Tonalin CLA Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Tonalin CLA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tonalin CLA is a dietary supplement by Olympian Labs Incorporated with 2 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, skin moisturizing, menstrual cramps.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tonalin CLA by Olympian Labs Incorporated
Ask about any prescription or over-the-counter medication and we check it for interactions with Tonalin CLA by Olympian Labs Incorporated — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tonalin CLA by Olympian Labs Incorporated
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Tonalin CLA is a softgel with 8 ingredients centered on conjugated linoleic acid (CLA), a fatty acid found naturally in beef and dairy. The product includes oleic acid (a monounsaturated fat), along with other fatty acids — stearic acid, alpha-linolenic acid, palmitic acid, and polyunsaturated and monounsaturated fats — plus safflower oil as a source.
The remaining 4 ingredients are inactive: gelatin (the capsule shell), glycerin, water, and caramel color.
Does it work?
Moderate evidence
Oleic acid, one of the active fatty acids in this product, is rated possibly effective for lowering cholesterol (hypercholesterolemia) and possibly effective for coronary heart disease based on the data we hold. Evidence for the other ingredients in this supplement — including conjugated linoleic acid itself — is not established in our data.
How safe is it?
Some data gaps
Oleic acid from food sources like olive oil is recognized as safe in normal amounts. However, concentrated supplement doses have not been well studied, especially in pregnancy and lactation.
Small amounts from foods are considered fine, but taking this product at supplement levels during pregnancy or while nursing lacks good safety data — talk it over with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Antidiabetes drugs (blood sugar medications) — oleic acid in this product may increase their effects, potentially lowering your blood glucose more than expected. Check with your doctor or pharmacist before adding this supplement if you take oral blood sugar medication.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.
Tonalin CLA may be worth considering if you're interested in conjugated linoleic acid and oleic acid from a concentrated source. If you take antidiabetes medications, check with your doctor or pharmacist before starting, since oleic acid may increase their effect on your blood sugar.
Pregnancy and nursing warrant a conversation with your healthcare provider first. Use the interaction checker below to confirm your exact medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tonalin CLA, straight from the product label.
| Brand | Olympian Labs Incorporated |
|---|---|
| Barcode (UPC) | 710013037039 |
| Net contents | 1 g; 90 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2012 |
| DSLD ID | 9926 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tonalin CLA by Olympian Labs Incorporated, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 {Calories} | -- |
| Stearic Acid | 4 % | -- |
| Calories from Fat | 27 {Calories} | -- |
| Total Fat | 3 g | 4.5% |
| Protein | 1 g | 3% |
| Saturated Fat | 150 mg | 1% |
| Polyunsaturated Fat | 2.4 g | -- |
| Monounsaturated Fat | 0.5 g | -- |
| Conjugated Linoleic Acid | 84 % | -- |
| Oleic Acid | 14 % | -- |
| Alpha-Linolenic Acid | 1.5 % | -- |
| Safflower Oil | 3 g | -- |
| Palmitic Acid | 5 % | -- |
| Conjugated Linoleic Acid | 38 % | -- |
| Conjugated Linoleic Acid | 38 % | -- |
Other ingredients: Gelatin, Glycerin, Water, Caramel color
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: As a dietary supplement, take three softgels daily before a meal, or as directed by a healthcare professional.
General Statements
OLYMPIAN LABS PRESIDENT'S GUARANTEE: I guarantee that all Olympian Labs products are of the highest quality ingredients and lab assayed to ensure that what we say on the label is actually in the product.
Made in USA
When you buy an Olympian Labs product, you can be sure you are buying the best.
These ratios will slightly vary batch to batch depending on the natural variation of the fatty acid content of the oil used to derive the CLA.
Formulation
All Olympian Labs products are free from most allergens such as corn, yeast, barley, gluten, wheat, soy, lactose, all milk products, fish, egg products, as well as added flavorings, sugars, sweeteners, salt, preservatives, salicylates, artificial colors and coatings.
Hexane, Pesticide and Herbicide Free
This product does not contain Trans Fatty Acids.
Precautions
KEEP OUT OF REACH OF CHILDREN.
Storage
STORE IN A COOL, DRY PLACE.
Seals/Symbols
Since 1992 OL
Tonalin(R) The Shape Of Things To Come(TM)
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Nutritional uses of Tonalin(R) licensed to Cognis under U.S. Patents #5,428,072; 5,554,646 and 5,430,066. Tonalin CLA is an exclusively licensed trademark of Cognis.
Formula
Conjugated Linoleic Acid
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tonalin CLA by Olympian Labs Incorporated label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tonalin CLA by Olympian Labs Incorporated
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Safflower Oil
Interacts with208 drugs
Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...
Safflower Oil monograph & interactions- › Stearic Acid
- › Conjugated Linoleic Acid
- › Oleic Acid
- › Alpha-Linolenic Acid
- › Palmitic Acid
Other (inactive) ingredients: Gelatin, Glycerin, Water, Caramel color. These complete the product’s ingredient list but are not active constituents.
Tonalin CLA by Olympian Labs Incorporated Drug Interactions
HelloPharmacist Interaction Report
Tonalin CLA by Olympian Labs contains oleic acid, which has documented interactions with medications.
The most serious concern is with antidiabetes drugs — oleic acid may increase their effects, potentially lowering your blood sugar more than intended.
Read the full breakdown — every affected drug type, severity by severity
Oleic acid is a monounsaturated fat that appears in this product as part of the conjugated linoleic acid blend. Research suggests that diets rich in oleic acid (like those from olive oil) can lower fasting blood glucose levels in people taking oral blood sugar medications.
Because this supplement delivers a concentrated dose rather than food amounts, the effect could be more pronounced.
Several other ingredients — stearic acid, polyunsaturated fat, monounsaturated fat, alpha-linolenic acid, palmitic acid, and conjugated linoleic acid — we could not check because we hold no interaction data for them. Safflower oil is a blend container, and its components are listed separately.
Altogether, these interactions span 86 individual medications. Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tonalin CLA?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tonalin CLA interact with 208 drugs. Click any drug to see the details.
1 of the 2 ingredients in Tonalin CLA interact with drugs. Each result below shows which ingredient is responsible. Safflower Oil
ErtugliflozinSteglatro
How Ertugliflozin interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Ertugliflozin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin, Metformin Hydrochloride interactionSafflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Ertugliflozin, Metformin Hydrochloride interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Esomeprazole, Naproxen interactionExenatideBydureon, Byetta
How Exenatide interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Exenatide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide Synthetic interactionSafflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Exenatide Synthetic interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Famotidine, Ibuprofen interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Fish Oil Triglycerides interactionFondaparinuxArixtra
How Fondaparinux interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Fondaparinux interactionGliclazideDiamicron
How Gliclazide interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Gliclazide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glimepiride interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glipizide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glipizide, Metformin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glucagon interactionSafflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glucagon interactionGlucoseIV Glucose
How Glucose interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glucose interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glyburide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Glyburide, Metformin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glyburide, Metformin interactionHeparinHeparin
How Heparin interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Heparin interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Hydrocodone, Ibuprofen interactionIbrutinibImbruvica
How Ibrutinib interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen interactionIbuprofen LysineNeoProfen
How Ibuprofen Lysine interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen Lysine interactionIbuprofen, AcetaminophenAdvil Dual Action
How Ibuprofen, Acetaminophen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
How Ibuprofen, Hydrocodone interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
How Ibuprofen, Oxycodone interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen, Oxycodone interactionIbuprofen, PseudoephedrineDristan
How Ibuprofen, Pseudoephedrine interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Ibuprofen, Pseudoephedrine interactionIcosapent Ethyl (prescription Drug)Vascepa
How Icosapent Ethyl (prescription Drug) interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Icosapent Ethyl (prescription Drug) interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Iloprost interactionInhaled InsulinExubera
How Inhaled Insulin interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Inhaled Insulin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Inhaled Insulin interactionInotersenTegsedi
How Inotersen interacts with Tonalin CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil + Inotersen interactionInsulinNovoRapid Insulin
How Insulin interacts with Tonalin CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil + Insulin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Insulin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tonalin CLA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Safflower Oil
Anticoagulant/Antiplatelet Drugs
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Antidiabetes Drugs
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.
Warfarin
Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Brand information
Manufacturer and brand details for Tonalin CLA, from the product label.
Olympian Labs Incorporated
See all Olympian Labs Incorporated products- Name
- OLYMPIAN LABS INCORPORATED
- Street Address
- P.O. Box 12461
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85267
- Phone Number
- 1-800-473-5883
- Web Address
- www.olympianlabs.com
Tonalin CLA by Olympian Labs Incorporated: Common Questions
Does Tonalin CLA by Olympian Labs Incorporated interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does Tonalin CLA work for weight loss or body composition?
Is it safe to take Tonalin CLA while pregnant?
Can I take this if I'm breastfeeding?
What is conjugated linoleic acid (CLA) and where does it come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Tonalin CLA is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tonalin CLA’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Safflower
Interacts with 208 drugsSafflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...
Read the full Safflower monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
Tonalin CLA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
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