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Dietary supplement

Olive 250 mg 17% Oleuropein Ingredients & Drug Interactions

by Solaray

Olive 250 mg 17% Oleuropein label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Olive 250 mg 17% Oleuropein against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Olive 250 mg 17% Oleuropein is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Olive 250 mg 17% Oleuropein by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Olive 250 mg 17% Oleuropein by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Olive 250 mg 17% Oleuropein by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Olive Leaf Extract” is listed as a grouped ingredient — the label gives one combined amount (250 mg) without saying how much of each component you get.

This product contains 2 active ingredients: lemon balm and oleuropein (the compound that makes up 17% of the olive leaf extract in the formula). Lemon balm is traditionally used for stress and cold sores, while oleuropein is a polyphenol found in olives.

The remaining ingredients are inactive excipients — rice concentrate, cellulose, dextrin, rice extract blend, and silica — which help form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lemon Balm's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Immune support.
  • We looked for evidence on: Chronic bronchitis, Exercise-induced respiratory infections, Influenza, Upper respiratory infection, Common cold, Immune function — and 1 related terms.
  • The closest evidence on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).

Lemon balm has Possibly Effective evidence for herpes labialis (cold sores) and stress, and Possibly Effective evidence for depression, according to the data we hold. That means the evidence suggests benefit, but it's not definitive.

We don't have effectiveness ratings on file for oleuropein or the overall olive leaf extract blend, so we can't speak to what research shows for those components.

The evidence, ingredient by ingredient Lemon Balm Olive

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in healthy adults, though long-term safety and effects of high doses haven't been well studied. The most commonly reported side effects are dizziness and sedation, but clinical trials show these don't occur more often with lemon balm than with placebo.

There's a rare case on record of heart rhythm changes in someone taking a multi-ingredient product containing lemon balm, but it's unclear whether lemon balm was the cause. During pregnancy, the safety data advises against use unless your doctor advises otherwise.

While breastfeeding, there isn't enough safety information — talk with your doctor before using it.

Side effects, ingredient by ingredient Lemon Balm Olive

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check any CNS depressants (sedatives, sleep aids, certain pain or anxiety medications) and thyroid hormone replacements against your exact prescriptions using the search tool on this page — both carry Moderate-severity interactions with lemon balm.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you don't take CNS depressants or thyroid medication, this product is worth checking against your full medication list using our tool below. If you do take either of those, have that conversation with your pharmacist first — the interactions may be manageable, but they need a look.

Lemon balm has some evidence for stress and cold sores, though it's not ironclad.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Olive 250 mg 17% Oleuropein, straight from the product label.

Brand Solaray
Barcode (UPC) 076280375718
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 339105
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Olive 250 mg 17% Oleuropein by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
60
UPC/BARCODE
076280375718
IngredientAmount% DV
Lemon Balm85 mg--
Oleuropein42.5 mg--
Olive Leaf Extract250 mg--

Other ingredients: whole Rice concentrate, Cellulose, Dextrin, Rice extract Blend, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A brighter way 1973

General Statements

Vital extracts

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR bottles

Formulation

Immune support

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified Vegan

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Directions: Use only as directed.

California residents only Warning: Reproductive harm - www.P65Warnings.ca.gov

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap two times daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Olive 250 mg 17% Oleuropein by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Olive 250 mg 17% Oleuropein label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Olive 250 mg 17% Oleuropein by Solaray

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lemon Balm

Interacts with
264 drugs
85 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm monograph & interactions

Olive Leaf Extract

No known
interactions
250 mg per serving

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive Leaf Extract monograph & interactions
  • › Oleuropein

Other (inactive) ingredients: Whole Rice concentrate, Cellulose, Dextrin, Rice extract Blend, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Olive 250 mg 17% Oleuropein by Solaray Drug Interactions

Want to check YOUR meds against Olive 250 mg 17% Oleuropein?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm 264

Individual Drug Interactions

The ingredients in Olive 250 mg 17% Oleuropein interact with 264 drugs. Click any drug to see the details.

1 of the 2 ingredients in Olive 250 mg 17% Oleuropein interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm

Each ingredient & the kinds of drugs it affects

For each ingredient in Olive 250 mg 17% Oleuropein with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Olive 250 mg 17% Oleuropein, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Olive 250 mg 17% Oleuropein by Solaray: Common Questions

Does Olive 250 mg 17% Oleuropein by Solaray interact with any medications?
Yes. Based on its ingredients, Olive 250 mg 17% Oleuropein has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Olive 250 mg 17% Oleuropein contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with cold sores?
Lemon balm is Possibly Effective for cold sores (herpes labialis), so there's evidence it may help, though the research isn't definitive. The data we hold doesn't speak to oleuropein's effectiveness for that purpose.
Can I take this while pregnant or breastfeeding?
During pregnancy, the safety data advises against lemon balm unless your doctor advises otherwise. While breastfeeding, there isn't enough safety information — talk with your doctor or pharmacist before using it.
What's oleuropein, and why is it in here?
Oleuropein is a natural compound found in olives; it makes up 17% of the olive leaf extract in this formula. We don't have effectiveness data on file for it specifically, but it's included as part of the olive leaf component.
Does this help with stress or depression?
Lemon balm is rated Possibly Effective for both stress and depression, meaning the evidence suggests it may help — but the research isn't conclusive. It's one reason people use it, but it's not a replacement for treatment your doctor recommends.
What side effects should I watch for?
Dizziness and sedation have been reported with lemon balm, though clinical trials show they don't happen more often than with placebo. In rare cases, heart rhythm changes have been reported, but it's unclear if lemon balm was responsible.
Is this safe long-term?
Lemon balm is generally well tolerated for short-term use, but long-term safety and the effects of high doses haven't been well studied. If you're thinking about taking it regularly, talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Olive 250 mg 17% Oleuropein is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Olive 250 mg 17% Oleuropein label
Go deeper

The Full Monographs Behind Olive 250 mg 17% Oleuropein’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph →
Sources

Sources & How We Checked

Olive 250 mg 17% Oleuropein's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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