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Dietary supplement

Skullcap Herb Ingredients & Drug Interactions

by Indiana Botanic Gardens

Skullcap Herb label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap Herb against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap Herb is a dietary supplement by Indiana Botanic Gardens with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap Herb by Indiana Botanic Gardens

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap Herb by Indiana Botanic Gardens — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap Herb by Indiana Botanic Gardens

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: skullcap, a dried herb used traditionally to support relaxation. The liquid also includes glycerin and water as inactive ingredients to hold and preserve it.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: anxiety stress and sleep support.
  • We looked for evidence on: Anxiety, Insomnia, Stress, nervous tension, relaxation.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence we hold rates skullcap as having insufficient reliable evidence for epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD). That means the studies so far aren't strong enough to say whether it works for these purposes.

If you're considering it for one of these reasons, talk with your doctor about what the current evidence really supports.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used only short-term, but evidence on its long-term safety is limited and product quality varies—so use it with care. The most common side effects reported are sedation, cognitive impairment (trouble thinking clearly), and digestive upset.

A small number of trial participants taking higher doses reported vivid dreams, though it's unclear whether skullcap caused this. You should avoid skullcap during pregnancy—there isn't enough safety data.

The same goes for breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any CNS depressants—sedatives, sleep aids, anxiety medications, pain relievers like codeine or morphine, or antihistamines that cause drowsiness. Skullcap may intensify their sedating effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may help some people relax, but the evidence for specific conditions is sparse. It's generally well tolerated at lower doses, though sedation and digestive upset can occur.

If you take any sedating medications or sleep aids, check with your doctor or pharmacist first. Pregnant or breastfeeding women should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap Herb, straight from the product label.

Brand Indiana Botanic Gardens
Barcode (UPC) 703308200799
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 77095
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap Herb by Indiana Botanic Gardens, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
UPC/BARCODE
703308200799
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Skullcap135 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 mL (approx. 28 drops) three times daily, in a small amount of water.

Best if used by date on bottle.

Shake well.

Precautions

Warning: If you are taking any medications or are pregnant or nursing do not use prior to consulting a physician.

Use only if seal is unbroken

Keep out of reach of children

Storage

Store in a dry, cool place.

Formulation

Alcohol free liquid extract

FDA Statement of Identity

Herbal Supplement

Brand IP Statement(s)

IBG Indiana Botanic Gardens

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap Herb by Indiana Botanic Gardens label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap Herb label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap Herb by Indiana Botanic Gardens

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Amounts shown are per serving.

Skullcap

Interacts with
248 drugs
135 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap Herb by Indiana Botanic Gardens Drug Interactions

Want to check YOUR meds against Skullcap Herb?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap 248

Individual Drug Interactions

The ingredients in Skullcap Herb interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap Herb interact with drugs. Each result below shows which ingredient is responsible. Skullcap

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap Herb with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap Herb, from the product label.

Indiana Botanic Gardens

See all Indiana Botanic Gardens products
Name
Indiana Botanic Gardens, Inc.
Street Address
3401 W. 37th Ave.
City
Hobart
State
IN
ZipCode
46342
Phone Number
1-800-644-8327
Web Address
www.botanicchoice.com
Pharmacist Counseling Corner

Skullcap Herb by Indiana Botanic Gardens: Common Questions

Does Skullcap Herb by Indiana Botanic Gardens interact with any medications?
Yes. Based on its ingredients, Skullcap Herb has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap Herb contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take skullcap if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. The same goes for breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before using it.
What are the side effects?
The most common ones are sedation, trouble thinking clearly, and digestive disturbances. Around 9% of people taking a higher dose (350 mg three times daily for 2 weeks) reported mild digestive upset. At lower doses, side effects appear less likely.
Does skullcap actually work for stress or sleep?
The evidence we have isn't strong enough to say. For stress, sleep, and the other conditions this product is marketed for, the research is insufficient to rate whether it works. If you're considering it for one of these reasons, talk with your doctor about what we actually know.
How much should I take?
The facts we hold don't specify a dose. Start low and follow the label on your bottle. If you have questions about the right dose for you, ask your pharmacist or doctor.
Can I take skullcap with my sleep medication?
Not without checking first. Skullcap can add to the sedating effect of sleep aids and other CNS depressants, which might make you too drowsy or impair your thinking. Talk with your doctor or pharmacist about your specific medications before starting it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap Herb is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap Herb label
Go deeper

The Full Monographs Behind Skullcap Herb’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap Herb's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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