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Dietary supplement

Tongkat Ali Tablets 100 mg Ingredients & Drug Interactions

by Nootropics Depot

Tongkat Ali Tablets 100 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tongkat Ali Tablets 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tongkat Ali Tablets 100 mg is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tongkat Ali Tablets 100 mg by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Tongkat Ali Tablets 100 mg by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tongkat Ali Tablets 100 mg by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tongkat Ali extract at 100 mg per tablet. Tongkat Ali (also called Eurycoma longifolia) is a plant root extract traditionally used to support sexual function and athletic performance.

The tablet also contains inactive ingredients — silicon dioxide, microcrystalline cellulose, croscarmellose sodium, stearic acid, and methyl cellulose — which are fillers and binders that help form and hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male sexual health and testosterone support.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence for Tongkat Ali's effects is mixed. For sexual desire, the research suggests it's possibly effective — some studies do show benefit.

For athletic performance, the evidence points toward it being possibly ineffective. The science isn't established well enough to rate it for back pain, osteoporosis, or diabetes, so we can't say whether it works for those uses based on the data we have.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali has been generally well tolerated in short-term studies, but we don't have solid data on what happens with long-term use or on the quality and purity of different products out there. Because it can raise testosterone levels — especially if yours are already low — there's a risk of testosterone-related side effects like acne, insulin resistance, and liver damage if levels climb too high.

The safety data isn't strong enough to use during pregnancy or while breastfeeding, so it's best to avoid it if you're pregnant or nursing.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop and check before using if you take propranolol (Inderal) — this supplement can reduce how well it works. Also screen any medications broken down by CYP1A2, CYP2C19, or CYP2A6 liver enzymes, or if you're on testosterone therapy.

Use the medication checker on this page with your full list before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tongkat Ali may be worth considering if you're interested in sexual function and don't take propranolol or medications metabolized by CYP1A2, CYP2C19, or CYP2A6 enzymes. If you take testosterone therapy or have low testosterone, talk to your pharmacist first — this supplement could push levels higher.

Anyone on heart medications or multiple prescriptions should check their exact drugs before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tongkat Ali Tablets 100 mg, straight from the product label.

Brand Nootropics Depot
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251521
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tongkat Ali Tablets 100 mg by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
IngredientAmount% DV
Tongkat Ali extract100 mg--

Other ingredients: Silicon Dioxide, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Methyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Minimum eurycomanone content: 10% by HPTLC

FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablet daily.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

General Statements

Lot: TAECS1120920

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tongkat Ali Tablets 100 mg by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tongkat Ali Tablets 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tongkat Ali Tablets 100 mg by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Tongkat Ali extract

Interacts with
248 drugs
100 mg per serving Form: Eurycomanone

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali extract monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Methyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tongkat Ali Tablets 100 mg by Nootropics Depot Drug Interactions

Want to check YOUR meds against Tongkat Ali Tablets 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali extract 248

Individual Drug Interactions

The ingredients in Tongkat Ali Tablets 100 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tongkat Ali Tablets 100 mg interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tongkat Ali Tablets 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tongkat Ali Tablets 100 mg, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Tongkat Ali Tablets 100 mg by Nootropics Depot: Common Questions

Does Tongkat Ali Tablets 100 mg by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Tongkat Ali Tablets 100 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tongkat Ali Tablets 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Tongkat Ali if I'm pregnant or breastfeeding?
No. There isn't enough safety data to know whether it's safe during pregnancy, and because it may affect hormone levels, the evidence advises against it. Similarly, there's no reliable safety information for breastfeeding, so it's best to avoid it then too. Talk to your doctor or pharmacist if you're planning pregnancy or nursing and interested in this supplement.
Does Tongkat Ali actually work for sexual function?
The research suggests it's possibly effective for sexual desire — some clinical studies do show a benefit. That said, results vary, and this isn't a guarantee it'll work for you. If you're curious, discuss it with your pharmacist to make sure it won't interact with anything you're taking.
What are the side effects I should watch for?
If Tongkat Ali raises your testosterone levels too high — especially if your levels are already low — you might get acne, insulin resistance, or liver damage. The product itself is generally well tolerated in studies, but long-term safety isn't well established, so it's smart to use it short-term and stay in touch with your pharmacist about how you're feeling.
Will this help my athletic performance?
The evidence suggests it's probably not effective for athletic performance. If that's your main goal, this supplement isn't your best bet based on what we know.
What's in each tablet besides the active ingredient?
Each tablet contains inactive ingredients that are fillers and binders: silicon dioxide, microcrystalline cellulose, croscarmellose sodium, stearic acid, and methyl cellulose. These help hold the tablet together.
Does Tongkat Ali interact with my heart medication?
If you take propranolol (Inderal), yes — this supplement can lower its levels by about 29%, which means it may not work as well to control your heart rate and blood pressure. Check with your pharmacist before starting. Other heart or blood-pressure drugs may also be affected, so use the medication checker on this page to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tongkat Ali Tablets 100 mg label
Go deeper

The Full Monographs Behind Tongkat Ali Tablets 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Tongkat Ali Tablets 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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