TheraCran Ingredients & Drug Interactions
by Theralogix
What is this page for?
First and foremost: checking TheraCran against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
TheraCran is a dietary supplement by Theralogix with 3 active ingredients. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 714 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pure Cranberry (fruit) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against TheraCran by Theralogix
Ask about any prescription or over-the-counter medication and we check it for interactions with TheraCran by Theralogix — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of TheraCran by Theralogix
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
TheraCran contains 3 active ingredients. The main one is pure cranberry fruit extract, which concentrates the compounds that give cranberry its reputation for urinary tract health.
The other two active components are proanthocyanidins and other flavonoids—the plant compounds thought to do the work. Beyond these actives, the capsule also contains inactive ingredients (gelatin, tricalcium phosphate, calcium silicate, magnesium stearate, and silicon dioxide) that serve as fillers and binders.
Does it work?
Moderate evidence
Cranberry is possibly effective for urinary tract infections (UTIs)—that's where the evidence is strongest. For age-related cognitive decline, benign prostatic hyperplasia, cancer, nonalcoholic fatty liver disease, and chronic fatigue syndrome, the evidence we hold isn't reliable enough to rate whether it works.
If you're considering TheraCran for something other than UTI prevention or treatment, talk with your doctor or pharmacist about what the current research actually shows for your specific situation.
How safe is it?
Well-documented data
Cranberry is generally well tolerated as a food or supplement. The most common side effects are diarrhea and stomach upset.
Very large doses—3 to 4 liters of juice per day—are more likely to cause digestive problems, especially in young children, and concentrated supplement doses haven't been studied as thoroughly as food amounts. One patient reported skin redness and itching.
Because concentrated supplements are less well studied than everyday cranberry amounts, check with your doctor or pharmacist before starting, especially if you have a sensitive stomach. Cranberry in pregnancy and lactation is rated likely safe, but concentrated supplement doses fall into a grayer zone—discuss it with your provider if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking TheraCran, double-check with your doctor or pharmacist if you take any statins or other cholesterol drugs (especially atorvastatin), blood thinners like warfarin, blood pressure medications like nifedipine, or pain relievers and anti-inflammatories. These are the medication types where cranberry has documented moderate or minor interactions that could change how your drugs work.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
TheraCran is most relevant if you're trying to prevent or support treatment of urinary tract infections. If you take a statin, blood thinner, blood pressure medication, or pain reliever, you'll need to check your specific drugs against the interaction list below before starting—the risks are real.
Talk with your doctor or pharmacist about whether this product fits your medications and health situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about TheraCran, straight from the product label.
| Brand | Theralogix |
|---|---|
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 174965 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for TheraCran by Theralogix, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pure Cranberry (fruit) extract | 650 mg | -- |
| Proanthocyanidins | 0 NP | -- |
| Other Flavonoids | 16.25 mg | -- |
Other ingredients: Gelatin, Tricalcium Phosphate, Calcium Silicate, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Nutritional Science
Promotes urinary tract health
Why TheraCran?
How is TheraCran different? TheraCran is the first and only cranberry supplement that has been independently tested and certified for Proanthocyanidin (PAC) and other flavonoid content. PACs are the compounds that researchers have determined to be the active component of cranberries. For a cranberry supplement to be effective, it must provide an adequate dose of these PACs.
If the actual content of PACs in a cranberry supplement has not been measured and independently certified, the efficacy of that product is uncertain.
Many supplements on the market contain cranberry powder with only 1% PACs. As a result, it may take up to six capsules per day of these other supplements to get the recommended amount of active ingredients.
Many other cranberry products contain cellulose binders and may not be effective. TheraCran’s bioactivity has been tested in a clinical study at Rutgers University.
Why Theralogix?
Theralogix is committed to providing only the highest quality nutritional supplements. TheraCran is certified by NSF International, a not-for-profit organization that is the world leader in standards development and product certification for public health and safety. NSF has implemented the highest quality control standards in the supplements industry. The NSF mark is your assurance of a dietary supplement’s content accuracy, purity, and freedom from contaminants. Manufactured in an NSF-Registered Facility The facility where TheraCran and other Theralogix nutritional supplements are manufactured is registered with NSF and is in compliance with current Good Manufacturing Practices (cGMPs). These guidelines define the manufacturing processes, procedures, and documentation and assure the identity, strength, composition, and quality of the product. Medical Advisory Board Oversight The leading academic physicians and scientists of the Theralogix Medical Advisory Board meet regularly to oversee all product formulations. You can be sure that TheraCran is safe and reflects ongoing review of the most current scientific evidence. Visit www.theralogix.com to learn more.
TheraCran vs. Cranberry Juice? There are several reasons why TheraCran makes more sense than cranberry juice. TheraCran costs less than 60 cents a day. That’s 20–50 percent less expensive than the bioequivalent amount of cranberry juice.
In comparison, 10 ounces of cranberry juice cocktail contain 175 calories, more than a can of Coke. TheraCran doesn’t lose its bioactivity over time. Dried cranberry powder is very stable, but cranberry juice loses its bioactivity the longer it sits on a shelf.
Ordering Instructions Our auto-refill program includes free delivery. Automatic refills are timed to arrive just before you run out. You will only be charged when your order ships. You may cancel, postpone, or change the interval of your shipments at any time. Theralogix products are not available in stores. Order TheraCran without a prescription online at www.theralogix.com or by phone 24/7 at (800)449-4447.
Theralogix nutritional supplements are recommended for use under the supervision of a healthcare provider; customers referred by providers receive preferred pricing. Please use the Provider Referral Code (PRC) printed below when you order. This informs your healthcare provider of your order and provides you with preferred pricing. Provider Referral Code (PRC)
Independently Certified NSF Contents tested
FDA Statement of Identity
Cranberry Supplement
Formula
Standardized to contain 36 mg of Cranberry PACs per capsule
TheraCran is a standardized, high-quality, high-potency cranberry supplement formulated to support and maintain normal urinary tract health.
TheraCran contains the amount of PACs found in 8–10 ounces of 27% cranberry juice cocktail, which has shown benefit in research studies.
TheraCran is the first cranberry supplement to use a new high-potency cranberry powder containing greater than 2.5% PACs.
TheraCran is the only cranberry supplement that you can be sure delivers the same amount of bioactive PACs as found in 8-10 ounces of cranberry juice cocktail.
Brand IP Statement(s)
Independently content-certified by NSF International
NSF International Dietary Supplements Certification
Suggested/Recommended/Usage/Directions
Because TheraCran provides a more concentrated dose of PACs, only two capsules per day are needed: one in the morning and one in the evening.
Suggested Use: Take one capsule, twice a day; one capsule in the morning and one capsule in the evening, with or without food.
Formulation
TheraCran contains no cellulose or other agents that can bind to PACs, reducing their effectiveness.
TheraCran is virtually calorie- and sugar-free.
FDA Disclaimer Statement
This statement has not been reviewed by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
WMCRPB 03-12
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
TheraCran by Theralogix label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in TheraCran by Theralogix
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pure Cranberry (fruit) extract
Interacts with714 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Pure Cranberry (fruit) extract monograph & interactionsProanthocyanidins
Other Flavonoids
Other (inactive) ingredients: Gelatin, Tricalcium Phosphate, Calcium Silicate, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
TheraCran by Theralogix Drug Interactions
HelloPharmacist Interaction Report
TheraCran by Theralogix, which contains pure cranberry extract, interacts with a number of medications—most notably blood thinners like warfarin (Coumadin) and several cholesterol and blood pressure drugs.
The most serious concern is with cholesterol medications in the statin family (CYP3A4 substrates): cranberry can slow how your liver breaks down these drugs, raising their levels and the risk of muscle breakdown and liver damage. One case reported upper back pain, muscle breakdown, and abnormal liver tests in a patient on atorvastatin (Lipitor) who drank 16 ounces of cranberry juice daily for 2 weeks.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also theoretically increases levels of blood pressure medications like nifedipine (Procardia) and blood thinners like warfarin, though evidence for the warfarin interaction is mixed—some reports show it raises your clotting time (INR), but research hasn't settled the question. Pain relievers and anti-inflammatories (CYP2C9 substrates and diclofenac) may also be affected, though the clinical evidence here is weaker and contradictory.
We could not check two ingredients in this product: proanthocyanidins and other flavonoids. Altogether, these interactions span 713 individual medications.
Before you start TheraCran, run your exact medications through the search tool on this page to see if any of them are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against TheraCran?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in TheraCran interact with 714 drugs. Click any drug to see the details.
1 of the 3 ingredients in TheraCran interact with drugs. Each result below shows which ingredient is responsible. Pure Cranberry (fruit) extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acalabrutinib interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with TheraCran — through 1 ingredient. Tap an ingredient for the detail:
Pure Cranberry (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Pure Cranberry (fruit) Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in TheraCran with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pure Cranberry (fruit) extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for TheraCran, from the product label.
Theralogix
See all Theralogix products- Name
- Theralogix, LLC
- Phone Number
- (888) 899-3899
- Web Address
- www.theralogix.com
TheraCran by Theralogix: Common Questions
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Sources & How We Checked
TheraCran's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC