Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Women's Probiotic + Prebiotic Ingredients & Drug Interactions

by MegaFood

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Women's Probiotic + Prebiotic is a dietary supplement by MegaFood with 5 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus gasseri, Lactobacillus crispatus, Lactobacillus jensenii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Women's Probiotic + Prebiotic by MegaFood

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Astarte Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 5 active ingredients: a prebiotic fiber called fructooligosaccharides (FOS) and four probiotic bacterial strains — Lactobacillus rhamnosus, L. gasseri, L. crispatus, and L. jensenii. The prebiotic feeds the good bacteria; the probiotics are live microorganisms meant to support your gut and urinary health.

The other ingredients you see listed — microcrystalline cellulose, hypromellose, rice, gum arabic, and sunflower oil — are inactive fillers and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports vaginal and digestive health.
  • We looked for evidence on: Bacterial vaginosis, Constipation, Diarrhea, Irritable bowel syndrome (IBS), Urinary tract infections (UTIs), Bloating — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Crispatus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation, Travelers' diarrhea.
  • Also on file: Lactobacillus Crispatus is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs).

For most uses, we don't have strong enough evidence to rate how well this works. L. crispatus is possibly effective for bacterial vaginosis — that's the clearest evidence we have for any ingredient here.

The other probiotics and the prebiotic are being studied for conditions like diarrhea, colds, UTIs, and hay fever, but the evidence isn't established yet in our data. Talk with your doctor about whether this is right for what you're trying to address.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

FOS (the prebiotic) is generally well tolerated but commonly causes gas, bloating, and abdominal pain, especially at higher doses — though studies show doses under 10 grams daily are usually mild. The probiotic strains are generally well tolerated in healthy adults, but safety data is limited.

Rare side effects from L. crispatus include nausea, gas, flatulence, and very rarely a swollen tongue. Since all the probiotics contain live microorganisms, there's a theoretical concern they could cause infection in people with weakened immune systems or other serious conditions — ask your doctor if that's a concern for you.

Pregnancy and breastfeeding safety data for these ingredients is not on file; talk with your doctor or midwife before using during pregnancy or while nursing.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Lactobacillus Crispatus, Lactobacillus Gasseri, Lactobacillus Jensenii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the key one to watch — Moderate severity. Taking antibiotics at the same time as any of the probiotic strains in this product can reduce the probiotic's effectiveness.

Separate them by a few hours if you can. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a solid probiotic-prebiotic combination for women's health, with the strongest evidence for L. crispatus and bacterial vaginosis. If you're on antibiotics, space them apart from this supplement so the antibiotics don't kill off the live cultures.

Anyone with a weak immune system, serious infection, or who is pregnant or breastfeeding should check with their doctor first. Run your medications through the checker below before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Women's Probiotic + Prebiotic, straight from the product label.

Brand MegaFood
Barcode (UPC) 051494105337
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333196
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, No Allergies, Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Women's Probiotic + Prebiotic by MegaFood, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
051494105337
IngredientAmount% DV
Fructooligosaccharides100 mg--
Lactobacillus rhamnosus0 NP--
Lactobacillus gasseri0 NP--
Lactobacillus crispatus0 NP--
Lactobacillus jensenii0 NP--
Astarte Probiotic Blend0 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Rice, Rice extract, Gum Arabic, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made without milk, eggs, peanuts, tree nuts, soy, wheat, fish, shellfish and sesame.

Tested for 125+ pesticides Glyphosate Residue free detoxproject.org Made without 9 Food Allergens Gluten Free

Supports vaginal & digestive health

Satisfaction guaranteed or your money back.

Vaginal Health Support Addresses concerns associated with vaginal bacterial imbalance. Digestive Regularity ASTARTE probiotic blend is shown to help reduce occasional bloating and constipation. Plus Prebiotic Prebiotics play a role in nourishing healthy bacteria in your gut because gut health = good health

General Statements

Learn more about our seals: megafood.com/standards

Our purpose is to grow a healthier world. This guides everything we do, from environmental impact and employee well-being to sourcing and how we make our products. We work with partners how we make our products. We work with partners who share our commitment to quality ingredients that make for premium supplements. We hope you enjoy this product.

Seals/Symbols

Tested for 125+ pesticides Glyphosate Residue free detoxproject.org Vegetarian Certified B Corporation

Certified Plastic Neutral Product

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

No refrigeration required.

Store tightly sealed in a cool place and avoid exposure to moisture. Once open, consume within three months.

Formula

Women's Probiotic + Prebiotic With Clinically Tested Strains ASTARTE probiotic blend is shown to help reduce occasional bloating and constipation.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 1 capsule per day with food and a beverage.

Precautions

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Brand IP Statement(s)

ASTARTE is a trademark of Chr. Hansen A/S.

See for yourself

Women's Probiotic + Prebiotic by MegaFood label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Women's Probiotic + Prebiotic by MegaFood

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fructooligosaccharides

No known
interactions
100 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Astarte Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Rice, Rice extract, Gum Arabic, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Women's Probiotic + Prebiotic by MegaFood Drug Interactions

Want to check YOUR meds against Women's Probiotic + Prebiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Women's Probiotic + Prebiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus gasseri1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D

Lactobacillus crispatus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L. crispatus.
Lactobacillus crispatus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. crispatus preparations by at least two hours.

Likelihood Probable Evidence D

Lactobacillus jensenii1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L. jensenii.
Lactobacillus jensenii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. jensenii preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Women's Probiotic + Prebiotic, from the product label.

MegaFood

See all MegaFood products
Name
MegaFood
Street Address
PO Box 5244
City
Manchester
State
NH
ZipCode
03108
Phone Number
800.848.2542
Web Address
MegaFood.com
Pharmacist Counseling Corner

Women's Probiotic + Prebiotic by MegaFood: Common Questions

Does Women's Probiotic + Prebiotic by MegaFood interact with any medications?
Yes. Based on its ingredients, Women's Probiotic + Prebiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Women's Probiotic + Prebiotic contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will antibiotics ruin this supplement?
Antibiotics can kill off the live probiotic organisms while you're taking them, which reduces how well the supplement works. So if you're on antibiotics, take them a few hours apart from this probiotic — ask your pharmacist for the best timing for your specific antibiotic.
Can I take this while pregnant?
We don't have enough safety data on these ingredients during pregnancy. Talk with your doctor or midwife before starting it — they can give you personalized advice based on your situation.
What does the prebiotic (FOS) actually do?
FOS is a fiber that feeds the good bacteria in your gut. It's generally well tolerated, but it can cause gas, bloating, and abdominal pain, especially at higher doses. Studies show doses under 10 grams daily tend to be milder.
Is there evidence this works for UTIs?
Not yet — at least not in the strong evidence we have on file. One of the strains, L. crispatus, does have good evidence for bacterial vaginosis, but UTI evidence is still insufficient.
What's in this besides the probiotics and prebiotic?
The inactive ingredients are just fillers and capsule materials — microcrystalline cellulose, hypromellose, rice, gum arabic, and sunflower oil — nothing unusual.
Can I take this if I have a weak immune system?
Check with your doctor first. Since these are live microorganisms, there's a rare theoretical concern they could cause infection in people with weakened immunity — your doctor can tell you whether it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Women's Probiotic + Prebiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Women's Probiotic + Prebiotic label
Sources

Sources & How We Checked

Women's Probiotic + Prebiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Lactobacillus Crispatus 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. DI Pierro F, Criscuolo AA, Dei Giudici A, et al. Oral administration of Lactobacillus crispatus M247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial. Minerva Obstet Gynecol 2021;73(5):621-631. PubMed
  8. DE Leo V, Lazzeri E, Governini L, et al. Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota. Minerva Obstet Gynecol 2022. PubMed
  9. Dellino M, Cascardi E, Laganà AS, et al. Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?. Infect Agent Cancer 2022;17(1):53. PubMed

See these in context on the Lactobacillus Crispatus monograph →

Lactobacillus Jensenii 6 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.

See these in context on the Lactobacillus Jensenii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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