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Dietary supplement

Standardized African Mango Ingredients & Drug Interactions

by Nature's Way

Standardized African Mango label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Standardized African Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Standardized African Mango is a dietary supplement by Nature's Way with 2 active ingredients. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 2,051 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glucomannan root extract, African Mango seed extract Irvingia gabonensis IGOB 131. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Standardized African Mango by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Standardized African Mango by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Standardized African Mango by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. African Mango seed extract (Irvingia gabonensis IGOB 131) is included for its traditional use, though the evidence for most claimed benefits is still being established.

Glucomannan is a soluble fiber derived from plant root extract; it acts as a bulking agent in the digestive tract. The capsule itself is plant-derived, and the inactive ingredients include cellulose as a filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss and appetite control support.
  • We looked for evidence on: Obesity, Hypercholesterolemia, Hyperlipidemia, Metabolic syndrome, appetite suppression, satiety.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for African Mango seed extract's effectiveness is insufficient for conditions like diabetes, high cholesterol, obesity, and metabolic syndrome — meaning the current research doesn't strongly support or rule out benefits. Glucomannan has more established data: it's possibly effective for constipation, diabetes management, and high cholesterol, and it may help with blood pressure, though that evidence is still being confirmed.

The evidence, ingredient by ingredient Irvingia Gabonensis Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated when used in the short term in studies. Common side effects from African Mango seed extract are flatulence, headache, insomnia, and nausea; glucomannan may cause abdominal pain, bloating, constipation, diarrhea, flatulence, nausea, and vomiting — especially at doses over 3 grams daily.

A rare but serious risk with glucomannan is choking or blockage in the esophagus or intestines if taken as a dry powder or tablet without enough liquid; always take it with plenty of water. One isolated case of liver inflammation (hepatitis) has been reported with African Mango seed extract use.

Long-term safety isn't well established. During pregnancy, the safety data for African Mango seed extract advises against use; for glucomannan, there isn't enough reliable safety information — talk with your doctor before using either during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Irvingia Gabonensis Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Glucomannan, Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 2,052 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before taking this product: antidiabetes drugs (blood sugar medications — there's a real risk of low blood sugar), testosterone products (additive hormone effects are possible), and any oral medications in general (glucomannan may reduce their absorption). All of these are Moderate-severity concerns documented in the research.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is not well studied for most of its claimed uses, and it carries real risks — especially if you take antidiabetes medications or testosterone products, or if you take other oral drugs that depend on normal absorption. Anyone on blood sugar medication should get their doctor's or pharmacist's clearance and close monitoring before starting.

Always take glucomannan with plenty of water to avoid digestive blockage. If you're pregnant or breastfeeding, discuss it with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Standardized African Mango, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674158470
Net contents 60 Veg. Capsule(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79524
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Standardized African Mango by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
033674158470
IngredientAmount% DV
African Mango seed extract Irvingia gabonensis IGOB 131150 mg--
Glucomannan root extract100 mg--

Other ingredients: Cellulose, plant-derived Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Our standardized african mango extract (patented IGOB 131) is carefully tested and produced to superior quality standards.

2017 Nature’s Way Brands, LLC

Irvingia gabonensis IGOB 131 proprietary extract is a registered trademark of Gateway Health Alliances, Inc., Fairfield, California. U.S. Patent 7,537,790. U.S. and international patents pending.

Precautions

Keep out of reach of children.

Safety sealed with printed outer shrink-wrap and inner seal. Do not use if either is broken or missing.

Warning: Take with a full glass of water. Taking without adequate fluid may cause it to swell and block your throat or esophagus, and may cause choking. Do not take this product if you have difficulty in swallowing. If you experience chest pain, vomiting or difficulty swallowing or breathing after taking this product, seek immediate medical attention.

If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Formulation

Gluten free. No sugar, salt, yeast, wheat, soy, corn, dairy products, artificial colors, flavors or preservatives.

Vegetarian

Non GMO

Seals/Symbols

Vegetarian

Non GMO Project Verified Nongmoproject.org

Certified Authentic Tru-ID

General

LN15847.04 BLK8772

General Statements

Premium extract

Formula

IGOB 131 7% albumins

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 capsule twice daily. For best results take 30-60 minutes before mealtime.

Warning: Take with a full glass of water.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Standardized African Mango by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Standardized African Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Standardized African Mango by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

African Mango seed extract Irvingia gabonensis IGOB 131

Interacts with
94 drugs
150 mg per serving Form: Irvingia gabonensis seed extract

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango seed extract Irvingia gabonensis IGOB 131 monograph & interactions

Glucomannan root extract

Interacts with
2,022 drugs
100 mg per serving

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Glucomannan root extract monograph & interactions

Other (inactive) ingredients: Cellulose, Plant-derived Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Standardized African Mango by Nature's Way Drug Interactions

Want to check YOUR meds against Standardized African Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,051Drugs
2,051 Moderate

Ingredients driving the most interactions

Glucomannan root extract 2,022
African Mango seed extract Irvingia gabonensis IGOB 131 94

Individual Drug Interactions

The ingredients in Standardized African Mango interact with 2,051 drugs. Click any drug to see the details.

2 of the 2 ingredients in Standardized African Mango interact with drugs. Each result below shows which ingredient is responsible. Glucomannan root extract African Mango seed extract Irvingia gabonensis IGOB 131

Each ingredient & the kinds of drugs it affects

For each ingredient in Standardized African Mango with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucomannan root extract1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Glucomannan root extract full monograph & interactions

African Mango seed extract Irvingia gabonensis IGOB 1312 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango seed extract Irvingia gabonensis IGOB 131 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Standardized African Mango, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Standardized African Mango by Nature's Way: Common Questions

Does Standardized African Mango by Nature's Way interact with any medications?
Yes. Based on its ingredients, Standardized African Mango has a known interaction with 2,051 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Standardized African Mango contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does African Mango actually work for weight loss or diabetes?
The evidence we have isn't strong enough yet to say it works for those — the rating is insufficient reliable evidence. That doesn't mean it doesn't; it means we need more and better research before making claims.
Can I take this if I'm on metformin or another diabetes medication?
Not without checking with your doctor or pharmacist first. Human research shows African Mango can lower blood sugar, and when combined with diabetes drugs, there's a real risk of blood sugar dropping too low. You'd need close monitoring and possibly a dose adjustment to your medication.
What are the most common side effects?
From African Mango seed extract: flatulence, headache, insomnia, and nausea. From glucomannan: abdominal pain, bloating, constipation, diarrhea, flatulence, nausea, and vomiting. Most people tolerate it short-term, but gastrointestinal upset is typical when taking glucomannan.
Is it safe to take while pregnant?
The safety data advises against African Mango seed extract during pregnancy. For glucomannan, there isn't enough reliable safety information to say either way. Talk with your doctor or pharmacist for personalized advice before using it.
Do I need to take this with food or water?
Yes — glucomannan especially must be taken with plenty of water or other liquid to reduce the risk of choking or intestinal blockage. Taking it as a dry powder or tablet without enough fluid is a serious risk.
Can this interact with birth control or hormone replacement therapy?
African Mango may interact with testosterone products specifically (animal research suggests it can raise testosterone levels), so caution is advised. For other hormones, the data we hold doesn't cover those — talk with your pharmacist about your specific medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Standardized African Mango label
Go deeper

The Full Monographs Behind Standardized African Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph → Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

Standardized African Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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