Green Bee Propolis Ingredients & Drug Interactions
by NaturaNectar
What is this page for?
First and foremost: checking Green Bee Propolis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Green Bee Propolis is a dietary supplement by NaturaNectar with 3 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flav-M. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Green Bee Propolis by NaturaNectar
Ask about any prescription or over-the-counter medication and we check it for interactions with Green Bee Propolis by NaturaNectar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Green Bee Propolis by NaturaNectar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 3 active ingredients. Two of them — Flav-M and PWE-MD — are both propolis extracts, a bee-hive compound traditionally used in herbal medicine.
The third ingredient is Total Polyphenols. We couldn't check Total Polyphenols for interactions because we hold no data on it.
The capsule itself also contains inactive ingredients (cellulose, magnesium stearate, and silicon dioxide) — the standard binders and fillers that hold a capsule together.
Does it work?
Not established
The propolis in this product is possibly effective for oral mucositis (mouth sores from cancer treatment) and herpes labialis (cold sores), meaning there's some promising evidence, though more research would strengthen the case. It's also possibly effective for diabetes.
The evidence for dengue fever isn't established enough to rate. If you're taking this for one of those first three uses, the data suggests it may help — but talk with your doctor about how it fits into your overall care.
How safe is it?
Well-documented data
Propolis is generally well tolerated when taken by mouth, especially short-term. The most common side effect is mild headache — around 7% of people in one trial reported it when taking 250 mg twice daily for 4 months.
Allergic reactions are possible, especially if you're sensitive to bee products; severe reactions are rare but can happen. Don't take this during pregnancy or while breastfeeding — there isn't enough safety information to know either way, and the data advises against it.
If you have a known allergy to bees or bee products, you're at higher risk for an allergic reaction to propolis.
Meds to double-check
Moderate interaction found
Check your medications against these types before taking this product: blood thinners and antiplatelet drugs (moderate risk of increased bleeding), and any drugs broken down by your liver's cytochrome P450 system — including heart medications, antidepressants, pain relievers, and many others (moderate risk of raised drug levels). Use the search tool on this page with your exact medication names.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Green Bee Propolis may help with cold sores, mouth sores, or blood sugar if that's why you're considering it. Because it interacts with many medication types — especially blood thinners and drugs your liver breaks down — talk with your pharmacist before you start, especially if you take prescription medications.
Avoid it in pregnancy and while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Green Bee Propolis, straight from the product label.
| Brand | NaturaNectar |
|---|---|
| Barcode (UPC) | 837654326541 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 320730 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Green Bee Propolis by NaturaNectar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Flav-M | 100 mg | -- |
| Total Polyphenols | 17 mg | -- |
| PWE-MD | 3 mg | -- |
Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
A trusted brand based on our scientific understanding of the magnificent benefits of honeybees and their bee propolis At NaturaNectar, we understand the nature and science behind the beehive and find our inspiration there. With the same focus and dedication of the honeybees to build sustainable and productive hives with their propolis, our company is dedicated to bringing you wellness products imbued with the same protective propolis to help you live an active and healthy life. We commit our corporate resources to the vital research needed to ensure that honeybees continue to be nature's true marvels as well as supporting the surrounding communities that help harvest our bee propolis in a sustainable way. We invite you to learn more at: beethereinitiative.com Quality from the source. NaturaNectar's sister company ALMAR Apiary is located in beautiful Brazil, the home of the verdant rain forests, where the world's finest and purest bee propolis is harvested. Our ground breaking and effective products are sourced for you directly from the Brazilian honeybees and their bio diverse forests! 30+ years perfecting the most advanced standardized propolis extracts Through our partnership with PRC-Propolis Research Center, our standardized, 100% water-based pure propolis extracts have become the foundation of NaturaNectar's extensive product line. The mission of NaturaNectar is to protect and activate wellness naturally through our commitment to developing trusted, science-based, doctor-formulated products while being socially and environmentally responsible. Protect & activate wellness naturally
naturanectar.com/green-bee-propolis
4190 R5 7841 Please recycle
Formula
Active propolis Artepillin-C
Featuring 100% Brazilian ultra-green bee propolis, a natural source of acclaimed active compound Artepillin-C, NaturaNectar Green Bee Propolis is appreciated for its therapeutic properties backed by hundreds of scientific studies indicating the benefits of its flavonoid content and antioxidant activity. It helps support heart and circulatory health, maintains healthy blood sugar levels when used as part of a healthy diet, supports healthy blood pressure levels are already within normal range and protects delicate nerve cells and overall brain health.
Formulation
Activates wellness of the brain & heart at the cellular level Natural ingredients
Gluten free
Today we are exposed to more noise, pollution, and life challenges than ever before, creating a potential overload that can threaten our wellness, mental alertness and happiness. Like the bees that protect their hives and health with their propolis, NaturaNectar's Green Bee Propolis supplement can support your health.
This product supports the health of: System Immune Nervous Circulatory Cells Brain Breast Heart Larynx Prostate
FLAV and PWE extracts are obtained by NaturaNectar's exclusive Green Extraction for purity, standardization and potency
NaturaNectar Green Bee Propolis does not contain alcohol, sugar, starch, wheat, gluten, yeast, milk (lactose), egg, shellfish, artificial preservatives, flavors, dyes or colors.
60 vegetarian capsules
FDA Statement of Identity
Daily Dietary Supplement
Brand IP Statement(s)
My Wellness Zone
Copyright 2013 NaturaNectar LLC
Seals/Symbols
G Extraction NSF Contents Certified
Technology from Denmark Made in USA from International Ingredients Premium Brazilian Propolis
Suggested/Recommended/Usage/Directions
Directions: Take one capsule by mouth one or two times daily to support overall health. May be taken in conjunction with our other unique life solutions daily or as recommended to help protect and activate your wellness naturally.
Precautions
Caution: As with any nutritional supplement, it is advised to consult your physician before taking, especially if pre-existing conditions are present.
Do not take if pregnant or breastfeeding.
Use with caution if allergic to bee products.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Green Bee Propolis by NaturaNectar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Green Bee Propolis by NaturaNectar
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Flav-M
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Flav-M monograph & interactionsTotal Polyphenols
PWE-MD
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
PWE-MD monograph & interactionsOther (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Green Bee Propolis by NaturaNectar Drug Interactions
HelloPharmacist Interaction Report
Green Bee Propolis by NaturaNectar contains propolis in two forms (Flav-M and PWE-MD), both of which interact with several drug types.
The most serious theoretical concern is with blood thinners (anticoagulants) and antiplatelet drugs — propolis may increase bleeding risk. Lab studies show propolis can block platelet clumping, and animal research hints the effect could extend to warfarin specifically, though this hasn't been seen in human patients yet.
Read the full breakdown — every affected drug type, severity by severity
The propolis ingredients may also raise blood levels of medications broken down by your liver's cytochrome P450 enzymes. This includes drugs processed by CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1 — a large group spanning heart drugs, antidepressants, pain relievers, and many others.
Lab work suggests propolis can block these enzymes, though animal studies at high doses didn't show a major effect in practice. The concern is mostly theoretical at typical doses.
We could not check Total Polyphenols for interactions — no data is on file for that ingredient. Altogether, these interactions span 911 individual medications.
Before you start, use the medication checker on this page to verify your exact prescriptions against the propolis ingredient.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Green Bee Propolis?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Green Bee Propolis interact with 921 drugs. Click any drug to see the details.
1 of the 3 ingredients in Green Bee Propolis interact with drugs. Each result below shows which ingredient is responsible. Flav-M
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Pwe-md + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
Read the full Pwe-md + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Pwe-md + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Pwe-md + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Pwe-md + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Green Bee Propolis — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Green Bee Propolis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Flav-M
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Green Bee Propolis, from the product label.
NaturaNectar
See all NaturaNectar products- Name
- NaturaNectar LLC
- Street Address
- 4631 NW 103rd Ave.
- City
- Sunrise
- State
- FL
- ZipCode
- 33351
- Phone Number
- 800.609.7794
- Web Address
- naturanectar.com
Green Bee Propolis by NaturaNectar: Common Questions
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The Full Monographs Behind Green Bee Propolis’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Green Bee Propolis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC