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Dietary supplement

Stress Guard Ingredients & Drug Interactions

by Longevity Medical Clinic

Stress Guard label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stress Guard against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stress Guard is a dietary supplement by Longevity Medical Clinic with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 944 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passionflower, Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stress Guard by Longevity Medical Clinic

Ask about any prescription or over-the-counter medication and we check it for interactions with Stress Guard by Longevity Medical Clinic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stress Guard by Longevity Medical Clinic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Stress Guard contains two active ingredients: phosphatidylserine and passionflower. Phosphatidylserine is a fat-like compound found in cell membranes; it may help with age-related thinking changes and cognitive decline.

Passionflower is a plant extract traditionally used for calming — the data shows it's possibly effective for insomnia and anxiety before procedures. The capsule also contains inactive ingredients: silica, rice flour, gelatin, and purified water, which serve as fillers and the capsule shell itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: help the body cope with stress.
  • We looked for evidence on: Stress, Pre-procedural anxiety, Adjustment disorders, Insomnia, Anxiety, Cortisol regulation — and 1 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Adjustment disorders, Stress.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer's disease. However, evidence for athletic performance, ADHD, general cognitive function, and dementia is insufficient — we just don't have reliable data yet on those uses.

Passionflower is rated possibly effective for insomnia and pre-procedural anxiety. For alcohol use disorder and benzoparazepine withdrawal, the evidence isn't established in our data.

The evidence, ingredient by ingredient Phosphatidylserine Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated, though long-term safety isn't fully established. Common side effects include flatulence, gastrointestinal upset, headache, insomnia (more likely at higher doses around 600 mg), and nausea.

The safety data advises against use during pregnancy. Breastfeeding safety is unknown, so avoidance is recommended.

Passionflower is generally well tolerated short-term but can cause drowsiness, dizziness, confusion, or sedation. There's a case report of severe nausea, vomiting, and heart rhythm changes at very high doses (1500–2000 mg), though symptoms resolved after stopping.

The safety data indicates it is possibly unsafe in pregnancy due to lack of safety data and possible effects on the uterus. Breastfeeding safety is unknown, so avoidance is recommended.

Side effects, ingredient by ingredient Phosphatidylserine Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Passion Flower, Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 945 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Stress Guard, check any anticholinergic drugs (like oxybutynin for overactive bladder) or cholinergic drugs — phosphatidylserine could theoretically interfere with them. Also check sedating medications (lorazepam, sleeping pills, anxiety drugs) because passionflower may add to drowsiness.

Finally, if you take any drugs metabolized by CYP3A4 enzymes or transported by OATP proteins, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Stress Guard may help with age-related cognitive decline and sleep or pre-procedure anxiety, but the evidence is limited for many other uses. If you take anticholinergic drugs, cholinergic drugs, sedating medications, or drugs metabolized by CYP3A4 or transported by OATP proteins, check your specific medications with the tool on this page first.

Avoid during pregnancy and breastfeeding. Talk with your pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stress Guard, straight from the product label.

Brand Longevity Medical Clinic
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 308090
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stress Guard by Longevity Medical Clinic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
IngredientAmount% DV
Phosphatidylserine150 mg--
Passionflower350 mg--

Other ingredients: Silica, Rice Flour, Gelatin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Formula

Stress Guard is a powerful formula to help the body cope with stress. Phosphatidylserine (PS) is phospholipid found in high concentrations in the nervous system which helps the body counterbalance excessive release of cortisol in response to stress. In addition to modulating cortisol levels, PS supports healthy brain function, memory, and focus. Passionflower is a well-known traditional herbal medicine that supports normal healthy nervous system function, restful sleep, and eases normal mild tension.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place.

Precautions

Tamper evident. Do not use if seal is broken.

Keep out of reach of children.

Consult your physician if you are pregnant or breastfeeding before using this product.

Contains: Soy.

Suggested/Recommended/Usage/Directions

Recommendations: Take one (1) capsule twice daily, or as recommended by your Longevity Physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stress Guard by Longevity Medical Clinic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stress Guard label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stress Guard by Longevity Medical Clinic

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylserine

Interacts with
219 drugs
150 mg per serving Form: Soy

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Passionflower

Interacts with
836 drugs
350 mg per serving Form: Passiflora incarnata

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower monograph & interactions

Other (inactive) ingredients: Silica, Rice Flour, Gelatin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stress Guard by Longevity Medical Clinic Drug Interactions

Want to check YOUR meds against Stress Guard?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
944Drugs
417 Moderate 527 Minor

Ingredients driving the most interactions

Passionflower 836
Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Stress Guard interact with 944 drugs. Click any drug to see the details.

2 of the 2 ingredients in Stress Guard interact with drugs. Each result below shows which ingredient is responsible. Passionflower Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Stress Guard with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Passionflower3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stress Guard, from the product label.

Longevity Medical Clinic

See all Longevity Medical Clinic products
Name
Longevity Medical Clinic
Street Address
9757 NE Juanita Drive
City
Kirkland
State
WA
ZipCode
98034
Phone Number
866-869-6864
Web Address
LMClinic.com
Pharmacist Counseling Corner

Stress Guard by Longevity Medical Clinic: Common Questions

Does Stress Guard by Longevity Medical Clinic interact with any medications?
Yes. Based on its ingredients, Stress Guard has a known interaction with 944 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stress Guard contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Stress Guard if I'm pregnant or breastfeeding?
No — avoid it during pregnancy because there isn't enough safety information and phosphatidylserine lacks safety data in pregnancy. Passionflower is rated possibly unsafe in pregnancy due to possible effects on the uterus. Breastfeeding safety is unknown for both ingredients, so avoidance is recommended. Talk with your doctor or pharmacist about alternatives.
Will Stress Guard make me drowsy?
Possibly. Passionflower is known to cause drowsiness, dizziness, or sedation, especially if you're already taking sedating medications. Phosphatidylserine can also cause insomnia (the flip side), particularly at higher doses around 600 mg. You may want to start with a lower dose and see how you respond.
What's phosphatidylserine, and what does it do?
Phosphatidylserine is a fat-like substance found naturally in cell membranes. In this product, it's included because it may help with age-related decline in thinking skills and Alzheimer's disease — though evidence for other uses like ADHD or general brain function is still being studied.
Is Stress Guard safe if I take other medications?
The ingredients have documented interactions with certain medication types: anticholinergic drugs, cholinergic drugs, sedating medications, and drugs processed by your liver's CYP3A4 enzymes or transported by OATP proteins. Use the checker on this page with your exact prescriptions, then talk to your pharmacist before starting.
What side effects should I watch for?
Phosphatidylserine may cause flatulence, nausea, gastrointestinal upset, headache, or insomnia — especially at higher doses. Passionflower can cause drowsiness, dizziness, confusion, or sedation. A single case report documented severe nausea, vomiting, and heart rhythm changes at very high doses (1500–2000 mg), though symptoms resolved after stopping. If anything feels off, stop and call your pharmacist or doctor.
Will Stress Guard help me sleep?
Passionflower is rated possibly effective for insomnia, so it may help — but your experience could vary. Phosphatidylserine, on the other hand, can actually cause insomnia in some people, especially at higher doses. The balance between the two ingredients is something worth discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stress Guard label
Go deeper

The Full Monographs Behind Stress Guard’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Stress Guard's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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