Triphala Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Triphala against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Triphala is a dietary supplement by Herbal Hills with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, cholesterol and heart health, immune support.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Terminalia belerica, Emblica officinalis, Terminalia chebula. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Triphala by Herbal Hills
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HelloPharmacist Scorecard of Triphala by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Triphala by Herbal Hills contains 3 active ingredients: Indian gooseberry (Emblica officinalis), Terminalia chebula, and Terminalia belerica — all plants traditionally used in Ayurvedic medicine. The product also contains inactive ingredients including xanthan gum, maize starch, silicon dioxide, HPMC, and magnesium stearate as binders and fillers.
Does it work?
Moderate evidence
The evidence for Triphala is mixed. Indian gooseberry is possibly effective for acid reflux (GERD) and possibly effective for high cholesterol (dyslipidemia), but we don't have reliable data to rate it for hair loss.
The other two ingredients — Terminalia chebula and Terminalia belerica — don't have established effectiveness ratings in our data for any condition; the evidence isn't there yet to say whether they work.
How safe is it?
Well-documented data
Indian gooseberry is generally well tolerated as a food, but supplement safety data are limited. Terminalia chebula is generally used in traditional medicine, though human safety data are sparse and product quality varies.
In a small trial, a few people reported stomach discomfort or dyspepsia, and there was one report each of fatigue and musculoskeletal pain — but these are from small numbers and may not be related to the product. During pregnancy, there's not enough safety data for Terminalia chebula or Terminalia belerica, so those are best avoided.
During breastfeeding, safety data for all three ingredients are absent or insufficient, so it's best to avoid this product. Talk with your pharmacist or doctor before using Triphala if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking Triphala, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — there's a Moderate risk of increased bleeding. Also check if you take diabetes medications, muscle relaxants like chlorzoxazone, or stomach drugs like omeprazole.
Because one ingredient affects liver enzymes that break down many drugs, any prescription medication should be reviewed.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Triphala might be worth considering if you have acid reflux or high cholesterol and don't take blood thinners or diabetes drugs. If you're on any prescription medications — especially anticoagulants, diabetes drugs, or anything metabolized by your liver — check with your pharmacist first.
Avoid it during pregnancy and breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Triphala, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906068413726 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2017 |
| DSLD ID | 75373 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Triphala by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Emblica officinalis | 0 NP | -- |
| Terminalia chebula | 0 NP | -- |
| Terminalia belerica | 0 NP | -- |
| Triphala extract & Triphala powder Blend | 500 mg | -- |
Other ingredients: Xanthan Gum, Maize Starch, Silicon Dioxide, HPMC, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Mfg. Lic. No. : PD/AYU/002/10
(An ISO 22000:2005 Certified Company)
Back to nature
Healthy digestion
~ Pure ~ Natural ~ Effective
Thought it is widely used as a laxative, but there are certain secrets about triphala. It is not just a laxative but is considered to be a powerful body stimulant that helps promote health and assist in managing overall conditions of the body. It may enhance detoxification of undesirable compounds. It supports healthy blood circulation.
Contents based on standard raw material as per Ayurvedic text
Brand IP Statement(s)
Product name: Triphalahills
Seals/Symbols
JAS-ANZ ICS ISO 22000:2005 Reg. No.: RH91/7301
GMP Good Manufacturing Practice
Halal India www.halalindia.com
Formula
Halal India www.halalindia.com
Standardized extract / 26% Tannins
Triphala literally means 3 fruits. It consists of Haritaki, Baheda & Amla.
Storage
Store in a cool dry place away from direct sunlight.
Precautions
Keep out of reach of children.
Do not use if inner seal is broken or missing.
Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.
Suggested/Recommended/Usage/Directions
Direction For Use: As a dietary supplement take 1 tablet twice daily, preferably after meals. For better results it should be taken with warm water.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Triphala by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Triphala by Herbal Hills
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Triphala extract & Triphala powder Blend
Other (inactive) ingredients: Xanthan Gum, Maize Starch, Silicon Dioxide, HPMC, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Triphala by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Triphala by Herbal Hills contains three plant ingredients, and research shows it does interact with several medication types.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — Indian gooseberry, one of the three active ingredients, can reduce platelet aggregation and increase bleeding time, raising the risk of bleeding if you're on drugs like warfarin or aspirin. This is rated a Moderate interaction.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you take diabetes medications. Both Indian gooseberry and Terminalia chebula (another ingredient) can lower blood sugar on their own, so combining them with diabetes drugs increases the risk of low blood sugar (hypoglycemia) — you may need a dose adjustment.
Terminalia chebula also interacts with the muscle relaxant chlorzoxazone and the reflux drug omeprazole by raising their blood levels and effects.
Terminalia belerica, the third ingredient, inhibits several liver enzymes (CYP2D6, CYP2C9, and CYP3A4) that break down many medications — this can increase levels and side effects of drugs metabolized through these pathways. Altogether, these interactions span 922 individual medications.
Run your exact medications through the checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Triphala?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Triphala interact with 933 drugs. Click any drug to see the details.
3 of the 3 ingredients in Triphala interact with drugs. Each result below shows which ingredient is responsible. Terminalia belerica Emblica officinalis Terminalia chebula
Buprenorphine HydrochlorideBelbuca, Probuphine
How Buprenorphine Hydrochloride interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Buprenorphine Hydrochloride interactionBuprenorphine Hydrochloride, Naloxone HydrochlorideBunavail
How Buprenorphine Hydrochloride, Naloxone Hydrochloride interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBuprenorphine, NaloxoneCassipa, Zubsolv
How Buprenorphine, Naloxone interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Buprenorphine, Naloxone interactionBuprenorphine/naloxoneSuboxone
How Buprenorphine/naloxone interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Buprenorphine/naloxone interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Terminalia Belerica + Buproprion, Dextromethorphan interactionBuspironeBuSpar
How Buspirone interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Buspirone interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Busulfan interactionCabazitaxelCabazitaxel, Jetvana
How Cabazitaxel interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Cabazitaxel interactionCabliviCablivi
How Cablivi interacts with Triphala — through 2 ingredients. Tap an ingredient for the detail:
Terminalia BelericaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Terminalia Belerica + Cablivi interactionEmblica OfficinalisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Emblica Officinalis + Cablivi interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Cabotegravir, Rilpivirine interactionCabozantinibCometriq
How Cabozantinib interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Cabozantinib interactionCabozantinib S-malateCabometyx
How Cabozantinib S-malate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Cabozantinib S-malate interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine , Sodium Benzoate interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine (prescription Drug)Migergot
How Caffeine, Ergotamine (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
How Caffeine, Ergotamine Tartrate (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine, Ergotamine Tartrate (prescription Drug) interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Caffeine, Potassium Salicylate, Salicylamide interactionCalcifediolRayaldee
How Calcifediol interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Calcifediol interactionCanagliflozinInvokana
How Canagliflozin interacts with Triphala — through 3 ingredients. Tap an ingredient for the detail:
Emblica OfficinalisAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Emblica Officinalis + Canagliflozin interactionTerminalia BelericaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Belerica + Canagliflozin interactionTerminalia ChebulaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Chebula + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Triphala — through 3 ingredients. Tap an ingredient for the detail:
Terminalia BelericaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Belerica + Canagliflozin, Metformin interactionTerminalia ChebulaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Chebula + Canagliflozin, Metformin interactionEmblica OfficinalisAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Emblica Officinalis + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Triphala — through 3 ingredients. Tap an ingredient for the detail:
Emblica OfficinalisAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Emblica Officinalis + Canagliflozin, Metformin Hydrochloride interactionTerminalia BelericaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Belerica + Canagliflozin, Metformin Hydrochloride interactionTerminalia ChebulaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Chebula + Canagliflozin, Metformin Hydrochloride interactionCangrelorKengreal
How Cangrelor interacts with Triphala — through 2 ingredients. Tap an ingredient for the detail:
Terminalia BelericaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Terminalia Belerica + Cangrelor interactionEmblica OfficinalisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Emblica Officinalis + Cangrelor interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Cannabidiol (prescription Drug) interactionCapivasertibTruqap
How Capivasertib interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Capivasertib interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Carbamazepine interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Triphala — through 1 ingredient. Tap an ingredient for the detail:
Terminalia BelericaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia Belerica + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Triphala with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Terminalia belerica
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.
Antidiabetes Drugs
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.
Omeprazole (Prilosec)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.
Emblica officinalis
Anticoagulant/Antiplatelet Drugs
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.
Aspirin
Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.
Clopidogrel (Plavix)
Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.
Terminalia chebula
Antidiabetes Drugs
Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal research suggests that Terminalia chebula fruit extract has hypoglycemic effects.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.
Omeprazole (Prilosec)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.
Brand information
Manufacturer and brand details for Triphala, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd.
- Street Address
- 55-A/B, Lonavala Co-op. Indl. Est. Ltd.
- City
- Nangargaon, Lonavala, Taluka-Maval, Dist. Pune,
- State
- Maharashtra
- ZipCode
- 410401
- Web Address
- 0091 22 2868 6868
Triphala by Herbal Hills: Common Questions
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The Full Monographs Behind Triphala’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Indian Gooseberry
Interacts with 208 drugsIndian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...
Read the full Indian Gooseberry monograph → Herb & supplement monographTerminalia Chebula
Interacts with 93 drugsTerminalia chebula, often called haritaki, is a fruit widely used in Ayurvedic medicine, most commonly for digestion and as a key part of the Triphala blend. Early laboratory and small human...
Read the full Terminalia Chebula monograph → Herb & supplement monographTerminalia
Interacts with 933 drugsTerminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...
Read the full Terminalia monograph →Sources & How We Checked
Triphala's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Indian Gooseberry 6 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
- Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
- Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
- Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu
Terminalia Chebula 9 references
- Chevallier A. Encyclopedia of Medicinal Plants. New York, NY: DK Publishing, 1996.
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
- Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
- Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
- Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
- Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
- Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
- Agrawal OD, Kulkarni YA. Treatment with Terminalia chebula extract reduces insulin resistance, hyperglycemia and improves SIRT1 expression in type 2 diabetic rats. Life (Basel) 2023;13(5):1168. PubMed
Terminalia 9 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
- Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
- Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
- Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
- Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
- Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
- Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
- Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC