Valerian Root Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Valerian Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root is a dietary supplement by Mountain Meadow Herbs with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root by Mountain Meadow Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root by Mountain Meadow Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root by Mountain Meadow Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 1 active ingredient: Valerian Root Extract. The extract delivers the plant's active compounds, which are thought to promote relaxation and sleep.
The powder also includes glycerin, distilled water, and grain alcohol as inactive ingredients to create the formulation.
Does it work?
Moderate evidence
Valerian is possibly effective for insomnia — some evidence supports its use for sleep, though the research isn't definitive. For restless legs syndrome, pre-procedural anxiety, stress, and period pain (dysmenorrhea), the evidence we hold is insufficient to rate whether it works.
If you're considering valerian for any of those other conditions, talk with your pharmacist or doctor about whether the data supports a trial.
How safe is it?
Well-documented data
Valerian is generally well tolerated over the short term, but long-term safety hasn't been well studied. The most common side effects are dizziness, drowsiness, mental slowness, headache, stomach upset, and vivid dreams.
A couple of important warnings: if you take it regularly and then stop abruptly, you may experience withdrawal symptoms like a racing heart, anxiety, irritability, and insomnia — taper slowly after extended use. Rare cases of liver injury have been reported, mostly in multi-ingredient products, and there's a report of heightened mood (hypomania) in one person taking it daily.
Valerian safety has not been established during pregnancy, so it's best avoided then. There isn't enough safety information for breastfeeding either, so avoid it while nursing.
Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding and considering this supplement.
Meds to double-check
Moderate interaction found
Before taking this, double-check with your pharmacist if you're on CNS depressants (sleeping pills, anti-anxiety drugs, or opioids) or alprazolam (Xanax) — valerian can add to sedation. Also flag any medications broken down by glucuronidation if that applies to your prescriptions.
Avoid alcohol while taking valerian. Minor interactions are possible with drugs processed through CYP2D6 and CYP3A4, but clinical risk is low.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may help with insomnia if you're looking for a plant-based option, but you'll want to avoid it if you take sedating medications, anti-anxiety drugs, opioids, or drink alcohol regularly. Check your exact medications with our tool before starting.
It's not for use in pregnancy or while breastfeeding — ask your pharmacist if you have questions about your personal situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root, straight from the product label.
| Brand | Mountain Meadow Herbs |
|---|---|
| Barcode (UPC) | 813086013051 |
| Net contents | 4 Fluid Ounce(s); 120 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2024 |
| DSLD ID | 310164 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian Root Extract | 1.25 mL | -- |
Other ingredients: Glycerin, Water, Distilled, Grain Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Valeriana officinalis
Formulation
Hand-made extract
Gluten free
Vegan
Natural calming supports Supports a healthy sleep cycle Promotes calmness Supports a positive mood
FDA Statement of Identity
Herbal Dietary Supplement
Seals/Symbols
Made in Montana USA
Suggested/Recommended/Usage/Directions
Suggested use: 1/8 -1/4 tsp. Take 1-3 times daily, or as needed. See catalog for dosage information.
Shake well.
Precautions
Caution: If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.
Keep out of reach of children.
Storage
Store in a cool, dry place out of sunlight.
General Statements
The MMH Three-Leaf Promise: Our high-standard produce nothing less than pure, safe, and effective herbal products. You will always feel that we care - through our products, our service, and our understanding. We deliver on time.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root by Mountain Meadow Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root by Mountain Meadow Herbs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.13 Teaspoon(s) Dosage formPowder Servings per container96 Amounts shown are per serving.
Valerian Root Extract
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian Root Extract monograph & interactionsOther (inactive) ingredients: Glycerin, Water, Distilled, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.
Valerian Root by Mountain Meadow Herbs Drug Interactions
HelloPharmacist Interaction Report
Valerian Root Extract by Mountain Meadow Herbs does interact with a number of medications, so it's worth checking before you start.
Read the full breakdown — every affected drug type, severity by severity
The biggest concern is with CNS depressants — drugs that slow down your nervous system, like sleeping pills, anti-anxiety medications, and opioids. Valerian can add to their sedative effects, making you drowsier or more mentally foggy than either substance alone.
Alprazolam (Xanax) deserves a special mention here: valerian can boost both sedation and might slightly raise alprazolam levels in your blood, though that level increase probably won't matter much in practice. Alcohol is another one to avoid while taking valerian — the combination can cause excessive drowsiness.
Valerian may also weakly inhibit how your body processes certain medications that are broken down by a specific enzyme system (glucuronidation). The clinical impact isn't well established, but it's worth knowing about if you take drugs metabolized that way.
On the brighter side, valerian appears to have minimal effect on two other major drug-processing pathways (CYP2D6 and CYP3A4 substrates), though we noted these as Minor interactions in the data.
Altogether, these interactions span 891 individual medications. Use the medication checker below to run through your exact prescriptions before adding this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root interact with drugs. Each result below shows which ingredient is responsible. Valerian Root Extract
Acetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs, Cns Depressants +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Alfentanil interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aminophylline, Amobarbital, Ephedrine interactionAmitriptylineElavil
How Amitriptyline interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Amitriptyline, Perphenazine interactionAmobarbitalAmytal
How Amobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Amobarbital, Secobarbital interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract + Apomorphine Hydrochloride interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aprobarbital, Butabarbital, Phenobarbital interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Aripiprazole Lauroxil interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian Root Extract
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root, from the product label.
Mountain Meadow Herbs
See all Mountain Meadow Herbs products- Name
- Mountain Meadow Herbs, Inc.
- Street Address
- 1019 Hard Rock Rd
- City
- Somers
- State
- MT
- ZipCode
- 59932
- Phone Number
- 888.528.8615
- Web Address
- www.mmherbs.com
Valerian Root by Mountain Meadow Herbs: Common Questions
Does Valerian Root by Mountain Meadow Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take valerian if I'm on a sleep medication?
What are the most common side effects?
Is it safe to stop taking valerian anytime?
Can I drink alcohol with valerian?
Is valerian safe during pregnancy or breastfeeding?
Does valerian actually work for sleep?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Valerian Root is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Valerian Root’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
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