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Dietary supplement

Tongkat Ali Tablets 100 mg Ingredients & Drug Interactions

by Nootropics Depot

Tongkat Ali Tablets 100 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tongkat Ali Tablets 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tongkat Ali Tablets 100 mg is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 249 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tongkat Ali Tablets 100 mg by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Tongkat Ali Tablets 100 mg by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tongkat Ali Tablets 100 mg by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tongkat Ali extract, at 100 mg per tablet. Tongkat Ali (Eurycoma longifolia) is a plant root traditionally used to support sexual function and athletic performance.

The tablet also contains inactive ingredients—silicon dioxide, microcrystalline cellulose, croscarmellose sodium, stearic acid, and methyl cellulose—which are common fillers and binders that help form and dissolve the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Eurycoma Longifolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Eurycoma Longifolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Natural Medicines).

The evidence we have shows Tongkat Ali extract is possibly effective for sexual desire. For athletic performance, the data points toward it being possibly ineffective.

The safety and effectiveness data for back pain, osteoporosis, and diabetes are not reliable enough to rate at this time. If you're considering this product, talk with your doctor or pharmacist about whether the evidence fits what you're hoping to address.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali extract is generally well tolerated in short-term studies, but long-term safety and product quality remain uncertain. The product should be avoided during pregnancy because safety data is insufficient and the ingredient may affect hormone levels.

It should also be avoided while breastfeeding, as reliable safety information is lacking. Because the extract may raise testosterone levels, there's a theoretical risk of testosterone-related side effects if your levels climb too high—these could include acne, insulin resistance, liver stress, and others.

If you have a condition affected by testosterone or take hormone medications, discuss this product with your pharmacist or doctor before starting.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 249 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tongkat Ali, check with your pharmacist or doctor if you take propranolol (Inderal) or any other beta-blocker heart medication—this extract reduces its effectiveness. Also flag any drugs processed through your liver's CYP1A2, CYP2C19, or CYP2A6 pathways, and any testosterone replacement therapy you may be on.

Use the medication search tool on this page to check your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tongkat Ali might appeal to someone interested in sexual function support based on the evidence available. However, it's essential to check your medications first—especially if you take propranolol or other heart drugs—because this extract can reduce how well certain medications work or raise the levels of others.

Avoid it during pregnancy and breastfeeding, and talk with your doctor or pharmacist before adding it to your routine, particularly if you take hormone therapies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tongkat Ali Tablets 100 mg, straight from the product label.

Brand Nootropics Depot
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251521
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tongkat Ali Tablets 100 mg by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
IngredientAmount% DV
Tongkat Ali extract100 mg--

Other ingredients: Silicon Dioxide, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Methyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Minimum eurycomanone content: 10% by HPTLC

FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablet daily.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

General Statements

Lot: TAECS1120920

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tongkat Ali Tablets 100 mg by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tongkat Ali Tablets 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tongkat Ali Tablets 100 mg by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Tongkat Ali extract

Interacts with
249 drugs
100 mg per serving Form: Eurycomanone

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali extract monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Methyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tongkat Ali Tablets 100 mg by Nootropics Depot Drug Interactions

Want to check YOUR meds against Tongkat Ali Tablets 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
249Drugs
3 Moderate 246 Minor

Ingredients driving the most interactions

Tongkat Ali extract 249

Individual Drug Interactions

The ingredients in Tongkat Ali Tablets 100 mg interact with 249 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tongkat Ali Tablets 100 mg interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tongkat Ali Tablets 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali extract5 drug types · 249 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tongkat Ali Tablets 100 mg, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Tongkat Ali Tablets 100 mg by Nootropics Depot: Common Questions

Does Tongkat Ali Tablets 100 mg by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Tongkat Ali Tablets 100 mg has a known interaction with 249 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tongkat Ali Tablets 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Tongkat Ali work for sexual desire?
The evidence rates it as possibly effective for sexual desire, so there's some research support, though it's not definitive. Whether it'll work for you depends on your individual situation—that's worth discussing with your doctor.
Can I take Tongkat Ali while pregnant or breastfeeding?
No, it's best to avoid it in both situations. There isn't enough safety data during pregnancy, and the ingredient may affect hormones; there's also no reliable safety information for breastfeeding. Talk with your doctor if you're planning pregnancy or nursing.
What are the side effects of Tongkat Ali?
Short-term use appears generally well tolerated in studies. The main concern is that it may raise testosterone levels; if levels go too high, you could experience acne, insulin resistance, liver stress, or other testosterone-related effects. Long-term safety isn't well established.
Does Tongkat Ali help with athletic performance?
The evidence we have suggests it's possibly ineffective for athletic performance, so it's not a reliable choice for that goal based on current data.
Why does this product interact with so many medications?
The 248 interactions aren't all equally serious. Most are theoretical—based on lab findings that the extract weakly affects liver enzymes that process many common drugs. The one documented clinical interaction is with propranolol. That's why checking your specific medications with your pharmacist is so important.
Is long-term use of Tongkat Ali safe?
Long-term safety isn't well established for this extract, and product quality varies. If you're thinking of using it long-term, your doctor or pharmacist can help you weigh the limited evidence against your individual health picture.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tongkat Ali Tablets 100 mg label
Go deeper

The Full Monographs Behind Tongkat Ali Tablets 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 249 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Tongkat Ali Tablets 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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