Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Super MiraForte With Standardized Lignans Ingredients & Drug Interactions

by Life Extension

Super MiraForte With Standardized Lignans label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super MiraForte With Standardized Lignans against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super MiraForte With Standardized Lignans is a dietary supplement by Life Extension with 7 active ingredients. Its ingredients are commonly taken for bodybuilding and testosterone support, anxiety and stress, anti-inflammatory.Based on those ingredients, 514 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chrysin, Nettle (Urtica dioica) Methanolic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super MiraForte With Standardized Lignans by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super MiraForte With Standardized Lignans by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super MiraForte With Standardized Lignans by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 7 ingredients. The active ones are chrysin (a plant compound), olive leaf extract, maca (a root vegetable), muira puama (a plant used traditionally in herbal medicine), stinging nettle extract, HMRlignan (a lignan from Norway spruce), and piperine (the active compound in black pepper, added to help absorption).

The remaining ingredients are fillers and capsule material—gelatin, microcrystalline cellulose, maltodextrin, vegetable stearate, and silica.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: maintain healthy testosterone and sexual function.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Sexual desire, Sexual dysfunction, Antidepressant-induced sexual dysfunction, Male infertility — and 4 related terms.
  • The closest evidence on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction (Natural Medicines).
  • Also on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Fatigue, Sexual desire, Age-related testosterone deficiency, and more.
  • Also on file: Muira Puama is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction.

The evidence for this product's ingredients is sparse. Stinging nettle is rated possibly effective for diabetes, meaning some clinical research supports its use.

The other ingredients—chrysin, olive leaf extract, maca, and muira puama—all have insufficient reliable evidence for their listed uses, so we don't have solid data yet showing how well they work. HMRlignan and piperine effectiveness data aren't on file.

The evidence, ingredient by ingredient Chrysin Olive Maca Muira Puama Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chrysin is generally well tolerated in the short term, but long-term safety hasn't been studied. Avoid it during pregnancy and breastfeeding—there's not enough data to know it's safe.

Olive leaf extract seems well tolerated overall; the most common side effects reported are headache and stomach discomfort, though one patient reported skin issues. Maca and muira puama are generally tolerated as foods or traditional supplements, but long-term supplement safety hasn't been established; avoid both during pregnancy and breastfeeding.

Stinging nettle is commonly well tolerated but may cause constipation or diarrhea. Rare cases of liver injury have been reported with stinging nettle in combination products.

Avoid stinging nettle during pregnancy and breastfeeding. We don't have adverse effect or safety data on file for HMRlignan or piperine.

Side effects, ingredient by ingredient Chrysin Olive Maca Muira Puama Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Stinging Nettle, Chrysin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 514 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you're on blood thinners like warfarin or aspirin (chrysin and stinging nettle may increase bleeding risk). Check if you take estrogen therapy or estrogen-containing birth control (chrysin may reduce their effectiveness).

If you're on diabetes medications, diuretics, lithium, the seizure drug mephenytoin, aromatase inhibitors, diclofenac, or other drugs metabolized by your liver, run them through the checker below first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient herbal supplement with the most serious interactions involving chrysin (affecting blood thinners, hormonal birth control, estrogen therapy, and several other drugs) and stinging nettle (affecting diabetes, diuretic, lithium, and blood-thinner medications). If you take any prescription medication—especially blood thinners, diabetes drugs, birth control, or seizure medications—check your exact drugs with the tool below before starting.

Talk to your pharmacist or doctor about whether this product fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super MiraForte With Standardized Lignans, straight from the product label.

Brand Life Extension
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47785
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super MiraForte With Standardized Lignans by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Chrysin750 mg--
Olive leaf extract7.5 mg--
Maca160 mg--
Muira Puama (Ptychopetalum olacoides) extract425 mg--
Nettle (Urtica dioica) Methanolic extract141 mg--
HMRlignan Norway Spruce (Picea abies) Lignan extract16.7 mg--
Bioperine(R) piperine7.5 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Foundation for longer life

Helps maintain healthy levels of testosterone

Maintaining normal testosterone levels is one of the most important steps men can take to regain their health and improve their performance. If you’re over 40, odds are you’re already starting to feel the effects of low testosterone. Research shows that by age 60, men typically produce 60% less testosterone than they did at age 20.33 The reduction of testosterone levels has been associated with the blues, cognitive decline, reduced sex drive and abdominal fat gain. Normal testosterone has been associated with maintaining a healthy cardiovascular system.

Muira puama is a rainforest herb classified in the Brazilian Pharmacopoeia as an aphrodisiac. In a trial of men with decreased libido and other sexual issues, 62% of those taking muira puama reported positive results in regard to libido, while 51% of those with a common sexual problem felt that the herb was helpful.37 A second trial examined men with decreased libido and found that 85% of the test subjects taking muira puama enjoyed an enhanced libido, 90% had improved sexual function, and 100% of test subjects experienced an increase in intercourse frequency.38

These lignans convert to enterolactone in the intestine. They are then rapidly absorbed into the bloodstream where they provide significant biological effects.39 Enterolactone has demonstrated biological effects that are of particular importance for the aging prostate gland.40,41

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.

FDA Statement of Identity

Dietary Supplement

Formula

Restoring Health and Sexual Vigor The reformulated Super Miraforte contains high potencies of chrysin and nettle root extract.

To augment these protective effects, a standardized lignan extract from Norwegian spruce has been added to Super Miraforte.

Brand IP Statement(s)

These ingredients reduce the aromatization (conversion) of testosterone to estrogen and enhance free testosterone levels.35,36 Bioperine(R) is included to facilitate the absorption of chrysin (a flavonoid) into the bloodstream.

All contents copyright (C) 1995-2013 Life Extension(R) All rights reserved

HMRlignan(TM) is a trademark used under sublicense from Linnea S.A. Bioperine(R) is a registered trademark of Sabinsa Corp

Suggested/Recommended/Usage/Directions

Dosage and Use ~ For adult men, take two (2) capsules in the morning and two (2) in the evening, or as recommended by a healthcare practitioner. ~ This product can be taken with or without food.

Precautions

Caution: If you are taking any medication, use only under physician supervision.

Men with existing prostate cancer may not be able to use this product. Elevations in free testosterone can unmask an occult (hidden) prostate cancer. Anyone with this concern should have a baseline PSA prior to using this product and a follow-up PSA test 60 days later. If a significant elevation of PSA is found, discontinue this product and advise physician. Do not take more than 15 mg per day of Bioperine(R).

Warnings ~ Keep out of reach of children

~ Do not exceed recommended dose ~ Do not purchase if outer seal is broken or damaged.

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super MiraForte With Standardized Lignans by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super MiraForte With Standardized Lignans label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super MiraForte With Standardized Lignans by Life Extension

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chrysin

Interacts with
358 drugs
750 mg per serving

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not show...

Chrysin monograph & interactions

Olive leaf extract

No known
interactions
7.5 mg per serving Form: Oleuropein

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Maca

No known
interactions
160 mg per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Maca monograph & interactions

Muira Puama (Ptychopetalum olacoides) extract

No known
interactions
425 mg per serving

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limite...

Muira Puama (Ptychopetalum olacoides) extract monograph & interactions

Nettle (Urtica dioica) Methanolic extract

Interacts with
164 drugs
141 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle (Urtica dioica) Methanolic extract monograph & interactions

HMRlignan Norway Spruce (Picea abies) Lignan extract

16.7 mg per serving Form: Hydroxymatairesinol Potassium Acetate

Bioperine(R) piperine

7.5 mg per serving Form: Black Pepper (Piper nigrum) extract

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super MiraForte With Standardized Lignans by Life Extension Drug Interactions

Want to check YOUR meds against Super MiraForte With Standardized Lignans?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
514Drugs
341 Moderate 173 Minor

Ingredients driving the most interactions

Chrysin 358
Nettle (Urtica dioica) Methanolic extract 164

Individual Drug Interactions

The ingredients in Super MiraForte With Standardized Lignans interact with 514 drugs. Click any drug to see the details.

2 of the 7 ingredients in Super MiraForte With Standardized Lignans interact with drugs. Each result below shows which ingredient is responsible. Chrysin Nettle (Urtica dioica) Methanolic extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Super MiraForte With Standardized Lignans with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chrysin9 drug types · 358 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.
In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor..

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Diclofenac (Voltaren, Others)

Theoretically, chrysin might increase the effects and adverse effects of diclofenac.
In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Mephenytoin (Mesantoin)

Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.
In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.

Likelihood Unlikely Evidence D
Glucuronidated Drugs

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).

Likelihood Unlikely Evidence D
Testosterone

Theoretically, chrysin might increase the effects and adverse effects of testosterone.
In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Chrysin full monograph & interactions

Nettle (Urtica dioica) Methanolic extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle (Urtica dioica) Methanolic extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super MiraForte With Standardized Lignans, from the product label.

Life Extension

See all Life Extension products
Phone Number
1-866-280-2852
Pharmacist Counseling Corner

Super MiraForte With Standardized Lignans by Life Extension: Common Questions

Does Super MiraForte With Standardized Lignans by Life Extension interact with any medications?
Yes. Based on its ingredients, Super MiraForte With Standardized Lignans has a known interaction with 514 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super MiraForte With Standardized Lignans contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The data advises against it. Chrysin, maca, muira puama, and stinging nettle all lack enough safety information during pregnancy and breastfeeding. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects?
The most commonly reported side effects are from olive leaf extract—headache and stomach discomfort. Stinging nettle may cause constipation or diarrhea. Fresh, uncooked maca may cause stomach pain. Rare cases of liver injury have been reported with stinging nettle in combination products.
Can I take this long-term?
Long-term safety hasn't been well studied for chrysin, maca, muira puama, or concentrated olive supplements. Short-term use seems okay for most, but we don't have good data on safety beyond that. Talk with your pharmacist about how long you plan to take it.
Does this product actually work?
The evidence is limited. Stinging nettle is possibly effective for diabetes based on some clinical research. The other ingredients don't have reliable evidence yet—that doesn't mean they don't work, just that solid studies are missing.
What is maca supposed to do?
Traditionally it's been used for sexual function, athletic performance, and hormonal balance, but we don't have reliable evidence backing those uses in our data. The ingredient list shows it's included, but we can't confirm it's effective for any specific condition.
Why does this product include piperine?
Piperine is black pepper extract. It's commonly added to herbal supplements to help your body absorb the other ingredients better. We don't have safety or interaction data on file for it in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super MiraForte With Standardized Lignans is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super MiraForte With Standardized Lignans label
Go deeper

The Full Monographs Behind Super MiraForte With Standardized Lignans’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chrysin

Interacts with 358 drugs

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the bo...

Read the full Chrysin monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Muira Puama

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limited, so its benefits are not well proven,...

Read the full Muira Puama monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Super MiraForte With Standardized Lignans's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 51 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chrysin 23 references
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
  3. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  4. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
  5. Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. PubMed
  6. Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22:309-12. PubMed
  7. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  8. Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
  9. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed
  10. Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
  11. Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
  12. O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
  13. Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
  14. Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. PubMed
  15. Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121 PubMed
  16. Moon, Y. J., Wang, X., and Morris, M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 2006;20(2):187-210. PubMed
  17. Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. PubMed
  18. Tsyrlov, I. B., Mikhailenko, V. M., and Gelboin, H. V. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim.Biophys Acta 4-13-1994;1205(2):325-335. PubMed
  19. Collins, B. M., McLachlan, J. A., and Arnold, S. F. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62(4):365-372. PubMed
  20. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139(10):4252-4263. PubMed
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Stinging Nettle 23 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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