Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Green Bee Propolis Ingredients & Drug Interactions

by NaturaNectar

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Green Bee Propolis is a dietary supplement by NaturaNectar with 3 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flav-M. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Green Bee Propolis by NaturaNectar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients. Two of them — Flav-M and PWE-MD — are both propolis extracts, a bee-hive compound traditionally used in herbal medicine.

The third ingredient is Total Polyphenols. We couldn't check Total Polyphenols for interactions because we hold no data on it.

The capsule itself also contains inactive ingredients (cellulose, magnesium stearate, and silicon dioxide) — the standard binders and fillers that hold a capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Propolis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Activate wellness of brain and heart.
  • We looked for evidence on: Depression, Cardiovascular health, Cognitive function, Cellular protection.
  • The closest evidence on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Depression (Natural Medicines).

The propolis in this product is possibly effective for oral mucositis (mouth sores from cancer treatment) and herpes labialis (cold sores), meaning there's some promising evidence, though more research would strengthen the case. It's also possibly effective for diabetes.

The evidence for dengue fever isn't established enough to rate. If you're taking this for one of those first three uses, the data suggests it may help — but talk with your doctor about how it fits into your overall care.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated when taken by mouth, especially short-term. The most common side effect is mild headache — around 7% of people in one trial reported it when taking 250 mg twice daily for 4 months.

Allergic reactions are possible, especially if you're sensitive to bee products; severe reactions are rare but can happen. Don't take this during pregnancy or while breastfeeding — there isn't enough safety information to know either way, and the data advises against it.

If you have a known allergy to bees or bee products, you're at higher risk for an allergic reaction to propolis.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against these types before taking this product: blood thinners and antiplatelet drugs (moderate risk of increased bleeding), and any drugs broken down by your liver's cytochrome P450 system — including heart medications, antidepressants, pain relievers, and many others (moderate risk of raised drug levels). Use the search tool on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Green Bee Propolis may help with cold sores, mouth sores, or blood sugar if that's why you're considering it. Because it interacts with many medication types — especially blood thinners and drugs your liver breaks down — talk with your pharmacist before you start, especially if you take prescription medications.

Avoid it in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Green Bee Propolis, straight from the product label.

Brand NaturaNectar
Barcode (UPC) 837654326541
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320730
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Green Bee Propolis by NaturaNectar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
837654326541
IngredientAmount% DV
Flav-M100 mg--
Total Polyphenols17 mg--
PWE-MD3 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

A trusted brand based on our scientific understanding of the magnificent benefits of honeybees and their bee propolis At NaturaNectar, we understand the nature and science behind the beehive and find our inspiration there. With the same focus and dedication of the honeybees to build sustainable and productive hives with their propolis, our company is dedicated to bringing you wellness products imbued with the same protective propolis to help you live an active and healthy life. We commit our corporate resources to the vital research needed to ensure that honeybees continue to be nature's true marvels as well as supporting the surrounding communities that help harvest our bee propolis in a sustainable way. We invite you to learn more at: beethereinitiative.com Quality from the source. NaturaNectar's sister company ALMAR Apiary is located in beautiful Brazil, the home of the verdant rain forests, where the world's finest and purest bee propolis is harvested. Our ground breaking and effective products are sourced for you directly from the Brazilian honeybees and their bio diverse forests! 30+ years perfecting the most advanced standardized propolis extracts Through our partnership with PRC-Propolis Research Center, our standardized, 100% water-based pure propolis extracts have become the foundation of NaturaNectar's extensive product line. The mission of NaturaNectar is to protect and activate wellness naturally through our commitment to developing trusted, science-based, doctor-formulated products while being socially and environmentally responsible. Protect & activate wellness naturally

naturanectar.com/green-bee-propolis

4190 R5 7841 Please recycle

Formula

Active propolis Artepillin-C

Featuring 100% Brazilian ultra-green bee propolis, a natural source of acclaimed active compound Artepillin-C, NaturaNectar Green Bee Propolis is appreciated for its therapeutic properties backed by hundreds of scientific studies indicating the benefits of its flavonoid content and antioxidant activity. It helps support heart and circulatory health, maintains healthy blood sugar levels when used as part of a healthy diet, supports healthy blood pressure levels are already within normal range and protects delicate nerve cells and overall brain health.

Formulation

Activates wellness of the brain & heart at the cellular level Natural ingredients

Gluten free

Today we are exposed to more noise, pollution, and life challenges than ever before, creating a potential overload that can threaten our wellness, mental alertness and happiness. Like the bees that protect their hives and health with their propolis, NaturaNectar's Green Bee Propolis supplement can support your health.

This product supports the health of: System Immune Nervous Circulatory Cells Brain Breast Heart Larynx Prostate

FLAV and PWE extracts are obtained by NaturaNectar's exclusive Green Extraction for purity, standardization and potency

NaturaNectar Green Bee Propolis does not contain alcohol, sugar, starch, wheat, gluten, yeast, milk (lactose), egg, shellfish, artificial preservatives, flavors, dyes or colors.

60 vegetarian capsules

FDA Statement of Identity

Daily Dietary Supplement

Brand IP Statement(s)

My Wellness Zone

Copyright 2013 NaturaNectar LLC

Seals/Symbols

G Extraction NSF Contents Certified

Technology from Denmark Made in USA from International Ingredients Premium Brazilian Propolis

Suggested/Recommended/Usage/Directions

Directions: Take one capsule by mouth one or two times daily to support overall health. May be taken in conjunction with our other unique life solutions daily or as recommended to help protect and activate your wellness naturally.

Precautions

Caution: As with any nutritional supplement, it is advised to consult your physician before taking, especially if pre-existing conditions are present.

Do not take if pregnant or breastfeeding.

Use with caution if allergic to bee products.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Green Bee Propolis by NaturaNectar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Green Bee Propolis by NaturaNectar

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Flav-M

Interacts with
921 drugs
100 mg per serving Form: Brazilian Bee Propolis Blend

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Flav-M monograph & interactions

Total Polyphenols

17 mg per serving

PWE-MD

Interacts with
921 drugs
3 mg per serving Form: Brazilian Brown Propolis Water Extract

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

PWE-MD monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Green Bee Propolis by NaturaNectar Drug Interactions

Want to check YOUR meds against Green Bee Propolis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

Flav-M 921

Each ingredient & the kinds of drugs it affects

For each ingredient in Green Bee Propolis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Flav-M8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Green Bee Propolis, from the product label.

NaturaNectar

See all NaturaNectar products
Name
NaturaNectar LLC
Street Address
4631 NW 103rd Ave.
City
Sunrise
State
FL
ZipCode
33351
Phone Number
800.609.7794
Web Address
naturanectar.com
Pharmacist Counseling Corner

Green Bee Propolis by NaturaNectar: Common Questions

Does Green Bee Propolis by NaturaNectar interact with any medications?
Yes. Based on its ingredients, Green Bee Propolis has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Green Bee Propolis contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin or aspirin?
Not without checking with your pharmacist first. Propolis may raise your bleeding risk and could interfere with warfarin's effectiveness. Your doctor or pharmacist needs to review your specific medications and dose before you start.
What's the most common side effect?
Mild headache — about 7% of people in a clinical trial reported it. Allergic reactions are possible too, especially if you're sensitive to bee products.
Is this safe during pregnancy or breastfeeding?
No. There isn't enough safety information, so the data advises against it during both pregnancy and breastfeeding. Talk with your doctor if you're pregnant or nursing and wondering about propolis.
Does this actually work for cold sores?
The evidence is promising — propolis is possibly effective for herpes labialis (cold sores). But that doesn't mean it'll work for everyone. See your doctor if your cold sores aren't improving.
Will this raise my blood sugar medication levels?
Possibly. Propolis may slow how your liver breaks down drugs, including diabetes medications. If you take medication for blood sugar, let your pharmacist know before starting this supplement.
What if I'm allergic to bees?
You're at higher risk for an allergic reaction to propolis, since it's a bee product. Avoid it unless your doctor says it's okay, and watch for signs of an allergic reaction if you do take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Green Bee Propolis is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Green Bee Propolis label
Go deeper

The Full Monographs Behind Green Bee Propolis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Green Bee Propolis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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