Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Herbal Sleep Ingredients & Drug Interactions

by MegaFood

Herbal Sleep label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herbal Sleep against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Herbal Sleep is a dietary supplement by MegaFood with 4 active ingredients. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 1,418 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Sensoril Ashwagandha root and leaf extract, organic Valerian root extract, organic Hops flower extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Herbal Sleep by MegaFood

Ask about any prescription or over-the-counter medication and we check it for interactions with Herbal Sleep by MegaFood — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Herbal Sleep by MegaFood

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Herbal Sleep contains 4 active herbal ingredients: organic valerian root extract, organic Sensoril ashwagandha root and leaf extract, organic passion flower extract, and organic hops flower extract. Each is included for its traditional role in supporting sleep and relaxation.

The product also contains inactive ingredients (maltodextrin, hypromellose, rice, rice extract blend, silica, and stearic acid) that serve as fillers, thickeners, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Promotes restful and restorative sleep.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Restless legs syndrome (RLS), Shift work disorder, Pre-procedural anxiety — and 4 related terms.
  • The strongest evidence on file: Valerian is rated "Possibly Effective" for Insomnia (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety, Insomnia.
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress.

Valerian is rated possibly effective for insomnia based on available evidence. Ashwagandha is also rated possibly effective for insomnia, and additionally possibly effective for anxiety and stress.

Passion flower is rated possibly effective for both insomnia and pre-procedural anxiety. Hops, however, has insufficient evidence to rate for insomnia or any of the conditions listed in our data—meaning we don't have enough reliable studies to say whether it works for sleep or not.

The evidence, ingredient by ingredient Valerian Ashwagandha Passion Flower Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Valerian is generally well tolerated short-term, but long-term safety isn't well studied. Common side effects include dizziness, drowsiness, mental slowness, headache, and vivid dreams.

If you stop valerian suddenly after extended use, withdrawal symptoms like increased heart rate, anxiety, and insomnia can occur—taper the dose slowly. Rare cases of liver damage have been reported.

Ashwagandha is generally well tolerated short-term in healthy adults, though quality and long-term safety data are limited; gastrointestinal upset, nausea, and drowsiness are the most common side effects, and rare cases of liver damage and abnormal thyroid effects have been reported. Passion flower is well tolerated short-term and may cause drowsiness, dizziness, or confusion; a rare case of heart rhythm disturbance occurred at high doses.

Hops is generally well tolerated short-term but may cause drowsiness, and long-term safety is not well studied. Valerian, ashwagandha, and passion flower should all be avoided during pregnancy; ashwagandha is rated likely unsafe, while valerian and passion flower are rated possibly unsafe.

None of these ingredients have adequate safety data for breastfeeding, so they should be avoided while nursing.

Side effects, ingredient by ingredient Valerian Ashwagandha Passion Flower Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Hops, Valerian, Passion Flower, Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Herbal Sleep, double-check with your doctor or pharmacist if you take any CNS depressants (sedatives, sleep aids, anesthetics), blood pressure medications, diabetes drugs, thyroid hormones, immunosuppressants, benzodiazepines (like alprazolam or diazepam), or drugs that are broken down by liver glucuronidation pathways. Also avoid alcohol while using this product.

All of these carry Moderate-severity interaction risks with one or more of the ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Herbal Sleep may be worth considering if you're looking for herbal support for sleep and you don't take sedatives, blood pressure medications, diabetes drugs, thyroid hormones, or immunosuppressants. It's generally well tolerated short-term, but long-term safety hasn't been established, and valerian and ashwagandha can cause withdrawal symptoms if stopped abruptly after weeks of use.

If you're pregnant, planning pregnancy, or breastfeeding, don't use this product. Before starting, check your medications with your doctor or pharmacist—especially if you take any prescription sleep aids, anxiety medications, or other CNS depressants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herbal Sleep, straight from the product label.

Brand MegaFood
Barcode (UPC) 051494104026
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 265191
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herbal Sleep by MegaFood, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
051494104026
IngredientAmount% DV
organic Valerian root extract300 mg--
organic Sensoril Ashwagandha root and leaf extract125 mg--
organic Passion Flower extract80 mg--
organic Hops flower extract60 mg--

Other ingredients: Maltodextrin, Hypromellose, Rice, Rice extract blend, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Certified B Corporation Glyphosate Residue Free detoxproject.org Tested 125+ Pesticides & Herbicides OK (Kosher)

Formulation

Vegetarian

Glyphosate Residue free detoxproject.org Tested 125+ pesticides & herbicides Tested Gluten free Dairy free Soy free

Doctor formulated Promotes restful & restorative sleep

Doctor Formulated Tieraona Low Dog, M.D., our Chief Medical Advisor, is an award-winning physician and expert in dietary supplementation, worked with our team to help pair some of her favorite herbs together to promote restful and restorative sleep

Formula

OK (Kosher)

With valerian, ashwagandha, passion flower & hops

MegaFood Herbal Sleep is formulated to provide a sense of relaxation and restorative sleep. Valerian and hops are used to promote restful sleep in those with occasional sleeplessness, while calming passion flower and Sensoril ashwagandha help to release tension.

Brand IP Statement(s)

MegaFood Fresh From Farm to Capsule

Sensoril is a registered trademark of Natreon, Inc.

General Statements

60 servings

We believe that the most nutritious food comes from healthy soils and valued farmers. Our goal is to work with farmers who share our commitment to organic and regenerative agriculture. megafood.com/farmers

Please recycle

To learn about our seals, please visit megafood.com/standards.

FDA Statement of Identity

Herbal Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule, 1-2 hours before bedtime. May be taken on an empty stomach. Recommended to take for at least one week for best results.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

If pregnant, nursing, or you have a health condition, consult your healthcare practitioner before taking this product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herbal Sleep by MegaFood label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herbal Sleep label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herbal Sleep by MegaFood

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Valerian root extract

Interacts with
902 drugs
300 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Organic Valerian root extract monograph & interactions

Organic Sensoril Ashwagandha root and leaf extract

Interacts with
1,372 drugs
125 mg per serving Form: Withanolides

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Organic Sensoril Ashwagandha root and leaf extract monograph & interactions

Organic Passion Flower extract

Interacts with
836 drugs
80 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Organic Passion Flower extract monograph & interactions

Organic Hops flower extract

Interacts with
863 drugs
60 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Organic Hops flower extract monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Rice, Rice extract blend, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herbal Sleep by MegaFood Drug Interactions

Want to check YOUR meds against Herbal Sleep?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,418Drugs
962 Moderate 456 Minor

Ingredients driving the most interactions

organic Sensoril Ashwagandha root and leaf extract 1,372
organic Valerian root extract 902
organic Hops flower extract 863
organic Passion Flower extract 836

Individual Drug Interactions

The ingredients in Herbal Sleep interact with 1,418 drugs. Click any drug to see the details.

4 of the 4 ingredients in Herbal Sleep interact with drugs. Each result below shows which ingredient is responsible. organic Sensoril Ashwagandha root and leaf extract organic Valerian root extract organic Hops flower extract organic Passion Flower extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Herbal Sleep with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Sensoril Ashwagandha root and leaf extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
organic Sensoril Ashwagandha root and leaf extract full monograph & interactions

organic Valerian root extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
organic Valerian root extract full monograph & interactions

organic Hops flower extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
organic Hops flower extract full monograph & interactions

organic Passion Flower extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
organic Passion Flower extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Herbal Sleep, from the product label.

MegaFood

See all MegaFood products
Name
MegaFood
Street Address
PO Box 5244
City
Manchester
State
NH
ZipCode
03108
Phone Number
800-848-2542
Web Address
megafood.com
Pharmacist Counseling Corner

Herbal Sleep by MegaFood: Common Questions

Does Herbal Sleep by MegaFood interact with any medications?
Yes. Based on its ingredients, Herbal Sleep has a known interaction with 1,418 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herbal Sleep contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Herbal Sleep if I'm pregnant or breastfeeding?
No. Valerian, ashwagandha, and passion flower should all be avoided during pregnancy—ashwagandha is rated likely unsafe based on traditional concerns about miscarriage risk. None of these ingredients have enough safety data for breastfeeding either, so avoid them while nursing. Talk with your doctor or pharmacist about safer sleep options during these times.
What are the most common side effects?
Drowsiness, dizziness, and mental slowness are the most common, along with headache, vivid dreams, and gastrointestinal upset. These are generally mild and short-term. If you take valerian or ashwagandha for weeks and then stop suddenly, you may experience withdrawal symptoms like increased heart rate, anxiety, or trouble sleeping—taper the dose slowly instead.
Does this product actually work for sleep?
Valerian, ashwagandha, and passion flower are each rated possibly effective for insomnia based on available research. Hops has insufficient evidence to say whether it helps sleep or not. Results vary from person to person, and it may take a few weeks to notice an effect.
Can I take this with alcohol?
No. Valerian has additive sedative effects with alcohol, meaning the combination can cause excessive drowsiness and impaired thinking. Avoid alcohol while using this product.
What if I suddenly stop taking Herbal Sleep after using it for a while?
Valerian and ashwagandha can cause withdrawal symptoms if stopped abruptly after extended use—such as increased heart rate, anxiety, irritability, insomnia, or vivid dreams. If you've been taking this product for more than a few weeks, taper the dose slowly rather than stopping all at once.
Are there any serious side effects I should watch for?
Rare cases of liver damage (hepatitis or liver failure) have been reported with valerian and ashwagandha. Passion flower at very high doses (over 1500 mg) has been linked to nausea, vomiting, and heart rhythm problems. If you develop yellowing of the skin or eyes, unusual fatigue, dark urine, or abdominal pain, stop the product and contact your doctor right away.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herbal Sleep label
Go deeper

The Full Monographs Behind Herbal Sleep’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Herbal Sleep's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 103 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Valerian 37 references
  1. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
  2. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
  3. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
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Ashwagandha 32 references
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Passion Flower 19 references
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Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
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