No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Standardized Olive Leaf Extract Ingredients & Drug Interactions

by 21st Century

Capsule Category: Botanical
No known interaction
The interaction bottom line No known interaction

Standardized Olive Leaf Extract is a dietary supplement by 21st Century with 1 active ingredient. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Standardized Olive Leaf Extract by 21st Century

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: olive leaf extract, a concentrated form of compounds from the olive plant. The capsule also includes inactive ingredients — rice bran, oat fiber, vegetable cellulose, magnesium silicate, and magnesium stearate — which serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: improved circulation and general well being.
  • We looked for evidence on: cardiovascular health, blood pressure, cholesterol.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for olive leaf extract isn't established yet. Our data rates it insufficient for osteoporosis, indigestion (dyspepsia), exercise-related respiratory infections, shingles, flu, and osteoarthritis.

That means either no reliable trials exist, the ones we have aren't strong enough, or results are mixed. It doesn't mean it doesn't work — it means we can't say based on what we know.

The evidence, ingredient by ingredient Olive

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Olive as food — the oil and the fruit — is very safe. Olive leaf extract itself appears well tolerated in the trials we have data for.

The most common side effects reported were headache and stomach discomfort. One person in one trial reported skin and acne.

Because concentrated olive leaf supplements are less studied than whole olives or olive oil, play it safe: talk to your doctor before starting unless you've used it before. If you're sensitive to olive tree pollen, be aware that may trigger seasonal allergies.

Side effects, ingredient by ingredient Olive

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for this product.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

If you're curious about olive leaf extract for general wellness, this product is well tolerated. But the evidence for any specific condition isn't strong yet.

Check with your doctor first, especially if you have never tried concentrated olive supplements before.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Standardized Olive Leaf Extract, straight from the product label.

Brand 21st Century
Barcode (UPC) 740985217160
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2012
DSLD ID 11492
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Standardized Olive Leaf Extract by 21st Century, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
740985217160
IngredientAmount% DV
Olive Leaf Extract500 mg--

Other ingredients: Rice Bran, Oat Fiber, Vegetable Cellulose, Magnesium Silicate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take up to two (2) vegetarian capsules daily with meals for maximum daily results, or as directed by your healthcare provider.

Precautions

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Formulation

No added Sugar, Salt, Yeast, Preservatives or Artificial Flavors.

Formula

100% Vegetarian Formula

General Statements

The Natural Alternative for Improved Circulation and General Well Being*

Unconditionally guaranteed for purity, freshness and label potency.

HERBAL EXTRACT

21st Century's Extract (Olea europaea) standardized to 8% oleuropein is a valued nutritional discovery in support of the immune system.* For centuries the cultures of the Mediterranean have used olive daily in food preparations promoting good health and long life. 21st Century's standardized herbal extracts are thoroughly tested to assure specific levels of the important active ingredients are present for maximum benefit.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

21ST Century(R)...for a healthier future.

Storage

Store at room temperature.

Seals/Symbols

MADE IN USA

General

0505

See for yourself

Standardized Olive Leaf Extract by 21st Century label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Standardized Olive Leaf Extract by 21st Century

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Olive Leaf Extract

No known
interactions
500 mg per serving Form: Olea europaea

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive Leaf Extract monograph & interactions

Other (inactive) ingredients: Rice Bran, Oat Fiber, Vegetable Cellulose, Magnesium Silicate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Standardized Olive Leaf Extract by 21st Century Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Standardized Olive Leaf Extract. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Standardized Olive Leaf Extract, from the product label.

21st Century

See all 21st Century products
Name
21st Century Healthcare, Inc.
Street Address
2119 S. Wilson Street
City
Tempe
State
AZ
ZipCode
85282
Web Address
www.21stcenturyvitamins.com
Pharmacist Counseling Corner

Standardized Olive Leaf Extract by 21st Century: Common Questions

Does Standardized Olive Leaf Extract by 21st Century interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Standardized Olive Leaf Extract. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Standardized Olive Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does olive leaf extract actually do anything?
The evidence isn't clear yet. Our data rates it insufficient for the conditions it's marketed for — osteoporosis, indigestion, respiratory infections, shingles, flu, and osteoarthritis. That means we don't have reliable trials showing it works for any of those. It doesn't mean it's useless, just that we can't prove it yet.
What are the side effects?
Olive leaf extract seems well tolerated overall. The most common side effects in trials were headache and stomach discomfort. One person reported skin and acne. If you're allergic to olive tree pollen, this might trigger symptoms.
Is olive leaf extract safe to take long-term?
Olive oil and olives as food are very safe, but concentrated supplements like this are less studied. We don't have enough long-term safety data to be certain. Talk to your doctor before starting, especially if you plan to take it regularly.
Can I take this while pregnant or breastfeeding?
We don't have safety data on file for olive leaf extract during pregnancy or breastfeeding. There isn't enough information to know either way. Talk with your doctor or pharmacist for personalized advice.
What's in the capsule besides the extract?
The capsule contains rice bran, oat fiber, vegetable cellulose, magnesium silicate, and magnesium stearate — all inactive fillers and binders to hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Standardized Olive Leaf Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Standardized Olive Leaf Extract label
Go deeper

The Full Monographs Behind Standardized Olive Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Standardized Olive Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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