Interactions on record — worth a quick check against your medications. Based on 3 of 10 ingredients. Check your meds →
Dietary supplement

Vine Essence Capsules Ingredients & Drug Interactions

by Kingsway Trading

Vine Essence Capsules label
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Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vine Essence Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vine Essence Capsules is a dietary supplement by Kingsway Trading with 10 active ingredients. Its ingredients are commonly taken for kidney 'yang' tonic in traditional chinese medicine, low libido and erectile concerns, bone and joint health.Based on those ingredients, 1,352 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fo_ti, Chinese licorice, Morinda. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vine Essence Capsules by Kingsway Trading

Ask about any prescription or over-the-counter medication and we check it for interactions with Vine Essence Capsules by Kingsway Trading — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Vine Essence Capsules by Kingsway Trading

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Ba Ji Tian, Fo-ti, Licorice.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,353 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 3 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vine Essence Capsules, straight from the product label.

Brand Kingsway Trading
Net contents 30 Capsule(s)
Market status Off market
Date entered into DSLD Oct 25, 2013
DSLD ID 26117
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vine Essence Capsules by Kingsway Trading, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
IngredientAmount% DV
Homalomena70 mg--
Japanese Kadsura70 mg--
Morinda70 mg--
Fo_ti70 mg--
Ligusticum wallichii65 mg--
Asia Ginseng50 mg--
Pubescent holly65 mg--
Gastrodia65 mg--
Chinese licorice40 mg--
Spatholobus70 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Asia Ginseng /Ren Shen{Foreign Characters} 50mg

Pubescent holly {Mao Dong Qin} {Foreign Characters}65mg

Chinese licorice {Gan Cao} {Foreign Characters}40mg

Spatholobus / Ding Gong Teng {Foreign Characters} 70mg

Japanese Kadsura {Foreign Characters} 70mg

Gastrodia {Tian Ma} {Foreign Characters}65mg

Homalomena {Foreign Characters} 70mg

Fo_ti {He Shou Wu } {Foreign Characters} 70mg

Morinda {Ba Ji Tian} {Foreign Characters} 70mg

Ligusticum wallichii {Chuan Xiong} {Foreign Characters} 65mg

Who can use it? Anyone who has rheumatoid arthritis, rheumatoid pain, weak limbs, osteoarthritis and bone joints pain can use it, except who is pregnant or breastfeeding . Vine Essence Capsules specially for people who are looking for natural herbal medicine with much less side effects to treat arthritis.

General Statements

Modern Science finds Asia Ginseng contains antioxidant substances called ginsenosides which eliminate free radicals and scale down their negative effects. It supports overall health such as boosting the immune system, lowering blood sugar and cholesterol, reducing liver toxicity, improving blood oxygen flow, heightening stamina and improving the health of people recovering from illness.

Tian Ma has sweet and neutral properties, entering liver channel. It has sedation and anti-seizure effects on the CNS, relieving convulsion and spasm. Also it can lower blood pressure and improve blood flow to heart and brain. Thus, it is very commonly used for hypertension, headache, dizziness, migraine, and nervous headache. Because of expelling wind evil and alleviating pain effects, it has been used to treat arthralgia and numbness and fatigue. What more, it can improve the immune system. It is relatively safe.

Gan Cao's common name is Licorice Root. It is sweet, neutral and nontoxic. It mainly acts on the heart, lung, spleen and stomach channels. It pacifies the mind and soul. It relieve convulsions and palpitations, restlessness and amnesia. It tonifes the spleen and enhances qi-energy; clears heat and rids of toxins; expels phlegm and stops cough; relieves stomach, muscle and tendon pain. it is used to lessen the harsh and toxic nature of other herbs and harmonizes the overall effects of a formula. Do not use with high blood pressure or edema. Using Licorice with aspirin may increase the irritation of the stomach. Dosage: 1.5-9 grams

Ding Gong Ten's Latin name is Erycibe obtusifolia Benth. For thousands years, Ding Gong Teng has been used in treatment of rheumatoid arthritis in traditional Chinese herbal medicine because it has a great ability of inhibiting the production of inflammatory. The current science research results indicate that the anti-inflammatory activities of it are related to Scopoletin, one of the chemical components of it. Scopoletin involves inhibition of eicosanoid biosynthesis, cell influx, and peroxidation. Ding Gong Teng has toxic, but the toxic of lower dose of it is mild. Dosage Oral: decoction: 3-6g. powdered: 0.3-0.6g

Ding Gong Ten's Latin name is Erycibe obtusifolia Benth. For thousands years, Ding Gong Teng has been used in treatment of rheumatoid arthritis in traditional Chinese herbal medicine because it has a great ability of inhibiting the production of inflammatory. The current science research results indicate that the anti-inflammatory activities of it are related to Scopoletin, one of the chemical components of it. Scopoletin involves inhibition of eicosanoid biosynthesis, cell influx, and peroxidation. Ding Gong Teng has toxic, but the toxic of lower dose of it is mild. Dosage Oral: decoction: 3-6g. powdered: 0.3-0.6g

Overall, Vine Essence Capsules is excellent herbal formula for arthritis, especially for rheumatoid arthritis. It not only treat symptoms, but also treat the course of diseases. It is relatively safe and very effective.

Vine essence Capsules are effective and satisfication is guaranteed. We guarantee money back without any question. If it does not work for you, just return the empty boxes

Pubescent holly {Mao Dong Qin} {Foreign Characters}65mg It has bitter, astringent, cool and non-toxic properties. It can reduces swelling and pain because it has a significant anti-inflammatory, detoxification and diuresis effects. Also it has a abilities to increase coronary blood flow, relax spasm of peripheral vascular, boost limb and muscle blood flow, and inhibit platelet aggregation and thrombosis. Usage and Dosage Oral: decoction, 10 ~ 30g per day.

Company Info: Vine Essence capsule is distributed to United Stated by Kingsway Trading Inc. All products from China that are represented by Kingsway as agent are manufactured by GMP(Good Manufacturing Practice) certified manufacturers. Imported products have all passed through quality control. Safety, effectiveness, tradition, science and professionalism are what Kingsway believes in and guarantees to its customers. Kingsway distributes over-the-counter herbal medicines that are registered with the USFDA with NDC numbers. All products Kingsway sell in the United States are covered by a local product liability insurance policy. Please ensure the products you purchased display a label or description of "KINGWAY TRADING INC." .

Product of China

FAQ: What is the different Vine Essence Capsule from conventional arthritis medicines ? Because of the mild toxicity of herbal ingredients, Vine Essence Capsule inhibits inflammation, reduces swollen, and eliminates pains just like what conventional arthritis medicines do. But it is much less toxic than conventional arthritis medicines. Beside, Vine Essence Capsule is a superior conventional arthritis medicine because it contains antioxidant substances and other nutritious components. By nourishing blood, enhancing the liver and kidney and quickening the blood circulation, it promotes the growth of tendon and bone, increases energy level, and restores the normal immune functions. So it can cure rheumatoid arthritis, osteoarthritis and joint pain. The success rate in treatment of arthritis is much higher than expected.

Japanese Kadsura 's Latin name is Kadsura coccinea (Lem.) A. C. Smith. With punge, warm and slightly bitter properties, the root of it has been used as a herb medicine. It prompotes qi-energy and blood circulation, expel blood stasis, open blocked meridians, reduces swelling, relieve pain, cure rheumatism, bone pain,bruises and fracture. Also, it is commonly used for stomach ailments such as gastric and duodenal ulcers, chronic gastritis, acute gastroenteritis. Because it has calm, analgesic and anti-inflammatory effects, pregnant women should be careful to use it. Dosage Oral: cecoction: 9 ~ 15g; powdered: 0.9 ~ 1.5g; or soaked in wine.

ChuanXiong's Latin name is Ligusticum chuanxiong Hort. It has acrid and warm properties, entering liver, gallbladder and pericardium channels. It is one of the most effective herbs for expelling Blood and Qi stasis. It dilates coronary arteries and improves blood flow to heart muscles. It has the effects of increasing cerebral blood flow, accelerating the velocity of blood flow, dilating the spastic artery and decreasing peripheral arterial resistance. Also it has antibiotic and anti-coagulation effects. In the traditional chinese medicine, it is used in treatment of muscles and joints pain, chest pain, headaches, dizziness and numbness, Blood Stagnation, and Blood Deficiency. Use with caution during pregnancy. Avoid in patients with excess menses or prone to bleeding. It may interfere with Anti-Coagulating drugs. Dosage: 3 ~10 g per day.

In traditional Chinese medicine, homalomena has bitter, pungent and warm properties, and is associated with the Liver and Kidney meridians. The extract of it not only can inhibit acute inflammation, but also inhibit chronic inflammation to eliminate pain. It shows it possesses the effect of anti-rheumatoid arthritis. It is used in treatment of rheumatoid arthritis , spastic arms and legs, pain and weakness in the lower back and knees, injuries from impact. It has mild toxic. Dosage Oral: cecoction: 9-15g; powdered: 0.9 ~ 1.5g; or soaked in wine.

He Shou Wu's Latin Name is Radix Polygonum Multiflorum. It is warm, sweet and acts on liver and kidney channels. It nourishes blood and Yin, strengthens liver and kidney. It blackens hair. Long-term use enables the growth of tendon and bone and prolongs the lifespan. It has functions of anti-aging, improving immune system, alleviating serum cholesterol, reversing hardening of arteries, regulate blood sugar, protecting liver function, improving the development of red blood cells.Dosage: 9 to 30 grams per day.

Vine Essence Capsules is a high potent natural herbal formula used in treatment of arthritis. It is a classical formula which was been used in treatment of emperors since thousand years ago. It can not only reduce the inflammation, relieve joints pain very fast and effect, but also have a great ability of improving the energy level and decreasing fatigue. Moreover, it can restore the immunity system normal function, restricting disordered immunity system attack joints and tissues, and strengthening bone and tendons. It is one of the best natural herbal formula used in treatment of arthritis, practically rheumatoid arthritis. Currently, it has been used in clinics and home remedy very successful. The success rate for treatment of rheumatoid arthritis is over 90%. It is highly recommended by Doctors for treatment of arthritis.

Packing: 30 Capsules / bottle

Ba-Ji-Tian's Latin name is Morindae Officinalis Radix. It has spicy, sweet, and warm properties. It can strengthens the tendons and bones. It is used for rheumatoid arthritis, osteoarthritis, muscle spasms, and lower back pain. It nourishes kidney and Yang. It is used in treatment of impotence, infertility, premature ejaculation, spermatorrhea, irregular menstruation and frequent urination and bedwetting. What more, it can boost immune system as well as strengthen the body’s system that releases hormones. Dosage: 10-15 grams

Does Vine Essence capsules hurt stomach? No, it is absolutely not.

Seals/Symbols

CUSTOMER SATISFACTION GUARANTEED 100% Satisfaction

100% SATISFACTION GUARANTEED MONEY BACK GUARANTEE

Precautions

Caution: Do not use if you are pregnant.

Who can use it? Anyone who has rheumatoid arthritis, rheumatoid pain, weak limbs, osteoarthritis and bone joints pain can use it, except who is pregnant or breastfeeding .

Caution: People with liver or kidney diseases should consult doctor or herbalist before using it.

Do not use it if you are pregnant or breastfeeding.

Suggested/Recommended/Usage/Directions

Direction: 2 capsules 3 times a day.

How long should Vine Essence Capsule be taken? After taking Vine Essence Capsule ten days, the pain of joints and tendons will be relieved a lot, the swollen will be much less. It is necessary taking Vine Essence Capsule two through six months for rheumatoid arthritis and one through three months for osteoarthritis, depending on the individual.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vine Essence Capsules by Kingsway Trading label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vine Essence Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vine Essence Capsules by Kingsway Trading

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Homalomena

70 mg per serving

Japanese Kadsura

70 mg per serving

Morinda

Interacts with
86 drugs
70 mg per serving

Ba Ji Tian is a root used in Traditional Chinese Medicine, mostly to 'tonify the kidneys' and support energy, sexual function, and bone health. Modern...

Morinda monograph & interactions

Fo_ti

Interacts with
1,257 drugs
70 mg per serving

Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair. High-quality human evidence for these be...

Fo_ti monograph & interactions

Ligusticum wallichii

65 mg per serving

Asia Ginseng

50 mg per serving

Pubescent holly

65 mg per serving

Gastrodia

65 mg per serving

Chinese licorice

Interacts with
1,040 drugs
40 mg per serving

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regu...

Chinese licorice monograph & interactions

Spatholobus

70 mg per serving
Interaction report

Vine Essence Capsules by Kingsway Trading Drug Interactions

Vine Essence Capsules contains 10 ingredients, and 3 of them have known drug interactions. Altogether they interact with 1,352 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Vine Essence Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,352Drugs
1,352 Moderate

Ingredients driving the most interactions

Fo_ti 1,257
Chinese licorice 1,040
Morinda 86

Individual Drug Interactions

The ingredients in Vine Essence Capsules interact with 1,352 drugs. Click any drug to see the details.

3 of the 10 ingredients in Vine Essence Capsules interact with drugs. Each result below shows which ingredient is responsible. Fo_ti Chinese licorice Morinda

Each ingredient & the kinds of drugs it affects

For each ingredient in Vine Essence Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fo_ti17 drug types · 1,257 drugs

Anticoagulant/Antiplatelet Drugs

Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery. Theoretically, concomitant use of fo-ti with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients. Until more is known, monitor patients taking fo-ti and drugs that affect bleeding.
Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, fo-ti might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Fo-ti reportedly has hypoglycemic effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fo-ti might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.

Likelihood Probable Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that fo-ti might inhibit CYP1A2. Additionally, in vitro research suggests that the degree of CYP1A2 inhibition depends on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, in an animal study, an aqueous extract of fo-ti inhibited CYP1A2 while an alcoholic extract of fo-ti induced CYP1A2. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.
Animal research suggests that fo-ti might inhibit CYP2B6. One in vitro study suggests that the degree of CYP2B6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C19.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C19. An in vitro study suggests that the degree of CYP2C19 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2C8.
In vitro research suggests that fo-ti might inhibit CYP2C8. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C9. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Animal research suggests that fo-ti might inhibit CYP2D6. Additionally, an in vitro study suggests that the degree of CYP2D6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research suggests that fo-ti might inhibit CYP3A4. One in vitro study suggests that the degree of CYP3A4 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this evidence conflicts with animal research suggesting that fo-ti does not inhibit CYP3A4. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia and cardiotoxicity when taken with digoxin.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia when taken with diuretic drugs.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects and compound diuretic-induced potassium loss. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fo-ti might interfere with hormone replacement therapy through competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Fo-ti has been linked to liver damage in many reports.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of fluid and electrolyte depletion when taken with stimulant laxatives.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. However, in vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.

Likelihood Possible Evidence D
Sulindac (Clinoril)

Theoretically, fo-ti might increase or decrease the levels and clinical effects of sulindac.
Animal research suggests that the type of fo-ti extract might affect the levels of sulindac differently; the raw plant may increase levels, but processed parts may decrease levels. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fo-ti might increase the effects and adverse effects of warfarin.
Fo-ti may have stimulant laxative effects and cause diarrhea, especially when the raw or unprocessed fo-ti root is used. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Also, fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of warfarin. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery.

Likelihood Possible Evidence D
Fo_ti full monograph & interactions

Chinese licorice18 drug types · 1,040 drugs

Antihypertensive Drugs

Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.

Likelihood Possible Evidence B
Cisplatin (Platinol-Aq)

Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.

Likelihood Possible Evidence D
Estrogens

Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.

Likelihood Possible Evidence D
Paclitaxel (Abraxane, Onxol)

Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.

Likelihood Unlikely Evidence D
Chinese licorice full monograph & interactions

Morinda1 drug type · 86 drugs

Antidiabetes Drugs

Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels. Theoretically ba ji tian might have additive effects or attenuate the effects antidiabetes drugs. Monitor blood glucose levels closely; dose adjustments of antidiabetes drugs might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Morinda full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vine Essence Capsules, from the product label.

Kingsway Trading

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Name
Kingsway Trading Inc
Pharmacist Counseling Corner

Vine Essence Capsules by Kingsway Trading: Common Questions

Does Vine Essence Capsules by Kingsway Trading interact with any medications?
Yes. Based on its ingredients, Vine Essence Capsules has a known interaction with 1,352 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vine Essence Capsules contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Go deeper

The Full Monographs Behind Vine Essence Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ba Ji Tian

Interacts with 86 drugs

Ba Ji Tian is a root used in Traditional Chinese Medicine, mostly to 'tonify the kidneys' and support energy, sexual function, and bone health. Modern evidence in humans is very limited, and...

Read the full Ba Ji Tian monograph → Herb & supplement monograph

Fo-ti

Interacts with 1,257 drugs

Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair. High-quality human evidence for these benefits is limited, and processed Fo-ti h...

Read the full Fo-ti monograph → Herb & supplement monograph

Licorice

Interacts with 1,040 drugs

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...

Read the full Licorice monograph →
Sources

Sources & How We Checked

Vine Essence Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ba Ji Tian 2 references
  1. Soon, Y. Y. and Tan, B. K. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43(2):077-085.
  2. Du Y, Zheng Q, Ou ZH, et al. Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis. Braz J Psychiatry 2021;43(3):306-313. PubMed

See these in context on the Ba Ji Tian monograph →

Fo-ti 28 references
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  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Park GJ, Mann SP, Ngu MC. Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol 2001;16:115-7.
  6. But PP, Tomlinson B, Lee KL. Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum. Vet Hum Toxicol 1996;38:280-2.
  7. Oerter Klein KO, Janfaza M, Wong JA, Chang RJ. Estrogen bioactivity in Fo-Ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab 2003;88:4077-9.. PubMed
  8. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  9. UK Medicines and Healthcare Products Regulatory Agency. Polygonum multiflorum and liver reactions. April 2006. Available at: www.mhra.gov.uk/home/idcplg?IdcService= SS_GET_PAGE&useSecondary=true&ssDocName= CON2023590&ssTargetNodeId= 833 (Accessed 10 May 2
  10. Panis B, Wong DR, Hooymans PM, De Smet PA, Rosias PP. Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation. J Pediatr Gastroenterol Nutr 2005;41:256-8. PubMed
  11. Mazzanti G, Battinelli L, Daniele C, et al. New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum. Ann Intern Med 2004;140:E589-90.
  12. Cardenas A, Restrepo JC, Sierra F, Correa G. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol 2006;40:629-32. PubMed
  13. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  14. Laird AR, Ramchandani N, deGoma EM, et al. Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking iron-overload syndrome. J Clin Gastroenterol 2008;42:861-2. PubMed
  15. Jung KA, Min HJ, Yoo SS, et al. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut Liver 2011;5(4):493-9. PubMed
  16. Kang, S. C., Lee, C. M., Choi, H., Lee, J. H., Oh, J. S., Kwak, J. H., and Zee, O. P. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res 2006;20(11):1017-1019. PubMed
  17. Yuen, M. F., Tam, S., Fung, J., Wong, D. K., Wong, B. C., and Lai, C. L. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study. Aliment.Pharmacol.Ther 10-15-2006;24(8):1179-1186. PubMed
  18. Zhang, L., Yang, X., Sun, Z., and Qu, Y. [Retrospective study of adverse events of Polygonum multiflorum and risk control]. Zhongguo Zhong.Yao Za Zhi. 2009;34(13):1724-1729.
  19. Bae, S. H., Kim, D. H., Bae, Y. S., Lee, K. J., Kim, D. W., Yoon, J. B., Hong, J. H., and Kim, S. H. [Toxic hepatitis associated with Polygoni multiflori]. Korean J.Hepatol. 2010;16(2):182-186. PubMed
  20. Furukawa, M., Kasajima, S., Nakamura, Y., Shouzushima, M., Nagatani, N., Takinishi, A., Taguchi, A., Fujita, M., Niimi, A., Misaka, R., and Nagahara, H. Toxic hepatitis induced by show-wu-pian, a Chinese herbal preparation. Intern.Med. 2010;49(15):1537-1 PubMed
  21. McGuffin, M., Hobbs, C., Upton, R., and Goldberg, A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC;1997.
  22. Dong H, Slain D, Cheng J, Ma W, Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complement Ther Med 2014;22(1):70-4. PubMed
  23. Lei X, Chen J, Ren J, et al. Liver damage associated with Polygonum multiflorum Thunb.: a systematic review of case reports and case series. Evid Based Complement Alternat Med 2015;2015:459749.
  24. Ma KF, Zhang XG, Jia HY. CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum. Genet Mol Res 2014;13(3):5637-43. PubMed
  25. Zhang Y, Ding T, Diao T, Deng M, Chen S. Effects of Polygonum multiflorum on the activity of cytochrome P450 isoforms in rats. Pharmazie 2015;70(1):47-54. DOI
  26. Yu J, Xie J, Mao XJ, et al. Comparison of laxative and antioxidant activities of raw, processed and fermented Polygoni multiflori radix. Chin J Nat Med 2012;10(1):63-7. DOI
  27. Shao YL, Ma CM, Wu JM, Guo FC, Zhang SC. Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report. World J Clin Cases 2022;10(27):9921-9928.
  28. Xing Y, Yu Q, Zhou L, et al. Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays. Phytomedicine 2023;112:154710. PubMed

See these in context on the Fo-ti monograph →

Licorice 92 references
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  3. Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
  4. Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
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  7. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
  8. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
  9. Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
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  15. Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
  16. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 2007;46:575-8. PubMed
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See these in context on the Licorice monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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