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Dietary supplement

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs Ingredients & Drug Interactions

by GNC Probiotics

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs is a dietary supplement by GNC Probiotics with 3 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

This product contains 2 active ingredients: Bacillus coagulans, a beneficial bacteria strain, and Fiber, which supports digestive health. Bacillus coagulans is a probiotic — live microorganisms meant to help balance your gut flora.

The Fiber component adds bulk to help move things along in your digestive tract. The product also contains inactive ingredients like milk powder, palm oil, natural flavors, and sweetener to make it palatable.

The Bacillus coagulans strain here is spore-forming, which helps these organisms survive storage and reach your digestive system intact.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: daily digestive maintenance and fiber support.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Postoperative ileus — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Diarrhea, Dyspepsia, Flatulence, and more.

Bacillus coagulans shows some promise for two digestive concerns: it's rated possibly effective for constipation and possibly effective for irritable bowel syndrome (IBS). That means the evidence suggests it may help, but more research is needed to be certain.

For other uses — antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease — we don't have enough reliable evidence to know whether it works. If you're thinking about this product for one of those conditions, talk with your doctor first.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though the quality and effectiveness of probiotic products can vary widely. There isn't enough reliable safety data overall; before you start, check in with your doctor or pharmacist.

One important caution: since this product contains live organisms, there's a theoretical risk of infection in people with severely weakened immune systems, central lines or catheters, or premature infants. Bacteremia and sepsis have been reported in those high-risk groups.

If you're in that category or unsure, absolutely talk with your doctor before taking it.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the main concern — they can kill the live bacteria in this product and make it less effective. Make sure to take them at different times, several hours apart.

Before starting, use the search tool to check all your other medications, then confirm the timing with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help if you're dealing with constipation or IBS, but the evidence is still emerging. If you take antibiotics, you'll need to space them away from this probiotic — they work against each other.

People with healthy, intact immune systems generally tolerate it well, but if you're immunocompromised or have a central catheter, talk with your doctor first. Check your other medications with the tool on this page, and run the whole plan by your pharmacist or doctor before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs, straight from the product label.

Brand GNC Probiotics
Barcode (UPC) 048107140182
Net contents 30 Soft Chew(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 63831
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Soft Chew(s)
Maximum serving Sizes:
5 Soft Chew(s)
UPC/BARCODE
048107140182
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Sugar1 Gram(s)--
Fiber2 Gram(s)8%
Bacillus coagulans0 NP--

Other ingredients: Proprietary Fiber Blend, Bacillus coagulans, non-fat dried Milk, Palm Oil, Natural flavors, Soy Lecithin, Glycerin, Caramel color, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

30 Delicious Soft Chews

Natural flavor

Probiotics work to keep a healthy balance of intestinal flora by reducing the amount of harmful bacteria in the digestive tract and replenishing and maintaining beneficial, "friendly" bacteria. Depletion of beneficial bacteria can occur as a result of poor diet, taking certain antibiotics,, stress, food poisoning, travelers' diarrhea or poor overall digestive health. Replenishing beneficial bacteria with probiotics helps to promote healthy digestion and support natural resistance. Each Ultra Probiotic Complex Soft Chew has 5 billion live and active cultures of Bacillus coagulans to provide daily replenishment of healthy bacteria in your digestive tract, along with dietary fiber, which aids in eliminating unwanted toxins from the body.

- Improves regularity & digestive health - Supports immune health

General

CODE 256134 LPG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1-5 soft chews daily. See dosing chart below.

To ensure a complete nutritional program, take daily with these GNC items: -Mega Men or Women's Ultra Mega Multivitamin -SuperFoods Blend -Triple Strength Fish Oil

Dose 1-2 soft chews Probiotics 5-10 Billion CFU Fiber 2-4 g % Daily Value 8-16% Benefit -Daily digestive maintenance. -Good source of fiber Dose 3-4 soft chews Probiotics 15-20 Billion CFU Fiber 6-8g % Daily Value 24-32% Benefit - Support for regularity and digestive health. - Excellent source of fiber. Dose 5 soft chews Probiotics 25 Billion CFU Fiber 10g % Daily Value 40% Benefit -Improve regularity, digestive health & satiety. -Optimal source of fiber for maximum benefits.

Formulation

- Gluten free

No Artificial Colors, no Preservatives, Sodium free, Gluten free, Yeast free.

Precautions

Contains: Milk and Soybeans.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking any medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children.

Seals/Symbols

Gf Gluten free

Storage

Keep in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

- 2 grams of dietary fiber per chew

Contains: Milk and Soybeans.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Soft Chew(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Fiber

2 Gram(s) per serving

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Other (inactive) ingredients: Proprietary Fiber Blend, Bacillus coagulans, Non-fat dried Milk, Palm Oil, Natural flavors, Soy Lecithin, Glycerin, Caramel color, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics Drug Interactions

Want to check YOUR meds against Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs, from the product label.

GNC Probiotics

See all GNC Probiotics products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics: Common Questions

Does Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs by GNC Probiotics interact with any medications?
Yes. Based on its ingredients, Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on antibiotics?
Not ideally. Antibiotics kill bacteria — including the beneficial ones in this product — so taking them together reduces how well the probiotic works. Space your antibiotic dose and this probiotic several hours apart. Your doctor or pharmacist can help you figure out the best schedule.
Is this safe if I'm pregnant or breastfeeding?
We don't have enough data to say one way or the other. Talk with your doctor or pharmacist; they can weigh your individual situation and advise you.
What is Bacillus coagulans, and why is it in here?
It's a type of beneficial bacteria — a probiotic — that can help restore balance to your gut. It's included specifically to support digestive health, especially for constipation and IBS.
What does the fiber do in this product?
Fiber adds bulk to your stool and helps move things through your digestive tract, supporting regularity. It works alongside the probiotic to support overall digestive function.
Can this cause an infection?
In healthy people with a strong immune system, it's very unlikely. However, people who are severely immunocompromised, have a central catheter or central line, or are premature infants have had rare cases of infection reported. If that describes you or someone in your care, check with a doctor before using it.
Does this product have a lot of fillers?
It does contain some inactive ingredients — milk powder, palm oil, natural flavors, sweetener, and others — to make it taste good and hold it together. If you have allergies to milk or soy, check the full list on the label, since it contains both.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs label
Go deeper

The Full Monographs Behind Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Ultra Probiotic Complex With Fiber Vanilla Caramel 5 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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