Major interaction on record — check this product against your medications before combining. Based on 25 of 30 ingredients. Check your meds →

Dietary supplement

Spectra Purples Ingredients & Drug Interactions

by DaVinci Laboratories

See full label image

Powder Category: Other Combinations

Most serious interaction: Major

Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Sep 16, 2026 · Label data from the NIH DSLD

What is this page for?

First and foremost: checking Spectra Purples against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Spectra Purples is a dietary supplement by DaVinci Laboratories with 30 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,184 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Goji berry powder, Pomegranate extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Spectra Purples by DaVinci Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Spectra Purples by DaVinci Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds

AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI

Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Spectra Purples by DaVinci Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure

Ingredient Transparency · database check

Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?

The label discloses an exact amount for 11 of its 29 active ingredients.
“Folate” is listed as a grouped ingredient — the label gives one combined amount (665 mcg DFE) without saying how much of each component you get.
“Proprietary Fruit Powder Blend” is a proprietary blend — the label gives one combined amount (4,900 mg) without saying how much of each component you get.
“Proprietary Vegetable Powder Blend” is a proprietary blend — the label gives one combined amount (1,250 mg) without saying how much of each component you get.

Spectra Purples contains 28 active ingredients, mostly whole-food powders and plant extracts. The standouts are folic acid (a B vitamin for energy and cell health), inositol (a compound that may support insulin function), phosphatidylserine (a fat-like substance in cell membranes), and alpha-GPC (a brain-supporting compound).

You'll also find fruit and berry powders—goji, camu camu, blueberry, plum, pomegranate, bilberry, black currant, acai, blackberry, and black raspberry—along with beet and eggplant powders. Stevia leaf extract sweetens it without sugar.

The product also includes sodium and potassium as minerals, and carnosine (an amino acid compound). Several inactive ingredients provide flavor, including raspberry, strawberry, cherry, vanilla, and spearmint flavors, plus banana powder and citric acid.

Does it work?

Strong evidence

Evidence for Intended Use · database check

By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Constipation via Black Psyllium Effective
Folate deficiency via Folic Acid Effective
Coronary heart disease (CHD) via Black Psyllium Likely Effective
Cystic fibrosis via Sodium Likely Effective
Methotrexate toxicity via Folic Acid Likely Effective

Why this rating?

The label markets general wellness (“healthy aging with antioxidant support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
On file: Constipation — rated "Effective" (Black Psyllium) (Natural Medicines).
On file: Folate deficiency — rated "Effective" (Folic Acid) (Natural Medicines).
On file: Coronary heart disease (CHD) — rated "Likely Effective" (Black Psyllium) (Natural Medicines).
On file: Cystic fibrosis — rated "Likely Effective" (Sodium) (Natural Medicines).
On file: Methotrexate toxicity — rated "Likely Effective" (Folic Acid) (Natural Medicines).

The evidence for Spectra Purples' active ingredients is mixed. Folic acid is effective for folate deficiency and likely effective for preventing neural tube birth defects and reducing methotrexate toxicity; it's possibly effective for depression and certain types of gingival overgrowth.

Inositol is possibly effective for polycystic ovary syndrome (PCOS), metabolic syndrome, and preterm labor, but shows no benefit for anxiety or depression. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease.

Alpha-GPC is possibly effective for Alzheimer's disease. For the fruit and berry powders—blueberry, beet, bilberry, goji, pomegranate, and others—the evidence for their intended uses ranges from insufficient to possibly ineffective; most lack solid data on effectiveness.

Camu camu, elderberry, and eggplant powders have no effectiveness data on file with us. Overall, this blend's benefit depends more on which ingredient addresses your specific need than on the product as a whole.

The evidence, ingredient by ingredient Sodium Potassium Folic Acid Black Psyllium Stevia Mangosteen Goji Camu Camu

How safe is it?

Well-documented data

Safety Information · database check

Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?

We hold adverse-effect (side-effect) data for 21 of the 25 matched ingredients.
Pregnancy & breastfeeding safety ratings cover 25 of 25.
General safety write-ups exist for 25 of 25.
Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid at recommended doses is generally well tolerated, but doses of 15 mg daily can cause confusion, sleep problems, irritability, and nausea. In late pregnancy, folic acid use has been associated with an increased risk of childhood asthma in population studies.

Inositol is generally well tolerated with mild digestive side effects; it is not recommended in pregnancy without medical supervision. Phosphatidylserine may cause insomnia, headache, and gastrointestinal upset; it should be avoided in pregnancy and breastfeeding due to insufficient safety data.

Alpha-GPC is generally well tolerated but rarely has been linked to stroke with use of 2 months or longer; avoid it in pregnancy and breastfeeding. Sodium is essential in small amounts but too much raises blood pressure and strains the heart; the product carries a caution about sodium use in late pregnancy.

Potassium from this powder is generally well tolerated, but supplements can dangerously raise blood levels in people with kidney disease. Bilberry, goji, mangosteen, and camu camu powders should be avoided in pregnancy and breastfeeding due to limited safety data.

Most other ingredients are generally safe as food but lack long-term supplement safety data.

Side effects, ingredient by ingredient Sodium Potassium Folic Acid Black Psyllium Stevia Mangosteen Goji Camu Camu

Meds to double-check

Major interaction found

Known Interaction Concern · database check

Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?

21 of the 25 matched ingredients can interact with medications — Black Psyllium, Cabbage, Bilberry, Inositol, Beet, among others.
The most serious interaction on file is rated Major.
Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
For scale: 2,185 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take warfarin or other blood thinners—goji berry raises bleeding risk. Also flag antidiabetes drugs (insulin, metformin), seizure medications (phenytoin, phenobarbital, primidone), methotrexate, chemotherapy drugs like capecitabine or 5-fluorouracil, blood pressure or heart medications, lithium, or any drug metabolized by liver enzymes (CYP2C9, CYP2D6, CYP2C19, CYP3A4).

Sodium and potassium in this formula can interact with diuretics, ACE inhibitors, and ARBs. Your pharmacist can tell you whether your specific medicines are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Spectra Purples may appeal to you if you're looking for a broad antioxidant and micronutrient powder with cognitive-support ingredients like phosphatidylserine and alpha-GPC. Be cautious if you take blood thinners (especially warfarin), seizure drugs, diabetes medications, heart or blood pressure drugs, lithium, or chemotherapy agents—this product interacts with many of them.

If you're pregnant, breastfeeding, or have kidney disease, talk with your pharmacist before taking it. Check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 25 of 29 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spectra Purples, straight from the product label.

Brand	DaVinci Laboratories
Barcode (UPC)	026664297631
Net contents	328.5 Gram(s); 11.59 Ounce(s)
Market status	On market
Date entered into DSLD	Dec 21, 2024
DSLD ID	322204
Product type	Other Combinations
Supplement form	Powder
Dietary claims / uses	Nutrient, All Other, Structure/Function
Intended target group(s)	Vegetarian, Adult (18 - 50 Years), Gluten Free

From the label

Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spectra Purples by DaVinci Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):

Adults and children 4 or more years of age

Minimum serving Sizes:

10.95 Gram(s)

Maximum serving Sizes:

10.95 Gram(s)

Servings per container

UPC/BARCODE

026664297631

Ingredient	Amount	% DV
Calories	40 Calorie(s)	--
Total Carbohydrates	9 Gram(s)	3%
Folic Acid	400 mcg	--
Sodium	70 mg	3%
Potassium	110 mg	2%
Total Sugars	3 Gram(s)	--
Folate	665 mcg DFE	166%
Dietary Fiber	2 Gram(s)	7%
Protein	1 Gram(s)	2%
Inositol	0 NP	--
Phosphatidylserine	0 NP	--
Stevia Leaf Extract	35 mg	--
Alpha-Glycerylphosphorylcholine	0 NP	--
Mangosteen Fruit Rind Extract	300 mg	--
Goji berry powder	200 mg	--
Camu Camu, Powder	300 mg	--
Beet, Powder	0 NP	--
Blueberry, Powder	0 NP	--
Plum, Powder	0 NP	--
L-Carnosine	0 NP	--
Pomegranate extract	40 mg	--
Blackberry, Powder	0 NP	--
Black Raspberry, Powder	0 NP	--
Acai, Powder	400 mg	--
Eggplant, Powder	0 NP	--
Elderberry, Powder	0 NP	--
Bilberry, Powder	0 NP	--
Black Currant, Powder	0 NP	--
Proprietary Fruit Powder Blend	4900 mg	--
Fibersol-2	2000 mg	--
Purple Cabbage, Powder	0 NP	--
Black Cherry, Powder	0 NP	--
Fig, Powder	0 NP	--
Raisin, Powder	0 NP	--
Proprietary Vegetable Powder Blend	1250 mg	--
Purple Carrot, Powder	0 NP	--
Proprietary "Brain Blend"	100 mg	--

Other ingredients: Raspberry flavor, Strawberry flavor, Cherry flavor, Vanilla flavor, Spearmint flavor, Banana, Powder, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements

These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.

General Statements

Truth We pledge total truth in labeling. Our family of products contains only the purest and most potent ingredients. Guaranteed.

Formula

Spectra Purples is a delicious healthy aging drink mix that combines 19 whole fruits, vegetables and extracts. Some of nature's most protective foods are darkly colored fruits & vegetables because they naturally contain potent antioxidant Vitamin C and a variety of cell protective nutrients. Also included are healthy aging nutrients: Alpha GPC, L-Carnosine and Folic Acid to support mental energy, focus and clarity. Spectra Purples has a delicious berry flavor enhanced by the natural sweetness of stevia and purple carrot. Spectra Purples contains powerful, color-rich phytonutrients that support: Healthy aging Memory, mental clarity & focus Digestive tract health Cell health & function Circulation & vascular health Smoother, healthier and more radiant skin Immune system function Nerve and brain function Color of this product may vary due to color variations of the natural ingredients.

Dietary fiber from digestion resistant maltodextrin was tested using AOAC method #2001.03. Alternatively, AOAC method 2009.01 could be used.

Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.

Caution: Jar contains desiccant to reduce moisture and clumping. Do not eat desiccant.

Keep out of reach of children.

If inner seal is broken, do not use.

Contains: Soy. Contains a bioengineered food ingredient

To obtain product information or report a serious adverse event, call 1-800-325-1776. Not labeled for sale in California.

Storage

Store in a cool, dry place. Do not refrigerate. This product is packaged by weight, not by volume. Some settling may occur.

Brand IP Statement(s)

Fibersol is a registered trademark of ADM/Matsutani LLC and Matsutani Chemical Industry Co.LTD. Fibersol-2 is a soluble dietary fiber produced by ADM/Matsutani LLC. Spectra Purples is a trademark of FoodScience LLC

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Age fighter A Delicious Phytonutrient Drink Mix Supplement to support healthy aging

Vegetarian

Gluten free

FDA Statement of Identity

A Delicious Phytonutrient Drink Mix Supplement to support healthy aging

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, mix 10.95 g (approximately 1 scoop), daily, in 6-8 oz. of cold water or juice, or as directed by your healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spectra Purples by DaVinci Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)

What’s inside

The Ingredients in Spectra Purples by DaVinci Laboratories

These are the 30 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.95 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs

70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs

110 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Folate

665 mcg DFE per serving

› Folic Acid

Dietary Fiber

Interacts with
2,025 drugs

2 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

1 Gram(s) per serving

Stevia Leaf Extract

Interacts with
259 drugs

35 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia Leaf Extract monograph & interactions

Mangosteen Fruit Rind Extract

Interacts with
125 drugs

300 mg per serving

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Mangosteen Fruit Rind Extract monograph & interactions

Goji berry powder

Interacts with
1,000 drugs

200 mg per serving

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they...

Goji berry powder monograph & interactions

Camu Camu, Powder

No known
interactions

300 mg per serving

Camu camu is an Amazonian berry that is very high in vitamin C and plant antioxidants, which is why it is popular as an immune and antioxidant supplem...

Camu Camu, Powder monograph & interactions

Pomegranate extract

Interacts with
922 drugs

40 mg per serving

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate extract monograph & interactions

Acai, Powder

Interacts with
86 drugs

400 mg per serving

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacki...

Acai, Powder monograph & interactions

Proprietary Fruit Powder Blend

4900 mg per serving

› Blueberry, Powder
› Plum, Powder
› Blackberry, Powder
› Black Raspberry, Powder
› Elderberry, Powder
› Bilberry, Powder
› Black Currant, Powder
› Black Cherry, Powder
› Fig, Powder
› Raisin, Powder

Fibersol-2

2000 mg per serving Form: Fiber, Soluble

Proprietary Vegetable Powder Blend

1250 mg per serving

› Beet, Powder
› Eggplant, Powder
› Purple Cabbage, Powder
› Purple Carrot, Powder

Proprietary "Brain Blend"

100 mg per serving

Other (inactive) ingredients: Raspberry flavor, Strawberry flavor, Cherry flavor, Vanilla flavor, Spearmint flavor, Banana, Powder, Citric Acid. These complete the product’s ingredient list but are not active constituents.

HelloPharmacist.com · Pharmacist card

Spectra Purples

by DaVinci Laboratories · label dated Dec 21, 2024

Scan for the full live report

Known drug interactions: 2,184 medications — most serious rated major

Active ingredients

Sodium, Potassium, Folate, Dietary Fiber, Protein, Stevia Leaf Extract, Mangosteen Fruit Rind Extract, Goji berry powder, Camu Camu, Powder, Pomegranate extract, Acai, Powder, Proprietary Fruit Powder Blend, …

Most serious documented interactions

Warfarin — Major (via Goji berry powder)
Warfarin Sodium — Major (via Goji berry powder)
ADO-Trastuzumab Emtansine — Moderate (via Beet, Powder)

Full interaction list, ingredient monographs & live checker: https://hellopharmacist.com/drug-supplement-interactions/supplements/spectra-purples-by-davinci-laboratories-2181350
Printed · Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

Interaction report

Spectra Purples by DaVinci Laboratories Drug Interactions

Spectra Purples — DaVinci Laboratories · HelloPharmacist interaction report
Active ingredients: Sodium, Potassium, Folate, Dietary Fiber, Protein, Stevia Leaf Extract, Mangosteen Fruit Rind Extract, Goji berry powder, Camu Camu, Powder, Pomegranate extract, Acai, Powder, Proprietary Fruit Powder Blend, Fibersol-2, Proprietary Vegetable Powder Blend, Proprietary "Brain Blend"
Source label: Dec 21, 2024 · Printed · HelloPharmacist.com
Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

HelloPharmacist Interaction Report

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Last generated Jul 11, 2026

30 active ingredients 21 with known interactions 2,184 medications covered

Spectra Purples by DaVinci Laboratories is a 28-ingredient powder with documented interactions affecting multiple medication types.

The most serious interaction is with warfarin (a blood thinner): goji berry in this product can increase warfarin's blood-thinning effects and raise the risk of bleeding.

Read the full breakdown — every affected drug type, severity by severity

Several ingredients interact with antidiabetes drugs (insulin, metformin, and others)—folic acid, inositol, stevia leaf extract, carnosine, acai, and bilberry can theoretically lower blood sugar further, raising the risk of low blood sugar (hypoglycemia). Folic acid also interacts with seizure medications (phenobarbital, phenytoin, and primidone), potentially reversing their effects and worsening seizure control.

Goji berry inhibits liver enzymes (CYP2C9, CYP2D6, CYP2C19, and CYP3A4) that break down many drugs, which could raise levels of those medications.

Folic acid reduces the effectiveness of methotrexate (a cancer and immune-disorder drug) and can worsen toxicity from capecitabine and 5-fluorouracil (chemotherapy agents). Sodium and potassium can dangerously raise blood levels if you're taking blood pressure drugs, heart medications, or certain electrolyte-altering drugs.

Bilberry theoretically reduces efficacy of erlotinib (a cancer drug). Altogether, these interactions span 1,368 individual medications.

Run your exact prescriptions through the checker on this page before starting.

Check your own medications below · Editorial policy · How we use AI

Want to check YOUR meds against Spectra Purples?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker

2,184Drugs

2 Major 1,380 Moderate 802 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025

Goji berry powder 1,000

Pomegranate extract 922

Raisin, Powder 910

Beet, Powder 861

Individual Drug Interactions

The ingredients in Spectra Purples interact with 2,184 drugs. Click any drug to see the details.

21 of the 30 ingredients in Spectra Purples interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Goji berry powder Pomegranate extract Raisin, Powder Beet, Powder Fig, Powder Purple Cabbage, Powder Bilberry, Powder Stevia Leaf Extract Phosphatidylserine Sodium Black Currant, Powder Mangosteen Fruit Rind Extract Plum, Powder Blueberry, Powder Acai, Powder Inositol L-Carnosine Potassium Folic Acid Alpha-Glycerylphosphorylcholine

All interactions 2,184 Major 2 Moderate 1,380 Minor 802

Showing 1–30 of 802 drugs.

"phentolamineOraVerse, Rogitine, Ryzumvi

Minor

"phentolamine belongs to Oral Drugs — the drug category that interacts with this product

How "phentolamine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + "phentolamine interaction

6-mercaptopurinePurinethol

Minor

6-mercaptopurine belongs to Oral Drugs — the drug category that interacts with this product

How 6-mercaptopurine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + 6-mercaptopurine interaction

See the 6-mercaptopurine drug page: uses, dosage & side effects

AbacavirZiagen

Minor

Abacavir belongs to Oral Drugs — the drug category that interacts with this product

How Abacavir interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Abacavir interaction

See the Abacavir drug page: uses, dosage & side effects

Abacavir Sulfate, Dolutegravir, LamivudineTriumeq

Minor

Abacavir Sulfate, Dolutegravir, Lamivudine belongs to Oral Drugs — the drug category that interacts with this product

How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Abacavir Sulfate, Dolutegravir, Lamivudine interaction

See the Abacavir Sulfate, Dolutegravir, Lamivudine drug page: uses, dosage & side effects

Abacavir, LamivudineEpzicom

Minor

Abacavir, Lamivudine belongs to Oral Drugs — the drug category that interacts with this product

How Abacavir, Lamivudine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Abacavir, Lamivudine interaction

AcamprosateCampral

Minor

Acamprosate belongs to Oral Drugs — the drug category that interacts with this product

How Acamprosate interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acamprosate interaction

See the Acamprosate drug page: uses, dosage & side effects

Acetohydroxamic AcidLithostat

Minor

Acetohydroxamic Acid belongs to Oral Drugs — the drug category that interacts with this product

How Acetohydroxamic Acid interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acetohydroxamic Acid interaction

AcetophenazineTindal

Minor

Acetophenazine belongs to Oral Drugs — the drug category that interacts with this product

How Acetophenazine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acetophenazine interaction

Acetylcysteine (prescription Drug)Cetylev, Legubeti

Minor

Acetylcysteine (prescription Drug) belongs to Oral Drugs — the drug category that interacts with this product

How Acetylcysteine (prescription Drug) interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acetylcysteine (prescription Drug) interaction

Acrivastine, PseudoephedrineSemprex D

Minor

Acrivastine, Pseudoephedrine belongs to Oral Drugs — the drug category that interacts with this product

How Acrivastine, Pseudoephedrine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acrivastine, Pseudoephedrine interaction

AcyclovirAvaclyr, Sitavig, Zovirax, Zovirax Injection

Minor

Acyclovir belongs to Oral Drugs — the drug category that interacts with this product

How Acyclovir interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Acyclovir interaction

See the Acyclovir drug page: uses, dosage & side effects

Adalimumab-bwwdHadlima

Minor

Adalimumab-bwwd belongs to Oral Drugs — the drug category that interacts with this product

How Adalimumab-bwwd interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Adalimumab-bwwd interaction

AdefovirHepsera

Minor

Adefovir belongs to Oral Drugs — the drug category that interacts with this product

How Adefovir interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Adefovir interaction

See the Adefovir drug page: uses, dosage & side effects

AdenosineATP Tablets

Minor

Adenosine belongs to Oral Drugs — the drug category that interacts with this product

How Adenosine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Adenosine interaction

Afatinib DimaleateGilotrif

Minor

Afatinib Dimaleate belongs to Oral Drugs — the drug category that interacts with this product

How Afatinib Dimaleate interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Afatinib Dimaleate interaction

See the Afatinib Dimaleate drug page: uses, dosage & side effects

AlbendazoleAlbenza

Minor

Albendazole belongs to Oral Drugs — the drug category that interacts with this product

How Albendazole interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Albendazole interaction

See the Albendazole drug page: uses, dosage & side effects

AlbuterolProAir HFA, Proventil, Ventolin (U.S.), Volmax

Minor

Albuterol belongs to Oral Drugs — the drug category that interacts with this product

How Albuterol interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Albuterol interaction

See the Albuterol drug page: uses, dosage & side effects

AlcuroniumAlcuronium

Minor

Alcuronium belongs to Oral Drugs — the drug category that interacts with this product

How Alcuronium interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alcuronium interaction

AlemtuzumabCampath

Minor

Alemtuzumab belongs to Oral Drugs — the drug category that interacts with this product

How Alemtuzumab interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alemtuzumab interaction

See the Alemtuzumab drug page: uses, dosage & side effects

AlendronateBinosto, Fosamax

Minor

Alendronate belongs to Oral Drugs — the drug category that interacts with this product

How Alendronate interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alendronate interaction

See the Alendronate drug page: uses, dosage & side effects

Alendronate Sodium

Minor

Alendronate Sodium belongs to Oral Drugs — the drug category that interacts with this product

How Alendronate Sodium interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alendronate Sodium interaction

See the Alendronate Sodium drug page: uses, dosage & side effects

Alendronate Sodium, CholecalciferolFosamax Plus D

Minor

Alendronate Sodium, Cholecalciferol belongs to Oral Drugs — the drug category that interacts with this product

How Alendronate Sodium, Cholecalciferol interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alendronate Sodium, Cholecalciferol interaction

Alginic Acid, Aluminum HydroxideRafton

Minor

Alginic Acid, Aluminum Hydroxide belongs to Oral Drugs — the drug category that interacts with this product

How Alginic Acid, Aluminum Hydroxide interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alginic Acid, Aluminum Hydroxide interaction

AllopurinolCaplenal, Cosuric, Rimapurinol, Zyloprim, Zyloric

Minor

Allopurinol belongs to Oral Drugs — the drug category that interacts with this product

How Allopurinol interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Allopurinol interaction

See the Allopurinol drug page: uses, dosage & side effects

AlosetronLotronex

Minor

Alosetron belongs to Oral Drugs — the drug category that interacts with this product

How Alosetron interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alosetron interaction

See the Alosetron drug page: uses, dosage & side effects

Alpha 1-proteinaseZemaira

Minor

Alpha 1-proteinase belongs to Oral Drugs — the drug category that interacts with this product

How Alpha 1-proteinase interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Alpha 1-proteinase interaction

AltretamineHexalen

Minor

Altretamine belongs to Oral Drugs — the drug category that interacts with this product

How Altretamine interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Altretamine interaction

Aluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol

Minor

Aluminum Chloride belongs to Oral Drugs — the drug category that interacts with this product

How Aluminum Chloride interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Aluminum Chloride interaction

Aluminum HydroxideAlu-Cap, Amphojel, Gaviscon

Minor

Aluminum Hydroxide belongs to Oral Drugs — the drug category that interacts with this product

How Aluminum Hydroxide interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Aluminum Hydroxide interaction

See the Aluminum Hydroxide drug page: uses, dosage & side effects

Aluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel

Minor

Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) belongs to Oral Drugs — the drug category that interacts with this product

How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Spectra Purples — through 1 ingredient. Tap an ingredient for the detail:

Dietary FiberOral Drugs Minor

Interaction Summary

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full Dietary Fiber + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interaction

Each ingredient & the kinds of drugs it affects

For each ingredient in Spectra Purples with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D

Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D

Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D

Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D

Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B

Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D

Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B

Dietary Fiber full monograph & interactions

Goji berry powder8 drug types · 1,000 drugs

Warfarin (Coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence D

Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.

Likelihood Possible Evidence D

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.

Likelihood Possible Evidence D

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D

Flecainide (Tambocor)

Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.

Likelihood Possible Evidence D

Antidiabetes Drugs

Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.

Likelihood Possible Evidence B

Goji berry powder full monograph & interactions

Pomegranate extract9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B

Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D

Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D

Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D

Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D

Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B

Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D

Pomegranate extract full monograph & interactions

Raisin, Powder9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D

Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D

Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D

Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B

Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D

Raisin, Powder full monograph & interactions

Beet, Powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D

Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D

Beet, Powder full monograph & interactions

Fig, Powder3 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.
A small clinical study in patients with type 1 diabetes shows that consuming a tea made from fig leaves modestly reduces postprandial glucose levels and insulin requirements.

Likelihood Probable Evidence B

Insulin

Fig leaf may enhance the blood glucose lowering effects of insulin.
A small clinical study in patients with type 1 diabetes shows that consuming a tea made from fig leaves modestly reduces postprandial glucose levels and insulin requirements.

Likelihood Probable Evidence B

Photosensitizing Drugs

Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Many cases of photodermatitis from fig leaf have been reported. Some drugs that also cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.

Likelihood Possible Evidence D

Fig, Powder full monograph & interactions

Purple Cabbage, Powder6 drug types · 325 drugs

Acetaminophen (Tylenol, Others)

Cabbage might increase clearance and reduce the effects of acetaminophen.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases acetaminophen levels by as much as 16%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B

Antidiabetes Drugs

Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vivo research suggests that cabbage might have hypoglycemic effects.

Likelihood Possible Evidence D

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Some animal research suggests that cabbage or its constituent indole-3-carbinol might increase drug metabolism and elimination by stimulating CYP1A2 activity.

Likelihood Possible Evidence D

Glucuronidated Drugs

Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.

Likelihood Probable Evidence B

Oxazepam (Serax)

Cabbage might increase clearance and reduce the effects of oxazepam.
A small clinical study shows that daily consumption of cabbage and brussels sprout decreases oxazepam levels by as much as 17%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B

Warfarin (Coumadin)

Theoretically, cabbage might decrease the anticoagulant effects of warfarin.
Cabbage contains vitamin K. If consumed in large quantities, cabbage might decrease the anticoagulant effects of warfarin.

Likelihood Possible Evidence D

Purple Cabbage, Powder full monograph & interactions

Bilberry, Powder4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D

Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D

Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D

Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D

Bilberry, Powder full monograph & interactions

Stevia Leaf Extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D

Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D

Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D

Stevia Leaf Extract full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B

Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B

Phosphatidylserine full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A

Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D

Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C

Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B

Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

Sodium full monograph & interactions

Black Currant, Powder2 drug types · 140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.
Gamma-linolenic acid (GLA), a constituent of black currant seed oil, appears to have antiplatelet effects.

Likelihood Possible Evidence D

Phenothiazines

Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures.

Likelihood Possible Evidence D

Black Currant, Powder full monograph & interactions

Mangosteen Fruit Rind Extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D

Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D

Mangosteen Fruit Rind Extract full monograph & interactions

Plum, Powder1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, plum juice might have antiplatelet effects.
Consuming plum juice while taking anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. In healthy volunteers, drinking plum juice 200 mL daily for 28 days prolonged clotting time and inhibited platelet aggregation.

Likelihood Possible Evidence B

Plum, Powder full monograph & interactions

Blueberry, Powder3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D

Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B

Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B

Blueberry, Powder full monograph & interactions

Acai, Powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.

Likelihood Possible Evidence D

Acai, Powder full monograph & interactions

Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A

Inositol full monograph & interactions

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D

L-Carnosine full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C

Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C

Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C

Potassium full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D

Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D

Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B

Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B

Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B

Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B

Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D

Folic Acid full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B

Alpha-Glycerylphosphorylcholine full monograph & interactions

The maker

Brand information

Manufacturer and brand details for Spectra Purples, from the product label.

DaVinci Laboratories

See all DaVinci Laboratories products

Name: DaVinci Laboratories a division of FoodScience LLC
Street Address: 929 Harvest Lane
City: Williston
State: VT
ZipCode: 05495
Phone Number: 1-800-325-1776
Web Address: www.davincilabs.com

Pharmacist Counseling Corner

Spectra Purples by DaVinci Laboratories: Common Questions

Does Spectra Purples by DaVinci Laboratories interact with any medications?

Yes. Based on its ingredients, Spectra Purples has a known interaction with 2,184 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.

How can one product interact with so many drugs?

Spectra Purples contains 30 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.

Where does this information come from?

The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Is folic acid safe during pregnancy?

Folic acid at standard prenatal doses is recommended during pregnancy to help prevent birth defects and is considered safe. However, use in late pregnancy has been associated in population studies with increased childhood asthma risk. Take it as directed by your doctor, and discuss timing with your obstetrician.

Can I take this if I'm on a blood thinner like warfarin?

No—not without checking with your pharmacist first. Goji berry in this product can increase warfarin's effects and raise your bleeding risk. You may need blood work monitoring if your doctor approves it, or you may need to skip the product altogether.

Will this powder lower my blood sugar?

Possibly. Folic acid, inositol, stevia, carnosine, acai, and bilberry can all theoretically lower blood glucose. If you take diabetes medication, this could increase your low blood sugar risk. Talk to your doctor before starting, and monitor your levels closely.

What does phosphatidylserine do?

Phosphatidylserine is a fat-like compound found in cell membranes. It's possibly effective for age-related cognitive decline and Alzheimer's disease. It may cause insomnia, headache, or digestive upset in some people.

Are all the fruit powders in here proven to work?

Most are not. Blueberry, acai, goji, bilberry, and the others are included for their antioxidants and nutrient profile, but solid evidence for specific health claims is limited or absent. They're generally well tolerated, but don't expect dramatic results.

Is this safe to take while breastfeeding?

Some ingredients—like folic acid and blueberry—are likely safe, but others like phosphatidylserine, alpha-GPC, goji, and mangosteen lack safety data in breastfeeding. Talk with your doctor or pharmacist before taking it to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Spectra Purples is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Go deeper

The Full Monographs Behind Spectra Purples’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph → Herb & supplement monograph

Goji

Interacts with 1,000 drugs

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune supp...

Read the full Goji monograph → Herb & supplement monograph

Camu Camu

Camu camu is an Amazonian berry that is very high in vitamin C and plant antioxidants, which is why it is popular as an immune and antioxidant supplement. Human research is still limited, so...

Read the full Camu Camu monograph → Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Acai

Interacts with 86 drugs

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often atta...

Read the full Acai monograph → Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph → Herb & supplement monograph

Plum

Interacts with 122 drugs

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as f...

Read the full Plum monograph → Herb & supplement monograph

Blackberry

Blackberry is a common edible berry that is safe and nutritious as a food, rich in vitamin C, fiber, and antioxidant plant compounds. The leaves and root have a long history of traditional u...

Read the full Blackberry monograph → Herb & supplement monograph

Black Raspberry

Black raspberry is a nutrient-rich fruit packed with antioxidants like anthocyanins and ellagic acid, and as a food it is generally safe and healthy. Some early research explores it for canc...

Read the full Black Raspberry monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Black Currant

Interacts with 140 drugs

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjoyed safely as a food and is popular as a...

Read the full Black Currant monograph → Herb & supplement monograph

Fig

Interacts with 410 drugs

Fig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally for blood sugar and coughs. The fruit is a safe a...

Read the full Fig monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Cabbage

Interacts with 325 drugs

Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims ar...

Read the full Cabbage monograph → Herb & supplement monograph

Carrot

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...

Read the full Carrot monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph →

Sources

Sources & How We Checked

Spectra Purples's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 349 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.
Ortiz Z, Shea B, Suarez Almazor M, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Cochrane Database Syst Rev 2000;2:CD000951. PubMed
Van Delden C, Hirschel B. Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome (letter). J Infect Dis 1996;173:1294-5. PubMed
Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7. PubMed
Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5. PubMed
Bonaa KH, Njolstad I, Ueland PM, et al. NORVIT: Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Enlg J Med 2006;354:1578-88. PubMed
Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 2007;99:754-64. PubMed
Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: Results from a randomized clinical trial. J Natl Cancer Inst 2009;101:432-5. PubMed
Clippe C, Freyer G, Milano G, Trillet-Lenoir V. Lethal toxicity of capecitabine due to abusive folic acid prescription. Clin Oncol (R Coll Radiol) 2003;15:299-300. PubMed
Bedford Laboratories. Leucovorin calcium [package insert]. Bedford, OH. September 2008. Available at: http://www.bedfordlabs.com/BedfordLabsWeb/products/inserts/LCV-P02.pdf.
Ebbing M, Bonaa KH, Nygard O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009;302:2119-26.
Haberg, S. E., London, S. J., Stigum, H., Nafstad, P., and Nystad, W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis.Child 2009;94(3):180-184. PubMed
Whitrow, M. J., Moore, V. M., Rumbold, A. R., and Davies, M. J. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 12-15-2009;170(12):1486-1493. PubMed
Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
Baggott, J. E., Oster, R. A., and Tamura, T. Meta-analysis of cancer risk in folic acid supplementation trials. Cancer Epidemiol. 2012;36(1):78-81. PubMed
Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
Taneja S, Strand TA, Kumar T, et al. Folic acid and vitamin B-12 supplementation and common infections in 6-30-mo-old children in India: a randomized placebo-controlled trial. Am J Clin Nutr 2013;98(3):731-7. PubMed
van Wijngaarden JP, Swart KM, Enneman AW, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin
Qin X, Fan F, Cui Y, Chen F, Chen Y, Cheng X, Li Y, Wang B, Xu X, Xu X, Huo Y, Wang X. Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. Clin Nutr. 2014;33(4):603-12. PubMed
Crider KS, Cordero AM, Qi YP, Mulinare J, Dowling NF, Berry RJ. Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(5):1272-81. PubMed
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Potassium 12 references

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Black Psyllium 18 references

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Inositol 14 references

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Phosphatidylserine 9 references

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Stevia 10 references

Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
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Alpha-gpc 4 references

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Mangosteen 6 references

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Goji 14 references

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Camu Camu 2 references

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Beet 14 references

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

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Blueberry 7 references

Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

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Plum 10 references

Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
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Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
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Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI
Johnson MC, Fisher JK. Plum pit ileus: a case report. Mo Med. 1991;88(10):696-8.

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Carnosine 5 references

Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

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Pomegranate 27 references

Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
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Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
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Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
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Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
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Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther PubMed
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Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
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Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. PubMed
Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. PubMed
Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. PubMed

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Blackberry 1 reference

Antioxidants: In Depth — NIH NCCIH Source

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Black Raspberry 4 references

An JH, Kim DL, Lee TB, et al. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016;30(10):1634-40.
Jeong HS, Hong SJ, Cho JY, et al. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial. Nutrition. 2016;32(4):461-7. PubMed
Mallery SR, Tong M, Shumway BS, et al. Topical application of a mucoadhesive freeze-dried black raspberry gel induces clinical and histologic regression and reduces loss of heterozygosity events in premalignant oral intraepithelial lesions: results from a
Jeong HS, Kim S, Hong SJ, et al. Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial. J Med Food. 2016;19(4):346-52. PubMed

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Acai 2 references

Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

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Bilberry 14 references

Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
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Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
Prokop J, Ln&ecaron;ni&ccaron;ková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

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Black Currant 6 references

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Cabbage 15 references

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Fig 13 references

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Grape 34 references

Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
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Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. PubMed
Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. PubMed
Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. PubMed
Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in
Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. PubMed
McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. PubMed
Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. PubMed
Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550. PubMed
Faircloth, D. E. and Robison, W. J. Obstruction of the sigmoid colon by grape seeds. JAMA 11-27-1981;246(21):2430. PubMed
Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167.
Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. PubMed
Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41. PubMed
Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5. PubMed
Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome mark
Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515. PubMed

See these in context on the Grape monograph →

Carrot 14 references

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Wetzel WE, Lehn W, Grieb A. [Carotene jaundice in infants with "sugar nursing bottle syndrome"]. Monatsschr Kinderheilkd 1989;137(10):659-61.
el-Arab AE, Khalil F, Hussein L. Vitamin A deficiency among preschool children in a rural area of Egypt: the results of dietary assessment and biochemical assay. Int J Food Sci Nutr 2002;53(6):465-74. PubMed
Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
Kaplan R. Carrot addiction. Aust N Z J Psychiatry 1996;30(5):698-700.
Ncube, T. N., Greiner, T., Malaba, L. C., and Gebre-Medhin, M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr 2001;131(5):1497-1502. PubMed
Mullins M, Froelke BR, Rivera MR. Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen. Clin Toxicol (Phila) 2009;47(2):112-5. PubMed
Kawai M, Tamagawa-Mineoka R, Hagura A, Masuda K, Katoh N. Allergic contact dermatitis due to carrots. J Dermatol 2014;41(8):753-4. PubMed
Xu X, Cheng Y, Li S, et al. Dietary carrot consumption and the risk of prostate cancer. Eur J Nutr 2014;53(8):1615-23. PubMed
Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med. 2001;1:7. PubMed
Chen H, Shao F, Zhang F, Miao Q. Association between dietary carrot intake and breast cancer: A meta-analysis. Medicine (Baltimore). 2018;97(37):e12164. PubMed
Bosanac SS, Clark AK, Sivamani RK. Phytophotodermatitis related to carrot extract-containing sunscreen. Dermatol Online J. 2018;24(1). pii: 13030/qt2nv2d1n0. DOI
Deding U, Baatrup G, Christensen LP, Kobaek-Larsen M. Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes. Nutrients 2020;12(2):332. PubMed
Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed

See these in context on the Carrot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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Spectra Purples Ingredients & Drug Interactions

Check Your Meds Against Spectra Purples by DaVinci Laboratories

HelloPharmacist Scorecard of Spectra Purples by DaVinci Laboratories

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General information

Supplement Facts

Supplement Facts

Spectra Purples by DaVinci Laboratories label

The Ingredients in Spectra Purples by DaVinci Laboratories

Folate

Protein

Proprietary Fruit Powder Blend

Fibersol-2

Proprietary Vegetable Powder Blend

Proprietary "Brain Blend"

Spectra Purples by DaVinci Laboratories Drug Interactions

HelloPharmacist Interaction Report

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Ingredients driving the most interactions

Individual Drug Interactions

Each ingredient & the kinds of drugs it affects

Dietary Fiber7 drug types · 2,025 drugs

Goji berry powder8 drug types · 1,000 drugs

Pomegranate extract9 drug types · 922 drugs

Raisin, Powder9 drug types · 910 drugs

Beet, Powder3 drug types · 861 drugs

Fig, Powder3 drug types · 410 drugs

Purple Cabbage, Powder6 drug types · 325 drugs

Bilberry, Powder4 drug types · 275 drugs

Stevia Leaf Extract3 drug types · 259 drugs

Phosphatidylserine2 drug types · 219 drugs

Sodium7 drug types · 205 drugs

Black Currant, Powder2 drug types · 140 drugs

Mangosteen Fruit Rind Extract2 drug types · 125 drugs

Plum, Powder1 drug type · 122 drugs

Blueberry, Powder3 drug types · 88 drugs

Acai, Powder1 drug type · 86 drugs

Inositol1 drug type · 86 drugs

L-Carnosine1 drug type · 86 drugs

Potassium3 drug types · 62 drugs

Folic Acid7 drug types · 40 drugs

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

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Spectra Purples by DaVinci Laboratories: Common Questions

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The Full Monographs Behind Spectra Purples’s Ingredients

Sodium

Potassium

Folic Acid

Black Psyllium

Stevia

Mangosteen

Goji

Camu Camu

Pomegranate

Acai

Blueberry

Plum

Blackberry

Black Raspberry

Bilberry

Black Currant

Fig

Grape

Beet

Cabbage

Carrot

Inositol

Phosphatidylserine

Alpha-gpc

Carnosine

Sources & How We Checked

The 349 references behind this product’s interaction data