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Dietary supplement

Tianaa Green Ingredients & Drug Interactions

by Tianaa Green

Tianaa Green label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tianaa Green against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Tianaa Green is a dietary supplement by Tianaa Green with 2 active ingredients. Its ingredients are commonly taken for depression (prescription use in some countries), anxiety, mood enhancement.Based on those ingredients, 541 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Tianeptine, Combretum quadrangulare. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tianaa Green by Tianaa Green

Ask about any prescription or over-the-counter medication and we check it for interactions with Tianaa Green by Tianaa Green — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tianaa Green by Tianaa Green

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (531 mg) without saying how much of each component you get.

Tianaa Green contains two active ingredients in a proprietary blend: tianeptine and Combretum quadrangulare. Tianeptine is a compound studied for depression and cognitive support.

Combretum quadrangulare is a plant leaf traditionally used as a tea in some cultures. The capsule shell is gelatin, and the product includes purified water and FDA-approved food colorants (yellow 5, yellow 6, and blue 1) plus a silver pearlescent pigment as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Depression — rated "Possibly Effective" (Tianeptine) (Natural Medicines).

Tianeptine is rated possibly effective for depression based on available evidence. For Alzheimer disease and anxiety, the evidence isn't strong enough to rate.

Combretum quadrangulare's effectiveness for hypertension is also not established in the data we hold — it's been studied preliminarily, but reliable human evidence is lacking.

The evidence, ingredient by ingredient Tianeptine Combretum Micranthum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tianeptine sold in supplements carries serious risks. It is not FDA-approved in the U.S., and the data show it has opioid-like effects with real potential for addiction, overdose, and death — especially at higher doses.

Common side effects at prescription doses include constipation, diarrhea, dizziness, drowsiness, headache, insomnia, nausea, and vomiting. Rare but serious effects include agitation, confusion, coma, high blood pressure, liver damage, and tremor.

Recreational misuse has been linked to seizures and a serious brain condition called toxic leukoencephalopathy. Pregnancy and breastfeeding: Tianeptine is rated possibly unsafe in pregnancy due to its opioid-like effects and withdrawal risks.

Safety while breastfeeding is unknown, but the opioid-like effects make it inadvisable. Combretum quadrangulare lacks sufficient safety data for pregnancy or breastfeeding, so avoid it during both.

Talk with your doctor or pharmacist before taking this product if you are pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Tianeptine Combretum Micranthum

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Combretum Micranthum, Tianeptine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 541 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Do not take Tianaa Green if you use MAOIs — the interaction is potentially life-threatening. Also check with your doctor or pharmacist if you take CNS depressants (including opioids or sedatives), aspirin (especially chronic use), blood pressure medications, diabetes drugs, diuretics, or drink alcohol regularly.

Tianeptine's opioid-like effects and high abuse potential make these interactions particularly serious.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Tianaa Green is marketed for mood and cognitive support, but contains tianeptine — a substance with serious addiction and overdose risks that is not approved by the FDA in the United States. If you take MAOIs, sedatives, aspirin, blood pressure or diabetes medications, or diuretics, check with your doctor or pharmacist before using this product.

Pregnancy and breastfeeding are contraindications based on available safety data. Given the risks documented in our data, discuss this product with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tianaa Green, straight from the product label.

Brand Tianaa Green
Barcode (UPC) 769498984543
Net contents 15 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232645
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tianaa Green by Tianaa Green, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
15
UPC/BARCODE
769498984543
IngredientAmount% DV
Proprietary Blend531 mg--
Tianeptine0 NP--
Combretum quadrangulare0 NP--

Other ingredients: Gelatin, purified Water, FD&C Yellow 5, FD&C Yellow 6, FD&C Blue 1, Silver pearlescent pigment

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: Take 1 capsule every 6 hours or as needed.

Precautions

Do not exceed 3 capsules in a 24-hour period. You must be 18 to use this product.

Do not use this product if you are pregnant, nursing, or taking MAOI's.

This product may impair your ability to drive or operate machinery. Prolonged use or exceeding the recommended dosage may be habit forming. Always consult your physician prior to taking any dietary supplements.

Warning Keep out of reach of children

FDA Disclaimer Statement

The Food & Drug Administration has neither reviewed these statements nor approved this product for consumption. It is not known to diagnose, treat, cure or prevent disease.

Formula

Contains natural products

FDA Statement of Identity

Dietary Supplement

Storage

Storage: Keep in 68 degrees Fahrenheit - 77 degrees Fahrenheit .

Brand IP Statement(s)

2019 Karma Green, LLC All rights reserved

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tianaa Green by Tianaa Green label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tianaa Green label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tianaa Green by Tianaa Green

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

531 mg per serving

Other (inactive) ingredients: Gelatin, Purified Water, FD&C Yellow 5, FD&C Yellow 6, FD&C Blue 1, Silver pearlescent pigment. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tianaa Green by Tianaa Green Drug Interactions

Want to check YOUR meds against Tianaa Green?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
541Drugs
9 Major 532 Moderate

Ingredients driving the most interactions

Tianeptine 277
Combretum quadrangulare 265

Individual Drug Interactions

The ingredients in Tianaa Green interact with 541 drugs. Click any drug to see the details.

2 of the 2 ingredients in Tianaa Green interact with drugs. Each result below shows which ingredient is responsible. Tianeptine Combretum quadrangulare

Each ingredient & the kinds of drugs it affects

For each ingredient in Tianaa Green with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Tianeptine4 drug types · 277 drugs

Monoamine Oxidase Inhibitors (Maois)

Tianeptine may increase the toxicity of MAOIs.
Concomitant use of tianeptine and non-selective MAOIs might increase the risk of cardiovascular collapse, hypertension, fever, convulsions, and death.

Likelihood Probable Evidence C
Alcohol (Ethanol)

Alcohol increases the clearance and might reduce the levels and clinical effects of tianeptine.
Clinical research shows that alcohol decreases tianeptine absorption rate and lowers tianeptine plasma levels by about 30%. Furthermore, an analysis of alcohol blood levels in 112 patients suggests that alcohol use disorder is associated with a 124% increase in clearance of tianeptine.

Likelihood Probable Evidence B
Aspirin

Chronic use of aspirin might increase the levels and clinical effects of tianeptine.
Aspirin is converted to salicylic acid in the body. In vitro research shows that salicylic acid binds to the same protein sites as tianeptine, displacing protein-bound tianeptine and leading to higher levels of tianeptine in the blood.

Likelihood Possible Evidence D
Cns Depressants

Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.
Higher doses of tianeptine have opioid like effects and may have additive effects with other sedative drugs. In one case report, a 42-year-old male presented with respiratory depression and aspiration pneumonia due to concomitant use of high-dose tianeptine and alprazolam.

Likelihood Possible Evidence D
Tianeptine full monograph & interactions

Combretum quadrangulare3 drug types · 265 drugs

Antidiabetes Drugs

Theoretically, taking Combretum micranthum leaf with antidiabetes drugs might increase the risk of hypoglycemia.
Some preliminary human and animal research suggests that Combretum micranthum leaf has hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking Combretum micranthum leaf with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that Combretum micranthum leaf reduces blood pressure.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, taking Combretum micranthum leaf with diuretic drugs might increase the risk of hyponatremia.
Combretum micranthum leaf has shown natriuretic effects in preliminary clinical research.

Likelihood Possible Evidence B
Combretum quadrangulare full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tianaa Green, from the product label.

Tianaa Green

See all Tianaa Green products
Name
MT Distribution, LLC
Street Address
912 SE 46th LN #204
City
Cape Coral
State
FL
ZipCode
33904
Phone Number
(888) 254-0924
Pharmacist Counseling Corner

Tianaa Green by Tianaa Green: Common Questions

Does Tianaa Green by Tianaa Green interact with any medications?
Yes. Based on its ingredients, Tianaa Green has a known interaction with 541 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tianaa Green contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is tianeptine safe? I've seen it sold online as a supplement.
Tianeptine sold as a supplement carries serious risks — it's not FDA-approved in the U.S., and the data show real potential for addiction, overdose, and death, especially at higher doses. Prescription-dose use is generally well tolerated, but misuse has been linked to seizures and severe brain damage. This is not a typical supplement — it's a pharmaceutical compound with opioid-like effects.
Can I take this if I'm on an antidepressant?
That depends on which antidepressant. If you take an MAOI, do not use this product — the interaction can cause cardiovascular collapse and death. For other antidepressants, check with your doctor or pharmacist first, as tianeptine's effects on the brain may not mix safely with yours.
What are the most common side effects?
At prescription doses, the most common side effects are constipation, diarrhea, dizziness, drowsiness, headache, insomnia, nausea, and vomiting. Rare but serious effects include confusion, coma, high blood pressure, and liver damage. Recreational misuse has caused seizures and toxic brain injury.
Can I take this while pregnant or breastfeeding?
No. Tianeptine is rated possibly unsafe in pregnancy because of its opioid-like effects and withdrawal risks. Safety while breastfeeding is unknown, but the opioid-like effects make it inadvisable. Combretum quadrangulare also lacks sufficient safety data for both. Talk with your doctor before taking this product if you are pregnant, planning pregnancy, or breastfeeding.
What does Combretum quadrangulare do in this product?
Combretum quadrangulare is a plant leaf traditionally used as a tea. The data show it may lower blood pressure and blood sugar in preliminary research, but reliable human evidence for effectiveness isn't established. It's generally well tolerated, though abdominal pain has been rarely reported.
Can I drink alcohol while taking this?
No. Alcohol lowers tianeptine levels in your blood by about 30%, reducing how well it may work — and combining alcohol with a substance that has opioid-like effects and sedative properties increases your risk of serious harm. Avoid alcohol while taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tianaa Green label
Go deeper

The Full Monographs Behind Tianaa Green’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tianeptine

Interacts with 277 drugs

Tianeptine is a prescription antidepressant in some countries, but it is NOT approved by the FDA in the United States and is illegally sold in dietary supplements and 'gas station' products....

Read the full Tianeptine monograph → Herb & supplement monograph

Combretum Micranthum

Interacts with 265 drugs

Combretum micranthum (kinkeliba) is a West African shrub whose leaves are brewed into a traditional tea for digestion, liver complaints, and fever. Solid human studies are lacking, so its be...

Read the full Combretum Micranthum monograph →
Sources

Sources & How We Checked

Tianaa Green's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tianeptine 18 references
  1. Bence C, Bonord A, Rebillard C, et al. Neonatal Abstinence Syndrome Following Tianeptine Dependence During Pregnancy. Pediatrics. 2016;137(1). PubMed
  2. El Zahran T, Schier J, Glidden E, et al. Characteristics of Tianeptine Exposures Reported to the National Poison Data System - United States, 2000-2017. MMWR Morb Mortal Wkly Rep. 2018;67(30):815-818. PubMed
  3. Goodnough R, Li K, Fouladkou F, et al. Notes from the Field: Toxic Leukoencephalopathy Associated with Tianeptine Misuse - California, 2017. MMWR Morb Mortal Wkly Rep. 2018;67(27):769-770.
  4. Grasela TH, Fiedler-Kelly JB, Salvadori C, Marey C, Jochemsen R. Development of a population pharmacokinetic database for tianeptine. Eur J Clin Pharmacol. 1993;45(2):173-9. PubMed
  5. Guelfi JD, Dulcire C, Le Moine P, Tafani A. Clinical safety and efficacy of tianeptine in 1,858 depressed patients treated in general practice. Neuropsychobiology. 1992;25(3):140-8. PubMed
  6. Lauhan R, Hsu A, Alam A, Beizai K. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018;59(6):547-553. PubMed
  7. Le Bricquir Y, Larrey D, Blanc P, Pageaux GP, Michel H. Tianeptine--an instance of drug-induced hepatotoxicity predicted by prospective experimental studies. J Hepatol. 1994;21(5):771-3. PubMed
  8. Lucaj S, Leo RJ. Tianeptine Sodium: A Nootropic With Potentially Lethal Consequences. Prim Care Companion CNS Disord. 2018;20(4).
  9. Salvadori C, Ward C, Defrance R, Hopkins R. The pharmacokinetics of the antidepressant tianeptine and its main metabolite in healthy humans--influence of alcohol co-administration. Fundam Clin Pharmacol. 1990;4(1):115-25. PubMed
  10. Samuels BA, Nautiyal KM, Kruegel AC, et al. The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor. Neuropsychopharmacology. 2017;42(10):2052-2063. PubMed
  11. Voican CS, Corruble E, Naveau S, Perlemuter G. Antidepressant-induced liver injury: a review for clinicians. Am J Psychiatry. 2014;171(4):404-15. PubMed
  12. Zini R, Morin D, Salvadori C, Tillement JP. The influence of various drugs on the binding of tianeptine to human plasma proteins. Int J Clin Pharmacol Ther Toxicol. 1991;29(2):64-6.
  13. Summary of Product Characteristics Stablo: Tianeptine. 2008. Available at: https://www.servier.com.ve/sites/default/files/spc-pil/spc-stablon.pdf
  14. Rushton W, Whitworth B, Brown J, Kurz M, Rivera J. Characteristics of tianeptine effects reported to a poison control center: a growing threat to public health. J. Clin Toxicol (Phila). 2021;59(2):152-7. PubMed
  15. García-Alberca JM, Gris E, de la Guía P, Mendoza S. Effects of Tianeptine Treatment on Depression and Cognitive Function in Patients with Alzheimer's Disease: A 12-Month Retrospective Observational Study. J Alzheimers Dis 2022;88(2):707-720. PubMed
  16. AQuadir M, Rine NI, Badeti J, et al. Tianeptine Exposures Reported to United States Poison Centers, 2015-2023. J Med Toxicol 2025;21(1):30-41. PubMed
  17. Hershey HL, Onyango EM, Durst K, Korona-Bailey J, Mukhopadhyay S. Tianeptine-involved emergency department visits, fatal overdoses, and substance seizures in Tennessee, 2021-2023. Drug Alcohol Depend Rep 2024;12:100272. PubMed
  18. Ikeri K, Anderson A, Eyal F, Whitehurst R. Neonatal Opioid Withdrawal Syndrome Following Prenatal Use of Supplements Containing Tianeptine. Pediatrics 2024;153(2):e2023062382. PubMed

See these in context on the Tianeptine monograph →

Combretum Micranthum 4 references
  1. Bourqui A, Niang EAB, Graz B, et al. Hypertension treatment with Combretum micranthum or Hibiscus sabdariffa, as decoction or tablet: a randomized clinical trial. J Hum Hypertens 2020. PubMed
  2. Kpemissi M, Potârniche AV, Lawson-Evi P, et al. Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments. J Ethnopharmacol 2020;261:113133. PubMed
  3. Chika A, Bello SO. Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2010;129(1):34-7. PubMed
  4. Seck SM, Doupa D, Dia DG, et al. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hypertens 2017;32(1):75-81. PubMed

See these in context on the Combretum Micranthum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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