Vitamin D3 5000 Orange Flavor Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Vitamin D3 5000 Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vitamin D3 5000 Orange Flavor is a dietary supplement by Nordic Naturals with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vitamin D3 5000 Orange Flavor by Nordic Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D3 5000 Orange Flavor by Nordic Naturals — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of Vitamin D3 5000 Orange Flavor by Nordic Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin D3, a form of vitamin D your body uses to regulate calcium and phosphate, support bone and immune health, and maintain normal muscle function. The softgel is filled with organic extra virgin olive oil and also contains D-Alpha-Tocopherol (a form of vitamin E), natural orange flavor, and rosemary extract as supporting ingredients, with a soft gel capsule made from gelatin.
Does it work?
Strong evidence
Vitamin D3 is rated effective for treating bone and mineral disorders: familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease linked to kidney failure), rickets (childhood bone disease), and hypoparathyroidism (low parathyroid hormone). The evidence we hold does not cover whether it works for general bone health, immune support, or other uses people sometimes take vitamin D for.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses, but the safety notes emphasize that very high doses taken over time can cause vitamin D toxicity. Symptoms of toxicity include high blood calcium (hypercalcemia) with signs like bone loss in adults and slowed growth in children, eye inflammation and light sensitivity, and in rare cases, kidney or blood abnormalities.
During pregnancy and breastfeeding, vitamin D is often used at recommended amounts, but the data advises using it only under your doctor's guidance and not taking higher amounts without checking first.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you take digoxin (Lanoxin) or any heart rhythm medication, thiazide diuretics or other blood pressure pills, verapamil (Calan) or diltiazem (Cardizem), atorvastatin (Lipitor) or other cholesterol drugs, calcipotriene (Dovonex) for psoriasis, or aluminum-containing antacids. These are the main medication types documented to interact with high-dose vitamin D.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Vitamin D3 is effective for specific bone and mineral disorders when prescribed by a doctor. Because this dose is higher than standard recommendations and interacts with heart, blood pressure, and cholesterol medications, it's not a casual supplement — check with your pharmacist before starting, especially if you take digoxin, calcium-channel blockers, thiazide diuretics, or atorvastatin.
Don't exceed the tolerable upper limit of 4000 IU daily without medical supervision.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vitamin D3 5000 Orange Flavor, straight from the product label.
| Brand | Nordic Naturals |
|---|---|
| Barcode (UPC) | 768990015038 |
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 221684 |
| Product type | Vitamin |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vitamin D3 5000 Orange Flavor by Nordic Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D3 | 125 mcg | 625% |
Other ingredients: organic extra virgin Olive Oil, Soft Gel Capsule, D-Alpha-Tocopherol, Vitamin D3, natural Orange flavor, Rosemary extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Surpasses the daily value for Vitamin D
Nordic Naturals products are never sold under any store brand.
Great taste Please recycle this container
Formula
Vitamin D has long been known for its important role in regulating calcium and phosphorus levels, and increasing mineralization in the bones. Nordic Naturals Vitamin D3 5000 is cholecalciferol, the natural, most easily absorbed and utilized form of vitamin D. Each serving provides 5000 IU of vitamin D3 in organic extra virgin olive oil.
5000 IU D3
Precautions
Note: People consuming more than 2000 IU per day should have their vitamin D blood levels monitored by a health care professional.
Do not take if tamper-evident seals is broken or missing.
Keep out of the reach of children.
Suggested/Recommended/Usage/Directions
Suggested Use: One soft gel daily, with food, or as directed by your health care professional or pharmacist.
Storage
Store in a cool, dry place, away from sunlight.
Brand IP Statement(s)
Product protected by U.S. patent #s 6346231 & 6641837.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Bone health Positive mood Healthy immunity
Supports healthy bones, mood, and immune system function
No gluten, milk derivatives, or artificial color or flavors.
Non GMO
Seals/Symbols
Non GMO Verified
Third-Party Purity Tested
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vitamin D3 5000 Orange Flavor by Nordic Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vitamin D3 5000 Orange Flavor by Nordic Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsOther (inactive) ingredients: Organic extra virgin Olive Oil, Soft Gel Capsule, D-Alpha-Tocopherol, Vitamin D3, Natural Orange flavor, Rosemary extract. These complete the product’s ingredient list but are not active constituents.
Vitamin D3 5000 Orange Flavor by Nordic Naturals Drug Interactions
HelloPharmacist Interaction Report
Vitamin D3 5000 by Nordic Naturals does interact with several medication types, and the concern centers on high-dose vitamin D raising calcium levels in your blood (hypercalcemia).
The most serious documented interaction is with digoxin (Lanoxin), a heart rhythm medication — high-dose vitamin D can trigger dangerously high calcium, which increases the risk of life-threatening arrhythmias when you're on digoxin. This is rated Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
Other moderate interactions include thiazide diuretics (water pills that lower blood pressure), which can worsen high calcium levels if combined with high-dose vitamin D. Calcium-channel blockers — verapamil (Calan) and diltiazem (Cardizem) — may lose effectiveness if vitamin D raises your calcium too much.
Atorvastatin (Lipitor) absorption may drop by up to 55% in one small study. Calcipotriene (Dovonex), a vitamin D-like topical psoriasis treatment, also raises the risk of high calcium.
Additionally, aluminum absorption could theoretically increase with vitamin D, though this has only been observed in people with kidney failure. A minor interaction exists with certain drugs your liver metabolizes (CYP3A4 substrates).
Although 5000 IU is higher than the standard recommendation of 600–800 IU daily for most adults, the tolerable upper limit is 4000 IU daily — and this product exceeds that. If you take any heart medication, blood pressure pills, cholesterol medication, or use topical psoriasis treatments, run your exact medications through the checker below before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vitamin D3 5000 Orange Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vitamin D3 5000 Orange Flavor interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in Vitamin D3 5000 Orange Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Atorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D3 + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with Vitamin D3 5000 Orange Flavor — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vitamin D3 5000 Orange Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Vitamin D3 5000 Orange Flavor, from the product label.
Nordic Naturals
See all Nordic Naturals products- Name
- Nordic Naturals, Mfg.
- Street Address
- 111 Jennings Drive
- City
- Watsonville
- State
- CA
- ZipCode
- 95076
- Phone Number
- 800-662-2544
- Web Address
- nordicnaturals.com
Vitamin D3 5000 Orange Flavor by Nordic Naturals: Common Questions
Does Vitamin D3 5000 Orange Flavor by Nordic Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is 5000 IU of vitamin D3 safe to take daily?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects of vitamin D3?
What is vitamin D3 used for?
Does the orange flavor or other inactive ingredients affect how it works?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vitamin D3 5000 Orange Flavor is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vitamin D3 5000 Orange Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Vitamin D3 5000 Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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