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Dietary supplement

Tulsi Cinnamon Rose Ingredients & Drug Interactions

by Organic India

Tulsi Cinnamon Rose label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tulsi Cinnamon Rose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tulsi Cinnamon Rose is a dietary supplement by Organic India with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 1,204 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Tulsi (Holy Basil) Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tulsi Cinnamon Rose by Organic India

Ask about any prescription or over-the-counter medication and we check it for interactions with Tulsi Cinnamon Rose by Organic India — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tulsi Cinnamon Rose by Organic India

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “East Indian Basil” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Proprietary Organic Blend” is a proprietary blend — the label gives one combined amount (1.80 Gram(s)) without saying how much of each component you get.
  • “organic Tulsi (Holy Basil) Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This tea blend contains 7 ingredients, most of them herbs. The active players are peppermint (which may help with irritable bowel syndrome and digestion), organic cinnamon, organic cardamom, holy basil (also called tulsi), organic stevia as a sweetener, and rose petals.

We also have organic chamomile, though we couldn't find interaction data for it. The product includes one inactive ingredient: organic Egyptian rose flavor for taste.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: stress relief and immune system support.
  • We looked for evidence on: Stress, Generalized anxiety disorder (GAD), Common cold, Respiratory tract infections, Anxiety, Immune function — and 1 related terms.
  • The closest evidence on file: Cardamom is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Peppermint is rated "Insufficient Reliable Evidence To Rate" for Pre-procedural anxiety, Common cold, Stress.
  • Also on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Common cold.

Peppermint in this blend is likely effective for irritable bowel syndrome and possibly effective for indigestion, nausea from chemotherapy, and reducing spasms during medical procedures. For the other herbs—cinnamon, cardamom, holy basil, and stevia—the evidence we have rates them as insufficient to establish they work for their proposed uses, including blood sugar control, cholesterol, or anxiety.

That doesn't mean they don't work; it means the research isn't solid enough yet to say.

The evidence, ingredient by ingredient Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint tea in the amounts you'd drink is generally well tolerated. The most common side effects are mild: abdominal pain, heartburn, nausea, or diarrhea.

A rare case of severe allergic reaction (anaphylaxis) has been reported with peppermint candy. Cinnamon at food amounts is safe, though large supplement doses over time raise concern about liver damage from coumarin, a compound it contains.

Holy basil is generally well tolerated short-term but lacks long-term safety data. The safety data advise against holy basil in pregnancy and breastfeeding because animal research raises concerns and human safety isn't established.

For cardamom and stevia, food amounts appear safe. Chamomile and rose petals: we have no pregnancy or breastfeeding data on file for these.

Side effects, ingredient by ingredient Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Stevia, Peppermint, Cassia Cinnamon, Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,205 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this tea, double-check these medication types: blood thinners and antiplatelet drugs (moderate risk from holy basil), blood-sugar-lowering drugs (moderate risk from cinnamon and holy basil), liver-damaging medications (moderate risk from cinnamon), cyclosporine (moderate risk from peppermint), blood pressure medications (minor risk from stevia), and sedatives like pentobarbital (moderate risk from holy basil). Also, peppermint may raise levels of drugs broken down by your liver enzymes CYP2C19, CYP2C9, and CYP3A4.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This tea is fine for most people who drink it occasionally and don't take blood thinners, diabetes medications, or certain immunosuppressants—but if you do, check with your pharmacist first. Holy basil isn't advised in pregnancy or while breastfeeding.

If you're on any prescription medications, especially for blood clotting, diabetes, or liver function, run them through the tool on this page before you brew a cup.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tulsi Cinnamon Rose, straight from the product label.

Brand Organic India
Barcode (UPC) 801541507726
Net contents 18 Infusion Bag(s); 1.14 Oz(s); 32.4 Gram(s)
Market status On market
Date entered into DSLD Feb 23, 2018
DSLD ID 81540
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tulsi Cinnamon Rose by Organic India, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Infusion Bag(s)
Maximum serving Sizes:
1 Infusion Bag(s)
UPC/BARCODE
801541507726
IngredientAmount% DV
organic Chamomile0 NP--
Peppermint0 NP--
organic Cinnamon0 NP--
organic Cardamom0 NP--
organic Stevia0 NP--
Holy Basil0 NP--
East Indian Basil0 NP--
Proprietary Organic Blend1.8 Gram(s)--
organic Tulsi (Holy Basil) Blend0 NP--
organic Rose Petals0 NP--

Other ingredients: organic Egyptian Rose flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

At the heart of Organic India is our commitment to be a living embodiment of love and consciousness in action. We work with thousands of small family farmers in India to cultivate thousands of acres of sustainable, organic farmland. All Organic India products promote health, happiness and true wellness and are made with loving care. Each of our products embodies a flow of love, respect and connectedness between Mother Nature, our farmers, our company and you. We provide a life of dignity to our local farmers, while bringing health & happiness to you. By choosing Organic India you're actively participating in our mission to create a sustainable global environment. Your own self-realization is the greatest service you can render then world. -Sri Ramana Maharshi- The photo on this package is one of our farmers or a family member.

Organic India is committed to responsible packaging. This carton is made from 100% recycled paperboard, with a minimum of 30% post-consumer content. Our infusion bags are made from unbleached, biodegradable fiber. Please support our environment by recycling this package.

Stress-relieving & mystical

Tulsi - Holy basil is an herb with healing properties that relieve stress and protect the immune system.

Individually wrapped for freshness

Product of India

NPOP/NAB/0010

Lic. No. 10015051001397

Earth seer

With a lovely touch of sweetness, this infusion will warm you. Tulsi - A legacy Of Good Health Reduces stress Support the immune system Abundant in antioxidants Build stamina Powerful adaptogen Aids digestion Anti aging Balances metabolism Balances energy levels Uplifts mood

About Tulsi Throughout India tulsi is acclaimed as “the queen of herbs” and is revered as a sacred plant infused with healing powers. Traditionally grown in an earthen pot in every family home or garden, tulsi (also known as holy basil) makes a delicious and nourishing herbal ‘tea’ abundant in a vast array of health benefits. Tulsi’s life-enhancing qualities, repeatedly noted in ancient Indian scriptures dating back over 5,000 years, are now here for you to fully enjoy. Blessings and namaste!

General

USOI1607A

Formula

Holy basil

Kosher

Halal Mumbai India Halal Committee Registration No. 0854

A delicate blend of rama, krishna and vana tulsi with cinnamon, cardamom, rose petals and peppermint make a harmonious, healing combination which inspires the senses.

Formulation

Caffeine free

Certified organic

Non GMO

Gluten free

Certified Organic by Control Union-801983 Product produced and processed according to NPOP standard of India & USDA-NOP www.controlunion.com

Seals/Symbols

USDA Organic

Non GMO Project Verified Nongmoproject.org

Control Union Certified

fssai

Certified B Corporation

India Organic

Halal Mumbai India Halal Committee Registration No. 0854

OU

FDA Statement of Identity

Herbal Supplement

Precautions

To enjoy while pregnant or nursing, consult a physician before use.

Suggested/Recommended/Usage/Directions

Directions: Pour 8 oz of freshly boiled water over infusion bag in a cup. Cover and steep for 5 - 10 minutes or longer. Double the strength when serving iced.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tulsi Cinnamon Rose by Organic India label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tulsi Cinnamon Rose label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tulsi Cinnamon Rose by Organic India

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Infusion Bag(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Proprietary Organic Blend

1.8 Gram(s) per serving

Other (inactive) ingredients: Organic Egyptian Rose flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tulsi Cinnamon Rose by Organic India Drug Interactions

Want to check YOUR meds against Tulsi Cinnamon Rose?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,204Drugs
1,062 Moderate 142 Minor

Ingredients driving the most interactions

organic Tulsi (Holy Basil) Blend 212

Individual Drug Interactions

The ingredients in Tulsi Cinnamon Rose interact with 1,204 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tulsi Cinnamon Rose interact with drugs. Each result below shows which ingredient is responsible. organic Tulsi (Holy Basil) Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Tulsi Cinnamon Rose with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Tulsi (Holy Basil) Blend3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
organic Tulsi (Holy Basil) Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tulsi Cinnamon Rose, from the product label.

Organic India

See all Organic India products
Name
Organic India Pvt. Ltd.
Street Address
Factory: Plot No. 266 Faizabad Road
City
Kamta P.O. Chinhat, Lucknow
State
U.P.
ZipCode
226028
Pharmacist Counseling Corner

Tulsi Cinnamon Rose by Organic India: Common Questions

Does Tulsi Cinnamon Rose by Organic India interact with any medications?
Yes. Based on its ingredients, Tulsi Cinnamon Rose has a known interaction with 1,204 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tulsi Cinnamon Rose contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I drink this if I'm pregnant or breastfeeding?
Peppermint and cinnamon are likely safe in food amounts during pregnancy and breastfeeding. However, the safety data advise against holy basil during pregnancy and breastfeeding because animal research raised concerns and human safety isn't established. There's no data on file for chamomile and rose petals. Talk with your doctor or pharmacist for personalized advice.
What are the most common side effects?
Peppermint tea is generally well tolerated, but if you drink a lot you might notice abdominal pain, heartburn, nausea, or diarrhea. Stevia may cause headache, dizziness, or nausea, though these usually resolve after the first week. Holy basil may cause loose stools or nausea.
Does this tea actually help with digestion?
Peppermint is likely effective for irritable bowel syndrome and possibly effective for indigestion. The other herbs in this blend—cinnamon, cardamom, and holy basil—lack solid evidence that they improve digestion, though they're traditionally used for that purpose.
Can I use this if I take diabetes medication?
Both cinnamon and holy basil may lower blood glucose, so they could add to the effect of your diabetes medication and increase the risk of low blood sugar. Check with your pharmacist or doctor before adding this tea to your routine.
Is this safe for long-term daily use?
Peppermint tea at food amounts is safe long-term. Holy basil is generally well tolerated short-term, but long-term safety data are limited, so talk to your provider if you plan to drink this regularly for months on end. Large doses of cinnamon over time raise liver-health concerns due to its coumarin content.
What about allergies to these herbs?
A rare but serious allergic reaction (anaphylaxis) has been reported with peppermint. Cinnamon has caused contact dermatitis in people with a cinnamon allergy. If you have a known allergy to any of these herbs, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tulsi Cinnamon Rose is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tulsi Cinnamon Rose label
Go deeper

The Full Monographs Behind Tulsi Cinnamon Rose’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph →
Sources

Sources & How We Checked

Tulsi Cinnamon Rose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 81 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
  35. Begas E, Tsioutsiouliti A, Kouvaras E, et al. Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 2017;100:80-9 PubMed
  36. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71. PubMed
  37. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8. PubMed
  38. Wu J, Xu R, Zhan R, et al. Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. Burns 2016;42(5):1059-66. PubMed
  39. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136. PubMed
  40. Nee J, Ballou S, Kelley JM, et al. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. Am J Gastroenterol 2021;116(11):2279-2285. PubMed
  41. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41. PubMed

See these in context on the Peppermint monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
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  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
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  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Cardamom 2 references
  1. Mobacken, H. and Fregert, S. Allergic contact dermatitis from cardamom. Contact Dermatitis 1975;1(3):175-176. PubMed
  2. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri PubMed

See these in context on the Cardamom monograph →

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
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  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Holy Basil 8 references
  1. Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
  2. Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
  3. Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
  4. Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
  5. Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
  6. Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
  7. Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
  8. Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

See these in context on the Holy Basil monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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