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Dietary supplement

Smooth Move Capsules Ingredients & Drug Interactions

by Traditional Medicinals

Smooth Move Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Smooth Move Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Smooth Move Capsules is a dietary supplement by Traditional Medicinals with 1 active ingredient.Based on those ingredients, 1,182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Smooth Move Capsules by Traditional Medicinals

Ask about any prescription or over-the-counter medication and we check it for interactions with Smooth Move Capsules by Traditional Medicinals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Smooth Move Capsules by Traditional Medicinals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,700 mg) without saying how much of each component you get.
  • “All Herbal Ingredients” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Smooth Move Capsules contain 3 active ingredients: organic licorice, ginger, and organic senna leaf dry extract. These three herbs work together as a natural stimulant laxative blend (senna is the primary active agent).

The capsule itself is made from vegetable material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Relieves occasional constipation.
  • We looked for evidence on: Constipation, Bowel preparation.
  • The strongest evidence on file: Senna is rated "Likely Effective" for Constipation (Natural Medicines).
  • Also on file: Senna is rated "Possibly Effective" for Bowel preparation.
  • Also on file: Ginger is rated "Insufficient Reliable Evidence To Rate" for Constipation.

Senna is likely effective for constipation and possibly effective for bowel preparation—that's the main reason this product is designed the way it is. Licorice shows possibly effective evidence for canker sores and eczema, though those aren't the intended uses here.

Ginger is possibly effective for pregnancy-related nausea, period pain, and osteoarthritis, but the evidence is mixed or limited for other conditions. The product's core claim—relief of occasional constipation—rests primarily on senna's established effectiveness.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Senna is generally well tolerated for short-term, occasional use, but it's not meant for daily long-term use without talking to your doctor first. Common short-term side effects include abdominal cramping, diarrhea, nausea, and urine discoloration.

Ginger at typical supplement doses is well tolerated by most healthy adults, though higher doses (above 5 grams per day) raise the risk of side effects like heartburn, diarrhea, and abdominal discomfort. Licorice is fine in small food amounts, but the glycyrrhizin compound in licorice supplements can cause serious problems with high doses or prolonged use.

Licorice is unsafe in pregnancy—glycyrrhizin has been linked to harmful fetal effects—and there isn't enough safety data to recommend it while breastfeeding. Ginger is likely safe in pregnancy at typical amounts, though you should still check with your doctor, and it's likely safe while breastfeeding.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Senna, Licorice, Ginger.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,183 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Smooth Move, check with your doctor or pharmacist if you take any blood thinners (warfarin, phenprocoumon), heart medications (digoxin, nifedipine), blood pressure drugs (losartan), diabetes medications, diuretics, estrogen-based birth control, cancer medications, sedatives like midazolam, or any drugs your liver processes via CYP2B6, CYP2C19, CYP3A4, or P-glycoprotein pathways. Moderate-severity interactions are documented across these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Smooth Move works best as a short-term remedy for occasional constipation; senna's effectiveness is well established for that purpose. If you take medications for your heart, blood clotting, diabetes, blood pressure, or hormone therapy, or if you're pregnant or breastfeeding, review your full medication list with your doctor or pharmacist before using this product.

Never use it as a daily laxative without medical guidance, and avoid it if you have a history of electrolyte problems or bowel obstruction.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Smooth Move Capsules, straight from the product label.

Brand Traditional Medicinals
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206087
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Smooth Move Capsules by Traditional Medicinals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
13
IngredientAmount% DV
Calories0 Calorie(s)--
Proprietary Blend1700 mg--
organic Licorice0 NP--
Ginger0 NP--
All Herbal Ingredients0 NP--
organic Senna leaf dry extract0 NP--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Since 1974 Laxative capsules Created by Herbalists Relieves Occasional Constipation

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Stop Peeling Here

Formula

Senna Stimulant Laxative

Notice: This product contains senna leaf extract.

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Certified Organic CCOF Organic is Non-GMO & more

Formulation

Certified by the California Certified Organic Farmers (CCOF) 77% Certified Organic Ingredients

Precautions

Notice: This product contains senna leaf extract. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because senna leaf extract may worsen these conditions and be harmful to your health.

Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Not to exceed 4 capsules per day.

Children under 12: consult a doctor or pharmacist.

Warnings: Do not use laxative products when abdominal pain, nausea, or vomiting are present unless directed by a doctor. If you have noticed a sudden change in bowel habits that persists over a period of 2 weeks, consult a doctor before using a laxative. Laxative products should not be used for a period longer than 1 week unless directed by a doctor. Use responsibly and follow all directions for use. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a serious condition. Discontinue use and consult your doctor. Senna may produce abdominal pain, spasm, or passage of liquid stools. Please remember that Smooth Move products are not meant to be used for cleansing or as diet aids.

Keep out of the reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Contraindications: Do not use if you have lleus, intestinal obstruction, intestinal stenosis, atonic bowel, acute intestinal inflammation (e.g. Crohn's disease, ulcerative colitis), appendicitis, abdominal pain of unknown origin, severe dehydration states with water and electrolyte depletion. Other information: Tamper-evident: Do not use this product if plastic seal around the bottle cap is cut, torn, broken or missing.

Suggested/Recommended/Usage/Directions

Use: Smooth Move capsules relieve occasional constipation (irregularity) and generally produce bowel movements in 6 to 12 hours. Directions: Swallow capsules with water. Follow directions of use unless directed otherwise by a doctor. Adults and children 12 years of age and older: 2 to 4 capsules at bedtime, and if needed, 2 to 4 capsules the following morning. Not to exceed 4 capsules per day. Children under 12: consult a doctor or pharmacist.

Storage

Store at room temperature.

Brand IP Statement(s)

2015

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Smooth Move Capsules by Traditional Medicinals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Smooth Move Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Smooth Move Capsules by Traditional Medicinals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container13 Amounts shown are per serving.

All Herbal Ingredients

0 NP per serving
  • › Proprietary Blend

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Smooth Move Capsules by Traditional Medicinals Drug Interactions

Want to check YOUR meds against Smooth Move Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,182Drugs
1,119 Moderate 63 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Smooth Move Capsules interact with 1,182 drugs. Click any drug to see the details.

0 of the 1 ingredient in Smooth Move Capsules interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Smooth Move Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Smooth Move Capsules, from the product label.

Traditional Medicinals

See all Traditional Medicinals products
Name
Traditional Medicinals
Street Address
4515 Ross Road
City
Sebastopol
State
CA
ZipCode
95472
Phone Number
1-800-543-4372
Web Address
www.traditionalmedicinals.com
Pharmacist Counseling Corner

Smooth Move Capsules by Traditional Medicinals: Common Questions

Does Smooth Move Capsules by Traditional Medicinals interact with any medications?
Yes. Based on its ingredients, Smooth Move Capsules has a known interaction with 1,182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Smooth Move Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Smooth Move safe to use long-term?
No—senna is designed for short-term, occasional use only. Long-term daily use without medical guidance isn't recommended because it can disrupt electrolytes and cause dependence on laxatives. If you need regular constipation relief, talk to your doctor about better options.
Can I take this while pregnant?
The licorice in this product is unsafe in pregnancy due to links with harmful fetal effects. Senna and ginger are possibly safe, but you should discuss any laxative use in pregnancy with your doctor first—they may recommend safer alternatives.
What's the most common side effect?
Abdominal cramping and diarrhea are the most common effects, especially in people sensitive to stimulant laxatives. Some people also report nausea. If cramping is severe, stop use and contact your healthcare provider.
Will this product interact with my heart or blood pressure medication?
Possibly—both licorice and ginger raise concerns with several heart and blood pressure drugs, and senna can complicate digoxin therapy. Use the interaction checker on this page with your specific medications, and confirm with your doctor or pharmacist before starting.
What does senna do in this formula?
Senna is a stimulant laxative leaf that triggers bowel contractions and speeds intestinal movement, relieving constipation. It's the primary active ingredient driving the product's laxative effect.
Can I take this if I'm on birth control?
Senna may reduce the absorption of estrogen-based birth control by speeding up how fast food moves through your gut. If you use hormonal contraception, ask your pharmacist or doctor whether Smooth Move is safe for you, or whether you need backup contraception.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Smooth Move Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Smooth Move Capsules label
Sources

Sources & How We Checked

Smooth Move Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 198 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Licorice 92 references
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  2. Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
  3. Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
  4. Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
  5. Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol 2001;153:1085-8. PubMed
  6. Sigurjonsdottir HA, Franzson L, Manhem K, et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549-52. PubMed
  7. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
  8. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
  9. Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
  10. Strandberg TE, Andersson S, Jarvenpaa AL, et al. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol 2002;156:803-5.. PubMed
  11. Hussain RM. The sweet cake that reaches parts other cakes can't! Postgrad Med J 2003;79:115-6.. PubMed
  12. Morris DJ, Davis E, Latif SA. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:849-50. PubMed
  13. Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003;88:2384-92. PubMed
  14. Westman EC, Guthrie GP. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:850. PubMed
  15. Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
  16. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 2007;46:575-8. PubMed
  17. Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). Am J Psychiatry 1994;151:617-8. PubMed
  18. de Klerk GJ, Nieuwenhuis G, Beutler JJ. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. BMJ 1997;314:731-2.
  19. Dellow EL, Unwin RJ, Honour JW. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. Nephol Dial Transplant 1999;14:218-20. PubMed
  20. Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc 2003;78:767-8. PubMed
  21. Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. J Intern Med 1999;245:307-10.
  22. Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. Neth J Med 2005;63:149-50.
  23. Lin SH, Yang SS, Chau T, Halperin ML. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Am J Med Sci 2003;325:153-6. PubMed
  24. van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Neth J Med 2005;63:146-8.
  25. van Uum SH. Liquorice and hypertension. Neth J Med 2005;63:119-20.
  26. Russo S, Mastropasqua M, Mosetti MA, et al. Low doses of liquorice can induce hypertension encephalopathy. Am J Nephrol 2000;20:145-8. PubMed
  27. Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Food Chem Toxicol 1993;31:303-12. PubMed
  28. Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. J Clin Hypertens (Greenwich) 2008;10:153-7. PubMed
  29. Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Phytother Res 2008;22:563-5. PubMed
  30. Lapi F, Gallo E, Bernasconi S, et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Br J Clin Pharmacol 2008;66:572-4. PubMed
  31. Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Jpn 1990;37:331-41. PubMed
  32. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990;335(8697):1060-3. PubMed
  33. Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. Klin Wochenschr 1983;61:303-5. PubMed
  34. Hukkanen J, Ukkola O, Savolainen MJ. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. Blood Press 2009;18:192-5. PubMed
  35. Bisogni V, Rossi GP, Calò LA. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Blood Press. 2014 Jun;23(3):189-92. PubMed
  36. Dehours E, Vallé B, Rougé-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. J Telemed Telecare. 2013 Jun;19(4):227-8. PubMed
  37. Kormann R, Languille E, Amiot HM, Hertig A. Dying for a cup of tea. BMJ Case Rep. 2012 Oct 19;2012. PubMed
  38. Panduranga P, Al-Rawahi N. Licorice-induced severe hypokalemia with recurrent torsade de pointes. Ann Noninvasive Electrocardiol. 2013 Nov;18(6):593-6. PubMed
  39. Räikkönen K, Seckl JR, Heinonen K, Pyhälä R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Järvenpää AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis fu
  40. Robles BJ, Sandoval AR, Dardon JD, Blas CA. Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism). BMJ Case Rep. 2013 Sep 19;2013. PubMed
  41. Chamberlain, J. J. and Abolnik, I. Z. Pulmonary edema following a licorice binge. West J Med 1997;167(3):184-185.
  42. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Ital.J Neurol.Sci 1997;18(4):217-220. PubMed
  43. Fugh-Berman, A. Herb-drug interactions. Lancet 2000;355(9198):134-138. PubMed
  44. Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Cardiovasc.Drugs Ther 1998;12(6):59 PubMed
  45. van Rossum, T. G., Vulto, A. G., Hop, W. C., Brouwer, J. T., Niesters, H. G., and Schalm, S. W. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol 199 PubMed
  46. Lozano, P., Flores, D., Martinez, S., Artigues, I., Rimbau, E. M., and Gomez, F. Upper limb ischemia induced by chronic licorice ingestion. J Cardiovasc.Surg (Torino) 2000;41(4):631-632.
  47. Brouwers, A. J. and van der, Meulen J. ['Licorice hypertension' also caused by licorice tea]. Ned.Tijdschr Geneeskd. 4-14-2001;145(15):744-747.
  48. van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. Am J Gastroenterol 2001;96(8):2432-2437. PubMed
  49. Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens 2003;17(2):125-131.
  50. Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of 2 cases and review of the literature. Eur Neurol 1992;32(1):44-51. PubMed
  51. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Endocrinol Jpn 1991;38(2):167-174. PubMed
  52. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull 2007;30(11):2191-2195. PubMed
  53. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. Minerva Med 2008;99(1):91-94.
  54. Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. Z Kardiol 1991;80(6):389-391.
  55. Tacconi, P., Paribello, A., Cannas, A., and Marrosu, M. G. Carpal tunnel syndrome triggered by excessive licorice consumption. J Peripher.Nerv.Syst. 2009;14(1):64-65. PubMed
  56. Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol 2010;66(8):805-810. PubMed
  57. Goultschin, J., Palmon, S., Shapira, L., Brayer, L., and Gedalia, I. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. A pilot study. J Clin Periodontol 1991;18(3):210-212. PubMed
  58. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. J Endocrinol Invest 1990;13(10):847-848. PubMed
  59. Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. B. Licorice-associated reversible cerebral vasoconstriction with PRES. Neurology 2010;75(21):1939-1941. PubMed
  60. Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. QJM 2011;104(12):1093-1095. PubMed
  61. van Beers, E. J., Stam, J., and van den Bergh, W. M. Licorice consumption as a cause of posterior reversible encephalopathy syndrome: a case report. Crit Care 2011;15(1):R64. PubMed
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See these in context on the Ginger monograph →

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See these in context on the Senna monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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