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Dietary supplement

Thyroid Health Formula Ingredients & Drug Interactions

by Natural Factors

Thyroid Health Formula label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Thyroid Health Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Thyroid Health Formula is a dietary supplement by Natural Factors with 7 active ingredients. Its ingredients are commonly taken for general nutrition and energy, skin and hair health, acne (topical and oral).Based on those ingredients, 1,478 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha (Withania somnifera) extract, Guggul (Commiphora mukul) extract, Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Thyroid Health Formula by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Thyroid Health Formula by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Thyroid Health Formula by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula contains 7 active ingredients designed to support thyroid function. Iodine and L-tyrosine are the building blocks thyroid cells need to make thyroid hormones.

Ashwagandha and guggul are plant extracts traditionally used in Ayurvedic medicine; ashwagandha is included for stress and sleep, while guggul has been studied for metabolic support. Pantothenic acid (a B vitamin), copper, and manganese are cofactors—they help your body run chemical reactions efficiently.

The capsule itself and the microcrystalline cellulose inside are inert ingredients that hold everything together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support thyroid gland health and metabolism.
  • We looked for evidence on: Iodine deficiency, Hypothyroidism, Cognitive function, Fatigue, Thyroid function, Metabolic rate — and 1 related terms.
  • The strongest evidence on file: Iodine is rated "Likely Effective" for Iodine deficiency (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Pantothenic Acid is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS).

The evidence for this blend is mixed. Iodine is well established for preventing and treating iodine deficiency and protecting the thyroid after radiation exposure.

L-tyrosine shows possibly effective evidence for memory and cognitive function. Ashwagandha is possibly effective for insomnia, anxiety, and stress.

For the other ingredients—pantothenic acid, copper, manganese, and guggul—the data on file either doesn't establish effectiveness for thyroid health specifically, or shows insufficient evidence. None of these are proven to improve an underactive thyroid on their own.

The evidence, ingredient by ingredient Pantothenic Acid Tyrosine Iodine Copper Manganese Ashwagandha Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses. Pantothenic acid, L-tyrosine, and iodine are well tolerated when taken in normal amounts.

Manganese and copper are safe in dietary doses, but high-dose supplements of either can be harmful. Ashwagandha and guggul should be avoided during pregnancy and breastfeeding—ashwagandha is traditionally thought to risk miscarriage, and guggul may stimulate the uterus.

Common side effects of ashwagandha and guggul are mild digestive upset (nausea, diarrhea, bloating). Ashwagandha has rare reports of liver damage, so if you develop jaundice, dark urine, or severe fatigue, stop and contact your doctor.

Side effects, ingredient by ingredient Pantothenic Acid Tyrosine Iodine Copper Manganese Ashwagandha Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Iodine, Manganese, Guggul, Copper, Ashwagandha, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,479 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take thyroid hormones, check this product with your pharmacist first—both ashwagandha and guggul may increase effects, and L-tyrosine and iodine can also interact. Blood thinners (anticoagulants) may be affected by guggul.

Heart medications like propranolol and diltiazem can be reduced by guggul. Birth control pills and estrogen may interact with guggul.

Antipsychotic drugs and antibiotics (quinolones and tetracyclines) could be affected by manganese. CNS depressants (sedatives, anxiety medications, benzodiazepines) may be potentiated by ashwagandha.

Blood sugar medications may interact with ashwagandha. Lithium and antithyroid drugs require monitoring if you're taking iodine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula makes sense if you have a documented iodine deficiency or need thyroid support after radiation, and if none of your medications interact with it. If you take thyroid hormone medication, blood thinners, heart drugs, birth control, or any psychiatric or antibiotic medication, check with your pharmacist first—guggul, ashwagandha, and other ingredients here have documented interactions.

If you're pregnant, breastfeeding, or have liver disease, avoid this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Thyroid Health Formula, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958035116
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36702
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Thyroid Health Formula by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
068958035116
IngredientAmount% DV
Pantothenic Acid100 mg1000%
L-Tyrosine500 mg--
Iodine100 mcg67%
Copper0.5 mg25%
Manganese0.5 mg25%
Ashwagandha (Withania somnifera) extract150 mg--
Guggul (Commiphora mukul) extract120 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: 2 capsules 1–2 times per day or as directed by a health professional.

Precautions

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

General Statements

Thyroid health is a dietary supplement designed to provide nutritional support to the thyroid gland – the major gland of metabolism.* Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

PRODUCT OF CANADA

Recyclable container and label.

Dr. Michael Murray Formulated Nourishes and Supports the Thyroid*

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

Suitable for vegetarians.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. T his product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Purity&Potency Guaranteed

FDA Statement of Identity

DIETARY SUPPLEMENT

General

R0

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Thyroid Health Formula by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Thyroid Health Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Thyroid Health Formula by Natural Factors

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pantothenic Acid

No known
interactions
100 mg per serving Form: Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

L-Tyrosine

Interacts with
21 drugs
500 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Iodine

Interacts with
7 drugs
100 mcg per serving Form: Potassium Iodide

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodine monograph & interactions

Copper

Interacts with
31 drugs
0.5 mg per serving Form: Copper Gluconate

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Manganese

Interacts with
83 drugs
0.5 mg per serving Form: Manganese Citrate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Ashwagandha (Withania somnifera) extract

Interacts with
1,372 drugs
150 mg per serving Form: Withanolides

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha (Withania somnifera) extract monograph & interactions

Guggul (Commiphora mukul) extract

Interacts with
757 drugs
120 mg per serving Form: Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul (Commiphora mukul) extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Thyroid Health Formula by Natural Factors Drug Interactions

Want to check YOUR meds against Thyroid Health Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,478Drugs
1,408 Moderate 70 Minor

Ingredients driving the most interactions

Ashwagandha (Withania somnifera) extract 1,372
Guggul (Commiphora mukul) extract 757
Manganese 83
Copper 31
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Thyroid Health Formula interact with 1,478 drugs. Click any drug to see the details.

6 of the 7 ingredients in Thyroid Health Formula interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha (Withania somnifera) extract Guggul (Commiphora mukul) extract Manganese Copper L-Tyrosine Iodine

Each ingredient & the kinds of drugs it affects

For each ingredient in Thyroid Health Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha (Withania somnifera) extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha (Withania somnifera) extract full monograph & interactions

Guggul (Commiphora mukul) extract9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul (Commiphora mukul) extract full monograph & interactions

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Iodine3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Iodine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Thyroid Health Formula, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Thyroid Health Formula by Natural Factors: Common Questions

Does Thyroid Health Formula by Natural Factors interact with any medications?
Yes. Based on its ingredients, Thyroid Health Formula has a known interaction with 1,478 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Thyroid Health Formula contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on levothyroxine (Synthroid)?
Not without checking with your pharmacist first. Ashwagandha, L-tyrosine, iodine, and guggul in this formula all interact with thyroid hormones and could push your levels too high. Your doctor may need to adjust your thyroid dose or monitor you more closely if you add this.
Does this formula actually work for thyroid problems?
Iodine is proven effective if you're deficient, but the evidence for the other ingredients to treat thyroid disease is not established in our data. If you have an underactive thyroid, talk to your doctor—prescription thyroid hormone is the standard treatment.
Is it safe to take while pregnant?
No. Both ashwagandha and guggul should be avoided in pregnancy. Ashwagandha is traditionally thought to risk miscarriage, and guggul may stimulate the uterus. While iodine is needed in pregnancy, talk to your doctor about the right amount instead of using a supplement like this.
What's L-tyrosine supposed to do?
L-tyrosine is an amino acid your thyroid uses to build thyroid hormones. It's also used by your brain for focus and memory. The evidence is possibly effective for memory and thinking, though not proven for thyroid disease on its own.
Can I take this with my anxiety medication?
Depends which one. Ashwagandha in this formula can increase the sedative effects of benzodiazepines like Valium or Xanax, and may boost other anxiety and sleep medications. Talk to your pharmacist about your specific medication before starting.
What's ashwagandha doing in a thyroid formula?
Ashwagandha is included for stress and sleep support, and preliminary research suggests it may have some thyroid-stimulating effects. But it's not proven for thyroid disease, and it can dangerously increase thyroid hormones if you're already medicated.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Thyroid Health Formula label
Go deeper

The Full Monographs Behind Thyroid Health Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph → Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Thyroid Health Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantothenic Acid 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
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Tyrosine 4 references
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Iodine 26 references
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Copper 11 references
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Manganese 21 references
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Ashwagandha 32 references
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Guggul 21 references
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