The Original Lemon-Lime Squeeze Ingredients & Drug Interactions
by XTEND
What is this page for?
First and foremost: checking The Original Lemon-Lime Squeeze against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
The Original Lemon-Lime Squeeze is a dietary supplement by XTEND with 12 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of The Original Lemon-Lime Squeeze by XTEND
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
The Original Lemon-Lime Squeeze contains 11 active ingredients. The primary ones are three branched-chain amino acids—L-leucine, L-isoleucine, and L-valine—which are building blocks your muscles can use directly during exercise and recovery.
L-glutamine is included to support muscle recovery and immune function. Citrulline malate is added for blood flow and workout performance.
You'll also get vitamin B6, plus electrolytes: sodium, potassium, sodium chloride, and sodium citrate, which replace minerals lost through sweat and help maintain hydration and muscle function. The product also contains inactive ingredients—citric acid, natural and artificial flavors, malic acid, sucralose, acesulfame potassium, and food colorants (FD&C Yellow #5 and FD&C Blue Lake #1)—which serve as sweeteners, flavor, and color.
Does it work?
Leans against
The evidence we hold rates L-glutamine as effective for sickle cell disease, and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma. Vitamin B6 is rated effective for sideroblastic anemia and vitamin B6 deficiency, likely effective for elevated homocysteine (hyperhomocysteinemia), and possibly effective for pregnancy-related nausea and vomiting.
Sodium appears likely effective for cystic fibrosis and possibly effective for amphotericin B kidney damage, though evidence is insufficient to rate it for bipolar disorder or heart failure. We don't hold effectiveness data for potassium, L-leucine, L-isoleucine, L-valine, or citrulline malate in the facts provided.
How safe is it?
Well-documented data
L-glutamine is generally well tolerated in healthy adults, but people with kidney or liver disease should use it only under medical supervision. Pregnancy and lactation are rated likely safe.
Common side effects include belching, bloating, constipation, nausea, and diarrhea; in rare cases, dizziness and headache have occurred, and a handful of reports link high doses to mood changes in people with bipolar disorder. Vitamin B6 is safe at normal food and supplement doses, but high doses over long periods can damage nerves (sensory neuropathy), especially at daily intakes above 1,000 mg or cumulative totals of 1,000 grams or more.
Pregnancy and lactation data aren't on file for B6. Sodium is well tolerated at normal intakes but too much is linked to high blood pressure, kidney disease, and cardiovascular strain; pregnancy is rated likely safe but lactation possibly unsafe.
Potassium is generally well tolerated from food and normal amounts, but high blood levels can cause dangerous heart rhythm problems, low blood pressure, and confusion; both pregnancy and lactation are rated likely safe.
Meds to double-check
Moderate interaction found
Before starting this product, check whether you take anticonvulsants (phenytoin, phenobarbital, or any anticonvulsant medication)—L-glutamine theoretically may work against them. Also double-check blood pressure medications (antihypertensive drugs), potassium-sparing diuretics, ACE inhibitors, ARBs, corticosteroids, lithium, and any sodium-containing drugs or supplements.
Amiodarone and levodopa without carbidopa also interact. No interactions are documented for L-leucine, L-isoleucine, L-valine, or citrulline malate in our data.
The bottom line
Scorecard at a glancePartially disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is designed for athletes and active people looking to support muscle recovery and hydration. If you take blood pressure medications, anticonvulsants, lithium, corticosteroids, or potassium-sparing diuretics, check with your pharmacist before starting—the electrolyte and vitamin content matters for your specific drugs.
People with kidney disease should talk to their doctor first. Run your full medication list through the checker below.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about The Original Lemon-Lime Squeeze, straight from the product label.
| Brand | XTEND |
|---|---|
| Barcode (UPC) | 181030000229 |
| Net contents | 1.26 Kilogram(s); 2.78 Pound(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 296441 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for The Original Lemon-Lime Squeeze by XTEND, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 0 Calorie(s) | -- |
| Total Carbohydrates | 0 Gram(s) | -- |
| L-Glutamine | 2500 mg | -- |
| Sugar | 0 Gram(s) | -- |
| Vitamin B6 | 640 mcg | 32% |
| Sodium | 220 mg | 9% |
| Potassium | 200 mg | 6% |
| L-Leucine | 3500 mg | -- |
| Potassium Chloride | 0 NP | -- |
| L-Isoleucine | 1750 mg | -- |
| L-Valine | 1750 mg | -- |
| Sodium Chloride | 0 NP | -- |
| Sodium Citrate | 0 NP | -- |
| Citrulline Malate | 1000 mg | -- |
| Electrolyte Blend | 1140 mg | -- |
Other ingredients: Citric Acid, Natural & Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Blue Lake #1
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended Use: As a dietary supplement, mix each scoop in 10-14 fl. oz. of water (adjust for taste preference) and shake well. On training days, consume 1 scoop during exercise and 1 scoop after exercise. On non-training days, consume 2 scoops throughout the day. For best results, use two scoops per day.
When to take XTEND for best results: Intra Workout XTEND Original Combine with any XTEND branded product every day, even on rest days, to help maximize your recovery.
Brand IP Statement(s)
Xtend is a trademark of Scivation, Inc.
Formulation
Made in the U.S.A. using strategically sourced domestic and imported ingredients and components.
Try all the sugar-free, mouthwatering flavors of Xtend to support your fitness goals.
Muscle recovery + electrolytes
0 Calories 0g Carb 0g Sugar Per serving
Seals/Symbols
NSF Contents Tested & Certified Informed-Choice.org Trusted by Sport
Precautions
Warning: This product is only intended for healthy adults, 18 years of age or older.
Do not use if pregnant or nursing. Consult with a licensed, qualified, healthcare professional before taking this or any dietary supplement product, especially if you are taking medication or have a medical condition.
Discontinue 2 weeks prior to surgery. Use only as directed. Do not use if safety seal is broken or missing.
Keep out of reach of children.
Storage
Store in a cool, dry place.
General Statements
This product is sold by weight, not volume. Some settling of powder may occur during shipping and handling, which may affect density of powder. This product contains the servings indicated when measured exactly by weight.
The official recovery brand of champions. Faster recovery is the key to better results. For over 10 years, Xtend has been making the best recovery products in the world.
When to take XTEND for best results: Pre Workout XTEND Energy Post Workout XTEND Pro The world's #1 BCAA brand Based upon cumulative global sales of all XTEND branded BCAA products from 2004 to present.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Powered by 7 grams of branched-chain amino acids (BCAAs), which have been clinically shown to support muscle recovery and growth, Xtend Original also contains hydrating electrolytes and additional performance ingredients to help you refuel, repair, and recover.
7g BCAA Muscle recovery + electrolytes
Lemon-Lime Squeeze Naturally & artificially flavored
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
The Original Lemon-Lime Squeeze by XTEND label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in The Original Lemon-Lime Squeeze by XTEND
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size14 Gram(s) Dosage formPowder Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Glutamine
Interacts with50 drugs
Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...
L-Glutamine monograph & interactionsSugar
Vitamin B6
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Vitamin B6 monograph & interactionsSodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsL-Leucine
L-Isoleucine
L-Valine
Citrulline Malate
Electrolyte Blend
Other (inactive) ingredients: Citric Acid, Natural & Artificial flavors, Malic Acid, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Blue Lake #1. These complete the product’s ingredient list but are not active constituents.
The Original Lemon-Lime Squeeze by XTEND Drug Interactions
HelloPharmacist Interaction Report
XTEND's Original Lemon-Lime Squeeze has documented interactions with a number of medications, primarily from its electrolytes and added vitamins.
The most serious concern is L-glutamine's potential to antagonize anticonvulsant medications (anticonvulsants)—though this hasn't been reported in humans, glutamine converts to an excitatory brain chemical that theoretically might work against these drugs.
Read the full breakdown — every affected drug type, severity by severity
Vitamin B6 in this product can interact with several medications at Moderate severity. High doses may reduce the effectiveness of phenobarbital and phenytoin (anticonvulsants), may increase photosensitivity from amiodarone, and may add blood-pressure-lowering effects when combined with blood pressure medications (antihypertensive drugs).
At lower severity, it can speed up the metabolism of levodopa when that drug is taken without carbidopa.
The sodium content (from sodium chloride and sodium citrate) poses Moderate-severity risks with blood pressure medications, corticosteroids, lithium, didanosine, sodium phosphates used for bowel prep, tolvaptan, and other sodium-containing drugs. Similarly, potassium and potassium chloride in the formula interact at Moderate severity with potassium-sparing diuretics and with ACE inhibitors (blood pressure drugs) or ARBs (angiotensin receptor blockers) when taken at higher doses—all carry a risk of dangerously high potassium levels (hyperkalemia).
We could not check L-leucine, L-isoleucine, L-valine, or citrulline malate. Altogether, these interactions span 295 individual medications.
Use the search tool below to verify your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against The Original Lemon-Lime Squeeze?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in The Original Lemon-Lime Squeeze interact with 297 drugs. Click any drug to see the details.
4 of the 12 ingredients in The Original Lemon-Lime Squeeze interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Potassium L-Glutamine
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with The Original Lemon-Lime Squeeze — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with The Original Lemon-Lime Squeeze — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with The Original Lemon-Lime Squeeze — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with The Original Lemon-Lime Squeeze — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with The Original Lemon-Lime Squeeze — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Levodopa, Carbidopa interactionEach ingredient & the kinds of drugs it affects
For each ingredient in The Original Lemon-Lime Squeeze with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B6
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Brand information
Manufacturer and brand details for The Original Lemon-Lime Squeeze, from the product label.
XTEND
See all XTEND products- Name
- Nutrabolt
- Street Address
- 3891 S. Traditions Dr.
- City
- Bryan
- State
- TX
- ZipCode
- 77807
- Phone Number
- 1.866.996.3489
- Web Address
- www.scivation.com
The Original Lemon-Lime Squeeze by XTEND: Common Questions
Does The Original Lemon-Lime Squeeze by XTEND interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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What are the side effects I should watch for?
Can I use this if I have kidney disease?
Will this help with my workouts?
Why does this have so much sodium and potassium?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if The Original Lemon-Lime Squeeze is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind The Original Lemon-Lime Squeeze’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glutamine
Interacts with 50 drugsGlutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...
Read the full Glutamine monograph → Herb & supplement monographVitamin B6
Interacts with 210 drugsVitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...
Read the full Vitamin B6 monograph → Herb & supplement monographSodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph →Sources & How We Checked
The Original Lemon-Lime Squeeze's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 93 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Vitamin B6 32 references
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
- South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
- Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
- Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
- Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
- Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
- Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
- Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
- Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
- Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
- Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
- Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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