Women's Wellness Vaginal & Urinary Complete Ingredients & Drug Interactions
by Renew Life
What is this page for?
First and foremost: checking Women's Wellness Vaginal & Urinary Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Women's Wellness Vaginal & Urinary Complete is a dietary supplement by Renew Life with 4 active ingredients. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 714 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry Concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Women's Wellness Vaginal & Urinary Complete by Renew Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Women's Wellness Vaginal & Urinary Complete by Renew Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Women's Wellness Vaginal & Urinary Complete by Renew Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 4 active ingredients designed to support urinary and vaginal health. Three of them are live probiotics — Bifidobacterium lactis BB-12, Lactobacillus reuteri RC-14, and Lactobacillus rhamnosus GR-1 — which are beneficial bacteria meant to promote healthy vaginal and urinary flora.
The fourth active is cranberry whole fruit extract, a concentrated form of the fruit commonly used for urinary tract support. The capsule itself contains inactive ingredients like microcrystalline cellulose (a filler), hypromellose (a capsule material), pectin, gellan gum, and plant-based extracts from rice and bamboo, which serve as binders and flow agents but have no therapeutic role.
Does it work?
Moderate evidence
Cranberry extract is possibly effective for urinary tract infections (UTIs) based on the evidence we have on file. For other conditions listed — age-related cognitive decline, benign prostatic hyperplasia, cancer, fatty liver disease, and chronic fatigue — the evidence is insufficient to say whether cranberry works.
We hold no effectiveness data for the probiotic ingredients in this product, so we can't speak to what research says about their role in vaginal or urinary health from our facts alone.
How safe is it?
Well-documented data
Cranberry is likely safe during pregnancy and lactation. Orally, it's generally well tolerated, but the most common side effects are diarrhea and gastrointestinal discomfort — especially at higher doses.
In very large amounts (3-4 liters of juice daily), it can cause significant stomach upset and diarrhea, particularly in young children. Nausea, vomiting, and abdominal discomfort have been reported even at moderate doses.
One person reported skin redness and itching. Because concentrated supplement doses haven't been well studied, talk with your doctor or pharmacist before starting, especially if you have a sensitive stomach or are taking other medications.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take any CYP3A4 substrates (a large group of medications metabolized through a specific liver enzyme), cholesterol drugs like atorvastatin, blood thinners like warfarin, blood pressure medications like nifedipine, or pain relievers like diclofenac — the cranberry extract may increase their levels and side effects. The three probiotic ingredients have no documented interactions in our data, but we have not checked them.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're looking for cranberry and probiotic support for urinary health, and the evidence supports cranberry's use for UTIs. However, cranberry interacts with several common medications — especially blood thinners, cholesterol drugs, and blood pressure medications — so check with your doctor or pharmacist first if you take any of those.
If you have a history of stomach upset, be aware that gastrointestinal discomfort is a common side effect.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Women's Wellness Vaginal & Urinary Complete, straight from the product label.
| Brand | Renew Life |
|---|---|
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 306966 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Female (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Women's Wellness Vaginal & Urinary Complete by Renew Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bifidobacterium lactis BB-12 | 0 NP | -- |
| Cranberry Whole Fruit Extract | 0 NP | -- |
| Lactobacillus reuteri RC-14 | 0 NP | -- |
| Lactobacillus rhamnosus GR-1 | 0 NP | -- |
| Cranberry Concentrate | 500 mg | -- |
| Women's Support Probiotic Blend | 66 mg | -- |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Pectin, Gellan Gum, Rice extract Blend, Bamboo Extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Science backed women focused
We formulate with Multiple diverse strains Clinically tested strains
Probiotics with cranberry Targeted probiotic Clinically studied level of cranberry to support urinary tract health
Female-focused probiotic strains scientifically proven to support women's health Clinically studied level of cranberry to support urinary tract health Guaranteed live cultures
Formulation
Potency through expiration
Delayed-release vegetarian capsules.
Supports vaginal health & pH balance
Non GMO Project Verified nongmoproject.org
Potency, quality and purity guaranteed through expiration.
Gluten free Dairy free Soy free
Our promise to you Feel the difference or your money back. Terms and conditions may apply. Call 1-800-830-1800.
Made in the USA of global ingredients.
Helps balance yeast and bacteria to support a healthy vaginal microbiome Digestive and immune support
General Statements
Feeling gutsy for 25 years and counting. Join us.
Questions or comments? 1-800-830-1800 or www.renewlife.com
FDA Statement of Identity
Probiotic Supplement
Seals/Symbols
Non GMO Project Verified nongmoproject.org
Suggested/Recommended/Usage/Directions
Directions: For best results, take two (2) capsules daily, with or without food.
Storage
Store at 77 degrees F (25 degrees C) or below. Best if refrigerated.
Precautions
Keep out of reach of children.
Consult your physician prior to using this product if you are pregnant, nursing, taking any medication or have a medical condition.
Tamper Evident: Do not use if safety seal on bottle is broken or missing.
Brand IP Statement(s)
BB-12, GR-1, and RC-14 are trademarks of Chr. Hansen A/S. Copyright 2022
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Women's Wellness Vaginal & Urinary Complete by Renew Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Women's Wellness Vaginal & Urinary Complete by Renew Life
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Cranberry Concentrate
Interacts with714 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry Concentrate monograph & interactionsWomen's Support Probiotic Blend
- › Bifidobacterium lactis BB-12
- › Lactobacillus reuteri RC-14
- › Lactobacillus rhamnosus GR-1
Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Pectin, Gellan Gum, Rice extract Blend, Bamboo Extract. These complete the product’s ingredient list but are not active constituents.
Women's Wellness Vaginal & Urinary Complete by Renew Life Drug Interactions
HelloPharmacist Interaction Report
Women's Wellness Vaginal & Urinary Complete by Renew Life contains cranberry extract, which interacts with a number of medications.
The main concern is with drugs that your liver metabolizes through a particular enzyme pathway (CYP3A4 substrates) — cranberry may raise their levels in your bloodstream and increase side effects. The most serious documented case involved a patient taking atorvastatin (a cholesterol drug) who developed muscle breakdown and liver problems after drinking concentrated cranberry juice daily for 2 weeks.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also theoretically affects blood thinners like warfarin, though the evidence is mixed — some case reports link it to bleeding risk, while other studies don't confirm it. It may also interact with calcium channel blockers used for high blood pressure (like nifedipine) and with certain pain relievers like diclofenac, though those interactions are considered minor and less well proven in real patients.
We could not check the three probiotic ingredients in this product — Bifidobacterium lactis BB-12, Lactobacillus reuteri RC-14, and Lactobacillus rhamnosus GR-1 — because we hold no interaction data for them. Altogether, these interactions span 713 individual medications.
Before you start this supplement, run your exact medications through the interaction checker on this page, and talk it over with your doctor or pharmacist if you take any blood thinners, cholesterol drugs, blood pressure medications, or pain relievers.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Women's Wellness Vaginal & Urinary Complete?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Women's Wellness Vaginal & Urinary Complete interact with 714 drugs. Click any drug to see the details.
1 of the 4 ingredients in Women's Wellness Vaginal & Urinary Complete interact with drugs. Each result below shows which ingredient is responsible. Cranberry Concentrate
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acalabrutinib interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Women's Wellness Vaginal & Urinary Complete — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Women's Wellness Vaginal & Urinary Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry Concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Women's Wellness Vaginal & Urinary Complete, from the product label.
Renew Life
- Name
- Renew Life Formulas, LLC
- City
- Durham
- State
- NC
- ZipCode
- 27701
- Phone Number
- 1-800-830-1800
- Web Address
- www.RenewLife.com
Women's Wellness Vaginal & Urinary Complete by Renew Life: Common Questions
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The Full Monographs Behind Women's Wellness Vaginal & Urinary Complete’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Women's Wellness Vaginal & Urinary Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC