Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Vital Joint Series Integrity Ingredients & Drug Interactions

by Village Vitality

Vital Joint Series Integrity label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vital Joint Series Integrity against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vital Joint Series Integrity is a dietary supplement by Village Vitality with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 702 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vital Joint Series Integrity by Village Vitality

Ask about any prescription or over-the-counter medication and we check it for interactions with Vital Joint Series Integrity by Village Vitality — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vital Joint Series Integrity by Village Vitality

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “SynovX Performance Proprietary Blend” is a proprietary blend — the label gives one combined amount (490 mg) without saying how much of each component you get.

Vital Joint Series Integrity contains 3 active ingredients. Hesperidin is a flavonoid (a type of plant compound) often studied for joint and cardiovascular health.

Hyal-Joint and Xanthohumol are the other two actives, though we don't have detailed monograph data on them in our system. The capsule also contains inactive ingredients — hydroxypropyl methylcellulose, dicalcium phosphate, ascorbyl palmitate, silica, and medium chain triglyceride oil — which serve as fillers, binders, and preservatives.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy joint fluid and athletic performance.
  • We looked for evidence on: Athletic performance, Joint mobility, Joint flexibility, Joint comfort.
  • The closest evidence on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

Evidence for hesperidin's effectiveness in joint health isn't well established in our data. For cholesterol and obesity, hesperidin rates as possibly ineffective based on available trials.

For nonalcoholic fatty liver disease (NAFLD), there isn't enough reliable evidence to say one way or the other. We don't have effectiveness ratings on file for Hyal-Joint or Xanthohumol, so we can't speak to how well those ingredients work.

The evidence, ingredient by ingredient Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin is generally well tolerated in food amounts and short-term supplement use, but long-term safety data of high quality is limited. During pregnancy, safety information isn't robust enough; the data advises against use.

The same holds for breastfeeding — there isn't enough safety information, so supplements should be avoided. One case of allergic skin reaction was reported in an older woman who applied topical hesperidin methyl chalchone, though she had no known allergies.

Side effects, ingredient by ingredient Hesperidin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 702 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Vital Joint Series Integrity, double-check any blood thinners or antiplatelet drugs you take (warfarin, aspirin, clopidogrel) — moderate risk of increased bleeding. Also flag blood pressure medications, sedating drugs (benzodiazepines), verapamil or diltiazem for heart rhythm, and celiprolol.

All are moderate-severity interactions documented only in animal or theoretical research so far.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking blood thinners, blood pressure medications, sedating drugs, or certain heart medications, check with your pharmacist before adding this to your routine. Avoid it during pregnancy and breastfeeding.

It's generally tolerated short-term, but long-term safety data are sparse.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vital Joint Series Integrity, straight from the product label.

Brand Village Vitality
Barcode (UPC) 871149009564
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 310338
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vital Joint Series Integrity by Village Vitality, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
871149009564
IngredientAmount% DV
Hesperidin0 NP--
Hyal-Joint0 NP--
Xanthohumol0 NP--
SynovX Performance Proprietary Blend490 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Dicalcium Phosphate, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule twice daily, or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Storage: Keep tightly closed in a cool, dry place out of reach of children.

Professional use only

Formulation

Vital Joint Series Integrity is a breakthrough formula designed for active adults who don't want to slow down or reduce their ability to perform athletic tasks - from walking to extreme sports. It promotes healthy joint fluid in synovial membranes, supports joint mobility, and help support cytokine and eicosanoids balance.

Does not contain: Wheat, gluten, corn, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Joint mobility support

Pharmaceutical grade

General Statements

Keep the fluid in your joints healthy just as you would change the oil in your car to get more mileage. Let Vital Joint Series Integrity help you stay active and perform well.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep tightly closed in a cool, dry place out of reach of children.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vital Joint Series Integrity by Village Vitality label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vital Joint Series Integrity label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vital Joint Series Integrity by Village Vitality

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SynovX Performance Proprietary Blend

490 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Dicalcium Phosphate, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vital Joint Series Integrity by Village Vitality Drug Interactions

Want to check YOUR meds against Vital Joint Series Integrity?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
702Drugs
702 Moderate

Ingredients driving the most interactions

Hesperidin 702

Individual Drug Interactions

The ingredients in Vital Joint Series Integrity interact with 702 drugs. Click any drug to see the details.

1 of the 3 ingredients in Vital Joint Series Integrity interact with drugs. Each result below shows which ingredient is responsible. Hesperidin

Each ingredient & the kinds of drugs it affects

For each ingredient in Vital Joint Series Integrity with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vital Joint Series Integrity, from the product label.

Village Vitality

See all Village Vitality products
Name
Village Vitality LLC
Pharmacist Counseling Corner

Vital Joint Series Integrity by Village Vitality: Common Questions

Does Vital Joint Series Integrity by Village Vitality interact with any medications?
Yes. Based on its ingredients, Vital Joint Series Integrity has a known interaction with 702 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vital Joint Series Integrity contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you right now.
Does hesperidin actually help with joint problems?
We don't have effectiveness data on file for how well hesperidin works specifically for joints. The evidence we do hold rates it possibly ineffective for cholesterol and obesity, and insufficient for liver disease. This is an area where the science isn't settled.
What's in the capsule besides the active ingredients?
The capsule contains hydroxypropyl methylcellulose, dicalcium phosphate, ascorbyl palmitate, silica, and medium chain triglyceride oil — these are inactive ingredients that help form, preserve, and stabilize the product.
Is hesperidin safe to use long-term?
It's generally well tolerated in food amounts and short-term supplement use, but high-quality long-term safety data are limited. If you're thinking about using this for weeks or months, ask your pharmacist what's known.
What's Hyal-Joint in this product?
Hyal-Joint is one of the three active ingredients, but we don't have a detailed monograph on it in our system, so we can't tell you much about how it works or its safety profile.
Why are there so many drug interactions listed?
Hesperidin interacts with multiple drug types — blood thinners, blood pressure drugs, sedatives, heart medications, and others. Many of these interactions are based on animal research or theory rather than human evidence, but they're worth checking with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vital Joint Series Integrity label
Go deeper

The Full Monographs Behind Vital Joint Series Integrity’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

Vital Joint Series Integrity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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