Valerian Root Standardized Extract 125 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Valerian Root Standardized Extract 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root Standardized Extract 125 mg is a dietary supplement by Martin Avenue Pharmacy with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian root extract 4:1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Valerian root extract, provided in a concentrated 4:1 form at 125 mg per capsule. The capsule itself is made of gelatin, an inactive ingredient that holds the extract together.
Does it work?
Moderate evidence
Valerian is possibly effective for insomnia — the evidence supports its use for sleep troubles, though it's not a slam-dunk cure. For restless legs syndrome, pre-procedural anxiety, stress, and period pain (dysmenorrhea), the evidence we hold isn't strong enough to say whether it works or not.
If you're considering valerian for anything other than sleep, talk with your pharmacist about what the research actually shows for your specific situation.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term, but we don't have solid long-term safety data. The most common side effects are dizziness, drowsiness, mental slowness, headache, stomach upset, and vivid dreams.
Some people report excitability instead of sedation. If you take valerian regularly for weeks or months and then stop abruptly, you might experience withdrawal symptoms — anxiety, irritability, insomnia, or rapid heartbeat — so it's best to taper your dose slowly when you're ready to quit.
Rare case reports have linked valerian in multi-ingredient products to liver injury, though it's hard to pinpoint valerian alone as the culprit. The safety data advises against valerian during pregnancy and breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you use any central nervous system depressants (sleep aids, anxiety medications, opioid painkillers, or sedating antihistamines). Also flag alcohol — drinking while on valerian can cause excess sedation.
If you take alprazolam (Xanax), that's a specific moderate concern. Ask your pharmacist about any drugs processed through glucuronidation, or any that depend on the liver enzymes CYP2D6 or CYP3A4, though those last two are minor risks.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian is a reasonable option if you're struggling with sleep and want to try something over the counter. But if you take any prescription medications — especially sedatives, anxiety drugs, pain relievers, or anything metabolized by your liver — check them against this product first.
Avoid it if you're pregnant or nursing, and be aware that stopping suddenly after regular use can cause withdrawal. Talk to your pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root Standardized Extract 125 mg, straight from the product label.
| Brand | Martin Avenue Pharmacy |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2013 |
| DSLD ID | 19042 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian root extract 4:1 | 125 mg | -- |
Other ingredients: Gelatin, May contain one or more of the following:
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Valerian is a perennial herb that is harvested in its natural environment in India and Western Asia. The pungent root has been used since ancient times.
QUALITY AND POTENCY GUARANTEED
"We Make It Better..."
Formulation
This product contains no added sugar, salt, dairy, yeast, wheat, corn, soy, preservatives, artificial colors or flavors.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, adults take one (1) capsule, two (2) to six (6) times daily with meals, or as directed by a health care professional.
Storage
Store in a cool, dry place and away from direct light.
Precautions
Keep out of reach of children.
General
#10144
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Valerian root extract 4:1
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian root extract 4:1 monograph & interactionsOther (inactive) ingredients: Gelatin, May contain one or more of the following:. These complete the product’s ingredient list but are not active constituents.
Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy Drug Interactions
HelloPharmacist Interaction Report
Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy does interact with a number of medications.
The most serious concern is with central nervous system depressants (CNS depressants) — drugs like sleep aids, anti-anxiety medications, and opioid pain relievers. Valerian can add to their sedative effect, which means you might feel extra drowsy, mentally sluggish, or impaired.
This is a moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Valerian also has moderate interactions with alcohol and with alprazolam (Xanax) specifically — both can cause additive sedation. Additionally, valerian might weakly affect how your body metabolizes certain drugs (those processed through glucuronidation), which could modestly raise their levels in your bloodstream.
There are also minor interactions documented with drugs metabolized by two common liver enzymes (CYP2D6 and CYP3A4 substrates), though clinical studies suggest these are unlikely to be significant in practice.
Altogether, these interactions span 891 individual medications. Use the interaction checker below to look up your exact medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root Standardized Extract 125 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root Standardized Extract 125 mg interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root Standardized Extract 125 mg interact with drugs. Each result below shows which ingredient is responsible. Valerian root extract 4:1
AcepromazineAtravet
How Acepromazine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract 4:1 + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cns Depressants +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 2d6 (cyp2d6) Substrates, Glucuronidated Drugs +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cns Depressants +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Cytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Valerian Root Standardized Extract 125 mg — through 1 ingredient. Tap an ingredient for the detail:
Valerian Root Extract 4:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Root Extract 4:1 + Acetaminophen, Chlorzoxazone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root Standardized Extract 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian root extract 4:1
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root Standardized Extract 125 mg, from the product label.
Martin Avenue Pharmacy
See all Martin Avenue Pharmacy products- Name
- Martin Avenue Pharmacy, Inc.
- City
- Naperville
- State
- IL
- ZipCode
- 60540
- Phone Number
- (630) 355-6400
Valerian Root Standardized Extract 125 mg by Martin Avenue Pharmacy: Common Questions
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The Full Monographs Behind Valerian Root Standardized Extract 125 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root Standardized Extract 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
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- Donovan JL, DeVane CL, Chavin KD, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32:1333-6. PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
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- Wells SR. International intravenous administration of a crude valerian root extract. NACCT 1995;33:542.
- Aydinoglu U, Özcan H, Yücel A, Yücel N, Mutlu M. Valerian induced hypomania: a case report. Bull Clin Psychopharma 2012;22(Suppl. 1):S63.
- Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res 2013;12(1):217-22.
- Thomas K, Canedo J, Perry PJ, et al. Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. Accid Anal Prev. 2016 Jul;92:240-4. PubMed
- Kia YH, Alexander S, Dowling D, Standish R. A case of steroid-responsive valerian-associated hepatitis. Intern Med J. 2016 Jan;46(1):118-9. PubMed
- Burke H, Jiang S, Chatham P, Stern TA. Delirium After Withdrawal From Valerian Root: A Case Report. Psychosomatics. 2020;61(6):787-790. PubMed
- Hajizadeh I, Jamshidi M, Kazemi M, Kargar H, Sadeghi T. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial. Ther Apher Dial 2023.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC