Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Throat Guardian Bee Berry Ingredients & Drug Interactions

by NaturaNectar

Throat Guardian Bee Berry label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Throat Guardian Bee Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Throat Guardian Bee Berry is a dietary supplement by NaturaNectar with 1 active ingredient. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are PWE-MD. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Throat Guardian Bee Berry by NaturaNectar

Ask about any prescription or over-the-counter medication and we check it for interactions with Throat Guardian Bee Berry by NaturaNectar — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.
Computed from our clinical databases

HelloPharmacist Scorecard of Throat Guardian Bee Berry by NaturaNectar

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “PWE-MD” is listed as a grouped ingredient — the label gives one combined amount (5 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Throat Guardian Bee Berry, straight from the product label.

Brand NaturaNectar
Barcode (UPC) 837654326596
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 320734
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Throat Guardian Bee Berry by NaturaNectar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.54 mL
Maximum serving Sizes:
0.54 mL
Servings per container
55
UPC/BARCODE
837654326596
IngredientAmount% DV
PWE-MD5 mg--
Organic Aromatic Acids0 NP--

Other ingredients: Water, Purified, Honey, Glycerin, Citric Acid, Potassium Sorbate, natural Mixed Berry flavor, Raspberry Flavor, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Protect & Activate wellness naturally

The mission of NaturaNectar is to protect and activate wellness naturally through our commitment to developing trusted, science-based, doctor-formulated products while being socially and enviromentally responsible.

PWE is clinically studied A placebo controlled clinical study, published in 2003, indicates that our PWE helps supports respiratory health and maintain a healthy inflammation response. To learn more visit naturanectar.com/throat-guardian

A trusted brand based on our scientific understanding of the magnificent benefits of honeybees and their bee propolis At NaturaNectar, we understand the nature and science behind the beehive and find our inspiration there. With the same focus and dedication of the honeybees to build sustainable and productive hives with their propolis, our company is dedicated to bringing you wellness products imbued with the same protective propolis to help you live an active and healthy life. We commit our corporate resources to the vital research needed to ensure that honeybees continue to be nature's true marvels as well as supporting the surrounding communities that help harvest our bee propolis in a sustainable way. We invite you to learn more at: beethereinitiative.com

Suggested/Recommended/Usage/Directions

Directions: Shake well before use. Apply three pumps two to four times a day into the throat and swallow. May be taken in conjunction with our other unique life solutions daily or as recommended to help protect and activate your wellness, naturally.

Formulation

NaturaNectar Throat Guardian does not contain alcohol, starch, wheat, gluten, yeast, milk (lactose), egg, shellfish, artificial flavors, dyes or colors.

Nobody likes the occasional irritated throat or raspy voice while you get through your day. NaturaNectar's Throat Guardian provides natural soothing and delicious relief and supports respiratory, oral and dental health.

This three-decade old Scandinavian formula from Saloman Propolis provides you and your family all the protection of bee propolis that respects your delicate mucous membrane because our formula contains no alcohol or propylene glycol, so you can protect and activate wellness, naturally.

This product supports the health of: System Immune Respiratory Cells Oral Lung Dental Bronchi

PWE Clinically tested Natural ingredients oral care Spray Fast, soothing relief and support for respiratory, oral and dental health

Alcohol & gluten free

Quality from the source. NaturaNectar's sister company ALMAR Apiary is located in beautiful Brazil, the home of the verdant rain forests, where the world's finest and purest bee propolis is harvested. Our ground breaking and effective products are sourced for you directly from the Brazilian honeybees and their bio diverse forests! 30+ Years perfecting the most advanced standardized propolis extracts Through our partnership with PRC-Propolis Research Center, our standardized, 100% water-based pure propolis extracts have become the foundation of NaturaNectar's extensive product line.

Precautions

Caution: As with any nutritional supplement, it is advised to consult your physician before taking, especially if pre-existing conditions are present.

Do not take if pregnant or breastfeeding.

Use with caution if allergic to bee products.

Avoid contamination of spray.

Keep out of reach of children.

Storage

Store in a cool, dry place.

To be used within first month of first use.

Store well closed in a cool and dry place away from direct light.

Seals/Symbols

Technology from Denmark Made in USA from International Ingredients Premium Brazilian Propolis

Brand IP Statement(s)

Copyright 2013 NaturaNectar LLC

My Wellness Zone

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

This three-decade old Scandinavian formula from Saloman Propolis provides you and your family all the protection of bee propolis that respects your delicate mucous membrane because our formula contains no alcohol or propylene glycol, so you can protect and activate wellness, naturally.

Product for the whole family Children 2 years and older

FDA Statement of Identity

Daily Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Throat Guardian Bee Berry by NaturaNectar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Throat Guardian Bee Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Throat Guardian Bee Berry by NaturaNectar

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.54 mL Dosage formLiquid Servings per container55 Amounts shown are per serving.

PWE-MD

Interacts with
921 drugs
5 mg per serving Form: Brazilian Bee Propolis Water Extract

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

PWE-MD monograph & interactions
  • › Organic Aromatic Acids

Other (inactive) ingredients: Water, Purified, Honey, Glycerin, Citric Acid, Potassium Sorbate, Natural Mixed Berry flavor, Raspberry Flavor, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Throat Guardian Bee Berry by NaturaNectar Drug Interactions

Throat Guardian Bee Berry contains a single active ingredient, and it has known interactions with 921 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Throat Guardian Bee Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

PWE-MD 921

Individual Drug Interactions

The ingredients in Throat Guardian Bee Berry interact with 921 drugs. Click any drug to see the details.

1 of the 1 ingredient in Throat Guardian Bee Berry interact with drugs. Each result below shows which ingredient is responsible. PWE-MD

Each ingredient & the kinds of drugs it affects

For each ingredient in Throat Guardian Bee Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

PWE-MD8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
PWE-MD full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Throat Guardian Bee Berry, from the product label.

NaturaNectar

See all NaturaNectar products
Name
NaturaNectar LLC
Street Address
4631 NW 103rd Ave.
City
Sunrise
State
FL
ZipCode
33351
Phone Number
800.609.7794
Web Address
naturanectar.com
Pharmacist Counseling Corner

Throat Guardian Bee Berry by NaturaNectar: Common Questions

Does Throat Guardian Bee Berry by NaturaNectar interact with any medications?
Yes. Based on its ingredients, Throat Guardian Bee Berry has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Throat Guardian Bee Berry contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Throat Guardian Bee Berry is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Throat Guardian Bee Berry label
Go deeper

The Full Monographs Behind Throat Guardian Bee Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propolis

Interacts with 921 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph →
Sources

Sources & How We Checked

Throat Guardian Bee Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team