Spinach Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Spinach Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Spinach Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, eye health, heart health and blood pressure.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spinach extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Spinach Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Spinach Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Spinach Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: spinach extract. It's a concentrated form of spinach, the leafy green vegetable.
The product has no inactive ingredients listed.
Does it work?
Couldn't assess
The evidence we hold doesn't establish how well spinach extract works for any condition. It's been studied for nonalcoholic fatty liver disease (NAFLD), cognitive function, muscle strength, obesity, and polycystic ovary syndrome (PCOS), but the research so far is insufficient to rate it.
That doesn't mean it won't help — it means we don't have reliable data yet on whether it does.
How safe is it?
Well-documented data
Spinach as a food is generally well tolerated and is considered safe during pregnancy and while breastfeeding. When taken as a supplement powder, it's also well tolerated by most people.
That said, serious adverse effects are rare but possible: methemoglobinemia (a blood oxygen issue) has been reported in infants under 4 months old; allergic reactions can occur in sensitive individuals; and in occupational or heavy-exposure settings, spinach powder has triggered asthma and lung inflammation in a small number of people.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before using this product if you take blood thinners (anticoagulants) like warfarin — spinach's vitamin K content can interfere with how they work. Also double-check if you take diabetes medications, since spinach may lower blood sugar and could increase your risk of low blood sugar when combined.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Spinach extract is a straightforward supplement if you're looking for a concentrated spinach source and you don't take blood thinners or diabetes medication. If you do take either of those, you can still use it — just keep your intake steady, monitor your blood sugar or clotting if relevant, and talk it over with your doctor or pharmacist first to see if a dose adjustment is needed.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Spinach Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X0018ELKPR |
| Net contents | 250 Gram(s); 8.8 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2024 |
| DSLD ID | 311640 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Spinach Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Spinach extract | 1000 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
Formulation
Color may vary
Free of: Added sugar, soy, dairy, yeast, gluten, additives
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1000 mg (about 1/3 tsp) once or twice daily, or as directed by a physician.
Storage
Store in a dry, cool place Contents are sold by weight, not volume. Settling may occur.
General Statements
New Use an accurate milligram scale.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Spinach Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Spinach Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1000 mg Dosage formPowder Servings per container250 Amounts shown are per serving.
Spinach extract
Interacts with88 drugs
Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants. While it is...
Spinach extract monograph & interactionsSpinach Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Spinach Extract by BulkSupplements.com does interact with medications — notably through its vitamin K content and compounds that may lower blood sugar.
Altogether, these interactions span 88 individual medications.
Read the full breakdown — every affected drug type, severity by severity
The most serious concern is with blood thinners (anticoagulants), particularly warfarin (Coumadin). Spinach is rich in vitamin K, which directly opposes how warfarin works.
A single meal with spinach won't knock your blood tests out of range, but daily use for a week can shift them enough to require a dose adjustment. If you take warfarin, you don't have to avoid spinach — you just need to keep your intake consistent and let your doctor know you're using a spinach supplement.
Spinach extract may also lower blood sugar. If you take diabetes medications, there's a theoretical risk of low blood sugar (hypoglycemia) when you combine them.
That doesn't mean you can't use both, but you'll want to monitor your blood glucose closely and work with your doctor on whether a dose adjustment makes sense.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Spinach Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Spinach Extract interact with 88 drugs. Click any drug to see the details.
1 of the 1 ingredient in Spinach Extract interact with drugs. Each result below shows which ingredient is responsible. Spinach extract
Metformin XrGlucophage XR
How Metformin Xr interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Metformin Xr interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Metformin, Sitagliptin interactionMiglitolGlyset
How Miglitol interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Miglitol interactionMuraglitazarPargluva
How Muraglitazar interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Muraglitazar interactionNateglinideStarlix
How Nateglinide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Nateglinide interactionPioglitazoneActos
How Pioglitazone interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Pioglitazone interactionPramlintideSymlin
How Pramlintide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Pramlintide interactionRepaglinideGlucoNorm, Prandin
How Repaglinide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Repaglinide interactionRosiglitazone MaleateAvandia
How Rosiglitazone Maleate interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Rosiglitazone Maleate interactionSaxagliptinOnglyza
How Saxagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Saxagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
How Semaglutide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Semaglutide interactionSimvastatin, SitagliptinJuvisync
How Simvastatin, Sitagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Simvastatin, Sitagliptin interactionSitagliptinJanuvia, Zituvio
How Sitagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Sitagliptin interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Sitagliptin, Metformin interactionSotagliflozinInpefa
How Sotagliflozin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Sotagliflozin interactionTirzepatideMounjaro, Zepbound
How Tirzepatide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Tirzepatide interactionTobutamideMobenol
How Tobutamide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Tobutamide interactionTolazamideTolinase
How Tolazamide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Tolazamide interactionTolbutamideOrinase
How Tolbutamide interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Tolbutamide interactionTroglitazoneRezulin
How Troglitazone interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Troglitazone interactionVildagliptinGalvus
How Vildagliptin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Vildagliptin interactionWarfarinWarfarin
How Warfarin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractWarfarin (coumadin) Moderate
Interaction Summary
Spinach contains vitamin K, which can interfere with the activity of warfarin.
Read the full Spinach Extract + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractWarfarin (coumadin) Moderate
Interaction Summary
Spinach contains vitamin K, which can interfere with the activity of warfarin.
Read the full Spinach Extract + Warfarin Sodium interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Pioglitazone, Metformin interactionRosiglitazone, GlimepirideAvandaryl
How Rosiglitazone, Glimepiride interacts with Spinach Extract — through 1 ingredient. Tap an ingredient for the detail:
Spinach ExtractAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach Extract + Rosiglitazone, Glimepiride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Spinach Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Spinach extract
Antidiabetes Drugs
There are claims that spinach leaves have hypoglycemic effects. Evidence from clinical research suggests that consumption of a spinach-rich meal reduces post-meal blood glucose levels. Theoretically, spinach might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Warfarin (Coumadin)
Spinach contains vitamin K, which can interfere with the activity of warfarin.
In human research, although eating spinach with one meal does not result in coagulation test results outside the therapeutic range, daily consumption for one week necessitates dose adjustment of warfarin. Individuals using anticoagulants should consume a consistent daily amount of spinach to maintain the effect of anticoagulant therapy.
Brand information
Manufacturer and brand details for Spinach Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Spinach Extract by BulkSupplements.com: Common Questions
Does Spinach Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take spinach extract if I'm pregnant or breastfeeding?
What are the side effects of spinach extract?
Does spinach extract actually work for fatty liver disease, weight loss, or PCOS?
Why do I need to be careful if I take warfarin?
Is this product just powdered spinach, or does it have other stuff in it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Spinach Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Spinach Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Spinach Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Spinach 6 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Karlson, B., Leijd, B., and Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. Acta Med Scand. 1986;220(4):347-350. PubMed
- Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375.
- Schuller, A., Morisset, M., Maadi, F., Kolopp Sarda, M. N., Fremont, S., Parisot, L., Kanny, G., and Moneret-Vautrin, D. A. Occupational asthma due to allergy to spinach powder in a pasta factory. Allergy 2005;60(3):408-409. PubMed
- Gustafsson, K., Asp, N. G., Hagander, B., and Nyman, M. Satiety effects of spinach in mixed meals: comparison with other vegetables. Int.J.Food Sci.Nutr. 1995;46(4):327-334. PubMed
- Schreiber, J., Muller, E., Becker, W. M., Zabel, P., Schlaak, M., and Amthor, M. [Spinach powder-induced exogenous allergic alveolitis]. Pneumologie 1998;52(1):61-65.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC