Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Vegan Collagen Builder Ingredients & Drug Interactions

by Reserveage Beauty

Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Vegan Collagen Builder is a dietary supplement by Reserveage Beauty with 8 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 214 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are PureWay-C, Bamboo Leaf, Stem Extract, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vegan Collagen Builder by Reserveage Beauty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 8 active ingredients.
  • “Amino Acid Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.
  • “Ceramosides” is listed as a grouped ingredient — the label gives one combined amount (30 mg) without saying how much of each component you get.

This product contains eight active ingredients designed to support collagen production. The main amino acids are glycine, lysine, and proline—building blocks your body uses to make collagen.

There's also an amino acid blend, plus PureWay-C (a form of vitamin C that your body absorbs well), bamboo leaf and stem extract, glycosylceramides, digalactosyl diglyceride, and white tea leaf extract. The inactive ingredients are rice bran, cellulose, microcrystalline cellulose, maltodextrin, rice extract, rice husk, gum arabic, sunflower oil, and silica—these are fillers and binders that make the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote collagen formation and hydrated skin.
  • We looked for evidence on: Aging skin, Skin elasticity, Dermal hydration, Skin firmness, Connective tissue health.
  • The closest evidence on file: Vitamin C is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Aging.

The evidence supporting these ingredients is limited. Glycine is possibly effective for schizophrenia, but the data on whether it actually helps build collagen or improve skin, bone, or joint health isn't established in our records.

Lysine is possibly effective for cold sores, but we don't have reliable evidence that it supports collagen production. Vitamin C is effective for preventing vitamin C deficiency and possibly effective for a few conditions like anemia of chronic disease and cataracts, though again the data on collagen building specifically isn't here.

For proline, bamboo extract, and the other plant-based ingredients, the evidence we hold doesn't establish their effectiveness for any particular condition.

The evidence, ingredient by ingredient Glycine Lysine Proline Vitamin C Bamboo

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C from this product is generally well tolerated at normal doses, but very high intakes can cause stomach cramps, heartburn, diarrhea, nausea, and vomiting—and in people prone to kidney stones, high doses have triggered them. Glycine is generally well tolerated at typical doses, though rare side effects include mild sedation, irritability, insomnia, and GI upset; long-term safety data are limited.

Lysine is also generally well tolerated, but high amounts may cause stomach upset including abdominal pain and diarrhea. Bamboo shoot supplements haven't been well studied; raw shoots can be toxic because they contain cyanide compounds, though properly cooked ones used in food are safe.

During pregnancy, vitamin C at normal dietary and prenatal levels is fine, but high-dose supplements should be avoided. For lysine and bamboo, supplement safety in pregnancy isn't well studied—check with your doctor.

Breastfeeding safety data for glycine, lysine, proline, and bamboo are insufficient, so caution is advised.

Side effects, ingredient by ingredient Glycine Lysine Proline Vitamin C Bamboo

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Lysine, Bamboo, Vitamin C, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments.
  • For scale: 214 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use: blood thinners like warfarin, oral contraceptives or hormone replacement therapy (estrogens), thyroid medication (levothyroxine), antipsychotics (clozapine or fluphenazine), chemotherapy drugs, antithyroid medication, or HIV drugs like indinavir. Vitamin C can affect how all of these work.

Also flag any 5-HT4 agonists you're on, as lysine may reduce their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support collagen with amino acids and vitamin C, this product is generally well tolerated at the doses in a capsule. However, if you take blood thinners, thyroid medication, antipsychotics, chemotherapy drugs, oral contraceptives, or hormone replacement therapy, you'll need to check your exact medications with the tool on this page first.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or have a history of kidney stones.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vegan Collagen Builder, straight from the product label.

Brand Reserveage Beauty
Barcode (UPC) 853427006038
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 327288
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vegan Collagen Builder by Reserveage Beauty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
853427006038
IngredientAmount% DV
Glycine0 NP--
Lysine0 NP--
Proline0 NP--
Amino Acid Blend100 mg--
PureWay-C60 mg67%
Bamboo Leaf, Stem Extract100 mg--
Glycosylceramides15 mg--
Digalactosyl Diglyceride12 mg--
White Tea Leaf Extract100 mg--
Ceramosides30 mg--

Other ingredients: Rice Bran, Cellulose, Microcrystalline Cellulose, Maltodextrin, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vegan Collagen Builder delivers 3 vital amino acids and plant based ingredients to help promote collagen formation and hydrated skin.

Ceramosides clinical trial participants reported that they began to see visible results starting in two weeks. Participants were fair-skinned Caucasian women between the ages of 30-60 and took 30 mg per day of Ceramosides for 8 weeks. Supports collagen formation and hydrated skin in 2 weeks

Vegan Collagen Builder with phytoceramides & pro-collagen nutrients

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 capsules daily to set the tone for a beautifully healthy day. The product can be taken on an empty stomach, with food or as recommended by your healthcare practitioner.

Storage

Best stored tightly closed in a cool, dry place.

Precautions

Warning: Keep out of reach of children and pets.

Please consult your healthcare professional before taking this product, especially if you are pregnant, nursing, on medication or under a doctor's care.

Do not use if outer seal is broken or missing.

Contains: Wheat Wheat has been processed to allow the Ceramosides Ceramide to meet the FDA requirement for a Gluten-Free claim.

Brand IP Statement(s)

Ceramosides is the trademark of E.P.I. France.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Gluten Free

Vegan

FDA Statement of Identity

Dietary Supplement

See for yourself

Vegan Collagen Builder by Reserveage Beauty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vegan Collagen Builder by Reserveage Beauty

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amino Acid Blend

100 mg per serving

PureWay-C

Interacts with
207 drugs
60 mg per serving Form: Vitamin C

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

PureWay-C monograph & interactions

Bamboo Leaf, Stem Extract

Interacts with
5 drugs
100 mg per serving Form: Bamboo Leaf Extract, Bamboo Stem Extract

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail,...

Bamboo Leaf, Stem Extract monograph & interactions

White Tea Leaf Extract

100 mg per serving Form: Camellia sinensis Leaf Extract

Ceramosides

30 mg per serving Form: Ceramide Wheat seed extract
  • › Glycosylceramides
  • › Digalactosyl Diglyceride

Other (inactive) ingredients: Rice Bran, Cellulose, Microcrystalline Cellulose, Maltodextrin, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vegan Collagen Builder by Reserveage Beauty Drug Interactions

Want to check YOUR meds against Vegan Collagen Builder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
214Drugs
107 Moderate 107 Minor

Ingredients driving the most interactions

PureWay-C 207
Lysine 1

Each ingredient & the kinds of drugs it affects

For each ingredient in Vegan Collagen Builder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

PureWay-C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B

Bamboo Leaf, Stem Extract1 drug type · 5 drugs

Antithyroid Drugs

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.
Animal research suggests that long-term consumption of bamboo shoot can decrease thyroid peroxidase activity, as well as levels of thyroxine (T4) and triiodothyronine (T3). This effect has not yet been reported in humans.

Likelihood Possible Evidence D

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B

Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Vegan Collagen Builder, from the product label.

Reserveage Beauty

See all Reserveage Beauty products
Name
Reserveage Beauty
Street Address
4800 T-Rex Avenue Suite 305
City
Boca Raton
State
FL
ZipCode
33431
Phone Number
800.553.1896
Web Address
RESERVEAGE.COM
Pharmacist Counseling Corner

Vegan Collagen Builder by Reserveage Beauty: Common Questions

Does Vegan Collagen Builder by Reserveage Beauty interact with any medications?
Yes. Based on its ingredients, Vegan Collagen Builder has a known interaction with 214 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vegan Collagen Builder contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm on birth control?
The vitamin C in this product can increase estrogen levels from oral contraceptives by up to 55% in some cases. This is a Moderate-severity interaction, so you'll need to check with your doctor or pharmacist before starting. They may want to monitor you or adjust your dose.
Can I take this if I'm on warfarin (a blood thinner)?
High doses of vitamin C can reduce how well warfarin works. This product contains vitamin C, so it's a Moderate interaction you need to discuss with your doctor before starting. Don't begin the supplement without confirming it's safe with your prescriber.
What does this collagen builder actually do?
This product contains amino acids (glycine, lysine, proline) and vitamin C, which are building blocks and cofactors your body uses to make collagen. However, the evidence that these specific ingredients actually improve skin, bone, or joint health isn't established in our data.
Can I take this while pregnant?
Vitamin C at normal dietary levels is fine in pregnancy, but the safety data for high-dose supplements are limited. For lysine and the other amino acids and plant extracts, there isn't enough studied safety data to know either way. Talk with your doctor before starting to get personalized advice.
Are there any common side effects?
At typical capsule doses, these ingredients are generally well tolerated. Vitamin C in high amounts can cause stomach upset, diarrhea, and headache. Glycine and lysine can rarely cause mild GI discomfort or sedation. If you notice any unusual symptoms, stop and talk to your pharmacist.
Is this safe if I take thyroid medication?
Vitamin C can increase how much levothyroxine your body absorbs, which may change your thyroid hormone levels. Bamboo extract may also affect thyroid function with long-term use. Check with your doctor or pharmacist before starting, as your dose might need adjustment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vegan Collagen Builder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vegan Collagen Builder label
Go deeper

The Full Monographs Behind Vegan Collagen Builder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Vegan Collagen Builder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  10. Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
  11. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  12. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  13. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  14. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  15. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
  16. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  17. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  18. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
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Bamboo 4 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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