth Certified Organic (OTCO)

Suggested/Recommended/Usage/Directions

Suggested Use: As an herbal supplement, take one capsules three times daily or as directed by your healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap by Oregon's Wild Harvest label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap by Oregon's Wild Harvest

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Skullcap

Interacts with
248 drugs
1200 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap monograph & interactions

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap by Oregon's Wild Harvest Drug Interactions

Want to check YOUR meds against Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap 248

Individual Drug Interactions

The ingredients in Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap interact with drugs. Each result below shows which ingredient is responsible. Skullcap

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap, from the product label.

Oregon's Wild Harvest

See all Oregon's Wild Harvest products
Name
Oregon's Wild Harvest
City
Redmond
State
OR
ZipCode
97756
Phone Number
800-316-6869
Web Address
oregonswildharvest.com
Pharmacist Counseling Corner

Skullcap by Oregon's Wild Harvest: Common Questions

Does Skullcap by Oregon's Wild Harvest interact with any medications?
Yes. Based on its ingredients, Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is skullcap used for?
Skullcap is traditionally used for nervous system support and relaxation, but the evidence showing it actually works for epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder is insufficient. Talk with your pharmacist about whether it's right for your needs.
Can I take this if I'm on sleeping pills or anti-anxiety medication?
Not without checking first. Skullcap can add to the sedating effects of those drugs and increase drowsiness and mental fog. Use the interaction checker on this page with your exact medications, or ask your pharmacist.
What are the side effects?
The most commonly reported side effects are cognitive impairment, digestive disturbances, and sedation. A small number of people taking higher doses had mild digestive trouble. Higher doses (200 mg and above) are more likely to cause sedation and cognitive impairment.
Is it safe to take during pregnancy or while breastfeeding?
There isn't enough safety data to know either way. The safety data advises against use during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
How long can I take this?
Skullcap is often used short-term, but evidence is limited and product quality varies. Use it with care and talk with your pharmacist about how long is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap label
Go deeper

The Full Monographs Behind Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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