Super Cranberry Extract Chewable Tablets 100 mg Ingredients & Drug Interactions
by Kirkman
What is this page for?
First and foremost: checking Super Cranberry Extract Chewable Tablets 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Super Cranberry Extract Chewable Tablets 100 mg is a dietary supplement by Kirkman with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Super Cranberry Extract Chewable Tablets 100 mg by Kirkman
Ask about any prescription or over-the-counter medication and we check it for interactions with Super Cranberry Extract Chewable Tablets 100 mg by Kirkman — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Super Cranberry Extract Chewable Tablets 100 mg by Kirkman
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: 100 mg of cranberry extract per chewable tablet. Cranberry is a concentrated form of compounds from the cranberry fruit, including flavonoids and other plant chemicals that give cranberry its potential health effects.
The tablet also contains several inactive ingredients — sorbitol, crospovidone, raspberry flavoring, stearic acid, magnesium stearate, silicon dioxide, and stevia leaf extract — which help form, stabilize, and flavor the tablet.
Does it work?
Moderate evidence
Cranberry extract is possibly effective for urinary tract infections (UTIs), based on the evidence we hold. The research supporting other uses — including age-related memory loss, prostate health, cancer prevention, fatty liver disease, and chronic fatigue — is insufficient to rate at this time.
If you're taking this tablet for UTI prevention, talk with your doctor about whether it's right for you and how it fits into your overall care plan.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when taken by mouth, though the concentrated supplements in tablet form haven't been studied as thoroughly as cranberry in regular food amounts. The most common side effects in trials are diarrhea and gastrointestinal upset; nausea, vomiting, and abdominal discomfort have also been reported.
Very large doses (3–4 liters of juice per day) can cause more severe digestive symptoms, especially in young children. One person reported skin redness and itching.
Cranberry in normal food amounts is likely safe in pregnancy and lactation, but concentrated supplement doses have not been well studied. Talk with your doctor or pharmacist before using these tablets if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Before you take these tablets, check with your doctor or pharmacist if you're on blood thinners like warfarin, cholesterol medications like atorvastatin, or the blood pressure drug nifedipine — cranberry can raise drug levels and side effects. Mention it also if you take other cholesterol drugs or nonsteroidal anti-inflammatory pain relievers like diclofenac.
Your pharmacist can look up your specific medications using the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
These tablets may help prevent urinary tract infections, though you'll want to confirm with your doctor that they're right for you. If you take blood thinners, cholesterol drugs, or blood pressure medications, check your exact prescriptions with your pharmacist or doctor before starting — cranberry can interact with several common drugs.
Talk it over with your own healthcare provider to make sure this supplement fits your needs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Super Cranberry Extract Chewable Tablets 100 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Super Cranberry Extract Chewable Tablets 100 mg by Kirkman, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cranberry Extract | 100 mg | -- |
Other ingredients: Sorbitol, Crospovidone, natural Raspberry flavor, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Stevia leaf extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
DOES NOT CONTAIN: Sugar, soy, wheat, casein, gluten, milk, preservatives, yeast, gelatin, artificial flavorings, colorings, fish, tree nuts or peanuts.
CASEIN & GLUTEN FREE
Storage
IMPORTANT: STORE IN A COOL DRY PLACE AND TIGHTLY CAPPED.
Precautions
KEEP OUT OF THE REACH OF CHILDREN.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: 1 tablet, three times daily or as directed by a physician.
General
407/100
General Statements
(503)694-1600
Country of Origin USA
Best Used by: June 2012
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
ShanStar
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Super Cranberry Extract Chewable Tablets 100 mg by Kirkman label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Super Cranberry Extract Chewable Tablets 100 mg by Kirkman
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.
Cranberry Extract
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry Extract monograph & interactionsOther (inactive) ingredients: Sorbitol, Crospovidone, Natural Raspberry flavor, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.
Super Cranberry Extract Chewable Tablets 100 mg by Kirkman Drug Interactions
HelloPharmacist Interaction Report
Kirkland's Super Cranberry Extract Chewable Tablets interact with a number of common medications through their single active ingredient, cranberry extract.
The most serious interaction is with blood thinners (anticoagulants) like warfarin — cranberry may raise your INR (a measure of how thin your blood is), though the research here is mixed. This is a Moderate-severity concern you'll want to discuss with your doctor or pharmacist before combining them.
Read the full breakdown — every affected drug type, severity by severity
Cranberry extract also has Moderate interactions with cholesterol-lowering statins like atorvastatin and with the blood pressure drug nifedipine. There's a case report of muscle pain, muscle breakdown, and liver trouble in someone taking atorvastatin with high-dose cranberry juice, though the extract dose in these tablets may differ.
With nifedipine, animal data suggest cranberry could raise drug levels by about 60 percent, but human studies are limited.
Minor interactions are documented with other cholesterol drugs and anti-inflammatory medications like diclofenac — the risk is lower, but still worth mentioning when you fill your prescription. Altogether, these interactions span 713 individual medications.
Use the interaction checker below to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Super Cranberry Extract Chewable Tablets 100 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Super Cranberry Extract Chewable Tablets 100 mg interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Super Cranberry Extract Chewable Tablets 100 mg interact with drugs. Each result below shows which ingredient is responsible. Cranberry Extract
ApremilastOtezla
How Apremilast interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aprepitant interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Armodafinil interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Extract + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Extract + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAvacopanTavneos
How Avacopan interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avacopan interactionAvanafilStendra
How Avanafil interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avapritinib interactionAxitinibInlyta
How Axitinib interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Super Cranberry Extract Chewable Tablets 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Super Cranberry Extract Chewable Tablets 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry Extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Super Cranberry Extract Chewable Tablets 100 mg, from the product label.
Kirkman
See all Kirkman products- Name
- Kirkman
- City
- Lake Oswego
- State
- OR
- ZipCode
- 97035
- Phone Number
- (800) 245-8282
- Web Address
- www.kirkmangroup.com
Super Cranberry Extract Chewable Tablets 100 mg by Kirkman: Common Questions
Does Super Cranberry Extract Chewable Tablets 100 mg by Kirkman interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help prevent urinary tract infections?
What side effects should I expect?
Is it safe to take during pregnancy or while breastfeeding?
Can I take this with my statin for cholesterol?
What is cranberry extract exactly?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Super Cranberry Extract Chewable Tablets 100 mg is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Super Cranberry Extract Chewable Tablets 100 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Super Cranberry Extract Chewable Tablets 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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