Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Vitamin B-12 2500 mcg Berry Blast Ingredients & Drug Interactions

by GNC

Other (e.g. Tea Bag) Category: Vitamin
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Vitamin B-12 2500 mcg Berry Blast is a dietary supplement by GNC with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vitamin B-12 2500 mcg Berry Blast by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: vitamin B12 (2500 mcg per serving), a B vitamin your body needs for nerve function, red blood cell formation, and DNA synthesis. The supplement is flavored and sweetened with several inactive ingredients including isomalt, maltitol syrup, corn syrup solids, modified potato starch, soy lecithin, natural flavors, palm oil, citric acid, malic acid, glycerin, carrageenan, fruit and vegetable juice, and stevia.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy production, metabolism, and neurological function.
  • We looked for evidence on: Fatigue, Cognitive function, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Vitamin B12 deficiency — and 4 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy, Cognitive function, Dementia, Diabetic neuropathy.

The evidence supports vitamin B12's use for Imerslund-Grasbeck disease and B12 deficiency—both rated Effective. It's rated Likely Effective for cyanide poisoning.

For canker sores and postherpetic neuralgia (nerve pain following shingles), the evidence is rated Possibly Effective, meaning some data supports it but more research would strengthen the case.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated, and your body removes excess amounts through your urine, so there's no established upper limit. The most common side effect from injections is mild irritation at the injection site; oral forms rarely cause problems.

Allergic reactions like rash or itching are uncommon but have been reported, and in rare cases may be linked to sensitivity to the cobalt in the B12 molecule. B12 is needed during pregnancy and breastfeeding and is considered safe at recommended amounts—follow your healthcare provider's guidance on dosing.

A very rare complication during correction of certain types of anemia involves a drop in potassium levels, but this is extremely uncommon.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (Glucophage) for diabetes, let your doctor or pharmacist know before you start this supplement—metformin can lower B12 absorption, and they may want to keep an eye on your levels. No other interactions are documented for the B12 in this product; use the search tool to check your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

B12 supplementation works well for established B12 deficiency and certain conditions like cyanide poisoning. If you take metformin for diabetes, check with your doctor or pharmacist before starting—they may want to monitor your levels.

B12 is safe during pregnancy and breastfeeding at normal doses. Run any medications you take through the checker on this page to confirm there are no other interactions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B-12 2500 mcg Berry Blast, straight from the product label.

Brand GNC
Barcode (UPC) 048107118488
Net contents 60 Delicious Soft Chew(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 75178
Product type Vitamin
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B-12 2500 mcg Berry Blast by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Soft Chew(s)
Maximum serving Sizes:
2 Soft Chew(s)
UPC/BARCODE
048107118488
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Sugar0 Gram(s)--
Vitamin B122500 mcg41667%

Other ingredients: Isomalt, Maltitol syrup, Corn Syrup, Solids, modified Potato Starch, Soy Lecithin, Natural Flavors, Palm Oil, Citric Acid, Malic Acid, Glycerin, Carrageenan, Fruit and Vegetable Juice, Stevia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Essential for energy production & metabolism of carbohydrates Supports healthy neurological function Required for proper red blood cell formation

Natural flavor

To ensure a complete nutritional program, take daily with these GNC products: Premium Multivitamin Triple Strength Fish Oil Protein Ultra Probiotic Complex 25

B-12 Soft Chews are a convenient alternative to pills and a great addition to your daily nutrition and health regimen.

Vitamin B-12 is required for energy production and metabolism of carbohydrates. It is also necessary for proper red blood cell formation and is a key nutrient in nerve tissue formation and proper neurological function. In addition, vitamin B-12 may play a role in the maintenance of normal homocysteine levels in the blood. Individually wrapped, great-tasting B-12 Soft Chews are easy to take with you on the go so you can enjoy the many benefits of vitamin B-12 any time.

GNC Quality Commitment For more than 79 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high-quality ingredients and are manufactured under the strictest quality controls.

GNC Guarantee If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store within 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help you live well.

Formulation

Gluten free & sugar free

FDA Statement of Identity

Dietary Supplement

General

CODE 534451 LPG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one to two soft chews daily. For maximum benefits, take as directed every day.

Formula

Contains: Soybeans.

^Adds a dietarily insignificant amount of sugar.

Each delicious, berry-flavored chew has 2,500 micrograms of vitamin B-12, an essential nutrient that provides a variety of important health benefits.

Precautions

Contains: Soybeans.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Seals/Symbols

Gf Gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Vitamin B-12 2500 mcg Berry Blast by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vitamin B-12 2500 mcg Berry Blast by GNC

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Soft Chew(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Vitamin B12

Interacts with
20 drugs
2500 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Isomalt, Maltitol syrup, Corn Syrup, Solids, Modified Potato Starch, Soy Lecithin, Natural Flavors, Palm Oil, Citric Acid, Malic Acid, Glycerin, Carrageenan, Fruit and Vegetable Juice, Stevia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B-12 2500 mcg Berry Blast by GNC Drug Interactions

Want to check YOUR meds against Vitamin B-12 2500 mcg Berry Blast?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B-12 2500 mcg Berry Blast with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
The maker

Brand information

Manufacturer and brand details for Vitamin B-12 2500 mcg Berry Blast, from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
www.gnc.com
Pharmacist Counseling Corner

Vitamin B-12 2500 mcg Berry Blast by GNC: Common Questions

Does Vitamin B-12 2500 mcg Berry Blast by GNC interact with any medications?
Yes. Based on its ingredients, Vitamin B-12 2500 mcg Berry Blast has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B-12 2500 mcg Berry Blast contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
I take metformin for type 2 diabetes. Can I take this B12 supplement?
B12 and metformin do interact, but it's a Minor interaction. Metformin can interfere with B12 absorption, so levels may drop over time with long-term use. This doesn't mean you can't take B12—just talk it over with your doctor or pharmacist first. They may want to check your B12 levels periodically to make sure they stay healthy.
Is this supplement really safe?
Yes, B12 is very safe and well tolerated. Your body removes any excess through urine, so there's no upper limit to worry about. The only common side effect is mild irritation if you get an injection; oral forms almost never cause problems. Allergic reactions like rash are rare.
I'm pregnant. Is it okay to take this?
B12 is considered Likely Safe during pregnancy and is actually needed for healthy pregnancy. Follow your provider's advice on dosing, and include this supplement in the conversation with your doctor or midwife so they can confirm it fits your prenatal care plan.
Can this B12 supplement really help a B12 deficiency?
Yes—B12 supplementation is rated Effective for treating B12 deficiency. If you think you have a deficiency, your doctor can run a blood test to confirm and recommend the right dose and form (oral, injection, or topical) for your situation.
What's in this besides the B12?
The supplement contains several inactive ingredients for flavor, sweetness, and texture: isomalt, maltitol syrup, corn syrup solids, modified potato starch, soy lecithin, natural flavors, palm oil, citric acid, malic acid, glycerin, carrageenan, fruit and vegetable juice, and stevia. If you have sensitivities—especially to soy—check the full list.
Will this help with canker sores or nerve pain?
B12 is rated Possibly Effective for both canker sores and postherpetic neuralgia (nerve pain after shingles), meaning some evidence supports it but more research is needed. It's worth discussing with your doctor if you're considering it for either condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B-12 2500 mcg Berry Blast is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B-12 2500 mcg Berry Blast label
Go deeper

The Full Monographs Behind Vitamin B-12 2500 mcg Berry Blast’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Vitamin B-12 2500 mcg Berry Blast's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring