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Dietary supplement

Ultra Omega Krill Oil Ingredients & Drug Interactions

by GNC

Ultra Omega Krill Oil label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Omega Krill Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Omega Krill Oil is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neptune Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Omega Krill Oil by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Omega Krill Oil by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Omega Krill Oil by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: Neptune Krill Oil, a concentrate of omega-3 fatty acids from Antarctic krill. The softgel capsule also contains inactive ingredients — gelatin, glycerin, and an enteric coating — that help deliver the krill oil to your intestines.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Antioxidant support and omega-3 supplementation.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Osteoarthritis, Rheumatoid arthritis (RA), Premenstrual syndrome (PMS) — and 4 related terms.
  • The strongest evidence on file: Krill Oil is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, and more.

The evidence we hold supports krill oil as possibly effective for dry eye. For aging skin, Alzheimer disease, cancer prevention, high cholesterol (hyperlipidemia), and cognitive function, the evidence isn't established — we don't have reliable data to rate it either way.

The evidence, ingredient by ingredient Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated at doses up to 4 grams daily. The most common side effects are mild stomach complaints — bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort.

Headache, tiredness, and dizziness have been reported rarely. These gastrointestinal effects tend to be less frequent or less severe with krill oil than with fish oil.

If you have a shellfish allergy, avoid this product — krill is a crustacean. If you have a bleeding disorder, use with caution.

There isn't enough safety data for pregnancy or breastfeeding; talk with your doctor or pharmacist before using it during either time.

Side effects, ingredient by ingredient Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood thinners and antiplatelet drugs (like warfarin, clopidogrel, or aspirin) before starting — krill oil may increase bleeding risk. Also double-check if you're on diabetes medications, since krill oil might lower blood sugar further.

Use the medication checker on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Krill oil may help with dry eye, and it's generally well tolerated. However, if you take blood thinners, antiplatelet drugs, or diabetes medications, you need to check with us or your doctor first — the interactions can be meaningful.

Not suitable if you're allergic to shellfish.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Omega Krill Oil, straight from the product label.

Brand GNC
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1072
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Omega Krill Oil by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
IngredientAmount% DV
Calories5 {Calories}--
Calories from Fat5 {Calories}--
Total Fat0.5 g1%
Neptune Krill Oil500 mg--

Other ingredients: Gelatin, Glycerin, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

CONTAINS: Crustaceans (Krill).

Not Less than 15% Total Omega-3 Fatty Acids.

Formulation

No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Soy, No Dairy, Yeast Free.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place.

General Statements

^In a randomized, double-blind, placebo controlled clinical study, 87 volunteers were supplemented with either 300 mg of Neptune Krill Oil or placebo. After 30 days, subjects receiving Neptune Krill Oil had a significant decrease in CRP, a biomarker for heart and joint health, as well as significant improvements in joint comfort, joint function and stiffness.

• Provides critical antioxidants like astaxanthin with higher antioxidant activity than other popular antioxidants to combat harmful free radicals associated with cell-aging.*

100% Pure Neptune Krill Oil - Neptune Krill Oil is manufactured by Neptune Technologies & Bioressources Inc, Qc, Canada.

500 mg of Neptune Krill Oil with enhanced omega absorption Clinically proven to promote joint and heart heaIth^* Provides enhanced antioxidant protection* Easy-to-swallow

ACTUAL SIZE

Conforms to USP <2091> for weight.

Enteric Coated

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

GNC Ultra Omega Krill Oil features 500 mg of clinically proven Neptune Krill Oil. Krill are tiny crustaceans that are harvested from the cold waters of the Antarctic. Neptune Krill Oil Benefits: · Delivers superior bioavailability of the omega-3 fatty acids, EPA and DHA, compared to other omega-3 sources. These omega-3 fatty acids are uniquely bound to phospholipids, enhancing their absorption. • Fast-acting, clinically proven to improve joint comfort and function.^ • Clinically proven to reduce C-Reactive Protein (CRP) levels by 30%, a key marker of joint and heart health.^

Neptune Krill Oil is Clinically Prove to Reduce C-Reactive Protein (CRP) Levels by 30%. A Key Marker of Joint and Heart Health^

Please recycle this box.

The enteric coating controls or reduces fishy burps by allowing the softgel capsule to break down and absorb in the small intestine.

General

CODE 884311 GLG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Omega Krill Oil by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Omega Krill Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Omega Krill Oil by GNC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Neptune Krill Oil

Interacts with
208 drugs
500 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Neptune Krill Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Omega Krill Oil by GNC Drug Interactions

Want to check YOUR meds against Ultra Omega Krill Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Neptune Krill Oil 208

Individual Drug Interactions

The ingredients in Ultra Omega Krill Oil interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ultra Omega Krill Oil interact with drugs. Each result below shows which ingredient is responsible. Neptune Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Omega Krill Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neptune Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Neptune Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Omega Krill Oil, from the product label.

GNC

See all GNC products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Ultra Omega Krill Oil by GNC: Common Questions

Does Ultra Omega Krill Oil by GNC interact with any medications?
Yes. Based on its ingredients, Ultra Omega Krill Oil has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Omega Krill Oil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does krill oil actually do?
Krill oil is an omega-3 fatty acid concentrate from tiny Antarctic crustaceans. The evidence we hold shows it's possibly effective for dry eye. For other uses like aging skin, cognitive function, or high cholesterol, there isn't enough reliable data yet to say whether it works.
Will krill oil upset my stomach?
Many people do experience mild gastrointestinal side effects — bloating, fishy burps, nausea, diarrhea, or heartburn — but these tend to be less frequent with krill oil than with fish oil. At the standard dose (up to 4 grams daily), it's generally well tolerated.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way. Talk with your doctor or pharmacist before using krill oil during pregnancy or while breastfeeding — they can help you decide what's right for your situation.
Is krill oil safe if I have a shellfish allergy?
No. Krill are crustaceans, so if you're allergic to shellfish, you should avoid this product.
Can I take this with my blood thinner?
Not without checking first. Krill oil may thin your blood further and increase bleeding risk when combined with blood thinners or antiplatelet drugs like warfarin, clopidogrel, or aspirin. Talk to your pharmacist before starting.
What's in the capsule besides the krill oil?
The softgel contains gelatin, glycerin, and an enteric coating — these are inactive ingredients that help protect and deliver the oil to your intestines.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Omega Krill Oil is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Omega Krill Oil label
Go deeper

The Full Monographs Behind Ultra Omega Krill Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Ultra Omega Krill Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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