Drug & supplement interaction

Lactobacillus Crispatus + Cefixime

Cefixime brand name: Suprax.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lactobacillus Crispatus has a moderate interaction with Cefixime. Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactobacillus Crispatus and Cefixime

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Cefixime

Cefixime falls under ANTIBIOTIC DRUGS — the group Lactobacillus Crispatus interacts with.

Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L. crispatus.
Lactobacillus crispatus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. crispatus preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Cefixime is an antibiotic, and Lactobacillus crispatus is a live probiotic. The whole point of this probiotic is that the bacteria stay alive once you take them. Since cefixime works by killing bacteria, taking the two at the same time can wipe out a good chunk of those friendly organisms before they ever do their job. So this isn't about cefixime becoming dangerous or weaker. Your antibiotic still works fine. It's the probiotic that loses some of its punch.

The easy fix is timing. Try to space them out by at least two hours so the cefixime isn't sitting in your gut killing off the probiotic. This is a theoretical, common-sense concern rather than a proven problem, so don't worry. Just check with your pharmacist if you're unsure how to schedule them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactobacillus Crispatus Also Interacts With Other Medications

Lactobacillus Crispatus has 181 moderate known drug interactions in our database — the Cefixime one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Cefixime)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Crispatus

Covers the 2,830 medications we’ve checked against Lactobacillus Crispatus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Cefixime

This page covers Lactobacillus Crispatus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefixime page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefixime page

“Cefixime (Suprax) is an oral antibiotic for bacterial infections, and this list of 60 supplements and herbs deserves a careful read, because three entries are rated major. Siberian cocklebur and asarabacca can both damage the kidneys, and activated charcoal can soak up the antibiotic in your gut so less of it reaches your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Cefixime interaction page

One more smart check

Taking Lactobacillus Crispatus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 48 real supplement products containing Lactobacillus Crispatus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Crispatus. Your product may carry other ingredients that interact with Cefixime too, on top of Lactobacillus Crispatus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Crispatus and Cefixime Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Crispatus
Steady interest

#1,076 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefixime
Top 25%

#435 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactobacillus Crispatus

What is Lactobacillus Crispatus?

  • Vaginal health support
  • Preventing recurrent bacterial vaginosis
  • Reducing recurrent urinary tract infections
  • Yeast infection support
  • General microbiome balance

Lactobacillus crispatus is a 'good' bacterium that naturally dominates a healthy vaginal microbiome and is sold as a probiotic, mainly for vaginal and urinary health. Early research is promising for preventing recurrent bacterial vaginosis and urinary tract infections, but evidence is still limited and product quality varies. Talk with your pharmacist or doctor before using it, especially if you are pregnant or have a weakened immune system.

Read the full Lactobacillus Crispatus monograph & all interactions
Medication

About Cefixime

What Is Cefixime Used For?

Brand name: Suprax

Cefixime treats several bacterial infections in adults and children six months and older. These include uncomplicated urinary tract infections (UTIs), otitis media (ear infections), pharyngitis and tonsillitis (strep throat and tonsil infections), acute exacerbations of chronic bronchitis (sudden worsening of ongoing bronchitis), and uncomplicated gonorrhea (cervical or urethral).

Cefixime tablets are indicated only for adults and children weighing more than 45 kg or older than 12 years, and tablets are not approved for otitis media — ear infections must be treated with the oral suspension or, where available, chewable tablets. Cefixime oral suspension and capsules are approved for the same infections across the full pediatric age range (six months and older).

See full Cefixime drug information
Keep checking

Other Drugs & Lactobacillus Crispatus

Browse every other medication we’ve checked against Lactobacillus Crispatus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactobacillus Crispatus page.

No interaction 2,648 drugs checked — show the list

We also checked Lactobacillus Crispatus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactobacillus Crispatus list.

See the full Lactobacillus Crispatus interactions page
See every supplement checked against Cefixime, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactobacillus Crispatus monograph › Uses, safety, and every drug interaction in one place Cefixime supplement interactions › Every supplement checked against Cefixime, ranked by severity Cefixime drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactobacillus Crispatus and Cefixime Together: Common Questions

Can you take Lactobacillus Crispatus with Cefixime?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactobacillus Crispatus and Cefixime interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cefixime and Lactobacillus Crispatus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.