Major interaction on record — check this product against your medications before combining. Based on 9 of 12 ingredients. Check your meds →
Dietary supplement

SuperEssentials Aminos Ingredients & Drug Interactions

by Living Fuel

SuperEssentials Aminos label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperEssentials Aminos against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

SuperEssentials Aminos is a dietary supplement by Living Fuel with 12 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 788 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine, L-Tryptophan, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SuperEssentials Aminos by Living Fuel

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperEssentials Aminos by Living Fuel — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SuperEssentials Aminos by Living Fuel

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “SuperEssentials Aminos Proprietary Blend” is a proprietary blend — the label gives one combined amount (10,000 mg) without saying how much of each component you get.

SuperEssentials Aminos contains 12 active amino acids: L-glutamine, glycine, L-leucine, L-arginine, L-isoleucine, L-methionine, L-lysine hydrochloride, L-phenylalanine, L-valine, L-histidine, L-threonine, and L-tryptophan. These are building blocks your body uses to make proteins and support muscle, immune, and nervous system function.

The product is a powder with no inactive fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: essential amino acids for protein and peak performance.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle damage, Muscle strength, Postoperative recovery, Critical illness (trauma) — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Low birth weight.

The evidence for this blend's effectiveness as a whole is not established in our data. Individually, L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

L-methionine is possibly effective for neural tube birth defects. L-lysine is possibly effective for cold sores.

L-histidine is possibly effective for cholera. Glycine is possibly effective for schizophrenia.

L-phenylalanine and L-threonine show insufficient or possibly ineffective evidence for the conditions studied. L-arginine, L-leucine, L-isoleucine, L-valine, and L-tryptophan have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Glutamine Glycine L-arginine Methionine Lysine Phenylalanine Histidine Threonine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these amino acids are generally well tolerated at typical doses in healthy adults, though long-term safety data are limited for several ingredients. Common side effects across the blend include gastrointestinal upset (nausea, bloating, diarrhea, abdominal pain, constipation), headache, and in some cases drowsiness or dizziness.

L-tryptophan carries additional caution: it was linked to a rare neurological condition called eosinophilia-myalgia syndrome (EMS) in a contamination event in the late 1980s, though that specific batch was traced to one Japanese manufacturer and has been unavailable since. L-arginine can lower blood pressure and L-methionine may raise homocysteine levels at high doses, both reasons to use it under medical guidance.

L-phenylalanine should be avoided entirely by anyone with phenylketonuria (PKU). For pregnancy and breastfeeding: L-glutamine and L-methionine are rated likely safe, and L-histidine is rated likely safe in pregnancy.

L-phenylalanine, L-tryptophan, and their product data advise against use during pregnancy and breastfeeding due to insufficient safety data. For the remaining ingredients, pregnancy and breastfeeding safety data are either limited or not available — talk with your doctor or pharmacist before use if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Glutamine Glycine L-arginine Methionine Lysine Phenylalanine Histidine Threonine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, L-arginine, Glutamine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 788 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take levodopa (Parkinson's disease), CNS depressants (sedatives, pain medications, alcohol), NMDA antagonists (certain anesthetics), anticonvulsants (seizure medications), blood pressure drugs (especially ACE inhibitors or ARBs), potassium-sparing diuretics, blood thinners or antiplatelet drugs, diabetes medications, serotonergic drugs (antidepressants, certain pain meds), baclofen (muscle relaxant), MAOIs (older antidepressants), sildenafil (Viagra), or 5-HT4 agonists. These carry Major or Moderate interactions with ingredients in this blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This amino acid blend may appeal to anyone looking to support muscle protein synthesis or recovery, but it is not appropriate for people taking levodopa (Parkinson's disease), certain seizure medications, NMDA antagonists, or CNS depressants without checking first. If you take blood pressure medications, blood thinners, diabetes drugs, or serotonergic medications like antidepressants, talk to your pharmacist before starting—L-arginine, L-tryptophan, and L-phenylalanine each create specific risks with these drugs.

Pregnant or breastfeeding? Check with your doctor before using.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperEssentials Aminos, straight from the product label.

Brand Living Fuel
Barcode (UPC) 850091001130
Net contents 10.6 oz.; 300 Gram(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 282560
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperEssentials Aminos by Living Fuel, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
30
UPC/BARCODE
850091001130
IngredientAmount% DV
L-Glutamine0 NP--
Glycine0 NP--
L-Leucine0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
L-Lysine Hydrochloride0 NP--
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
L-Threonine0 NP--
L-Tryptophan0 NP--
SuperEssentials Aminos Proprietary Blend10000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Living Fuel's SuperEssentials Aminos is the most powerful free form amino acid supplement for Maximum Human Nutrition. Amino acids are the building blocks of protein and, in fact, the building blocks of life itself. They are essential to optimal metabolic function and critical to growing and maintaining both muscle mass and lean body mass, therefore, the key to human performance. These amino acids are called 'essential amino acids' because they must be supplied to the body by food or supplementation to maintain life, metabolic function and to optimize health and maximize performance. Essential amino acids are the primary reason humans eat protein. Unfortunately, not all protein is alike. Protein comes in varying levels and strengths of essential amino acids and all protein requires time to digest and assimilate in the body, some quite a long time. SuperEssentials Aminos is more powerful than any protein source because of it's superior formulation and rapid absorption. SuperEssentials Aminos contains an optimized proprietary blend of twelve essential and conditionally essential amino acids which have been scientifically formulated to provide the essential amino acids strengths of nature's best protein sources plus enhanced levels of branched chain amino acids. SuperEssentials Aminos are quickly absorbed by the body to help boost energy levels, increase mental clarity and maximize muscle growth and performance.

Certified for use in amateur & professional athletics

Ultra pure free form essential amino acids

Certified for sport

General Statements

For more on the importance and the strategic use of essential amino acids for peak performance, weight optimization and Super Health read The Super Health Diet: The Last Diet You Will Ever Need! by Living Fuel Founder KC Craichy. Visit www.LivingFuel.com or call 1-866-580-FUEL (3835).

The ultimate in essential amino acids

Visit www.livingfuel.com for product videos and more information.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Ideal for vegetarians

No added flavors, colors, preservatives or sweeteners

Purity guaranteed

Contains no fat, sodium, sugar, yeast, gluten, soy, corn, wheat, rice, GMO, preservatives, excipients, dairy or animal products. Contains no added flavors, colors or sweeteners.

Contains no fat, sodium, sugar, yeast, gluten, soy, corn, wheat, rice, GMO, preservatives, excipients, dairy or animal products. Contains no added flavors, colors or sweeteners.

FDA Statement of Identity

All Natural Dietary Supplement

Seals/Symbols

Scott Analytics Certified for Sport

AjiPure Amino Acids

Suggested/Recommended/Usage/Directions

Directions Take one scoop with 3-4 ounces of water, juice, or sports drink in a shaker or blender 1-2 times per day or as directed by a healthcare practitioner. To maximize blood levels of essential amino acids, take with water only on an empty stomach 20-30 minutes prior to a meal or in lieu of a regular snack and at bedtime. For more information, see The Stealth Technique of Preloading with Essential Amino Acids in the book The Super Health Diet: The Last Diet You Will Ever Need! by Living Fuel Founder KC Craichy. To use in lieu of a protein source or to enhance the essential amino acid intake of a meal, take during a meal in a smoothie, in water or in juice. Mix with water or a carbohydrate beverage before, during and after workouts or athletic events.

Storage

Store in a cool, dry place and keep out of reach of children.

Precautions

Store in a cool, dry place and keep out of reach of children.

Brand IP Statement(s)

AjiPure is a registered trademark of Ajinomoto AminoScience.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperEssentials Aminos by Living Fuel label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperEssentials Aminos label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperEssentials Aminos by Living Fuel

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SuperEssentials Aminos Proprietary Blend

10000 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

SuperEssentials Aminos by Living Fuel Drug Interactions

Want to check YOUR meds against SuperEssentials Aminos?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
788Drugs
256 Major 524 Moderate 8 Minor

Ingredients driving the most interactions

L-Arginine 403
L-Tryptophan 394
L-Glutamine 50
L-Phenylalanine 16
L-Threonine 3

Individual Drug Interactions

The ingredients in SuperEssentials Aminos interact with 788 drugs. Click any drug to see the details.

7 of the 12 ingredients in SuperEssentials Aminos interact with drugs. Each result below shows which ingredient is responsible. L-Arginine L-Tryptophan L-Glutamine L-Phenylalanine L-Threonine Glycine L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperEssentials Aminos with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperEssentials Aminos, from the product label.

Living Fuel

See all Living Fuel products
Name
Living Fuel, Inc.
Street Address
P.O. Box 1048
City
Tampa
State
FL
ZipCode
33601
Phone Number
866-580-3835
Web Address
www.livingfuel.com
Pharmacist Counseling Corner

SuperEssentials Aminos by Living Fuel: Common Questions

Does SuperEssentials Aminos by Living Fuel interact with any medications?
Yes. Based on its ingredients, SuperEssentials Aminos has a known interaction with 788 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperEssentials Aminos contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
L-glutamine, L-methionine, and L-histidine are rated likely safe in pregnancy. However, L-phenylalanine and L-tryptophan should be avoided during pregnancy and breastfeeding due to insufficient safety data. For the other ingredients, safety data are limited or unavailable. Talk with your doctor or pharmacist for personalized advice—this is an individual decision that depends on your health and needs.
What are amino acids and why take them?
Amino acids are building blocks your body uses to make proteins. They support muscle repair and growth, immune function, and neurotransmitter production. This blend provides essential and non-essential amino acids that may help with recovery, muscle maintenance, or general protein intake—though the evidence for the blend as a whole is not established.
Will this give me side effects?
Most people tolerate it well, but common side effects include bloating, gas, nausea, diarrhea, abdominal pain, headache, and sometimes drowsiness. High doses may cause more stomach upset. If you experience dizziness or unusual neurological symptoms, stop and talk to a pharmacist.
Is this safe if I have kidney or liver disease?
L-glutamine requires medical supervision in kidney or liver disease due to how your body processes it. Since this blend contains L-glutamine, talk to your doctor before using it if you have either condition.
Can I take this with my blood pressure medication?
L-arginine in this product can lower blood pressure and may have additive effects with blood pressure drugs, raising the risk of dangerously low blood pressure. If you take ACE inhibitors, ARBs, or other blood pressure medications, check with your pharmacist before starting this product.
Does this work for depression or anxiety?
L-tryptophan is rated possibly ineffective for depression, and there is insufficient evidence for anxiety. The blend's effectiveness for mood or mental health is not established in our data—talk to your doctor if you're using it for these purposes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperEssentials Aminos label
Go deeper

The Full Monographs Behind SuperEssentials Aminos’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph →
Sources

Sources & How We Checked

SuperEssentials Aminos's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 149 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

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Glycine 5 references
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L-arginine 66 references
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See these in context on the L-tryptophan monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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