True Tranquility Valerian Root 530 mg Ingredients & Drug Interactions
by Sundown
What is this page for?
First and foremost: checking True Tranquility Valerian Root 530 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
True Tranquility Valerian Root 530 mg is a dietary supplement by Sundown with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against True Tranquility Valerian Root 530 mg by Sundown
Ask about any prescription or over-the-counter medication and we check it for interactions with True Tranquility Valerian Root 530 mg by Sundown — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of True Tranquility Valerian Root 530 mg by Sundown
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: valerian root at 530 mg per capsule. Valerian is a plant extract used primarily to support sleep.
The capsule itself is made from gelatin, an inactive ingredient.
Does it work?
Moderate evidence
Valerian has possibly effective evidence for helping with insomnia. For other uses listed on the label—restless legs syndrome, pre-procedural anxiety, stress, and dysmenorrhea—the evidence isn't established enough in our data to rate it one way or the other.
If you're considering valerian for sleep, talk to your pharmacist about whether the research fits your situation.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term. The most common side effects are dizziness, drowsiness, and mental slowness; some people also report headache, stomach upset, excitability, and vivid dreams.
If you've taken valerian for a while, don't stop it abruptly—taper slowly to avoid withdrawal symptoms like anxiety, irritability, insomnia, and a racing heartbeat. Long-term safety hasn't been well studied.
Valerian is not recommended during pregnancy—safety data advises against it. There also isn't enough safety information to use it while breastfeeding.
Rare cases of liver problems have been reported with valerian-containing products, though most involved multiple ingredients. Tell your doctor or pharmacist if you have liver disease.
Meds to double-check
Moderate interaction found
Before you take this, double-check with your pharmacist if you're on any CNS depressants (sedatives, sleep aids, opioids), benzodiazepines like alprazolam (Xanax), drugs metabolized by glucuronidation, or if you drink alcohol regularly. These are Moderate severity interactions.
Valerian may also affect some drugs your liver breaks down through CYP2D6 or CYP3A4, though that risk is Minor.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian is an option if you're looking for a plant-based sleep aid and have no major health concerns. Be cautious if you take any sedating medications, benzodiazepines like Xanax, or drink alcohol regularly.
Avoid it in pregnancy and while breastfeeding. Check your exact medications with your pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about True Tranquility Valerian Root 530 mg, straight from the product label.
| Brand | Sundown |
|---|---|
| Barcode (UPC) | 030768003432 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2020 |
| DSLD ID | 212420 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for True Tranquility Valerian Root 530 mg by Sundown, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Clean Nutrition Sundown believes in clean nutrition and being transparent. That's why you won't find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products. Non-GMO No gluten No wheat No milk No lactose No artificial color No artificial flavor No artificial sweetener No preservatives No sugar No soy No starch No yeast No peanuts No tree nuts No fish Sodium free
Traditionally used for calm, tranquil rest Traditional use claims are based on historical or traditional practices.
Formula
Valerian has a long history of use for relaxation and occasional sleeplessness dating back to traditional Greek medicine.
Valerian root 530 mg per capsule
Precautions
Keep out of reach of children.
Tamper Resistant: Do not use if seal under cap is broken or missing.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur. Excessive consumption may impair ability to drive a motor vehicle or operate heavy equipment.
Not intended for use by persons under the age of 18.
Storage
Store at room temperature and avoid excessive heat.
General Statements
Made in the USA with select ingredients from around the world
US Only Discard seal & empty before recycling Check locally Plastic bottle how2recycle.info Not recycled in all communities
Brand IP Statement(s)
2019
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take four (4) capsules, one hour before bedtime, as needed. As a reminder, discuss the supplements and medications you take with your health care providers.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
True Tranquility Valerian Root 530 mg by Sundown label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in True Tranquility Valerian Root 530 mg by Sundown
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container25 Amounts shown are per serving.
Valerian
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian monograph & interactionsOther (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
True Tranquility Valerian Root 530 mg by Sundown Drug Interactions
HelloPharmacist Interaction Report
True Tranquility Valerian Root 530 mg by Sundown does interact with medications.
The most serious concern is with CNS depressants—drugs that slow your central nervous system like sedatives, sleep aids, and some pain relievers. Valerian can add to their sedative effects, potentially causing excessive drowsiness, mental slowness, or dizziness.
This is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Valerian also has Moderate interactions with alcohol (same additive sedative effect), alprazolam (Xanax) and other benzodiazepines, and a class of drugs metabolized through glucuronidation—a pathway your liver uses to clear certain medications. The glucuronidation effect could theoretically raise levels of those drugs in your blood.
Additionally, valerian has Minor interactions with drugs broken down by the enzymes CYP2D6 and CYP3A4; clinical studies suggest these are unlikely to be a real problem, but the data is there.
Altogether, these interactions span 891 individual medications. Use the search tool below to check any specific prescriptions you're taking before you start this product.
Check your own medications below · Editorial policy · How we use AI
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Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in True Tranquility Valerian Root 530 mg interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in True Tranquility Valerian Root 530 mg interact with drugs. Each result below shows which ingredient is responsible. Valerian
Aspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Glucuronidated Drugs Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Aspirin, Meprobamate interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Aspirin, Pentazocine interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Atorvastatin Calcium interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian + Atropine, Morphine Sulfate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Bazedoxifene Acetate, Conjugated Estrogens interactionBelinostatBeleodaq
How Belinostat interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Belinostat interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna Extract, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, OpiumB & O Supprettes
How Belladonna, Opium interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna, Opium interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Bellafoline, Phenobarbital interactionBelzutifanWelireg
How Belzutifan interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Belzutifan interactionBenactyzine, MeprobamateDeprol
How Benactyzine, Meprobamate interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs, Cns Depressants Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Benactyzine, Meprobamate interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with True Tranquility Valerian Root 530 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Glucuronidated Drugs +2 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Benzhydrocodone, Acetaminophen interactionEach ingredient & the kinds of drugs it affects
For each ingredient in True Tranquility Valerian Root 530 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for True Tranquility Valerian Root 530 mg, from the product label.
Sundown
See all Sundown products- Name
- Rexall Sundown, Inc.
- City
- Boca Raton
- State
- FL
- ZipCode
- 33487
- Phone Number
- 1-888-848-2435
- Web Address
- www.sundownnutrition.com
True Tranquility Valerian Root 530 mg by Sundown: Common Questions
Does True Tranquility Valerian Root 530 mg by Sundown interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take valerian if I'm pregnant or breastfeeding?
What are the most common side effects?
Does valerian actually help you sleep?
Is it safe to use long-term?
Can I take this with alcohol?
What's in the capsule besides valerian?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if True Tranquility Valerian Root 530 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind True Tranquility Valerian Root 530 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
True Tranquility Valerian Root 530 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
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