Stamina Formula Powder Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Stamina Formula Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Stamina Formula Powder is a dietary supplement by TerraVita Premium Collection with 3 active ingredients. Its ingredients are commonly taken for low libido / aphrodisiac, anxiety and stress, mood and mild low energy.Based on those ingredients, 1,140 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eleuthero powder, Damiana, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Stamina Formula Powder by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Stamina Formula Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Stamina Formula Powder by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This powder contains 3 active ingredients: Damiana (a traditional botanical), Eleuthero (also called Siberian ginseng), and Witch Hazel. These are combined in a proprietary blend, which means the exact amount of each ingredient per serving isn't broken out separately on the label — it's listed as a total blend weight.
Witch Hazel is typically used topically and is not meant to be taken by mouth, so check the label to understand how this product is intended to be used.
Does it work?
Moderate evidence
The evidence for this formula's individual ingredients is mixed and limited. Damiana has insufficient reliable evidence for the uses sometimes claimed for it — sexual dysfunction, asthma, headache, cognitive function, constipation, and depression are all listed as having insufficient evidence to rate.
Eleuthero shows possibly effective evidence for genital herpes, but insufficient evidence for familial Mediterranean fever, bipolar disorder, osteoporosis, and chronic fatigue syndrome. Witch Hazel is possibly effective for hemorrhoids, though it rates as possibly ineffective for eczema.
Overall, the ingredients lack strong evidence for a broad 'stamina' benefit.
How safe is it?
Well-documented data
Damiana is likely fine in small amounts but human safety data are limited — a very high dose (200 grams of extract) has caused serious muscle-related side effects in case reports. Eleuthero is generally well tolerated short-term, but long-term safety data are sparse.
Common side effects include diarrhea, nausea, headache, and stomach upset; some people report nervousness or anxiety, especially at higher doses, and it may raise blood pressure. Witch Hazel is generally well tolerated topically but is not meant to be swallowed — oral use at high doses may harm the kidneys or liver due to its tannin content.
Pregnancy and breastfeeding: the safety data for all three ingredients are insufficient; the facts advise against use during pregnancy and while breastfeeding, so talk with your doctor or pharmacist for personalized guidance.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs, diabetes medications, heart medications like digoxin, drugs that suppress your immune system, or any medication metabolized by your liver enzymes (CYP1A2, CYP2C9, or CYP2D6). Eleuthero is the main source of these Moderate-severity concerns.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This formula combines three botanicals with limited evidence for stamina and a number of potential interactions, especially with blood thinners, diabetes medications, heart medications, and drugs that affect immune function. If you take any prescription medications — particularly for blood clotting, blood sugar, heart rhythm, or immunity — check them against the tool on this page before you start.
Talk to your pharmacist about whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Stamina Formula Powder, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435120108 |
| Net contents | 4 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 287902 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Stamina Formula Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1000 mg | -- |
| Damiana, Powder | 0 NP | -- |
| Eleuthero powder | 0 NP | -- |
| Witch Hazel, Powder | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Damiana, eleuthero and witch hazel
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Stamina Formula Powder by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Stamina Formula Powder by TerraVita Premium Collection
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container113 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Stamina Formula Powder by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
Stamina Formula Powder by TerraVita Premium Collection contains two checked ingredients with documented interactions: Damiana and Eleuthero.
The most serious concern is Eleuthero, which may affect a large number of medications through several pathways. Eleuthero theoretically inhibits multiple liver enzymes and a drug-transport protein, potentially raising levels of medications metabolized by CYP1A2, CYP2C9, and P-glycoprotein — all listed as Moderate severity.
Additionally, Eleuthero may increase bleeding risk with blood thinners (anticoagulants) or antiplatelet drugs (Moderate), could interfere with drugs that suppress the immune system (Moderate), and may lower blood sugar when used with diabetes medications (Moderate). There's also a documented case of Eleuthero raising digoxin levels in a heart patient (Moderate).
Read the full breakdown — every affected drug type, severity by severity
Damiana carries a separate Moderate-severity concern: it may lower blood sugar and theoretically increase the risk of low blood sugar (hypoglycemia) if taken alongside diabetes medications.
Witch Hazel, the third ingredient, was checked and no interactions are documented in our data — though it is not formulated for oral use, and the product label should be verified for intended route.
Altogether, these interactions span 1,123 individual medications. Use the medication checker on this page to see if any of your specific drugs are affected before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Stamina Formula Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Stamina Formula Powder interact with 1,140 drugs. Click any drug to see the details.
2 of the 3 ingredients in Stamina Formula Powder interact with drugs. Each result below shows which ingredient is responsible. Eleuthero powder Damiana, Powder
Acetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Powder + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetohexamideDymelor
How Acetohexamide interacts with Stamina Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Damiana, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana, Powder + Acetohexamide interactionEleuthero PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Powder + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Powder + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Adalimumab-fkjp interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Powder + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Eleuthero Powder + Afatinib Dimaleate interactionAgomelatineValdoxan
How Agomelatine interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
Read the full Eleuthero Powder + Agomelatine interactionAlbiglutideTanzeum
How Albiglutide interacts with Stamina Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Powder + Albiglutide interactionDamiana, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana, Powder + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Powder + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Stamina Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero PowderAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Powder + Alogliptin interactionDamiana, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana, Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Stamina Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Damiana, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana, Powder + Alogliptin, Metformin interactionEleuthero PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Stamina Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero PowderAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Powder + Alogliptin, Pioglitazone interactionDamiana, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana, Powder + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Stamina Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Stamina Formula Powder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Eleuthero powder
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Damiana, Powder
Antidiabetes Drugs
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.
Brand information
Manufacturer and brand details for Stamina Formula Powder, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Stamina Formula Powder by TerraVita Premium Collection: Common Questions
Does Stamina Formula Powder by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on a blood thinner or aspirin?
Is this safe during pregnancy or while breastfeeding?
What are the common side effects?
Does this actually improve stamina or energy?
Why is Witch Hazel in a stamina powder if it's not meant to be taken by mouth?
Will this interact with my diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Stamina Formula Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Damiana
Interacts with 86 drugsDamiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...
Read the full Damiana monograph → Herb & supplement monographEleuthero
Interacts with 1,140 drugsEleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...
Read the full Eleuthero monograph → Herb & supplement monographWitch Hazel
Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a topical product for short-term use, but...
Read the full Witch Hazel monograph →Sources & How We Checked
Stamina Formula Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Damiana 2 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Alarcon-Aquilar FJ, Roman-Ramos R, Perez-Gutierrez S, et al. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10. PubMed
Eleuthero 24 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
- Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
- Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
- Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
- Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
- Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
- Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
- Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
- Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
- Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
- Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
- Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
- Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
- Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
- Schmolz, M. W., Sacher, F., and Aicher, B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother.Res 2001;15(3):268-270.
- Huang, D. B., Ran, R. Z., and Yu, Z. F. [Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer]. Zhongguo Zhong.Yao Za Zhi. 2005;30(8):621-624.
- Niu, H. S., Hsu, F. L., Liu, I. M., and Cheng, J. T. Increase of beta-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats. Horm.Metab Res 2007;39(12):894-898
- Watanabe, K., Kamata, K., Sato, J., and Takahashi, T. Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption. J Ethnopharmacol. 10-28-2010;132(1):193-199. PubMed
- Bazaz'ian, G. G., Liapina, L. A., Pastorova, V. E., and Zvereva, E. G. [Effect of Eleutherococcus on the functional status of the anticoagulation system in older animals]. Fiziol.Zh.SSSR Im I.M.Sechenova 1987;73(10):1390-1395.
- Kaloeva, Z. D. [Effect of the glycosides of Eleutherococcus senticosus on the hemodynamic indices of children with hypotensive states]. Farmakol.Toksikol. 1986;49(5):73.
- Martinez, B. and Staba, E. J. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984;35(2):79-85. DOI
- Medon, P. J., Thompson, E. B., and Farnsworth, N. R. Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and chronic administration in mice. Zhongguo Yao Li Xue.Bao. 1981;2(4):281-285.
- Freye E, GLeske J. Siberian ginseng results in beneficial effects on glucose metabolism in diabetes type 2 patients: a double blind placebo-controlled study in comparison to panax ginseng. Int J Clin Nutr. 2013;1(1):11-17.
Witch Hazel 7 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948. PubMed
- Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410. PubMed
- Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201 PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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