Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

WholeMune Ingredients & Drug Interactions

by Ortho Molecular Products

WholeMune label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking WholeMune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

WholeMune is a dietary supplement by Ortho Molecular Products with 2 active ingredients. Its ingredients are commonly taken for immune support, cold and flu prevention, digestive and gut health.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Larch Arabinogalactan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against WholeMune by Ortho Molecular Products

Ask about any prescription or over-the-counter medication and we check it for interactions with WholeMune by Ortho Molecular Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of WholeMune by Ortho Molecular Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

WholeMune has 2 active ingredients. Larch arabinogalactan is a prebiotic fiber derived from larch tree wood; it's meant to support gut health and immune function.

Bakers yeast extract is included for its potential immune-supporting properties. The capsules also contain several inactive ingredients: microcrystalline cellulose, stearic acid, magnesium stearate, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Larch Arabinogalactan's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune support.
  • We looked for evidence on: Common cold, Immune function, Immune response, Respiratory health.
  • The closest evidence on file: Larch Arabinogalactan is rated "Insufficient Reliable Evidence To Rate" for Common cold (Natural Medicines).

The evidence we have doesn't establish that larch arabinogalactan reliably helps with either the common cold or high cholesterol. The effectiveness ratings for both uses show insufficient evidence—meaning the research so far hasn't been strong enough to say whether it actually works.

We hold no effectiveness data for Bakers yeast extract in this product.

The evidence, ingredient by ingredient Larch Arabinogalactan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Larch arabinogalactan is generally well tolerated as a fiber, though long-term safety data are limited. Some people do experience bloating and flatulence.

Because safety data aren't extensive, the manufacturer advises caution and recommends you talk with your doctor before taking it, especially if you have any underlying health concerns. We have no pregnancy or breastfeeding safety information on file for either ingredient in this product, so check with your pharmacist or doctor if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Larch Arabinogalactan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Larch Arabinogalactan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take immunosuppressant medications—azathioprine, cyclosporine, tacrolimus, mycophenolate, or others used after transplant or for autoimmune disease—check with your pharmacist before adding WholeMune. The larch arabinogalactan may reduce how well your immunosuppressant works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

WholeMune is a simple two-ingredient immune-support supplement. It's not proven to prevent colds or lower cholesterol, and it might interfere with immunosuppressant medications.

If you take drugs to suppress your immune system, skip this one or talk with your doctor first. For everyone else, the biggest consideration is tolerating the fiber—some people get bloating.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about WholeMune, straight from the product label.

Brand Ortho Molecular Products
Barcode (UPC) 615033004996
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2018
DSLD ID 174303
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for WholeMune by Ortho Molecular Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
615033004996
IngredientAmount% DV
Larch Arabinogalactan85 mg--
Bakers Yeast extract250 mg--

Other ingredients: natural Vegetable Capsules, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Professional Strength: Not for sale through Amazon.com

Learn more

Immune health

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule per day or as recommended by your health care professional.

Formulation

Formulated To Be Free Of Allergens Derived From: Gluten, corn, yeast, artificial colors and flavors.

Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Do not accept if label shows signs of tampering

Storage

Keep container tightly closed. Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Vcaps

General

Product #499030 Label ID L-OMP100-499030-C V1

Brand IP Statement(s)

FiberAid wellmune wgp

VitaSecure

Because efficacy matters

FiberAid is a trademark of Lonza Inc. Wellmune WGP is a trademark of Biothera Inc.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

WholeMune by Ortho Molecular Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

WholeMune label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in WholeMune by Ortho Molecular Products

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Larch Arabinogalactan

Interacts with
121 drugs
85 mg per serving

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

Larch Arabinogalactan monograph & interactions

Bakers Yeast extract

250 mg per serving Form: Beta-Glucan

Other (inactive) ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

WholeMune by Ortho Molecular Products Drug Interactions

Want to check YOUR meds against WholeMune?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Larch Arabinogalactan 121

Individual Drug Interactions

The ingredients in WholeMune interact with 121 drugs. Click any drug to see the details.

1 of the 2 ingredients in WholeMune interact with drugs. Each result below shows which ingredient is responsible. Larch Arabinogalactan

Each ingredient & the kinds of drugs it affects

For each ingredient in WholeMune with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Larch Arabinogalactan1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Larch Arabinogalactan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for WholeMune, from the product label.

Ortho Molecular Products

See all Ortho Molecular Products products
Name
Ortho Molecular Products, Inc.
Street Address
1991 Duncan Place
City
Woodstock
State
IL
ZipCode
60098
Web Address
OrthoMolecularProducts.com
Pharmacist Counseling Corner

WholeMune by Ortho Molecular Products: Common Questions

Does WholeMune by Ortho Molecular Products interact with any medications?
Yes. Based on its ingredients, WholeMune has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
WholeMune contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will WholeMune help prevent colds or cut short the ones I get?
The evidence we have isn't strong enough to say. Larch arabinogalactan has been studied for that, but we don't yet have reliable proof it works.
Can this supplement help with high cholesterol?
Not based on the evidence we hold. Larch arabinogalactan's effectiveness for lowering cholesterol is rated as insufficient—meaning the research hasn't established whether it does.
What are the side effects I should know about?
Most people tolerate it well. The main ones to watch are bloating and flatulence, since larch arabinogalactan is a fiber. If you're not used to fiber supplements, start slowly and increase gradually.
Is it safe to take while pregnant or breastfeeding?
We don't have enough safety data on either ingredient to say either way. Talk with your doctor or pharmacist for personalized advice before taking it.
What's in this supplement besides the active ingredients?
The capsules contain microcrystalline cellulose, stearic acid, magnesium stearate, and silicon dioxide—all standard inactive ingredients that help hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if WholeMune is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

WholeMune label
Go deeper

The Full Monographs Behind WholeMune’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph →
Sources

Sources & How We Checked

WholeMune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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