Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Vitamin D3 1000 IU (25 mcg) Ingredients & Drug Interactions

by MegaFood

Vitamin D3 1000 IU (25 mcg) label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin D3 1000 IU (25 mcg) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin D3 1000 IU (25 mcg) is a dietary supplement by MegaFood with 7 active ingredients. Its ingredients are commonly taken for high blood pressure, exercise and athletic performance, heart and circulation support.Based on those ingredients, 1,078 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Beet, Vitamin D3, Parsley. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vitamin D3 1000 IU (25 mcg) by MegaFood

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D3 1000 IU (25 mcg) by MegaFood — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Vitamin D3 1000 IU (25 mcg) by MegaFood

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Food Blend” is a proprietary blend — the label gives one combined amount (724 mg) without saying how much of each component you get.

This product contains 7 ingredients, including the active Vitamin D3 at 1000 IU (25 mcg) per serving, plus a food blend of beet, carrot, brown rice, broccoli, and parsley. These whole foods provide naturally occurring nutrients and compounds — beet and broccoli contain compounds that affect how your body processes certain drugs, while parsley brings vitamin K and other active constituents.

The inactive ingredients are typical tablet fillers and binders: microcrystalline cellulose, stearic acid, silicon dioxide, rice protein, yeast, autolyzed yeast extract, and hypromellose.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports immune and bone health.
  • We looked for evidence on: Fall prevention, Fractures, Frailty, Corticosteroid-induced osteoporosis, Hyperparathyroidism-related bone loss, Kidney transplant-related bone loss — and 3 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Vitamin D deficiency (Natural Medicines).
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.
  • Also on file: Vitamin D is rated "Possibly Effective" for Hyperparathyroidism-related bone loss.

Vitamin D3 is Effective for treating rickets, osteomalacia (soft bones), renal bone disease, hypoparathyroidism, and familial hypophosphatemia — these are clinical conditions where vitamin D deficiency or metabolism problems exist. For general wellness at this 1000 IU dose, the evidence we hold doesn't establish effectiveness.

Among the food ingredients, beet shows Possibly Effective evidence for athletic performance and exercise-related muscle soreness. The data on the other food components (carrot, brown rice, broccoli, parsley) for any health claim either isn't established or falls into the Insufficient Reliable Evidence category.

The evidence, ingredient by ingredient Beet Carrot Brown Rice Broccoli Parsley Brewer's Yeast Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is well tolerated at recommended doses; toxicity from excessive long-term supplementation is rare but possible. The food ingredients are generally safe when eaten as part of a normal diet.

Beet and broccoli supplements in concentrated form have less safety data than whole foods, so use caution with high doses. Parsley as a culinary herb is fine, but medicinal or large amounts are not advised — concentrated extracts and essential oils carry rare risks of serious effects at very high doses.

Carrot may cause allergic reactions in a small number of people (hives, swelling, respiratory or gastrointestinal symptoms). Brown rice is considered safe as food; the main caution is overall arsenic exposure from frequent rice consumption, which is why varying your grains helps.

No pregnancy or breastfeeding safety data is on file for beet or parsley; carrot, brown rice, and broccoli are likely safe in normal food amounts during pregnancy and lactation, and vitamin D is often used during pregnancy under medical guidance.

Side effects, ingredient by ingredient Beet Carrot Brown Rice Broccoli Parsley Brewer's Yeast Vitamin D

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Beet, Brewer's Yeast, Parsley, Vitamin D, Broccoli.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,079 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.) — parsley carries a Moderate interaction. Diabetes medications and diuretics should be reviewed with your pharmacist, as parsley theoretically lowers blood sugar and affects fluid balance.

If you take heart rhythm drugs like verapamil, diltiazem, or digoxin, or the statin atorvastatin, bring this product to your pharmacist — Vitamin D3 at higher doses can interfere with these. Thiazide diuretics and the immunosuppressant sirolimus also warrant a check.

No interactions are documented for brown rice or carrot, and we could not check the S. cerevisiae ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a whole-food based vitamin D3 supplement, which appeals to people wanting nutrients from recognizable ingredients rather than isolates. If you take blood thinners, heart rhythm drugs, diabetes medications, diuretics, or statin cholesterol drugs, check your specific medications with our tool first — parsley and vitamin D carry documented interactions with these categories.

Brown rice, carrot, and beet are generally gentle; broccoli's enzyme effects matter mainly at higher doses than in a food blend. Talk to your pharmacist if you're pregnant, breastfeeding, or on any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin D3 1000 IU (25 mcg), straight from the product label.

Brand MegaFood
Barcode (UPC) 051494101155
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327587
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin D3 1000 IU (25 mcg) by MegaFood, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
051494101155
IngredientAmount% DV
Beet0 NP--
Carrot0 NP--
Brown Rice0 NP--
Broccoli0 NP--
Parsley0 NP--
Food Blend724 mg--
Vitamin D325 mcg125%
S. cerevisiae0 NP--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Rice Protein, Yeast, Autolyzed Yeast Extract, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Learn about our seals: megafood.com/standards

We believe the most nutritious food comes from healthy soil. Our goal is to partner with farmers who share our commitment to regenerative agriculture, working to nourish the soil for quality ingredients that make for premium supplements.

Seals/Symbols

Tested for 125+ Pesticides & Herbicides Glyphosate Residue Free detoxfreeproject.org Vegetarian Certified B Corporations OK (Kosher) Non GMO Project Verified nongmoproject.org

Formulation

Made without milk, eggs, peanuts, tree nuts, soy, wheat, fish, shellfish and sesame. Tested for 125+ Pesticides & Herbicides Made without 9 food allergens Glyphosate Residue Free detoxfreeproject.org Gluten free Non GMO Project Verified nongmoproject.org

Vegetarian

Supports immune & bone health

Satisfaction guaranteed or your money back.

Formula

OK (Kosher)

Vitamin D3 1000 IU (25 mcg) Plus real food

MegaFood Vitamin D3 1000 IU (25 mcg) promotes healthy immune function and bone health. Vitamin D3 cholecalciferol is more easily absorbed and utilized form of vitamin D.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

MegaFood From farm to tablet

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 1 tablet daily with a beverage. May be taken any time of day, even on an empty stomach.

Precautions

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store tightly sealed in a cool place and avoid exposure to moisture. Once open, consume within three months.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin D3 1000 IU (25 mcg) by MegaFood label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin D3 1000 IU (25 mcg) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin D3 1000 IU (25 mcg) by MegaFood

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Food Blend

724 mg per serving

Vitamin D3

Interacts with
715 drugs
25 mcg per serving Form: Cholecalciferol, Fermented

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Rice Protein, Yeast, Autolyzed Yeast Extract, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin D3 1000 IU (25 mcg) by MegaFood Drug Interactions

Want to check YOUR meds against Vitamin D3 1000 IU (25 mcg)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,078Drugs
9 Major 965 Moderate 104 Minor

Ingredients driving the most interactions

Beet 861
Vitamin D3 715
Parsley 443
Broccoli 187
S. cerevisiae 136

Individual Drug Interactions

The ingredients in Vitamin D3 1000 IU (25 mcg) interact with 1,078 drugs. Click any drug to see the details.

5 of the 7 ingredients in Vitamin D3 1000 IU (25 mcg) interact with drugs. Each result below shows which ingredient is responsible. Beet Vitamin D3 Parsley Broccoli S. cerevisiae

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin D3 1000 IU (25 mcg) with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet full monograph & interactions

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Parsley8 drug types · 443 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.

Likelihood Possible Evidence D
Aspirin

Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.

Likelihood Unlikely Evidence D
Parsley full monograph & interactions

Broccoli2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli full monograph & interactions

S. cerevisiae4 drug types · 136 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.
Brewer's yeast contains tyramine. Taking brewer's yeast with MAOIs might increase the risk for hypertensive crisis.

Likelihood Likely Evidence D
Antidiabetes Drugs

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking chromium-containing brewer's yeast can decrease levels of blood glucose in diabetic patients being treated with antidiabetes drugs.

Likelihood Possible Evidence B
Lithium

Theoretically, taking brewer's yeast with lithium might cause additive effects and side effects.
Some brewer's yeast products contains lithium.

Likelihood Possible Evidence D
Antifungals

Theoretically, taking antifungals with some brewer's yeast products might decrease the effectiveness of brewer's yeast.
Some brewer's yeast products contain live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
S. cerevisiae full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin D3 1000 IU (25 mcg), from the product label.

MegaFood

See all MegaFood products
Name
MegaFood
Street Address
PO Box 5244
City
Manchester
State
NH
ZipCode
03108
Phone Number
800.848.2542
Web Address
MegaFood.com
Pharmacist Counseling Corner

Vitamin D3 1000 IU (25 mcg) by MegaFood: Common Questions

Does Vitamin D3 1000 IU (25 mcg) by MegaFood interact with any medications?
Yes. Based on its ingredients, Vitamin D3 1000 IU (25 mcg) has a known interaction with 1,078 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin D3 1000 IU (25 mcg) contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is parsley in this product the same as parsley I cook with?
Yes, it's the same plant, but here it's dried into a concentrated food blend rather than a fresh culinary herb. The interactions documented are mainly a concern with large medicinal amounts or supplements; the amount in this food blend is much smaller. Still, if you take blood thinners, diabetes meds, or diuretics, mention it to your pharmacist.
Will this turn my poop red?
Red or even dark stools have been reported with beet supplements, but this isn't harmful — it's just the beet pigment passing through your system. It's not a sign of bleeding.
Can I take this while pregnant?
We don't have safety data on file for beet or parsley during pregnancy. Vitamin D, carrot, brown rice, and broccoli are likely safe at normal food amounts, but talk with your doctor or pharmacist before adding any supplement during pregnancy, since it's an individual medical decision.
What does the vitamin D do in this product?
At 1000 IU, vitamin D supports calcium absorption and bone health. This dose is below the tolerable upper limit for daily intake, but is lower than high-dose vitamin D supplements used to treat deficiency diseases like rickets.
Is there anything in this I should avoid if I have a carrot allergy?
Yes — this product contains carrot as an ingredient. People with carrot allergies can have reactions ranging from mild (hives, mouth itching) to severe (swelling of the throat, difficulty breathing). If you have a known carrot allergy, don't use this product.
Does this product have any fillers?
It contains inactive ingredients typical of tablets: microcrystalline cellulose, stearic acid, silicon dioxide, rice protein, yeast, autolyzed yeast extract, and hypromellose. These are the binders and capsule materials that hold the product together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin D3 1000 IU (25 mcg) label
Go deeper

The Full Monographs Behind Vitamin D3 1000 IU (25 mcg)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Carrot

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...

Read the full Carrot monograph → Herb & supplement monograph

Brown Rice

Brown rice is a whole grain that keeps its fiber-rich bran and nutrient-packed germ, making it more nutritious than white rice. As part of a balanced diet, it may support heart health, diges...

Read the full Brown Rice monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Parsley

Interacts with 443 drugs

Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...

Read the full Parsley monograph → Herb & supplement monograph

Brewer's Yeast

Interacts with 136 drugs

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some types of diarrhea. Most other health cla...

Read the full Brewer's Yeast monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph →
Sources

Sources & How We Checked

Vitamin D3 1000 IU (25 mcg)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 87 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
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See these in context on the Beet monograph →

Carrot 14 references
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Brown Rice 1 reference
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See these in context on the Brown Rice monograph →

Broccoli 5 references
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Parsley 21 references
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See these in context on the Parsley monograph →

Vitamin D 26 references
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Brewer's Yeast 6 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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See these in context on the Brewer's Yeast monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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