Valerian Root 600 mg Ingredients & Drug Interactions
by Inside
What is this page for?
First and foremost: checking Valerian Root 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root 600 mg is a dietary supplement by Inside with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root 600 mg by Inside
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root 600 mg by Inside — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root 600 mg by Inside
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: valerian root extract at 600 mg per capsule. Valerian is a plant extract traditionally used to promote sleep and ease anxiety.
The capsule also contains inactive ingredients—rice flour, gelatin, silica, and magnesium stearate—which are fillers and binders that hold the supplement together.
Does it work?
Moderate evidence
Valerian root has possibly effective evidence for helping with insomnia—so it may help some people fall or stay asleep, but the proof isn't rock-solid. For restless legs syndrome, pre-procedural anxiety, stress, and dysmenorrhea (period pain), the evidence is insufficient to say whether it works.
If sleep is your goal, valerian is worth discussing with your pharmacist, but don't expect a miracle.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term, though long-term safety hasn't been thoroughly studied. The most common side effects are dizziness, drowsiness, and mental slowness; some people also report headache, upset stomach, vivid dreams, or excitability.
If you use valerian for a while and then stop abruptly, you may experience withdrawal symptoms like anxiety, irritability, rapid heartbeat, or insomnia—taper your dose slowly after extended use. Valerian should be avoided during pregnancy and while breastfeeding because safety hasn't been established in either situation.
Rare case reports have linked valerian in multi-ingredient products to liver injury, though the culprit wasn't always clear. Tell your pharmacist or doctor if you develop yellowing of the skin or eyes, dark urine, or abdominal pain while taking this supplement.
Meds to double-check
Moderate interaction found
Before taking Valerian Root 600 mg, check with your pharmacist if you take central nervous system depressants (sedatives, sleeping pills, anesthetics), alprazolam (Xanax) or other anti-anxiety medications, alcohol in regular amounts, or drugs that are metabolized by glucuronidation, CYP2D6, or CYP3A4 liver pathways. The biggest risk is additive sedation and drowsiness.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may help with insomnia, but it interacts with a large number of medications—especially sedating drugs and anti-anxiety medications. If you take any prescription or over-the-counter drugs, check them against the interaction tool on this page before starting.
Don't use it in pregnancy or while breastfeeding, and taper slowly if you've been taking it long-term.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root 600 mg, straight from the product label.
| Brand | Inside |
|---|---|
| Barcode (UPC) | 850011557464 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 336607 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root 600 mg by Inside, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian Root Extract | 600 mg | -- |
Other ingredients: Rice Flour, Gelatin, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: For adults, take one (1) capsule daily, at bedtime or as directed by a doctor.
Precautions
Warning: Do not take this product if you are pregnant or nursing. Consult a doctor before taking this product if you have a medical condition or are taking any medications.
Do not consume alcohol, drive, or operate machinery after taking this product. Do not use if safety seal under cap is broken or missing.
Keep out of reach of children.
Storage
Store at room temperature.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Questions or Comments? Call 1800.213.9370 insidevitamins.com
FDA Statement of Identity
Herbal Supplement
Formulation
Benefits: Supports restful sleep. Promotes a sense of relaxation.
Free of: Artificial Color, Artificial Flavor, GMO's, Gluten, Soy.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root 600 mg by Inside label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root 600 mg by Inside
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Valerian Root Extract
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian Root Extract monograph & interactionsOther (inactive) ingredients: Rice Flour, Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Valerian Root 600 mg by Inside Drug Interactions
HelloPharmacist Interaction Report
Valerian Root 600 mg by Inside does interact with medications.
The ingredient valerian root extract has documented moderate interactions with central nervous system depressants (CNS depressants)—drugs that slow brain activity, like sedatives and anesthetics. When you combine valerian with these medications, you risk additive sedation, meaning deeper drowsiness and mental fog than either drug alone would cause.
Read the full breakdown — every affected drug type, severity by severity
Valerian also moderately interacts with glucuronidated drugs—a large group cleared from your body by specific liver enzymes—and specifically with alprazolam (Xanax), a common anti-anxiety medication. With alprazolam, the concern is the same additive sedation, though valerian may also slightly raise alprazolam levels in your blood.
Alcohol is another moderate concern; combining it with valerian increases sedative effects. Additionally, valerian has minor interactions with drugs broken down by the liver enzymes CYP2D6 and CYP3A4, though clinical studies suggest these are unlikely to be meaningful.
Alpogether, these interactions span 891 individual medications. Check your exact prescriptions and over-the-counter drugs with the search tool below before you start valerian.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root 600 mg interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root 600 mg interact with drugs. Each result below shows which ingredient is responsible. Valerian Root Extract
BrexanoloneZulresso
How Brexanolone interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Brexanolone interactionBromazepamLectopam
How Bromazepam interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Bromazepam interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Buprenorphine interactionBuprenorphine HydrochlorideBelbuca, Probuphine
How Buprenorphine Hydrochloride interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Buprenorphine Hydrochloride interactionBuprenorphine Hydrochloride, Naloxone HydrochlorideBunavail
How Buprenorphine Hydrochloride, Naloxone Hydrochloride interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBuprenorphine, NaloxoneCassipa, Zubsolv
How Buprenorphine, Naloxone interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Buprenorphine, Naloxone interactionBuprenorphine/naloxoneSuboxone
How Buprenorphine/naloxone interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Buprenorphine/naloxone interactionButabarbital SodiumButisol Sodium, Sarisol #2
How Butabarbital Sodium interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Butabarbital Sodium interactionButabarbital, Phenobarbital, SecobarbitalS.B.P.
How Butabarbital, Phenobarbital, Secobarbital interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Butabarbital, Phenobarbital, Secobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Butalbital, Phenobarbital, Secobarbital interactionButorphanolStadol
How Butorphanol interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Butorphanol interactionCabotegravirApretude
How Cabotegravir interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Cabotegravir interactionCabotegravir SodiumVocabria
How Cabotegravir Sodium interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Cabotegravir Sodium interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Cabotegravir, Rilpivirine interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Cannabidiol (prescription Drug) interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Carbamazepine interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Carbidopa, Levodopa, Entacapone interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Celecoxib, Tramadol interactionCenobamateXcopri
How Cenobamate interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Cenobamate interactionCetirizineCetirizine, Quzyttir, Zyrtec
How Cetirizine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Cetirizine interactionChloral HydrateChloral Hydrate
How Chloral Hydrate interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Chloral Hydrate interactionChlordiazepoxideLibrium
How Chlordiazepoxide interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Chlordiazepoxide interactionChlordiazepoxide, Clidinium BromideLibrax
How Chlordiazepoxide, Clidinium Bromide interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Chlordiazepoxide, Clidinium Bromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Chlorpheniramine Polistirex, Codeine Polistirex interactionChlorpheniramine, Hydrocodone, PseudoephedrineTussend
How Chlorpheniramine, Hydrocodone, Pseudoephedrine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Chlorpheniramine, Hydrocodone, Pseudoephedrine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Chlorpromazine interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with Valerian Root 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Clobazam interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian Root Extract
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root 600 mg, from the product label.
Inside
See all Inside products- Name
- Inside Vitamins & Supplements
- City
- Pembroke Pines
- State
- FL
- ZipCode
- 33332
- Phone Number
- 1800.213.9370
- Web Address
- insidevitamins.com
Valerian Root 600 mg by Inside: Common Questions
Does Valerian Root 600 mg by Inside interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are the most common side effects of valerian?
Can I take valerian if I'm pregnant or breastfeeding?
What happens if I stop valerian suddenly after taking it for a while?
Does valerian actually work for sleep?
Can I drink alcohol while taking this supplement?
Is valerian safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Valerian Root 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Valerian Root 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
- Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
- Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
- Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
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