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Dietary supplement

Uva Ursi (Bearberry Leaf Extract) Ingredients & Drug Interactions

by BulkSupplements.com

Uva Ursi (Bearberry Leaf Extract) label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi (Bearberry Leaf Extract) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi (Bearberry Leaf Extract) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bearberry leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bearberry leaf extract, also called uva ursi. It's been used traditionally for urinary tract support, though the research backing that use is limited.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Uva Ursi product and its label doesn't state a use — see Uva Ursi's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for uva ursi is mixed and sparse. For urinary tract infections (UTIs), it's rated possibly ineffective — meaning the evidence leans against its use for that purpose.

For bronchitis and benign prostatic hyperplasia (BPH), there simply isn't enough reliable evidence to say whether it works or not. If you're thinking about this for a specific condition, talk it over with your doctor first.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated in low doses over the short term. The most common side effects are mild — diarrhea, nausea, stomach upset, and vomiting.

At high doses (20 grams or more of the dried herb), serious effects like convulsions, delirium, shortness of breath, and collapse have been reported, and very high doses of 30 grams or more may be fatal. Because of toxicity risk with prolonged use, this is meant for short-term use only.

Avoid it during pregnancy — it may stimulate the uterus and safety data is lacking. There isn't enough safety information for breastfeeding, so avoid it then too.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of these: medications metabolized by CYP2C19 or CYP3A4 enzymes (this includes many heart, antibiotic, and psychiatric drugs), lithium, drugs cleared by glucuronidation, medications that acidify the urine, or drugs transported by P-glycoprotein. These are broad categories — your pharmacist can look up your specific medications on this page's interaction checker.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi is primarily of interest if you're looking for urinary tract support, though the evidence for UTIs is weak. The bigger consideration is medication interactions — it affects how your liver processes a large number of drugs.

If you take any prescription medications, especially heart, mood, or antibiotic drugs, check with your doctor or pharmacist before starting this. Keep it short-term and at low doses, and never use it during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi (Bearberry Leaf Extract), straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0014BPCGH
Net contents 500 Gram(s); 17.6 Oz(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254321
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
750 mg
Maximum serving Sizes:
750 mg
Servings per container
667
UPC/BARCODE
X0014BPCGH
IngredientAmount% DV
Bearberry leaf extract750 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - Bulksupplements Bearberry Leaf Extract (Uva Ursi) Powder (500 grams)

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free Of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 750 mg (about 1/3 tsp) once or twice daily with food, or as directed by a physician. Not intended for long-term use.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi (Bearberry Leaf Extract) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size750 mg Dosage formPowder Servings per container667 Amounts shown are per serving.

Bearberry leaf extract

Interacts with
803 drugs
750 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Bearberry leaf extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Uva Ursi (Bearberry Leaf Extract)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Bearberry leaf extract 803

Individual Drug Interactions

The ingredients in Uva Ursi (Bearberry Leaf Extract) interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi (Bearberry Leaf Extract) interact with drugs. Each result below shows which ingredient is responsible. Bearberry leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi (Bearberry Leaf Extract) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bearberry leaf extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Bearberry leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi (Bearberry Leaf Extract), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com: Common Questions

Does Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Uva Ursi (Bearberry Leaf Extract) has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi (Bearberry Leaf Extract) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — avoid it during pregnancy because it may stimulate the uterus and safety data is lacking. There also isn't enough safety information for breastfeeding. Talk to your doctor or midwife if you're considering it for any reason in these periods.
What are the most common side effects?
At normal low doses taken short-term, the main side effects are mild gastrointestinal issues: diarrhea, nausea, stomach upset, and vomiting. Serious side effects are rare but can happen at high doses.
How long can I safely take uva ursi?
This supplement is meant for short-term use only. It can be toxic if you take it at high doses or for prolonged periods, so don't use it as a long-term daily supplement.
Does uva ursi actually work for urinary tract infections?
The evidence suggests it probably doesn't — it's rated possibly ineffective for UTIs. For other uses like bronchitis or prostate health, there just isn't enough reliable evidence to say either way.
Will this interact with my medications?
Possibly — uva ursi may slow how your liver breaks down a large number of medications and could affect lithium levels. Use the interaction checker on this page with your exact medications, and talk with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva Ursi (Bearberry Leaf Extract) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi (Bearberry Leaf Extract) label
Go deeper

The Full Monographs Behind Uva Ursi (Bearberry Leaf Extract)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi (Bearberry Leaf Extract)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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