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Dietary supplement

Wild Yam Root 700 mg Ingredients & Drug Interactions

by Nature's Way

Wild Yam Root 700 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam Root 700 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam Root 700 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam Root 700 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam Root 700 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam Root 700 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild yam root at 700 mg per capsule. Wild yam has been used traditionally for various female health concerns, though the evidence for most uses is limited or weak.

The capsule also contains hypromellose and magnesium stearate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Wild Yam's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Women's traditional health support.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Premenstrual syndrome (PMS), Postmenopausal conditions, Hormone balance, Menstrual health — and 1 related terms.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions, Premenstrual syndrome (PMS), Dysmenorrhea.

The evidence for wild yam is mixed and sparse. For menopausal symptoms — probably its most common use — it's rated possibly ineffective based on available data.

For gallbladder disease, sexual dysfunction, period pain, and infertility, there isn't enough reliable evidence to say whether it works or not. If you're considering this for a specific condition, talk with your pharmacist or doctor about what the science actually supports.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, wild yam is generally well tolerated. The most common side effects are fever, headache, upset stomach, and vomiting — and headache and fever can be worse at higher doses.

Anaphylaxis is rare but serious. The safety data advises against use during pregnancy and while breastfeeding; there isn't enough information to know it's safe in those situations.

For short-term use in otherwise healthy adults, it's likely fine, but we don't have good long-term safety data.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take estrogens — whether birth control, hormone replacement therapy, or any other estrogen-containing medication — check your specific drug with the tool on this page. Wild yam might interfere with how well your estrogen works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Wild yam might be worth considering if you're exploring options for menopausal symptoms or other female health concerns, but the evidence that it actually works is weak. If you're on any estrogen-based medication or hormone therapy, check with your pharmacist first.

Pregnancy and breastfeeding are reasons to skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam Root 700 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674178706
Net contents 100 Vegan Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328088
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam Root 700 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
033674178706
IngredientAmount% DV
Wild Yam700 mg--

Other ingredients: Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Women's traditional health support

Wild Yam Root 700 MG per 2-capsule serving

Formulation

Made with the quality you trust Botanicals are sourced where they grow best

Gluten free. No wheat, corn, soy, dairy, gelatin, or artificial colors or flavors.

Bottled and tested in the USA

V Vegan Gelatin free

V Vegan Gelatin free

Women's traditional health support Plant powered

Non GMO Project Verified nongmoproject.org

General Statements

Explore more products at naturesway.com

Questions: 1-800-962-8873 / naturesway.com 50% Bottle made from 50% post-consumer recycled plastic

Brand IP Statement(s)

Copyright 2024 Nature's Way Brands, LLC

Seals/Symbols

V Vegan Gelatin free

Non GMO Project Verified nongmoproject.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 2 capsules daily, preferably with food.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam Root 700 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam Root 700 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam Root 700 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Wild Yam

Interacts with
41 drugs
700 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam Root 700 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Wild Yam Root 700 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam 41

Individual Drug Interactions

The ingredients in Wild Yam Root 700 mg interact with 41 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Yam Root 700 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Yam

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam Root 700 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam Root 700 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Wild Yam Root 700 mg by Nature's Way: Common Questions

Does Wild Yam Root 700 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Wild Yam Root 700 mg has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam Root 700 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will wild yam help with my hot flashes and night sweats?
The evidence suggests it's probably not effective for menopausal symptoms like hot flashes and night sweats. If you're looking for relief, talk with your doctor about options with better-supported research behind them.
What are the most common side effects?
Fever, headache, upset stomach, and vomiting are the most common. Headache and fever can be worse if you take higher doses. Most people don't experience side effects, but they can happen.
Is it safe to take long-term?
Short-term use in healthy adults is likely fine, but we don't have good safety data for long-term use. If you're thinking about taking it regularly, check with your pharmacist or doctor first.
Can I take this while I'm pregnant or breastfeeding?
No — there isn't enough safety data for either situation. The safety data advises against use during pregnancy and while breastfeeding, so you should skip it in both cases.
What is wild yam actually used for?
Traditionally it's been used for menopausal symptoms, sexual dysfunction, period pain, gallbladder disease, and infertility. Unfortunately, the evidence for most of these uses is limited or not established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam Root 700 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam Root 700 mg label
Go deeper

The Full Monographs Behind Wild Yam Root 700 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam Root 700 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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